Drug Dosing Tool: Prezista (U.S. Department of Veterans Affairs)

Prezista (darunavir, TMC-114)

Type of Drug: Protease Inhibitor

Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Approved adult dosing

one 600 mg tablet Prezista + one 100 mg capsule Norvir, two times a day

Morning
Prezista
+
Norvir
Evening
Prezista
+
Norvir

Note: Prezista has been available as a 300 mg tablet (dose is two 300 mg tablets + one 100 mg capsule Norvir, two times a day), but this is being phased out.

Notes on taking this medication

Must take Prezista with Norvir; it is approved only with the use of Norvir
Must take with food
Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider

Side effects

Nausea; diarrhea; stomach discomfort
Rash
Liver inflammation and increased liver enzyme levels
Elevations in cholesterol and triglycerides
Elevated blood sugar
Abnormal accumulation of body fat
Persons who are allergic to sulfa drugs may be allergic to Prezista

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer:

This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.

Drug Dosing Toolkit

Prezista (darunavir, TMC-114)

Approved adult dosing

Morning

Evening

Notes on taking this medication

Side effects

My doctor's instructions

Disclaimer:

ContentsScroll over drug name to see other names for the drug.