Marriott D, Harkness J; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 361 (abstract no. 2031).
Microbiology Department, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia
OBJECTIVE: To quantitate C.albicans (C.a) in the oral cavity of HIV-infected men with and without oropharyngeal candidiasis (opc). METHODS: 382 men with no evidence of opc and who were not receiving antifungal therapy and 40 patients (pts) with opc gargled with 10ml of sterile distilled water. 0.1 ml was plated on to Sabouraud's agar and the number of colony-forming units (cfu)/ml was calculated. C.a was identified by standard methods. RESULTS: 104 of 382 men (27%) with a normal oropharynx had no C.a isolated. The count in the remaining 278 ranged from 10-44,000 cfu/ml (median 160 cfu/ml; mean 848 cfu/ml), and was greater than 1000 cfu/ml in 33 samples (12%). Of 39 pts with dentures but no clinical evidence of opc, 8 (20.5%) had 0 cfu/ml, with counts of 31 pts ranging from 10-7,000 cfu/ml median 250 cfu/ml; mean 782 cfu/ml). In 40 symptomatic pts examined the yeast count was 10-30,000 cfu/ml (median 2420 cfu/ml; mean 6409 cfu/ml). The difference in cfu/ml between asymptomatic and symptomatic pts was significant (p less than 0.0001, unpaired Student's t-test). CONCLUSION: This study has shown that there is considerable overlap in yeast counts between asymptomatic men those with opc, although there is a significant trend towards higher counts in symptomatic pts. Thus the diagnosis of opc remains a clinical diagnosis with a low yeast count not excluding the disease and a high yeast count found in HIV-infected individuals with a normal oropharynx.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Candida albicans
- Candidiasis
- Gastrointestinal Diseases
- HIV Infections
- HIV Seropositivity
- Humans
- Male
- Mouth
- Oropharynx
- Respiratory Tract Infections
Other ID:
UI: 102197038
From Meeting Abstracts