HLA Linkage Disequilibrium

 

This tool takes a series of tab-delimited HLA types and returns any linkage disequilibrium found by a Fisher's exact test. For more information, see details below, and try Sample Input.

Input

Paste your HLA data here Sample Input
or browse to select a file

Options

Compare what class of HLA types?	Leave HLAs as presented 4-digit HLA comparison 2-digit HLA comparison
Show all linkages with a p-value that is	Significant considering the number of tests performed, or Less than a p-value of

Submit  Reset

 

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Details

HLA frequency

HLA frequences can be counted two different ways, which differ in how homozygous alleles are counted.

Population

Frequencies of HLA type per person. Homozygous HLAs are counted once.

Allele

Frequencies of HLA type per allele. Homozygous HLAs are counted twice.

HLA 2/4 digit conversion

HLA type are reported with various resolutions (2, 4 or more digits). This tools provied three options for handling this.

Leave HLAs as presented

The HLA type are left unchanged and each distinct type is counted seperately.

4-digit HLA comparison

Silent mutations are ignored; HLA types with more than 4 digits precision are truncated. HLA type with 2 digits are left unchanged.

2-digit HLA comparison

All HLA type are converted to 2 digits. The conversion serotype information if available or else the 2-digit HLA family.