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Artificial Sweeteners and Cancer: Questions and Answers This fact sheet reviews research studies on the possible connection between cancer and artificial sweeteners, including saccharin, aspartame, and cyclamate.... Details > National Cancer Institute, National Institutes of Health Sugar Substitutes: Americans Opt for Sweetness and Lite This article describes low-calorie sugar substitutes available and how they fit into your diet. Onoing questions surrounding two approved sugar substitutes, saccharin and aspartame, are discussed.... Details > Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration