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- ADMINISTRATIVE INSTRUCTIONS UNDER THE PCT

Appendices

Appendix 1: Numeric Identifiers

Appendix 2: Nucleotide and Amino Acid Symbols and Feature Table

	Table 1:	List of Nucleotides
	Table 2:	List of Modified Nucleotides
	Table 3:	List of Amino Acids
	Table 4:	List of Modified and Unusual Amino Acids
	Table 5:	List of Feature Keys Related to Nucleotide Sequences
	Table 6:	List of Feature Keys Related to Protein Sequences

Appendix 3: Specimen Sequence Listing

[Appendices 1 to 3 to Annex C follow]

Numeric Identifiers

Only numeric identifiers as defined below may be used in sequence listings submitted in applications. The text of the data element headings given below shall not be included in the sequence listings.

Numeric identifiers of mandatory data elements, that is, data elements which must be included in all sequence listings (see paragraph 25 of this Standard: items 110, 120, 160, 210, 211, 212, 213 and 400) and numeric identifiers of data elements which must be included in circumstances specified in this Standard (see paragraphs 26, 27, 28, 29 and 30 of this Standard: items 130, 140, 141, 150 and 151, and 220 to 223) are marked by the symbol "M."

Numeric identifiers of optional data elements (see paragraph 31 of this Standard) are marked by the symbol "O."

Numeric Identifier	Numeric Identifier Description	Mandatory (M) or Optional (O)	Comment
<110>	Applicant name	M	where the name of the applicant is written in characters other than those of the Latin alphabet, the same shall also be indicated in characters of the Latin alphabet either as a mere transliteration or through translation into English
<120>	Title of Invention	M
<130>	File Reference	M, in the circumstances specified in paragraph 26 of this Standard	see paragraph 26 of this Standard
<140>	Current patent application	M, in the circumstances specified in paragraph 27 of this Standard	see paragraph 27 of this Standard; the current patent application shall be identified, in the following order, by the two-letter code indicated in accordance with WIPO Standard ST.3 and the application number (in the format used by the industrial property Office with which the current patent application is filed) or, for an international application, by the international application number
<141>	Current filing date	M, in the circumstances specified in paragraph 27 of this Standard	see paragraph 27 of this Standard; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<150>	Earlier patent application	M, in the circumstances specified in paragraph 28 of this Standard	see paragraph 28 of this Standard; the earlier patent application shall be identified, in the following order, by the two-letter code indicated in accordance with WIPO Standard ST.3 and the application number (in the format used by the industrial property Office with which the earlier patent application was filed) or, for an international application, by the international application number
<151>	Earlier application filing date	M, in the circumstances specified in paragraph 28 of this Standard	see paragraph 28 of this Standard; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<160>	Number of SEQ ID NOs	M
<170>	Software	O
<210>	Information for SEQ ID NO: x	M	response shall be an integer representing the SEQ ID NO shown
<211>	Length	M	sequence length expressed in number of base pairs or amino acids
<212>	Type	M	type of molecule sequenced in SEQ ID NO: x, either DNA, RNA or PRT; if a nucleotide sequence contains both DNA and RNA fragments, the value shall be "DNA"; in addition, the combined DNA/RNA molecule shall be further described in the <220> to <223> feature section
<213>	Organism	M	Genus Species (that is, scientific name) or "Artificial Sequence" or "Unknown"
<220>	Feature	M, in the circumstances specified in paragraph 29 and 30 of this Standard	leave blank; see paragraphs 29 and 30 of this Standard; description of points of biological significance in the sequence in SEQ ID NO: x) (may be repeated depending on the number of features indicated)
<221>	Name/key	M in the circumstances specified in paragraph 29 of this Standard	see paragraph 29 of this Standard; only those keys as described in Table 5 or 6 of Appendix 2 shall be used
<222>	Location	M, in the circumstances specified in paragraph 29 of this Standard	see paragraph 29 of this Standard; - from (number of first base/amino acid in the feature) - to (number of last base/amino acid in the feature) - base pairs (numbers refer to positions of base pairs in a nucleotide sequence) - amino acids (numbers refer to positions of amino acid residues in an amino acid sequence) - whether feature is located on the complementary strand to that filed in the sequence listing
<223>	Other information:	M, in the circumstances specified in paragraphs 29 and 30 of this Standard	see paragraphs 29 and 30 of this Standard; any other relevant information, using language neutral vocabulary, or free text (preferably in English); any free text is to be repeated in the main part of the description in the language thereof (see paragraph 36 of this Standard); where any modified base or modified/unusual L-amino acid appearing in Appendix 2, Tables 2 and 4, is in the sequence, the symbol associated with that base or amino acid from Appendix 2, Tables 2 and 4, should be used
<300>	Publication information	O	leave blank; repeat section for each relevant publication
<301>	Authors	O
<302>	Title	O	title of publication
<303>	Journal	O	journal name in which data published
<304>	Volume	O	journal volume in which data published
<305>	Issue	O	journal issue number in which data published
<306>	Pages	O	journal page numbers on which data published
<307>	Date	O	journal date on which data published; if possible, the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<308>	Database accession number	O	accession number assigned by database including database name
<309>	Database entry date	O	date of entry in database; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<310>	Document number	O	document number, for patent type citations only; the full document shall specify, in the following order, the two-letter code indicated in accordance with WIPO Standard ST.3, the publication number indicated in accordance with WIPO Standard ST.6, and the kind-of-document code indicated in accordance with WIPO Standard ST.16
<311>	Filing date	O	document filing date, for patent-type citations only; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<312>	Publication date	O	document publication date; for patent-type citations only; the date shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)
<313>	Relevant residues in SEQ ID NO: x: from to	O
<400>	Sequence	M	SEQ ID NO: x should follow the numeric identifier and should appear on the line preceding the sequence (see Appendix 3)

Nucleotide and Amino Acid Symbols and Feature Table

Table 1: List of Nucleotides

Table 2: List of Modified Nucleotides

Table 3: List of Amino Acids

Table 4: List of Modified and Unusual Amino Acids

Table 5: List of Feature Keys Related to Nucleotide Sequences

Table 6: List of Feature Keys Related to Protein Sequences

Specimen Sequence Listing

[Annex C-bis follows]

TECHNICAL REQUIREMENTS FOR THE PRESENTATION OF TABLES RELATED TO NUCLEOTIDE AND AMINO ACID SEQUENCE LISTINGS IN INTERNATIONAL PATENT APPLICATIONS UNDER THE PCT

Introduction

1. These technical requirements have been elaborated so as to provide standardization of the presentation of tables related to nucleotide and amino acid sequence listings in international patent applications. These technical requirements are intended to allow the applicant to draw up such tables in a manner which is acceptable to all receiving Offices, International Searching Authorities, International Preliminary Examining Authorities and to the International Bureau for the purposes of the international phase and to all designated and elected Offices for the purposes of the national phase.

Definition

2. For the purposes of these technical requirements, "competent Authority" is the International Searching Authority that is to carry out the international search on the international application, or the International Preliminary Examining Authority that is to carry out the international preliminary examination on the international application, or the designated/elected Office before which the processing of the international application has started.

Tables related to sequence listings

3. Tables filed in computer readable form under Section 801(a) shall comply with one of the following character formats:

(i) UTF-8-encoded Unicode 3.0; or

(ii) XML format conforming to the "Application-Body" Document Type Definition referred to in Appendix I of Annex F;

4. The spatial relationships (e.g., columns and rows) of the table elements shall be maintained.

5. At the option of the competent Authority, file compression is acceptable, so long as the compressed file is in a self-extracting format that will decompress on a Personal Computer Operating system that is acceptable to the competent Authority and to the International Bureau.

6. Each table shall be contained within a separate electronic file on any electronic medium that is acceptable to the competent Authority. The file recorded on the electronic medium that is acceptable to the competent Authority shall be encoded using IBM Code Page 437, IBM Code Page 932 or a compatible code page. A compatible code page, as would be required for, for example, Japanese, Chinese, Cyrillic, Arabic, Greek or Hebrew characters, is one that assigns the Roman alphabet and numerals to the same hexadecimal positions as do the specified code pages.

7. Tables filed in computer readable form may be created by any means, as long as the table on an electronic medium that is acceptable to the competent Authority is readable under a Personal Computer Operating system that is acceptable to the competent Authority and to the International Bureau.

8. If the electronic medium that is acceptable to the competent Authority is submitted after the date of filing of an application, the labels shall also include the filing date of the application and the application number.

[Annex D follows]

INFORMATION FROM PAMPHLET FRONT PAGE TO BE INCLUDED IN THE GAZETTE UNDER

RULE 86.1(a)(i)

The following information shall be extracted from the front page of the pamphlet of each published international application and shall, in accordance with Rule 86.1(a)(i), appear in the corresponding entry of the Gazette:

1. as to the international publication:

1.1 the international publication number

1.2 the date of the international publication

1.3 an indication whether the following items were published in the pamphlet:

1.31 international search report

1.32 declaration under Article 17(2)

1.33 claims amended under Article 19(1)

1.34 statement under Article 19(1)

1.35 [Deleted]

1.36 request for rectification under the third sentence of Rule 91.1(f)

1.37 information concerning a priority claim which was considered not to have been made, published upon request made under Rule 26^bis.2(c)

1.4 the language in which the international application was filed

1.5 the language of publication of the international application

2. as to the international application:

2.1 the title of the invention

2.2 the symbol(s) of the International Patent Classification (IPC)

2.3 the international application number

2.4 the international filing date

3. as to any priority claim:

3.1 the application number of the earlier application

3.2 the date on which the earlier application was filed

3.3 where the earlier application is:

3.31 a national application: the country in which the earlier application was filed

3.32 a regional application: the authority entrusted with the granting of regional patents under the applicable regional patent treaty and, in the case referred to in Rule 4.1 0(b)(ii), a country party to the Paris Convention for the Protection of Industrial Property for which that earlier application was filed

3.33 an international application: the receiving Office with which it was filed

4. as to the applicant, inventor and agent:

4.1 their name(s)

4.2 their mailing address(es)

5. as to the designated States:

5.1 their names

5.2 the indication of any wish for a regional patent

5.3 the indication of kind of protection sought, unless a patent is sought

6. as to a statement concerning non-prejudicial disclosure or exception to lack of novelty:

6.1 the date of the disclosure

6.2 the place of the disclosure

6.3 the kind of the disclosure (e.g., exhibition, scientific publication, conference reports, etc.)

6.4 the title of the exhibition, publication or conference

7. as to any indication in relation to deposited biological material furnished under Rule 13^bis separately from the description:

7.1 the fact that such indication is published

7.2 the date on which the International Bureau received such indication

8. as to any declaration referred to in Rule 4.17 which was received by the International Bureau before the expiration of the time limit under Rule 26^ter.1:

8.1 the fact that such a declaration was made and a reference to the applicable item in Rule 4.17 under which it was made

8.2 an indication of those designations for the purposes of which such declaration was made.

INFORMATION TO BE PUBLISHED IN THE GAZETTE UNDER

RULE 86.1(a)(v)

1. The time limits applicable under Articles 22 and 39 in respect of each Contracting State.

2. The list of the non-patent literature agreed upon by the International Searching Authorities for inclusion in the minimum documentation.

3. The names of the national Offices which do not wish to receive copies under Article 13(2)(c).

4. The provisions of the national laws of Contracting States concerning international-type search.

5. The text of the agreements entered into between the International Bureau and the International Searching Authorities or the International Preliminary Examining Authorities.

6. The names of the national Offices which entirely or in part waived their rights to any communication under Article 20.

7. The names of the Contracting States which are bound by Chapter II of the PCT.

8. Index of concordance of international application numbers and international publication numbers, listed according to international application numbers.

9. Index of applicants' names giving, for each name, the corresponding international publication number(s).

10. Index of international publication numbers, grouped according to the International Patent Classification symbols.

11. Indication of any subject matter that will not be searched or examined by the various International Searching and Preliminary Examining Authorities under Rules 39 and 67.

12. Requirements of designated and elected Offices under Rules 49.5 and 76.5 in relation to the furnishing of translations.

13. The names of those designated Offices wishing to receive notifications under Rule 24.2 (b).

14. The dates defining the period referred to in Rule 32.1(b) during which the international application, whose effects may be extended to a successor State under Rule 32.1, must have been filed.

[Annex F follows]

STANDARD FOR THE ELECTRONIC FILING AND PROCESSING OF INTERNATIONAL APPLICATIONS

[The text of Annex F, which is not reproduced here, is available from WIPO's website at http://www.wipo.org/pct/en/index.html. To view Annex F, click on "PCT Gazette" and see PCT Gazette Special Issue S-04/2001 (27 December 2001). To see the complete text of the Administrative Instructions under the PCT, click on "PCT Legal Texts." Annex F consists of nine main sections and four appendices, the titles of which are reproduced below.

1. Introduction

2. The E-PCT standard: Overview and vision

3. E-PCT submission structure and format

4. IA documents packaging

5. Transmission

6. Electronic filing software

7. PCT workflow transactions

8. Principles of electronic records management

9. Abbreviated expressions, interpretation and glossary Appendix I XML DTDs for the E-PCT Standard Appendix II PKI Architecture for the E-PCT Standard Appendix III Basic Common Standard for Electronic Filing Appendix IV Use of Physical Media for the E-PCT Standard] [End of Appendix, Annex and document]

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