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Selected Publications

DNA Repair & Mitochondrial Damage Group

  1. Croteau DL, Peng P, Van Houten B. DNA repair gets physical: mapping a XPA binding site on ERRC1 . DNA repair 7(5) (2008) 819-826. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18343204) Exit NIEHS
  2. JN Meyer, WA Boyd, GA Azzam, AC Haugen, J.H. Freedman and B. Van Houten. Decline of nucleotide excision repair capacity in aging caenorhabditis elegans. Genome biology 5 (2007) R70-R70. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17472752) Exit NIEHS
  3. Q. Ruan, T. Liu, A. Kolbanovskiy, Y. Liu, J. Ren, M. Skorvaga, Y. Zou, J. Lader, B. Malkani, S. Amin, B. Van Houten and N.E. Geacintov. Sequence context- and temperature-dependent nucleotide excision repair of a benzo[a]pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins. Biochemistry 46 (2007) 7006-7015. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17506530&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  4. J.N. Meyer, W.A. Boyd, G.A. Azzam, A.C. Haugen, J.H. Freedman and B. Van Houten. Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. Genome Biol 8 (2007) R70. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17472752&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  5. E. Karakas, J.J. Truglio, D. Croteau, B. Rhau, L. Wang, B. Van Houten and C. Kisker. Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J 26 (2007) 613-622. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17245438&query_hl=13&itool=pubmed_docsum) Exit NIEHS
  6. S.S. Chan, J.H. Santos, J.N. Meyer, B.S. Mandavilli, D.L. Cook, Jr., C.L. McCash, G.E. Kissling, A. Nyska, J.F. Foley, B. van Houten, W.C. Copeland, V.E. Walker, K.L. Witt and J.B. Bishop. Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Environ Mol Mutagen 48 (2007) 190-200. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16395692&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  7. A.R. Wielgus, C.F. Chignell, D.S. Miller, B. Van Houten, J. Meyer, D.N. Hu and J.E. Roberts. Phototoxicity in Human Retinal Epithelial Cells Promoted by Hypericin, a Component of St. John's Wort. Photochem Photobiol 83 (2006) 706-713. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17576381&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  8. H. Wang, M.J. DellaVecchia, M. Skorvaga, D.L. Croteau, D.A. Erie and B. Van Houten. UvrB domain 4, an autoinhibitory gate for regulation of DNA binding and ATPase activity. J Biol Chem 281 (2006) 15227-15237. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16595666&query_hl=17&itool=pubmed_DocSum) Exit NIEHS
  9. B. Van Houten, V. Woshner and J.H. Santos. Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amst) 5 (2006) 145-152. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15878696&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  10. J.J. Truglio, E. Karakas, B. Rhau, H. Wang, M.J. DellaVecchia, B. Van Houten and C. Kisker. Structural basis for DNA recognition and processing by UvrB. Nat Struct Mol Biol 13 (2006) 360-364. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16532007&query_hl=13&itool=pubmed_docsum) Exit NIEHS
  11. J.J. Truglio, D.L. Croteau, B. Van Houten and C. Kisker. Prokaryotic nucleotide excision repair: the UvrABC system. Chem Rev 106 (2006) 233-252. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16464004&query_hl=13&itool=pubmed_docsum) Exit NIEHS
  12. G.R. Stuart, J.H. Santos, M.K. Strand, B. Van Houten and W.C. Copeland. Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Hum Mol Genet 15 (2006) 363-374. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16368709&query_hl=17&itool=pubmed_DocSum) Exit NIEHS
  13. J.H. Santos, J.N. Meyer and B. Van Houten. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet 15 (2006) 1757-1768. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16613901&query_hl=17&itool=pubmed_DocSum) Exit NIEHS
  14. J.H. Santos, J.N. Meyer, B.S. Mandavilli and B. Van Houten. Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol 314 (2006) 183-199. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16673882&query_hl=17&itool=pubmed_DocSum) Exit NIEHS
  15. T.A. Kunkel and B. Van Houten. Survival choices. Nat Cell Biol 8 (2006) 547-549. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16738701&query_hl=17&itool=pubmed_DocSum) Exit NIEHS
  16. G.H. Jiang, M. Skorvaga, D.L. Croteau, B. Van Houten and J.C. States. Robust incision of Benoz[a]pyrene-7,8-dihyrodiol-9,10-epoxide-DNA adducts by a recombinant thermoresistant interspecies combination UvrABC endonuclease system. Biochemistry 45 (2006) 7834-7843. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16784235&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  17. D.L. Croteau, M.J. DellaVecchia, H. Wang, R.J. Bienstock, M.A. Melton and B. Van Houten. The C-terminal zinc finger of UvrA does not bind DNA directly but regulates damage-specific DNA binding. J Biol Chem 281 (2006) 26370-26381. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16829526&query_hl=17&itool=pubmed_DocSum) Exit NIEHS
  18. B. Van Houten, D.L. Croteau, M.J. DellaVecchia, H. Wang and C. Kisker. 'Close-fitting sleeves': DNA damage recognition by the UvrABC nuclease system. Mutat Res 577 (2005) 92-117. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15927210&query_hl=5&itool=pubmed_docsum) Exit NIEHS
  19. J.J. Truglio, B. Rhau, D.L. Croteau, L. Wang, M. Skorvaga, E. Karakas, M.J. DellaVecchia, H. Wang, B. Van Houten and C. Kisker. Structural insights into the first incision reaction during nucleotide excision repair. Embo J 24 (2005) 885-894. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15692561&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  20. T. Nakano, A. Katafuchi, R. Shimizu, H. Terato, T. Suzuki, H. Tauchi, K. Makino, M. Skorvaga, B. Van Houten and H. Ide. Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress. Nucleic Acids Res 33 (2005) 2181-2191. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15831791&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  21. I.G. Minko, A.J. Kurtz, D.L. Croteau, B. Van Houten, T.M. Harris and R.S. Lloyd. Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease. Biochemistry 44 (2005) 3000-3009. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15723543&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  22. B.S. Mandavilli, I. Boldogh and B. Van Houten. 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells. Brain Res Mol Brain Res 133 (2005) 215-223. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15710238&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  23. Members of the Toxicogenomics Research Consortium. Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods 2 (2005) 351-356. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15846362&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  24. E. Trushina, R.B. Dyer, J.D. Badger, 2nd, D. Ure, L. Eide, D.D. Tran, B.T. Vrieze, V. Legendre-Guillemin, P.S. McPherson, B.S. Mandavilli, B. Van Houten, S. Zeitlin, M. McNiven, R. Aebersold, M. Hayden, J.E. Parisi, E. Seeberg, I. Dragatsis, K. Doyle, A. Bender, C. Chacko and C.T. McMurray. Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol 24 (2004) 8195-8209. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15340079&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  25. J.J. Truglio, D.L. Croteau, M. Skorvaga, M.J. DellaVecchia, K. Theis, B.S. Mandavilli, B. Van Houten and C. Kisker. Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair. Embo J 23 (2004) 2498-2509. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15192705&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  26. M. Skorvaga, M.J. DellaVecchia, D.L. Croteau, K. Theis, J.J. Truglio, B.S. Mandavilli, C. Kisker and B. Van Houten. Identification of residues within UvrB that are important for efficient DNA binding and damage processing. J Biol Chem 279 (2004) 51574-51580. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15456749&ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  27. J.H. Santos, J.N. Meyer, M. Skorvaga, L.A. Annab and B. Van Houten. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell 3 (2004) 399-411. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15569357&ordinalpos=15&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  28. A.C. Haugen, R. Kelley, J.B. Collins, C.J. Tucker, C. Deng, C.A. Afshari, J.M. Brown, T. Ideker and B. Van Houten. Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol 5 (2004) R95. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15575969&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  29. M.J. DellaVecchia, D.L. Croteau, M. Skorvaga, S.V. Dezhurov, O.I. Lavrik and B. Van Houten. Analyzing the handoff of DNA from UvrA to UvrB utilizing DNA-protein photoaffinity labeling. J Biol Chem 279 (2004) 45245-45256. [Abstract] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15308661&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum) Exit NIEHS
  30. Imoto S, Bransfield LA, Croteau DL, Van Houten B, Greenberg MM. DNA tandem lesion repair by strand displacement synthesis and nucleotide excision repair. Biochemistry 47 (2008) 4306-4316. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18341293) Exit NIEHS
  31. Croteau DL, DellaVecchia MJ, Perera L , Van Houten B. Cooperative damage recognition by UvrA and UvrB: Identification of UvrA residues that mediate DNA binding. DNA repair 7 (2008 ) 392-404. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieveamp;&db=pubmed&dopt=Abstract&list_uids=18248777) Exit NIEHS
  32. Wolski SC, Kuper J, Hanzelmann P, Truglio JJ, Croteau DL, Van Houten B, Kisker C. Crystal Structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PLoS biology 6(6) (2008) e149-. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18578568) Exit NIEHS

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Last Reviewed: September 05, 2007