Publication Details
X-Ray Luminescence of LaF3:Tb3+ and LaF3:Ce3+, Tb3+ Water Soluble Nanoparticles.Citation
Liu Y, W Chen, S Wang, AG Joly, SL Westcott, and BK Woo.2008."X-Ray Luminescence of LaF3:Tb3+ and LaF3:Ce3+, Tb3+ Water Soluble Nanoparticles."Journal of Applied Physics 103(6):Art. No. 063105. doi:10.1063/1.2890148
Abstract
Utilizing scintillation nanoparticles as agents for photodynamic therapy for cancer treatment necessitates the use of biocompatible and water soluble nanoparticles. In this article, we report the synthesis and X-ray luminescence of water soluble Ce and Tb doped LaF3 nanoparticles. The nanoparticles are conjugated with folic acid and meso-tetra (o-carboxyphenyl) porphyrin. X-ray luminescence is observed from the nanoparticles in both powder and solution samples. More importantly, singlet oxygen has been detected from the conjugated system following X-ray excitation. These preliminary observations indicate that water-soluble scintillation nanoparticles can be potentially used in photodynamic therapy for deep-tissue cancer treatment.
