Protocols
03-AA-0283 Influence of Age and Sex on Alcohol Metabolism and Acute Responses (PI: Vijay A. Ramchandani, PhD).
07-AA-0026 OPRM1 A118G SNP, Alcohol Response, and Striatal Dopamine (PI: Markus Heilig, MD, PhD)
NIAAA Clinical Protocols & link to all NIH Clinical Protocols
Selected Publications
ORIGINAL PUBLICATIONS
Gilman JM, Ramchandani VA , Davis MB, Bjork JM and Hommer DW. Why we like to drink: An fMRI Study of the Rewarding and Anxiolytic Effects of Alcohol. Journal of Neuroscience. 28(18):4583-91, 2008. PDF
Salloum JB, Ramchandani VA, Bodurka J, Rawlings R, Momenan R, George D, Hommer DW. Blunted rostral anterior cingulate response during a simplified decoding task of negative emotional facial expressions in alcoholic patients. Alcohol Clin Exp Res. 31(9):1490-1504, 2007 September. PDF
Plawecki MH, DeCarlo R, Ramchandani VA, O’Connor S. Improved transformation of morphometric measurements for a priori parameter estimation in a physiologically-based pharmacokinetic model of ethanol. Biomedical Signal Processing and Control. 2(2):97-110, 2007 April. PDF
Ramchandani VA, O’Connor S, Neumark YD, Zimmermann US, Morzorati SL, de Wit H. The alcohol clamp: Applications, challenges and new directions – An RSA 2004 symposium summary. Alcohol Clin Exp Res. 30(1):155-164, 2006 January. PDF
Han J-J, Plawecki MH, Doerschuk PC, Ramchandani VA, O’Connor S. Ordinary differential equation models for ethanol pharmacokinetics based on anatomy and physiology. IEEE Engineering in Medicine and Biology Society International Conference Proceedings. (article 4029183) 1:5033-5036, 2006. PDF
Khaole NC, Ramchandani VA, Viljoen DL, Li T-K. A pilot study of alcohol exposure and pharmacokinetics in women with or without children with fetal alcohol syndrome. Alcohol Alcohol. 39(6):503-508, 2004 November-December. PDF
Kareken DA, Claus ED, Sabri M, Dzemidzic M, Kosobud AEK, Radnovich AJ, Hector D, Ramchandani VA, O’Connor SJ, Lowe M, Li T-K. Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: Preliminary findings. Alcohol Clin Exp Res. 28(4):550-557, 2004 April. PDF
Neumark YD, Friedlander Y, Durst R, Leitersdorf E, Jaffe D, Ramchandani VA, O’Connor S, Carr LG, Li T-K. Alcohol dehydrogenase (ADH2) polymorphisms influence alcohol elimination rates in a male Jewish population. Alcohol Clin Exp Res. 28(1):10-14, 2004 January. PDF
Plawecki MH, DeCarlo RA, Ramchandani VA, O’Connor S. Estimation of ethanol infusion profile to produce a specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models. IEEE Engineering in Medicine and Biology Society International Conference Proceedings. 1:778-781, 2004. PDF
Ramchandani VA, Flury L, Morzorati S, Kareken D, Blekher T, Foroud T, Li T-K, O'Connor S. Recent Drinking History: Association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp. J Stud Alcohol. 63:734-744, 2002. PDF
Ramchandani VA, Kwo PY, Li T-K. Influence of food and food composition on alcohol elimination rates in healthy men and women. J Clin Pharmacol. 41:1345-1350, 2001. PDF
Li T-K, Yin S-J, Crabb DW, O’Connor S, Ramchandani VA. Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res. 25:136-144, 2001. PDF
Ramchandani VA, Bolane J, Li T-K, O'Connor S. A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping. Alcohol Clin Exp Res. 23:617-623, 1999. PDF
REVIEWS AND BOOK CHAPTERS
Ramchandani VA, O’Connor S. Studying alcohol elimination using the alcohol clamp method. Alcohol Research and Health. 29(4):286-290, 2006. PDF
Ramchandani VA. Genetic aspects of alcohol metabolism. In Alcohol in disease: Nutrient interactions and dietary intake (Watson RR and Preedy VR, ed). Boca Raton: CRC Press. 187-199, 2004. PDF
Ramchandani VA, Bosron WF, Li T-K. Research advances in ethanol metabolism. Pathologie Biologie. 49(9):676-682, 2001 November. PDF
Alcohol publications can also be found using the ETOH Database
FIND PUBLICATIONS USING PubMed
NIH Research and Training Opportunities
Updated: July 2008