03 December 2008

Article

Spliceosomal cleavage generates the 3' end of telomerase RNA

Jessica A. Box, Jeremy T. Bunch, Wen Tang & Peter Baumann

doi:10.1038/nature07584

Abstract | Full Text | PDF (598K) | Supplementary information

Letters

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

Cristina Lo Celso, Heather E. Fleming, Juwell W. Wu, Cher X. Zhao, Sam Miake-Lye, Joji Fujisaki, Daniel Côté, David W. Rowe, Charles P. Lin & David T. Scadden

doi:10.1038/nature07434

First paragraph | Full Text | PDF (1,458K) | Supplementary information

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

Patrick Narbonne & Richard Roy

doi:10.1038/nature07536

First paragraph | Full Text | PDF (697K) | Supplementary information

A simple model of bipartite cooperation for ecological and organizational networks

Serguei Saavedra, Felix Reed-Tsochas & Brian Uzzi

doi:10.1038/nature07532

First paragraph | Full Text | PDF (363K) | Supplementary information

Detection of functional haematopoietic stem cell niche using real-time imaging

Yucai Xie, Tong Yin, Winfried Wiegraebe, Xi C. He, Diana Miller, Danny Stark, Katherine Perko, Richard Alexander, Joel Schwartz, Justin C. Grindley, Jungeun Park, Jeff S. Haug, Joshua P. Wunderlich, Hua Li, Simon Zhang, Teri Johnson, Ricardo A. Feldman & Linheng Li

doi:10.1038/nature07639

First paragraph | Full Text | PDF (1,309K) | Supplementary information

30 November 2008

Letters

The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear

Jessica R. Colantonio, Julien Vermot, David Wu, Adam D. Langenbacher, Scott Fraser, Jau-Nian Chen & Kent L. Hill

doi:10.1038/nature07520

First paragraph | Full Text | PDF (1,349K) | Supplementary information

Protein kinase R reveals an evolutionary model for defeating viral mimicry

Nels C. Elde, Stephanie J. Child, Adam P. Geballe & Harmit S. Malik

doi:10.1038/nature07529

First paragraph | Full Text | PDF (637K) | Supplementary information

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

Céline M. O'Gorman, Hubert T. Fuller & Paul S. Dyer

doi:10.1038/nature07528

First paragraph | Full Text | PDF (723K) | Supplementary information

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Thomas Thum, Carina Gross, Jan Fiedler, Thomas Fischer, Stephan Kissler, Markus Bussen, Paolo Galuppo, Steffen Just, Wolfgang Rottbauer, Stefan Frantz, Mirco Castoldi, Jürgen Soutschek, Victor Koteliansky, Andreas Rosenwald, M. Albert Basson, Jonathan D. Licht, John T. R. Pena, Sara H. Rouhanifard, Martina U. Muckenthaler, Thomas Tuschl, Gail R. Martin, Johann Bauersachs & Stefan Engelhardt

doi:10.1038/nature07511

First paragraph | Full Text | PDF (958K) | Supplementary information

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, Micah Hamady, Tanya Yatsunenko, Brandi L. Cantarel, Alexis Duncan, Ruth E. Ley, Mitchell L. Sogin, William J. Jones, Bruce A. Roe, Jason P. Affourtit, Michael Egholm, Bernard Henrissat, Andrew C. Heath, Rob Knight & Jeffrey I. Gordon

doi:10.1038/nature07540

First paragraph | Full Text | PDF (429K) | Supplementary information

26 November 2008

Letters

Major gradients in putatively nitrifying and non-nitrifying Archaea in the deep North Atlantic

Hélène Agogué, Maaike Brink, Julie Dinasquet & Gerhard J. Herndl

doi:10.1038/nature07535

First paragraph | Full Text | PDF (332K) | Supplementary information

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Theresa Alenghat, Katherine Meyers, Shannon E. Mullican, Kirstin Leitner, Adetoun Adeniji-Adele, Jacqueline Avila, Maja Buan, Rexford S. Ahima, Klaus H. Kaestner & Mitchell A. Lazar

doi:10.1038/nature07541

First paragraph | Full Text | PDF (489K) | Supplementary information

Parallel adaptations to high temperatures in the Archaean eon

Bastien Boussau, Samuel Blanquart, Anamaria Necsulea, Nicolas Lartillot & Manolo Gouy

doi:10.1038/nature07393

First paragraph | Full Text | PDF (348K) | Supplementary information

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

Masako Kohyama, Wataru Ise, Brian T. Edelson, Peter R. Wilker, Kai Hildner, Carlo Mejia, William A. Frazier, Theresa L. Murphy & Kenneth M. Murphy

doi:10.1038/nature07472

First paragraph | Full Text | PDF (632K) | Supplementary information

Ferritin is used for iron storage in bloom-forming marine pennate diatoms

Adrian Marchetti, Micaela S. Parker, Lauren P. Moccia, Ellen O. Lin, Angele L. Arrieta, Francois Ribalet, Michael E. P. Murphy, Maria T. Maldonado & E. Virginia Armbrust

doi:10.1038/nature07539

• PDB code

  • 3E6R
  • 3E6S

• 3D view

  • 3E6R
  • 3E6S

First paragraph | Full Text | PDF (476K) | Supplementary information

23 November 2008

Letters

Analysis of combinatorial cis-regulation in synthetic and genomic promoters

Jason Gertz, Eric D. Siggia & Barak A. Cohen

doi:10.1038/nature07521

First paragraph | Full Text | PDF (518K) | Supplementary information

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

Samir M. Hamdan, Joseph J. Loparo, Masateru Takahashi, Charles C. Richardson & Antoine M. van Oijen

doi:10.1038/nature07512

First paragraph | Full Text | PDF (1,346K) | Supplementary information

Pulsed contractions of an actin–myosin network drive apical constriction

Adam C. Martin, Matthias Kaschube & Eric F. Wieschaus

doi:10.1038/nature07522

First paragraph | Full Text | PDF (1,295K) | Supplementary information

Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids

Zhongfu Ni, Eun-Deok Kim, Misook Ha, Erika Lackey, Jianxin Liu, Yirong Zhang, Qixin Sun & Z. Jeffrey Chen

doi:10.1038/nature07523

First paragraph | Full Text | PDF (759K) | Supplementary information

19 November 2008

Article

The replisome uses mRNA as a primer after colliding with RNA polymerase

Richard T. Pomerantz & Mike O'Donnell

doi:10.1038/nature07527

Abstract | Full Text | PDF (1,991K) | Supplementary information

Letters

Successful range-expanding plants experience less above-ground and below-ground enemy impact

Tim Engelkes, Elly Morriën, Koen J. F. Verhoeven, T. Martijn Bezemer, Arjen Biere, Jeffrey A. Harvey, Lauren M. McIntyre, Wil L. M. Tamis & Wim H. van der Putten

doi:10.1038/nature07474

First paragraph | Full Text | PDF (211K) | Supplementary information

Detecting influenza epidemics using search engine query data

Jeremy Ginsberg, Matthew H. Mohebbi, Rajan S. Patel, Lynnette Brammer, Mark S. Smolinski & Larry Brilliant

doi:10.1038/nature07634

First paragraph | Full Text | PDF (242K) | Supplementary information

Emergence of complex cell properties by learning to generalize in natural scenes

Yan Karklin & Michael S. Lewicki

doi:10.1038/nature07481

First paragraph | Full Text | PDF (908K) | Supplementary information

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

Sandra Rebouissou, Mohamed Amessou, Gabrielle Couchy, Karine Poussin, Sandrine Imbeaud, Camilla Pilati, Tina Izard, Charles Balabaud, Paulette Bioulac-Sage & Jessica Zucman-Rossi

doi:10.1038/nature07475

First paragraph | Full Text | PDF (578K) | Supplementary information

16 November 2008

Letters

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

Maria Barna, Aya Pusic, Ornella Zollo, Maria Costa, Nadya Kondrashov, Eduardo Rego, Pulivarthi H. Rao & Davide Ruggero

doi:10.1038/nature07449

First paragraph | Full Text | PDF (594K) | Supplementary information

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

Jiyun V. Kim, Silvia S. Kang, Michael L. Dustin & Dorian B. McGavern

doi:10.1038/nature07591

First paragraph | Full Text | PDF (1,086K) | Supplementary information

Low conservation of gene content in the Drosophila Y chromosome

Leonardo B. Koerich, Xiaoyun Wang, Andrew G. Clark & Antonio Bernardo Carvalho

doi:10.1038/nature07463

First paragraph | Full Text | PDF (302K) | Supplementary information

Structural recognition and functional activation of FcR by innate pentraxins

Jinghua Lu, Lorraine L. Marnell, Kristopher D. Marjon, Carolyn Mold, Terry W. Du Clos & Peter D. Sun

doi:10.1038/nature07468

• PDB code

  • 3D5O

• 3D view

  • 3D5O

First paragraph | Full Text | PDF (817K) | Supplementary information

Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis

Steven J. Malcolmson, Simon J. Meek, Elizabeth S. Sattely, Richard R. Schrock & Amir H. Hoveyda

doi:10.1038/nature07594

First paragraph | Full Text | PDF (660K) | Supplementary information

12 November 2008

Letters

Experience leaves a lasting structural trace in cortical circuits

Sonja B. Hofer, Thomas D. Mrsic-Flogel, Tobias Bonhoeffer & Mark Hübener

doi:10.1038/nature07487

First paragraph | Full Text | PDF (739K) | Supplementary information

Neural processing of auditory feedback during vocal practice in a songbird

Georg B. Keller & Richard H. R. Hahnloser

doi:10.1038/nature07467

First paragraph | Full Text | PDF (789K) | Supplementary information

Memory CD8 T-cell compartment grows in size with immunological experience

Vaiva Vezys, Andrew Yates, Kerry A. Casey, Gibson Lanier, Rafi Ahmed, Rustom Antia & David Masopust

doi:10.1038/nature07486

First paragraph | Full Text | PDF (993K) | Supplementary information

09 November 2008

Letters

A role for VEGF as a negative regulator of pericyte function and vessel maturation

Joshua I. Greenberg, David J. Shields, Samuel G. Barillas, Lisette M. Acevedo, Eric Murphy, Jianhua Huang, Lea Scheppke, Christian Stockmann, Randall S. Johnson, Niren Angle & David A. Cheresh

doi:10.1038/nature07424

First paragraph | Full Text | PDF (791K) | Supplementary information

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

Jinyan Liu, Kara L. O'Brien, Diana M. Lynch, Nathaniel L. Simmons, Annalena La Porte, Ambryice M. Riggs, Peter Abbink, Rory T. Coffey, Lauren E. Grandpre, Michael S. Seaman, Gary Landucci, Donald N. Forthal, David C. Montefiori, Angela Carville, Keith G. Mansfield, Menzo J. Havenga, Maria G. Pau, Jaap Goudsmit & Dan H. Barouch

doi:10.1038/nature07469

First paragraph | Full Text | PDF (352K)

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

Christian Stockmann, Andrew Doedens, Alexander Weidemann, Na Zhang, Norihiko Takeda, Joshua I. Greenberg, David A. Cheresh & Randall S. Johnson

doi:10.1038/nature07445

First paragraph | Full Text | PDF (465K) | Supplementary information

05 November 2008

Letters

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Nicolas Bocquet, Hugues Nury, Marc Baaden, Chantal Le Poupon, Jean-Pierre Changeux, Marc Delarue & Pierre-Jean Corringer

doi:10.1038/nature07462

• PDB code

  • 3eam

• 3D view

  • 3eam

First paragraph | Full Text | PDF (1,137K) | Supplementary information

X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus

Zachary A. Bornholdt & B. V. Venkataram Prasad

doi:10.1038/nature07444

• PDB code

  • 3EU6

• 3D view

  • 3EU6

First paragraph | Full Text | PDF (917K) | Supplementary information

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

Jérôme Gros, Olivier Serralbo & Christophe Marcelle

doi:10.1038/nature07564

First paragraph | Full Text | PDF (6,955K) | Supplementary information

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

Ricarda J. C. Hilf & Raimund Dutzler

doi:10.1038/nature07461

• PDB code

  • 3EHZ
  • 3EI0

• 3D view

  • 3EHZ
  • 3EI0

First paragraph | Full Text | PDF (1,418K) | Supplementary information

G protein G_i functions immediately downstream of Smoothened in Hedgehog signalling

Stacey K. Ogden, Dennis Liang Fei, Neal S. Schilling, Yashi F. Ahmed, John Hwa & David J. Robbins

doi:10.1038/nature07459

First paragraph | Full Text | PDF (651K) | Supplementary information

02 November 2008

Letters

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

Marina Cella, Anja Fuchs, William Vermi, Fabio Facchetti, Karel Otero, Jochen K. M. Lennerz, Jason M. Doherty, Jason C. Mills & Marco Colonna

doi:10.1038/nature07537

First paragraph | Full Text | PDF (678K) | Supplementary information

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

Bernard T. Kelly, Airlie J. McCoy, Kira Späte, Sharon E. Miller, Philip R. Evans, Stefan Höning & David J. Owen

doi:10.1038/nature07422

• PDB code

  • 2jkr
  • 2jkt

• 3D view

  • 2jkr
  • 2jkt

First paragraph | Full Text | PDF (976K) | Supplementary information

Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons

Marta Morey, Susan K. Yee, Tory Herman, Aljoscha Nern, Enrique Blanco & S. Lawrence Zipursky

doi:10.1038/nature07419

First paragraph | Full Text | PDF (989K) | Supplementary information

Temporal identity in axonal target layer recognition

Milan Petrovic & Thomas Hummel

doi:10.1038/nature07407

First paragraph | Full Text | PDF (1,109K) | Supplementary information

29 October 2008

Article

Brain metabolism dictates the polarity of astrocyte control over arterioles

Grant R. J. Gordon, Hyun B. Choi, Ravi L. Rungta, Graham C. R. Ellis-Davies & Brian A. MacVicar

doi:10.1038/nature07525

Abstract | Full Text | PDF (1,427K) | Supplementary information

Letter

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

Helen Weavers, Silvia Prieto-Sánchez, Ferdinand Grawe, Amparo Garcia-López, Ruben Artero, Michaela Wilsch-Bräuninger, Mar Ruiz-Gómez, Helen Skaer & Barry Denholm

doi:10.1038/nature07526

First paragraph | Full Text | PDF (2,229K) | Supplementary information

26 October 2008

Letter

Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions

Pankaj Dhonukshe, Hirokazu Tanaka, Tatsuaki Goh, Kazuo Ebine, Ari Pekka Mähönen, Kalika Prasad, Ikram Blilou, Niko Geldner, Jian Xu, Tomohiro Uemura, Joanne Chory, Takashi Ueda, Akihiko Nakano, Ben Scheres & Jií Friml

doi:10.1038/nature07409

First paragraph | Full Text | PDF (722K) | Supplementary information

22 October 2008

Letters

Transcription inactivation through local refolding of the RNA polymerase structure

Georgiy A. Belogurov, Marina N. Vassylyeva, Anastasiya Sevostyanova, James R. Appleman, Alan X. Xiang, Ricardo Lira, Stephen E. Webber, Sergiy Klyuyev, Evgeny Nudler, Irina Artsimovitch & Dmitry G. Vassylyev

doi:10.1038/nature07510

• PDB code

  • 3EQL

• 3D view

  • 3EQL

First paragraph | Full Text | PDF (681K) | Supplementary information

Generation of a prostate from a single adult stem cell

Kevin G. Leong, Bu-Er Wang, Leisa Johnson & Wei-Qiang Gao

doi:10.1038/nature07427

First paragraph | Full Text | PDF (1,245K) | Supplementary information

Experience with moving visual stimuli drives the early development of cortical direction selectivity

Ye Li, Stephen D. Van Hooser, Mark Mazurek, Leonard E. White & David Fitzpatrick

doi:10.1038/nature07417

First paragraph | Full Text | PDF (955K) | Supplementary information

19 October 2008

Letter

Strong effect of dispersal network structure on ecological dynamics

Matthew D. Holland & Alan Hastings

doi:10.1038/nature07395

First paragraph | Full Text | PDF (379K) | Supplementary information

12 October 2008

Letter

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Andrea L. Bredemeyer, Beth A. Helmink, Cynthia L. Innes, Boris Calderon, Lisa M. McGinnis, Grace K. Mahowald, Eric J. Gapud, Laura M. Walker, Jennifer B. Collins, Brian K. Weaver, Laura Mandik-Nayak, Robert D. Schreiber, Paul M. Allen, Michael J. May, Richard S. Paules, Craig H. Bassing & Barry P. Sleckman

doi:10.1038/nature07392

First paragraph | Full Text | PDF (609K) | Supplementary information