Drug Dosing Tool: Crixivan (U.S. Department of Veterans Affairs)

Crixivan (indinavir)

Type of Drug: Protease Inhibitor

Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.

Approved adult dosing

two 400 mg capsules Crixivan + one 100 mg capsule Norvir, two times a day

Morning
Crixivan
+
Norvir
Evening
Crixivan
+
Norvir

two 400 mg capsules Crixivan + two 100 mg capsules Norvir, two times a day

Morning
Crixivan
+
Norvir
Evening
Crixivan
+
Norvir

two 400 mg capsules Crixivan, every 8 hours

6AM
Crixivan
2PM
Crixivan
10PM
Crixivan

Notes on taking this medication

Take on an empty stomach 2 hours after or 1 hour before meal
When boosted with Norvir, Crixivan can be taken with food
Drink 6-8 glasses of water per day to reduce risk of kidney stones
Crixivan interacts with many other drugs; persons using Crixivan with those drugs may need an adjustment to their dose of Crixivan or the other drugs; consult your medical provider

Side effects

Kidney stones; flank or back pain
Nausea; vomiting; diarrhea; headache
Abnormal accumulation of body fat
Increased blood sugar
Elevations in cholesterol and triglycerides
Liver inflammation and increased liver enzyme levels
Hair loss; dry skin; ingrown nails
Jaundice (yellowing of the eyes or skin)

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Disclaimer:

This information is not meant to substitute for advice from your medical provider or pharmacist. If you have any questions about your medication dosing, talk to your medical provider or pharmacist.

Drug Dosing Toolkit

Crixivan (indinavir)

Approved adult dosing

Morning

Evening