ANNUAL REPORT

 

 

Board of Scientific Counselors
Scientific Director’s Preface
Workshops

 

Bone and Extracellular Matrix Branch
Genetic Disorders of Bone and Extracellular Matrix: Joan Marini

Cell Biology and Metabolism Branch
Mechanism and Regulation of Hepatocellular Polarity, AMC transports, Bile secretion, and Cholestasis: Irwin Arias
Protein Sorting in the Endosomal-Lysosomal System: Juan Bonifacino
Regulation of Secretory and Membrane Protein Biogenesis: Ramanujan Hegde
Regulation of Membrane Dynamics and Protein Transport by the SEC7-Domain Guanine Nucleotide Exchange Factors: Catherine Jackson
Cell Cycle Regulation During Oogenesis: Mary Lilly
Dynamics of Secretory Membrane Trafficking, Sorting, and Compartmentalization: Jennifer Lippincott-Schwartz
Regulation of Intracellular Iron Metabolism and Implications for Human Disease: Tracey Rouault
Microbial Responses to Oxidative Stress and Functions of Noncoding Ribonucleic Acids: Gisela Storz

Developmental Endocrinology Branch
Neuroendocrinology of Stress: Greti Aguilera
Regulation of Skeletal Growth: Jeffrey Baron
The X chromosome and Gender-Specific Differences in Physiology, Disease Susceptibility, and Longevity: Carolyn Bondy
The Menstrual Cycle and Human Reproduction: Lawrence Nelson
Molecular Genetics of Adrenocortical Tumors and Related Disorders: Constantine Stratakis
Physiology, Psychology, and Genetics of Obesity: Jack Yanovski

Endocrinology and Reproduction Research Branch
Phosphatidylinositol 4-Kinases and Cell Regulation: Tamás Balla
Peptide Hormone Receptors and Signal Transduction: Kevin Catt
Structure and Function of Peptide and Protein Hormones: Hao-Chia Chen
Gonadal Receptors and Actions of Peptide Hormones and Regulatory Proteins in Steroidogensis and Spermatogensis: Maria Dufau
Signal Transduction in Synaptic Transmission and Plasticity: Kuo-Ping Huang
Calcium Signalling and Calcium-Controlled Cellular Functions: Stanko Stojilkovic
The Biotransformation of Endobiotics by Sulfonation: Charles Strott

Heritable Disorders Branch

Molecular Genetics of Heritable Human Disorders: Janice Chou
Heritable Neurodegenerative and Autoimmune Disorders: Anil Mukherjee
Molecular Biology, Regulation, and Biochemistry of UDP-Glucuronosyltransferase Isozymes: Ida Owens
Dysmorphic Syndromes and Birth Defects: Forbes Porter

Laboratory of Cellular and Molecular Biophysics

Membrane Remodeling in Fusion Mediated by Viral Glycoproteins and in Cell Entry of Cell-Penetrating Peptides: Leonid Chernomordik
Microbial Pathogens in Human Lymphoid Tissue: Leonid Margolis
Applications of Mass Spectrometry to Biophysics, Biochemistry, and Medicine: Alfred Yergey
Membrane Remodeling During Viral Infection, Parasite Invasion, and Apoptosis; Components and Kinetics in Exocytosis: Joshua Zimmerberg

Laboratory of Cellular and Molecular Neurophysiology
Glutamate Receptor Structural Biology: Mark Mayer

Laboratory of Cellular and Synaptic Neurophysiology
Potassium Channels and Dendritic Function in Hippocampal Pyramidal Neurons: Dax Hoffman
Neurotrophic Regulation of Synapse Development and Plasticity: Bai Lu
Hippocampal Interneurons and Their Role in Controlling Excitability: Chris McBain
Olfactory Coding and Decoding by Ensembles of Neurons: Mark Stopfer

Laboratory of Clinical Genomics
Developmental Genomics: Owen Rennert
Copper Transport to the Developing Brain: Stephen Kaler

Laboratory of Comparative Ethology
Child and Family Development in the First Two Decades of Life: Marc Bornstein
Neuroethology of Crying: John Newman
Genetic and Environmental Determinants of Primate Biobehavioral Development: Stephen Suomi

Laboratory of Developmental and Molecular Immunity
Synthetic Vaccines Against Human Pathogenic Bacteria: John Robbins
Conjugate Vaccines: Rachel Schneerson

Laboratory of Gene Regulation and Development
Mitotic Regulation in Higher Eukaryotes by Ran and SUMO-1: Mary Dasso
Mechanism and Regulation of Eukaryotic Protein Synthesis: Thomas Dever
Transcriptional and Translational Regulatory Mechanisms in Nutrient Control of Gene Expression: Alan Hinnebusch
Epigenetic Gene Silencing: Rohinton Kamakaka
The Development and Function of Color-Vision Circuitry in Drosophila: Chi-Hon Lee
Retrotransposons as Models for the Replication of Retroviruses: Henry Levin
Molecular Mechanism of Frog Metamorphosis: Yun-Bo Shi
SMC Family Proteins and Associated Factors in Mitotic Chromosome Segregation: Alexander Strunnikov

Laboratory of Genomic Integrity
Studies on DNA Replication, Repair, and Mutagenesis in Eukaryotic and Prokaryotic Cells: Roger Woodgate

Laboratory of Integrative and Medical Biophysics
Tissue Biophysics and Biomimetics: Peter Basser
Medical Biophysics: Robert Bonner
Stochastic Modeling of Biological Processes: Quantitative Optical Imaging and Tumor-Induced Angiogenesis: Amir Gandjbakhche
Cell Biophysics: Ralph Nossal

Laboratory of Mammalian Genes and Development
Signals Regulating T Cell Development: Paul Love
Molecular Genetics of an Imprinted Gene Cluster on Mouse Distal Chromosome 7: Karl Pfeifer
Genes that Pattern the Mouse Embryo: Heiner Westphal

Laboratory of Molecular Genetics
Nutrient Control of Bacterial Gene Expression: Michael Cashel
Regulating Neurogenesis in the Zebrafish Embryo: Ajay Chitnis
Physiological, Biochemical, and Molecular Genetic Events of Recognition and Resolution of RNA-DNA Hybrids: Robert Crouch
Molecular Genetics of Embryogenesis in Xenopus and Zebrafish: Igor Dawid
Control of Gene Expression During Development: Judith Kassis
Regulation of Homeotic Gene Function in Drosophila: James Kennison
Molecular Genetics of Mammalian Retrovirus Replicaiton: Judith Levin
Transcriptional Control of Ectodermal Development in Xenopus: Thomas Sargent
Organogenesis of the Zebrafish Vasculature: Brant Weinstein
Mechanisms for Controlling Gene Expression in Bacteria and Bacteriophages: Robert Weisberg

Laboratory of Molecular Growth Regulation
Chromatin Remodeling and Gene Activation: David Clark
Regulation of Mammalian Cell Proliferation and Development: Melvin DePamphilis
The Chromatin-Based Epigenome in Development and Aging: Bruce Howard
La Antigen and Associated RNA Metabolism in Cell Biology, Growth, and Development: Richard Maraia
Developmental Gene Regulation of the Immune System: Keiko Ozato

Laboratory of Physical and Structural Biology
Biophysics of Large Membrane Channels: Sergey Bezrukov
Physical Forces Organizing Biomolecules: Adrian Parsegian
Intermolecular Forces, Recognition, and Dynamics: Donald Rau

Perinatology Research Branch
Mechanisms of Disease in Pre-Term Labor and Complications of Prematurity and Prenatal Diagnosis of Congenital Anomalies: Roberto Romero

Physical Disabilities Branch
Research in Physical Disabilities: Steven Stanhope

Reproductive Biology and Medicine Branch
The Hypothalamic-Pituitary-Adrenal Axis: Its Endocrine Disorders and Its Interactions with the Immune System: George Chrousos
Hypercortisolism and Endometrial Physiology: Lynnette Nieman
Diagnosis, Localization, Pathophysiology, and Molecular Biology of Pheochromocytoma: Karel Pacak
Reproductive Endocrinology and Infertility: James Segars

Section on Cell Biology and Signal Transduction
Calcium-Based Excitability in Glial Cells: James Russell

Section on Cellular Neurobiology
Secretory Protein Trafficking and Granule Biogenesis in Neuroendocrine Cells: Peng Loh

Section on Molecular Neurobiology
Developmental Regulation of Neuronal and Muscle Plasticity: Andres Buonanno

Section on Nervous System Development and Plasticity
Nervous System Development and Plasticity: Douglas Fields

Section on Neuroendocrinology
Pineal Gland and Chronobiology; Regulation of Pineal Function: David Klein

Section on Physical Biochemistry
Physical Principles of Biomolecular Recognition, Self-Assembly, and Regulation: Sergey Leikin

Unit on Biologic computation
Scientific Software Support and Bioinformatics: Jonathan Epstein

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