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LMBB - Unit of Molecular Biology (MB)


BJ_Song's picture

 

Byoung J. (B.J.) Song, PhD, Unit Chief

National Institute on Alcohol Abuse and Alcoholism

National Institutes of Health

5625 Fishers Lane, Room 2S30:MSC 9410

Bethesda MD 20892-9410

telephone: +1 301 496 3985

fax: +1 301 594 3113

e-mail: bjs@mail.nih.gov

 

Oxidative stress is one of the major contributing factors to alcohol-mediated cell/organ damage.  Members of the Unit of Molecular Biology are studying the functional implications of increased oxidative stress and molecular signaling mechanisms during cell/organ damage caused by ethanol and other compounds including clinically used drugs.  Our main research projects are to study the regulations and functional roles of ethanol-inducible cytochrome P450 2E1 (CYP2E1) and mitochondrial aldehyde dehydrogenase in cellular protection against damage caused by ethanol and other potentially toxic compounds.  To achieve these goals, we employ cellular, biochemical, proteomics, and molecular biological approaches.

 

 

Mission Statement

  1. Investigates molecular regulatory mechanisms of the enzymes involved in alcohol metabolism. These enzymes include the ethanol-inducible cytochrome P450 2E1 (CYP2E1) and the mitochondrial aldehyde dehydrogenase; and
  2. investigates molecular mechanisms of cell (or tissue) damage caused by reactive oxygen species, free radical metabolites and lipid peroxides caused by alcohol and other toxic compounds 

 

Current staff

Bongjo_k's picture

 

Bong-Jo Kim, PhD
Visiting Fellow

301.496.3984

bjkim@mail.nih.gov

Current projects: Studies the cell signaling pathways during cell damage caused by alcohol and other toxic compounds.   Particularly interested in studying the role of stress-activated protein kinases in phosphorylation of Bax and other critical proteins in apoptosis after treatment with various toxic compounds including alcohol and clinically used drugs.

   
KwanHoon_Moon's picture  


Kwan-Hoon Moon, PhD
Visiting Fellow

301.496.3984

kwanhoonm@mail.nih.gov

Current projects: Studies and characterizes the oxidized and/or S-nitrosylated proteins in different sub-cellular organelles after treatment with alcohol and other toxic compounds as well as pathological conditions.  Particularly interested in the mechanism and functional implication of the inhibition of mitochondrial aldehyde dehydrogenase (ALDH2).

 

 

 

Youngmi_Lee's picture  


Young-Mi Lee, PhD
Guest Worker
301.496.3984
leeyoungm@mail.nih.gov

Current projects: Studies the cell signaling pathways during cell damage caused by alcohol and other toxic compounds.   Particularly interested in studying the role of stress-activated protein kinases in phosphorylation of Bax and other critical proteins in apoptosis after treatment with various toxic compounds including alcohol and clinically used drugs.

 

 

 
 
Section Alumni
 

Dr.  Dr. Huh, Tae-Lin, Professor, Department of Genetic Engineering, College of Natural Science, Kyungpook National University, Korea; Chief Scientific Officer, TG Biotech Venture Company, Technopark, Kyungpook Taegu, Korea (1988-1992).

 

Dr. Chi, Youn-Tae, Professor, Department of Genetic Engineering, College of Agriculture, Chonnam National University, Korea (1988-1990).

 

Dr. Huh, Jae-Wook, Deputy Director, Central Research Institute, Green Cross Pharmaceutical Company, Korea (1989-1994).

 

Dr. Yun, Yeo-Pyo, Professor, Department of Toxicology, College of PharmacyChoongpook National University, Korea (1989-1991).

 

Dr. Sohn, Dong Hwan, Professor and Dean, Department of Pharmaceutics, College of Pharmacy, Wongwang University, Korea (1990-1992).

 

Dr. Park, Kwang-Shik, Assistant Professor, College of Pharmacy, DongDuk Women’s University, Seoul, Korea (1991-1993).

 

Dr. Ryu, Jae-Ha, Professor, Department of Analytical Chemistry, College of Pharmacy, Sookmyung Women's University, Korea (1992-1994).

 

Mr. Kim, Byung Moon, Research Manager, Central Research Laboratories, Dong-A Pharmaceutical Company, Korea (1993-1994).

 

Dr. Jeong, Kyu-Shik, Assistant professor, Kyungpook National University College of Veterinary Medicine, Taegu, Korea (1994-1996).

 

Dr. Jeng, Jiingjau, Senior System Analyst, Lockheed Martin Incorp, Gaithersburg, MD, U.S.A. (1994-1999)

 

Dr. Soh, Yunjo, Assistant Professor, JeonBuk National University College of Dentistry, Jeonju, Korea (1994-1999).

 

Dr. Lee, I. James, Research Assistant Professor, Unviersity of Maryland College of Pharmacy, Baltimore, Maryland, U.S.A. (1994-1999).

 

Dr. Kallarakal, Abraham T., Senior Principal Scientist, SAIC Inc., NCI-Frederick, Frederick, MD, U.S.A. (1995-1998).

 

Dr. Bae, Myung-Ae, Senior Research Scientist, Laboratory of Molecular Pharmacology, Korea Research Institute of Chemical Technology, Daejon, Korea (1999-2003).

 

Dr. Pie, Jae-Eun, Assistant Professor, An-Yang University, Department of Food Science and Nutrition, Anyang, Korea (1999-2000).

 

Dr. Lee, Yunsik, Research Associate, Department of Endocrinology, University of Pennsylvania Medical School, Philadelphia, PA, U.S.A. (2000-2002).

 

Dr. Herman Rhee, Expert Review Pharmacologist, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD, U.S.A. (1998-2002).

 

Dr. Suh, Soo-Kyung, Senior Research Scientist, Department of Pharmacology and Toxicology, National Institute of Toxicology, Seoul, Korea (2003-2004).

 

Dr. Lee, Youn-Ju, Research Associate, Department of Pharmacology, University of Missouri Medical School,  Columbia, MO, U.S.A. (2004-2004). 

 

Dr. Aragon, Richard A., Program Director, National Cancer Institute, NIH, Bethesda, MD, U.S.A. (2004-2005).

 

 

Selected Recent Publications

 

Kim BJ, Hood BL, Aragon RA, Hardwick JP, Conrads TP, Veenstra TD and Song BJ. Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. Proteomics.  6: 1250-1260, 2006.  PubMed  [PDF]


Lee YS, Wan J, Kim BJ, Bae MA, and Song BJ.  Ubiquitin-dependent degradation of p53 tumor suppressor protein despite phosphorylation at its N-terminus by acetaminophen.  J. Pharmacol. Expt. Ther.  317: 202-208, 2006. 
PubMed  [PDF]

 

Kim BJ, Ryu SW, and Song BJ. JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation, mitochondrial translocation and apoptosis of human hepatoma HepG2 cells.  J. Biol. Chem. Epub May 18, 2006.  PubMed  [PDF]

 

Wan J, Ernstgard L, Song BJ, and Shoaf SE.  Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats. J. Pharm.  Pharmacol.  58: 51-61, 2006.  PubMed  [PDF]

   

Moon KH, Kim BJ, and Song BJ.  Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation.  FEBS Lett.  579: 6115-6120, 2005.  PubMed  [PDF]

 

Jeng JJ, Goldman D, Eriksson PP, Kallarakal AT, Wang TT, Weiner H, and Song BJ. Accumulation of hepatic acetaldehyde and reduced alcohol drinking in transgenic mice carrying the Oriental variant of the human aldehyde dehydrogenase dehydrogenase 2 gene. (In: H. Weiner, B. Plapp, and R. Lindahl ed.) Enzymology and Molecular Biology of Carbonyl Metabolism 12, pp. 42-49, Purdue University Press, West Lafayette, IN, 2005.  [PDF]

 

Wan J, Bae MA, and Song BJ.  Acetaminophen-induced oxidative damage through reduction of Ogg1 DNA repair enzyme in C6 glioma cells.  Exp. Mol. Med.  36: 71-77, 2004PubMed  [PDF]

 

Koh HJ, Lee SM, Son BG, Lee SH, Ryoo ZY, Chang KT, Park JW, Park DC, Song BJ, Veech RL, Song H, and Huh TL.  Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism.  J. Biol. Chem.  279: 39968-74, 2004.  PubMed   [PDF]

  

Ryu J, Lee MS, Na JG, Chung K, Song BJ, and Park KS. Molecular cloning of cytochrome P4501A cDNA of medaka (Orizias Latipes) and messenger ribonucleic acid regulation by environmental pollutants. Environ. Toxicol. Chem. 23: 1004-1011, 2004.  PubMed  [PDF]


Suh SK, Hood BL, Kim BJ, Conrads T, Veenstra TD, and Song BJ. Identification of oxidatively modified mitochondrial proteins in hepatoma cells after alcohol exposure.   Proteomics.  4: 394-3400, 2004.  PubMed  [PDF]

Jeong WI, Do SH, Yun HS, Song BJ, Kim SJ, Kwak WJ, Yoo SE, Park HY, and Jeong KS.  Hypoxia potentiates transforming growth factor-beta expression of hepatocytes during the cirrhostic condition in rat liver.  Liver International.  24: 658-668, 2004.  PubMed  [PDF]

 

Bae MA and Song BJ. Critical role of the c-Jun N-terminal protein kinase activation in Troglitazone-induced apoptosis of HepG2 human hepatoma cells.  Mol. Pharmacol.  63: 401-408, 2003PubMed  [PDF]

Bae MA, Rhee HM, and Song BJ. Troglitazone but not rosiglitazone induced G1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines.  Tox. Letters.  139: 67-75, 2003PubMed  [PDF]

 

Lee SM, Koh H-J, Park D-C, Song BJ, Huh T-L, and Park JW.  Cytosolic NADP+-dependent isocitrate dehydrogenase status modulates oxidative damage to cells.  Free Radic. Biol. Med.  32: 1185-1196, 2002.  PubMed  [PDF]

 

Song BJ, Soh Y, Bae MA, Pie J, Wan J, and Jeong KS.  Apoptosis of PC12 cells by 4-hydroxynonenal is mediated through selective activation of the c-Jun N-terminal protein kinase pathway.  Chem. Biol. Int.  130-132(1-3): 943-954, 2001.  PubMed  [PDF]

 

Jo SH, Son MK, Koh HJ, Lee SM, Song IH, Kim YO, Lee YS, Jeong KS, Kim WB, Park JW, Song BJ, and Huh TL.  Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase.  J. Biol. Chem.  276: 16168-16176, 2001.  PubMed  [PDF]

 

Bae ME, Pie J, and Song BJ.  Acetoaminophen induces apoptosis of C6 glioma cells by activating the c-Jun N-terminal kinase related cell death pathway.  Mol. Pharmacol. 60: 847-856, 2001.  PubMed  [PDF]


Soh Y, Jeong KS, Lee IJ, Bae MA, Kim YC, and Song BJ.  Selective activation of c-Jun N-terminal kinase pathway during apoptosis of PC12 cells by 4-hydroxynonenal. 
Mol. Pharmacol.  58: 535-541, 2000.  PubMed  [PDF]

 

Jeong KS, Soh Y, Jeng J, Felder M, Hardwick JP, and Song BJ.  CYP2E1 dependent production of a 37 kDa acetaldehyde-protein adduct.  Arch. Biochem. Biophys.  384: 81-87, 2000.  PubMed  [PDF]

 

 

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Last updated: November 2007 

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