HLA Typing and Epitope Mapping

Introduction

A new class of immunological data has been accruing. Several studies defining reactive peptide maps scanning either most or all of HIV proteins have been obtained, where optimal epitopes are not usually defined, but reactive peptides and the individual's HLA types are defined for a large population-based study. In order that such data can be cross-compared between different studies, the NIH has requested we make such data available through the Los Alamos HIV database.

This site contains data tables, organized by study, that describe:

1. Peptides: a list of the subjects that react with each peptide and their HLA type, and the IFN γ Elispot results.
2. Subjects: each person's HLA, ethnicity, CD4 and viral load at time of sampling, and reactive peptides.
3. Maps of overlapping peptides and HLA types of responding individuals, relative to the HXB2 reference strain.

If you would like to make analogous data from you own work available to others through this database, please contact us at immuno@lanl.gov.

Data Sets

Study 1: Consistent CTL targeting of immunodominant regions in HIV across different ethnicities. N. Frahm et al. J. Virol. 78(5), 2004.

Study 2: REACH (Reaching for Excellence in Adolescent Care and Health) study of the Adolescent Medicine HIV/AIDS Research Network.

Study 3: A cohort from Durban, South Africa. HIV-1, subtype C.

Sequence Data for the South Africa cohort.

Study 4: further analysis of the cohort from Durban, South Africa. HIV-1, subtype C.

Study 5: HLA Class-I Driven Evolution of Human Immunodeficiency Virus Type1 Subtype C

Last modified: Tue Nov 13 12:11:16 MST 2007