Serotonergic transcriptional programming determine...[Nat Neurosci. 2008]

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1: Nat Neurosci. 2008 Aug 17. [Epub ahead of print] Links

Serotonergic transcriptional programming determines maternal behavior and offspring survival.

Lerch-Haner JK, Frierson D, Crawford LK, Beck SG, Deneris ES.

Department of Neurosciences, Case Western Reserve University, School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106, USA.

Central serotonergic signaling influences many physiological processes, but a requirement for reproductive success has not been demonstrated. Using mouse dams with a specific disruption in serotonin neuron development, we found that serotonergic function is required for the nurturing and survival of offspring. Full rescue of survival depended on the mother's expression level of the upstream serotonergic transcriptional cascade. Thus, intrinsic transcriptional programming of maternal serotonergic activity determines the quality of nurturing and whether or not the organism survives.

PMID: 18711398 [PubMed - as supplied by publisher]

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Serotonergic transcriptional programming determines maternal behavior and offspring survival.

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