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Antipsychotic Medications for Schizophrenia on Equal Footing in Improving Patients’ Thinking Skills
June 4, 2007 • Science Update
Patients with schizophrenia taking antipsychotic medications experience a small improvement in thinking and reasoning skills (neurocognition), but no one medication appears to be better than the others in improving these skills during the first two crucial months of treatment, according to the latest results from the NIMH-funded Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE).
NIMH Funds Research for Early Intervention in Childhood Bipolar Disorder
June 4, 2007 • Science Update
NIMH recently approved funding to test the effectiveness of an early intervention in children at high risk for developing bipolar disorder.
Genetic Roots of Bipolar Disorder Revealed by First Genome-Wide Study of Illness
May 8, 2007 • Press Release
The likelihood of developing bipolar disorder depends in part on the combined, small effects of variations in many different genes in the brain, none of which is powerful enough to cause the disease by itself, a new study shows.
Bipolar Spectrum Disorder May Be Underrecognized and Improperly Treated
May 7, 2007 • Press Release
A new study supports earlier estimates of the prevalence of bipolar disorder in the U.S. population, and suggests the illness may be more accurately characterized as a spectrum disorder.
Cell Networking Keeps Brain’s Master Clock Ticking
May 4, 2007 • Science Update
Each day, a master clock in the brain synchronizes the timing of lesser clocks in cells throughout the body to the rising and setting of the sun, regulating such daily rhythms as sleep, body temperature, eating, and activity. Scientists funded in part by the National Institute of Mental Health have now discovered that the secret to this master clock’s robust time-keeping ability lies in the unique way its cells work together.
In Second Try to Treat Depression, Cognitive Therapy Generally As Effective As Medication
May 1, 2007 • Science Update
Switching to or adding cognitive therapy (CT) after a first unsuccessful attempt at treating depression with an antidepressant medication is generally as effective as switching to or adding another medication, but remission may take longer to achieve.
Cortex Area Thinner in Youth with Alzheimer’s-Related Gene
April 24, 2007 • Press Release
A part of the brain first affected by Alzheimer’s disease is thinner in youth with a risk gene for the disorder, a brain imaging study by researchers at the National Institute of Mental Health (NIMH), one of the National Institutes of Health (NIH), has found.
Benefits of Antidepressants May Outweigh Risks for Kids
April 17, 2007 • Science Update
The benefits of antidepressant medications likely outweigh their risks to children and adolescents with major depression and anxiety disorders, according to a new comprehensive review of pediatric trials conducted between 1988 and 2006. The study, partially funded by NIMH, was published in the April 18, 2007, issue of the Journal of the American Medical Association.
Gene Knockout Unleashes Manic Mouse
April 5, 2007 • Science Update
Mice engineered to lack a specific gene showed behaviors similar to human mania in a study funded in part by NIMH; they were hyperactive, slept less, appeared less depressed and anxious, and craved sugar, cocaine and pleasure stimulation.
Scientists Switch Neurons On and Off Using Light
April 5, 2007 • Science Update
Researchers have invented a genetically-engineered way to turn the electrical impulses of brain cells on and off with pulses of blue and yellow light — in synch with the split-second pace of real time neuronal activity.
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