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Selected Publications

Transgenic Carcinogenesis Group

  1. Kang-Sickel J-CC , Fox DD, Nam T, Jayaraj K, Ball LM, French JE, Klapper DG, Gold A, Nylander-French LA. S-Arylcysteine-Keratin Adducts as Biomarkers of Human Dermal Exposure to Aromatic Hydrocarbons. Chemical research in toxicology 21(4):852-858, (2008). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18361511) Exit NIEHS
  2. Qu, W., Ke, H., Broderick, D., French J.E., Webber, M..M., and Waalkes, M.P. Apoptotic resistance in cadmium-transformed human prostate epithelial cells. Toxicol. Sci., P222, 2027, (2006).
  3. Martin, Keith R., Jokinen, Michael P., Honeycutt, Hayden P., Quinn, Anita, Kari, Frank W. Barrett, J. Carl and French, John E. Tumor profile of novel p53 heterozygous Tg.AC (v-Ha-ras) bitransgenic mice treated with benzo[a]pyrene and fed dietary N-acetyl-L-cysteine (NAC). Toxicological Sciences, 81: 293-301, (2004). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15254344)
  4. Martin, KR, Jokinen, MP, Honeycutt, HP, Quinn, A, Kari, FW, Barrett, JC and French, JE. Tumor spectrum in the p53 heterozygous zeta globin-promoted Tg.AC (v-Ha-ras) bi-transgenic mouse model. Toxicol. Path. 32:418-425, (2004). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15204965)
  5. Nwosu, V., Kissling, GE, Trempus, CS, Honeycutt, H, French, J.E. Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways. Toxicol Applied Pharmacol, 196:37-46, (2004). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15050406)
  6. French, JE, Identification and characterization of potential human carcinogens using B6.129tm1Trp53 heterozygous null mice and loss of heterozygosity at the Trp53 locus. IARC Workshop Publications, 157:271-287, (2004). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15055301)
  7. Gold, A., Nam, T-G, Jayaraj, K., Sangaiah, R., Klapper, D.G., Ball, L.M., French, J.E., Nylander-French, LA. Synthesis of S-aryl-D, L-cysteines and incorporation into keratin sequences. Organic Preparations Procedures Int’l. 35:375-382, (2003).
  8. Nam, T-G, Sangaiah, R, Gold, A, Lacks, GD, Nylander-French, LA, French, JE. Synthesis of FMOC-protected S-arylcysteines and modified keratin sequence peptides as specific epitopes as immunogens. Polycylic Aromatic Compounds, 12:239-248, (2002).
  9. Martin, KR, Saulnier, MJ, Kari, F.K., Barrett, J.C., and French, JE. Timing of supplementation with the antioxidant NAC reduces tumor multiplicity in novel cancer prone p53 haploinsufficient Tg.AC (v-Ha-ras) transgenic mice. Nutrition & Cancer 43:59-66 (2002). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12467136)
  10. Boley, SE, Wong, VA, French, JE, Recio, L. p53 heterozygosity alters mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene. Tox. Sci., 66, 209-15 (2002). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11896287)
  11. Martin, KR, Trempus, C, Saulnier, M, Kari, FW, Barrett, JC, and French, JE. Dietary N-acetyl-L-cysteine (NAC) modulates benzo[a]pyrene-induced skin tumors in p53 haploinsufficient Tg.AC (v-Ha-ras) mice. Carcinogenesis, 22 1373-1378 (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11532857)
  12. Healy LN, Pluta LJ, James RA, Janszen DB, Torous D, French JE, Recio L. Induction and time-dependent accumulation of micronuclei in peripheral blood of transgenic p53 +/- mice, Tg.AC (v-Ha-ras) and parental wild-type (C57BL/6 and FVB/N) mice exposed to benzene by inhalation Mutagenesis 16: (2) 163-168 (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11230560)
  13. French, J., Lacks, G., Trempus, C., Dunnick, J., Mahler, J., Foley, J., Tice, R., and Tennant, R. Loss of heterozygosity frequency at the Trp53 locus in p53 haploinsufficient mice is carcinogen and tissue dependent, Carcinogenesis. 22:98-106 (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11159747)
  14. Hulla, JE., French, JE., and Dunnick, JK. Chromosome 11 loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein reveals mitotic recombination. Toxicol Sci, 60:264-70 (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11248138)
  15. Hulla, JE. , French, JE. and Dunnick, JK. Chromosome 11 Allelotypes Reflect Mechanism of Chemical Carcinogenesis in Heterozygous p53-Deficient Mice, Carcinogenesis. 22:89-98 (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11159746)
  16. French, J.E. and Saulnier, M. Benzene Leukemogenesis: An Environmental Carcinogen Induced Tissue Specific Model of Neoplasia using Genetically Altered Mouse Models. J Toxicol Env Health, 61:101-103 (2000). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11086942)

Selected Chapters/Reviews

  1. Donehower LA, French JE, Hursting SD. The utility of genetically altered mouse models for cancer research. Mutat Res. 576(1-2):1-3, (2005). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15982676)
  2. MacDonald, J., French, JE, Gerson, RJ, Goodman, J, Inoue, T, Jacobs, A, Kasper, P, Keller, D, Lavin, A, Long, G, McCullough, B, Sistare, FD, Storer, R, van der Laan, JW. The utility of genetically-modified mouse assays for identifying human carcinogens – A basic understanding and a path forward. Toxicol Sciences, 77:188-94, (2004). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14657512)
  3. Pritchard, J. B., French, J.E., Davis, B.J., Haseman, J. K. Transgenic Mouse Models: Their Role in Carcinogen Identification. Env Health Persp, 111;444-454, (2003). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12676597)
  4. Storer RD, French JE, Donehower LA, Gulezian D, Mitsumori K, Recio L, Schiestl RH, Sistare FD, Tamaoki N, Usui T, van Steeg H; IWGT Working Group. Transgenic tumor models for carcinogen identification: the heterozygous Trp53-deficient and RasH2 mouse lines. Mutat Res. 540(2): 165-76, (2003). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11695560)
  5. Storer, RD, French, JE, Haseman, J., Hajian, G., LeGrand, EK, Long, GG, Mixson, Ochoa, R, Sagartz, JE, and Soper, KA. p53+/- Hemizygous Knockout Mouse: Overview of Available Data. Toxicol Pathol, 29 (suppl) 30-50 (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11695560)
  6. French, J, Storer, R, and Donehower, LA. The Nature of the Heterozygous Trp53 Knockout Model for Identification of Mutagenic Carcinogens. Toxicol Pathol, 29 (suppl) 24-29, (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11695559)
  7. Venkatachalam, S., Tyner, SD, Harvey, Sands, A., Boley, S., Recio, L., French, JE and Donehower, LA. Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53+/- Mouse Model in Carcinogenicity Testing. Toxicol Pathol, 29 (suppl) 147-154, (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11695551)
  8. Sills, RS, French, JE, and Cunningham, ML. New models for assessing carcinogenesis: An ongoing process. Toxicol Lett 120:187-98, (2001). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11323177)

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Last Reviewed: May 12, 2008