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Cartoon cat thinking five points Peer reviewers can adjust your priority score based on your responses to the five points in the Vertebrate Animals Section of the Research Plan.

  1. Provide a detailed description of the use of animals in the work previously outlined in the experimental design and methods section. Identify species, strains, ages, sex, and numbers of animals to be used.
  1. Justify the use of animals, choice of species, and numbers used. If animals are in short supply, costly, or to be used in large numbers, provide additional rationale for their selection and numbers.
  1. Provide information on veterinary care.
  1. Describe procedures for ensuring that discomfort, distress, pain, and injury will be limited to that which is unavoidable to conduct scientifically sound research. Describe the use of analgesic, anesthetic, and tranquilizing drugs and comfortable restraining devices, where appropriate, to minimize discomfort, distress, pain, and injury.
  1. Describe any euthanasia method to be used and the reasons for its selection. State whether this method is consistent with the recommendations of the Panel on Euthanasia of the American Veterinary Medical Association. If not, present a justification for not following the recommendations.

For electronic applications, follow the instructions for Vertebrate Animals in the Grant Application Guide. For paper applications, follow the instructions for Vertebrate Animals in the PHS 398.

Since there is no page limit for this section, use as much space as you need to convince reviewers that you'll do everything right. Don't assume reviewers will automatically know what you're talking about. Help them understand why your approach will yield the best results and how you will limit animal pain and distress to that which is scientifically necessary.

See Part 5. Research Plan and Part 6. Other Application Sections in the NIH Grant Cycle: Application to Renewal for more advice on drafting your application.

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