Kaplan RM, Anderson JP, Patterson TL, McCutchan A, Weinrich JD, Heaton RK, Atkinson JH, Chandler J, Grant I; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 72 (abstract no. TU.D.61).
the HNRC Group, Naval Hospital, San Diego, CA, USA
OBJECTIVE: This paper offers a method for capturing the diverse outcomes of HIV disease. The Quality of Well-being Scale (QWB) combines preference-weighted measures of symptoms and functioning to provide a numerical point-in-time expression of well-being that ranges from zero (0) for death to one (1.0) for asymptomatic optimal function---i.e., higher scores represent better health. In the General Health Policy Model, QWB inputs are integrated with terms for the number of people affected and the duration of time affected to produce the output measure, which is known as the "well-year". METHODS: This study reports data for 86 male adults in three categories: CDC IV, CDC II/III, and gay male control. The QWB as well as a variety of neuropsychological and biochemical measures were administered to all participants. RESULTS: The CDC IV group scored about .74 on the 0 to 1.0 scale. When QWB was broken down by HIV grouping, the CDC IV group significantly differed from the CDC II/III groups and the control groups. The differences between the Class IV and Class II/III is about .07 units of well being, suggesting that individuals lose 7/100 equivalents of well years of life for each year they are in the AIDS category in comparison to the asymptomatic groups. In comparison to the controls, this would equal a one year of life loss for each 14 infected individuals. The QWB was shown to be significantly associated with CD4+ lymphocytes (p less than .01), clinician ratings neuropsychological impairment (p less than .04), neurologists ratings of dysfunction (p less than .03) and several psychiatric variables including POMS scores for vigor (p less than .001) and depression (p less than .001). Multivariate models are used to adjust for covariation between predictors of QWB. CONCLUSION: We conclude that the QWB is a significant correlate of biological, neuropsychological, and psychiatric outcomes for male HIV infected patients. In related studies we have shown that the QWB is a strong significant prospective predictor of mortality. Future work will use mathematical modeling techniques to translate observed QWB differences into quality adjusted life units for use in policy analysis.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Adult
- Centers for Disease Control and Prevention (U.S.)
- HIV Infections
- HIV Seropositivity
- Health Policy
- Humans
- Life
- Longitudinal Studies
- Male
- Personality Inventory
- Quality of Life
- Quality-Adjusted Life Years
- Research Design
- methods
Other ID:
UI: 102184549
From Meeting Abstracts