Jeffrey B, Weisinger H, Neuringer M, Mitchell. The Role of Docosahexaenoic Acid in Retinal Function. Lipids 2001, in press.
Koenig B, Mitchell DC, Konig S, Grzesiek S, Litman B, Bax A. Measurement of dipolar couplings in a transducin peptide fragment weakly bound to oriented photo-activated rhodopsin . J of Biomolecular NMR 2000;16:121-125.
Litman BJ, Niu SL, Polozova A, Mitchell DC. The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways visual transduction. J Mol Neurosci 2001;16:237-42; discussion 279-84.
Litman BJ, Mitchell DC: Rhodopsin structure and function. In: Lee AG (ed). Biomembranes 2. New York:JAI Press:1996, pp 1-32.
Litman BJ, Mitchell DC: A role for phospholipid polyunsaturation in modulating membrane protein function. Lipids 1996;31:S193-7. pdf
Mitchell DC, Litman B. Modulation of Receptor Signaling by Phospholipid Acyl Chain Composition. In Fatty Acids: Physiological and Behavioral Functions. Mostofsky DI, Yehuda S, Salem N, eds. New Jersey:Humana Press 2001;23-40 pp.
Mitchell DC, Niu SL, Litman BJ. Optimization of receptor-G protein coupling by bilayer lipid composition I kinetics of Rhodopsin-transducin binding. J Biol Chem 2001;276:42801-42806. pdf
Mitchell DC, Litman BJ: Effect of ethanol and osmotic stress on receptor conformation. Reduced water activity amplifies the effect of ethanol on metarhodopsin II formation. J Biol Chem. 2000;275:5355-60.
Mitchell DC, Litman BJ: Effect of protein hydration on receptor conformation: decreased levels of bound water promote metarhodopsin II formation. Biochemistry. 1999;38:7617-23.
Mitchell DC, Litman BJ: Effect of cholesterol on molecular order and dynamics in highly polyunsaturated phospholipid bilayers. Biophys J 1998;75:896-908.
Mitchell DC, Litman BJ: The phospholipid bilayer mediates the effect of primary alcohols on rhodopsin activation. Proc 4th Int Cong Essential Fatty Acids and Eicosanoids (in press).
Mitchell DC, Gawrisch K, Litman BJ, et al: Why is docosahexaenoic acid essential for nervous system function? Biochem Soc T 1998;26(3):365-70.
Mitchell DC, Litman BJ: Molecular order and dynamics in bilayers consisting of highly polyunsaturated phospholipids. Biophys J 1998:74(2 Pt 1):879-89.
Mitchell DC, Litman BJ: Docosahexaenoic acid-containing phospholipids optimally promote rhodopsin activation. Proc 4th Int Cong Essential Fatty Acids and Eicosanoids.
Mitchell DC, Lawrence TR, Litman BJ: Primary alcohols modulate the activation of the G protein-coupled receptor rhodopsin by a lipid-mediated mechanism. J Biol Chem 1996;271:19033-6. pdf
Niu SL, Mitchell DC, Litman BJ. Optimization of Receptor-G Protein Coupling by Bilayer Lipid Composition. II. Formation of Metarhodopsin II-Transducin Complex. J Biol Chem 2001;276:42807-42811. pdf
Mailing Address
Park Bldg Rm 158, MSC8115
12420 Parklawn Dr.
Bethesda, MD 20892-8115