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Drug Dosing Toolkit

Trizivir (AZT + Epivir + Ziagen)

Type of Drug: Fixed-Dose Combination

Approved adult dosing

AZT 300 mg + Epivir 150 mg + Ziagen 300 mg in a single tablet

one tablet, two times a day

  • Morning

    Trizivir

    Trizivir

  • Evening

    Trizivir

    Trizivir

My doctor's instructions

Notes on taking this medication

  • No food restrictions, can take with or without food
  • Do not take Trizivir with Zerit
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, and have to take them separately, not as one pill

Same side effects as

AZT

  • Nausea; stomach discomfort; headache
  • Symptoms of anemia (low red blood cell count): fatigue; shortness of breath
  • More rarely: muscle wasting; neutropenia (low white blood cell count)
  • Changes in body-fat distribution

Epivir

  • Side effects are rare but include headaches and general sense of feeling ill
  • Epivir is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

Ziagen

  • Mild nausea; vomiting; diarrhea; loss of appetite
  • Rash

Caution! Ziagen can cause a serious allergic reaction that includes at least 2 of the following: fever, malaise, severe nausea, diarrhea, abdominal pain, sore throat, cough, shortness of breath, and rash. Symptoms usually begin within 6 weeks of starting medication.

If you think you are having an allergic reaction, call your doctor at once. If allergic, you will have to stop Ziagen and never take it again. Starting it again can cause serious illness or death.