Annual report

 

 

Board of Scientific Counselors
Scientific Director’s Preface
Workshops
 

Bone and Extracellular Matrix Branch
Genetic Disorders of Bone and Extracellular Matrix: Joan Marini

Cell Biology and Metabolism Branch
Protein Sorting in the Endosomal-Lysosomal System: Juan Bonifacino
Regulation of Secretory and Membrane Protein Biogenesis: Ramanujan Hegde
Regulation of Membrane Dynamics and Protein Transport by the Sec7 Domain Guanine Nucleotide Exchange Factors: Catherine Jackson
Cell Cycle Regulation during Oogenesis: Mary Lilly
Dynamics of Secretory Membrane Trafficking, Sorting and Compartmentalization: Jennifer Lippincott-Schwartz
Regulation of Intracellular Iron Metabolism:Tracey Rouault
Microbial Responses to Oxidative Stress and Noncoding RNAs: Gisela Storz

Developmental Endocrinology Branch
Neuroendocrinology of Stress: Greti Aguilera
Regulation of Skeletal Growth: Jeffrey Baron
Gender-Specific Differences in Disease Susceptibility: Carolyn Bondy
The Menstrual Cycle and Human Reproduction: Lawrence Nelson
Molecular Genetics of Adrenocortical Tumors and Related Disorders: Constantine Stratakis
Physiology, Psychology and Genetics of Obesity: Jack Yanovski

Endocrinology and Reproduction Research Branch
Phosphoinositide-Calcium Signaling in Cell Regulation: Tamás Balla
Peptide Hormone Receptors and Signal Transduction: Kevin Catt
Structure and Function of Peptide and Protein Hormones: Hao-Chia Chen
Gonadal Receptors and Mechanism of Action of Peptide Hormones in Steroidogenesis and Spermatogenesis: Maria Dufau
Signal Transduction In Synaptic Transmission and Plasticity: Kuo-Ping Huang
Calcium Signalling and Calcium-Controlled Cellular Functions: Stanko Stojilkovic
The Biotransformation of Endobiotics by Sulfonation: Charles Strott

Heritable Disorders Branch
Molecular Genetics of Heritable Human Disorders: Janice Chou
Heritable Neurodegenerative and Autoimmune Disorders: Anil Mukherjee
Molecular Biology, Regulation, and Biochemistry of UDP-Glucuronosyltransferase Isozymes: Ida Owens
Dysmorphic Syndromes and Birth Defects: Forbes Porter

Laboratory of Cellular and Molecular Biophysics
Protein-Driven Expansion of Fusion Pores in Viral Fusion and Developmental Cell Fusion: Leonid Chernomordik
Secretory Vesicle Elasticity and Mobility: Andreas Chrambach
Microbial Pathogens in Human Lymphoid Tissue: Leonid Margolis
Applications of Mass Spectrometry to Biophysics, Biochemistry and Medicine: Alfred Yergey
Membrane Remodeling During Viral Infection, Parasite Invasion, and Apoptosis and Components and Kinetics in Exocytosis: Joshua Zimmerberg

Laboratory of Cellular and Molecular Neurophysiology
Structure and Function of Glutamate Receptors: Mark Mayer

Laboratory of Cellular and Synaptic Neurophysiology
Potassium Channels and Dendritic Function in Hippocampal Pyramidal Neurons: Dax Hoffman
Neurotrophic Regulation of Synapse Development and Plasticity: Bai Lu
Hippocampal Interneurons and their Role in Controlling Excitability: Chris McBain
Olfactory Coding and Decoding by Ensembles of Neurons: Mark Stopfer 

Laboratory of Clinical Genomics
Clinical Genomics: Owen Rennert
Bridging the Gap between Rare Diseases and Complex Inherited Disorders of Childhood: Stephen Kaler

Laboratory of Comparative Ethology
Child and Family Development in the First Two Decades of Life: Marc Bornstein
Child Development in Context: Michael Lamb
Mechanisms Regulating Auditory Communication and Social Behavior in Primates: John Newman
Genetic and Environmental Determinants of Primate Biobehavioral Development: Stephen Suomi

Laboratory of Developmental and Molecular Immunity
Conjugate Vaccines Against Enteric Pathogens: John Robbins
Human Immune Response to Polysaccharide-Protein Conjugate Vaccines: Rachel Schneerson

Laboratory of Developmental Neurobiology
Developmental Regulation of Neuronal and Muscle Plasticity: Andres Buonanno
The Pineal Gland and Chronobiology: David Klein
Secretory Protein Trafficking and Granule Biogenesis in Neuroendocrine Cells: Peng Loh
Mechanisms of Neurodevelopment in Health and Disease: Phillip Nelson

Laboratory of Gene Regulation and Development
Mitotic Regulation in Higher Eukaryotes by Ran and SUMO-1: Mary Dasso
Mechanism and Regulation of Eukaryotic Protein Synthesis: Thomas Dever
Transcriptional and Translational Control Mechanisms in Nutrient Regulation of Gene Expression: Alan Hinnebusch
Epigenetic Gene Silencing: Rohinton Kamakaka
Molecular Mechanism of Neuronal Connectivity: Chi-Hon Lee
Retrotransposons as Models for the Replication of Retroviruses: Henry Levin
Molecular Mechanism of Frog Metamorphosis: Yun-Bo Shi
Control of Chromosome Transmission Fidelity by the SMC Protein Complexes: Alexander Strunnikov

Laboratory of Genomic Integrity
Studies on DNA Replication, Repair and Mutagenesis in Eukaryotic and Prokaryotic Cells: Roger Woodgate
 
Laboratory of Integrative and Medical Biophysics
Tissue Biophysics and Biomimetics: Peter Basser
Medical Biophysics: Robert Bonner
AStochastic Modeling of Biological Processes: Quantitative Optical Imaging and Tumor-Induced Angiogenesis: Amir Gandjbakhche
Cell Biophysics: Ralph Nossal 

Laboratory of Mammalian Genes and Development
Signals Regulating T Cell Development: Paul Love
Molecular Genetics of an Imprinted Gene Cluster on Mouse Distal Chromosome 7: Karl Pfeifer
Genes that Pattern the Mouse Embryo: Heiner Westphal

Laboratory of Molecular Genetics
Nutrient Control of Bacterial Gene Expression: Michael Cashel
Patterning Neurogenesis in the Zebrafish Embryo: Ajay Chitnis
Physiological, Biochemical, and Molecular Genetic Events of Recognition and Resolution of RNA-DNA Hybrids: Robert Crouch
Molecular Genetics of Embryogenesis in Xenopus and Zebrafish: Igor Dawid
Control of Gene Expression During Development: Judith Kassis
Regulation of Homeotic Gene Function in Drosophila: James Kennison
Molecular Genetics of Mammalian Retrovirus Replication: Judith Levin
Control of Ectodermal Development in Xenopus: Thomas Sargent
Organogenesis of the Zebrafish Vasculature: Brant Weinstein
Mechanisms for Controlling Gene Expression in Bacteria and Bacteriophage: Robert Weisberg

Laboratory of Molecular Growth Regulation
Chromatic Remodeling and Gene Activation: David Clark
Regulation of Mammalian Cell Proliferation and Development: Melvin DePamphilis
Mapping Higher Order Chromatin Structures: Bruce Howard
La Antigen and Associated RNA Metabolism in Cell Biology, Growth and Development: Richard Maraia
Developmental Gene Regulation of the Immune System: Keiko Ozato

The Laboratory of Physical and Structural Biology
Biophysics of Large Membrane Channels: Sergey Bezrukov
Physical Forces Organizing Biomolecules: Adrian Parsegian
Intermolecular Forces, Recognition, and Dynamics: Donald Rau
 
Pediatric and Reproductive Endocrinology Branch
The Hypothalamic-Pituitary-Adrenal Axis: Its Endocrine Disorders and Interactions with the Immune System: George Chrousos
Hypercortiolism and Reproductive Disorders: Endometrial Physiology: Lynnette Nieman
Diagnosis, Localization, Pathophysiology, and Molecular Biology of Pheochromocytoma: Karel Pacak
Reproductive Endocrinology and Infertility: James Segars
 
Perinatology Research Branch
Pathophysiology of Premature Labor and Complications of Prematurity; Prenatal Diagnosis of Congenital Anomalies: Roberto Romero

Physical Disabilities Branch
Research in Physical Disabilities: Steven Stanhope

Section on Cell Biology and Signal Transduction
Calcium-Based Excitability in Glial Cells: James Russell

Section on Nervous System Development and Plasticity
Nervous System Development and Plasticity: Douglas Fields

Section on Physical Biochemistry
Physical Principles of Biomolecular Recognition, Self-Assembly, and Regulation: Sergey Leikin

Unit on Biologic Computation
Scientific Software Support and Bioinformatics: Jonathan Epstein