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2008
July 2008
Journal of Molecular Biology - 2008
Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein.
Stricher F, Huang CC, Descours A, Duquesnoy S, Combes O, Decker JM, Do Kwon Y, Lusso P, Shaw GM, Vita C, Kwong PD, Martin L.
J Mol Biol. 2008 Jul 1.
Proceedings of the national Academy of Sciences - 2008
A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys.
Santra S, Korber BT, Muldoon M, Barouch DH, Nabel GJ, Gao F, Hahn BH, Haynes BF, Letvin NL.
June 2008
Nature - Medicine - 2008
CD8+ T cell efficacy in vaccination and disease.
Appay V, Douek DC, Price DA.
Nat Med. 2008 Jun;14(6):623-8.
Journal of Leukocyte Biology - 2008
Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
Johnson TR, Rothenberg ME, Graham BS.
J Leukoc Biol. 2008 Jun 2. [Epub ahead of print]
May 2008 Public Library of Sciences - Pathogens - 2008
Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization.
Nelson S, Jost CA, Xu Q, Ess J, Martin JE, Oliphant T, Whitehead SS, Durbin AP, Graham BS, Diamond MS, Pierson TC.
PLoS Pathog. 2008 May 9;4(5):e1000060.
Journal of Virology - 2008
Cross-Reactive Human Immunodeficiency Virus Type 1- Neutralizing Human Monoclonal Antibody which Recognizes A Novel Conformational Epitope on gp41 and Lacks Reactivity against Self Antigens.
Zhang MY, Vu BK, Choudhary A, Lu H, Humbert M, Ong H, Alam M, Ruprecht RM, Quinnan G, Jiang S, Montefiori DC, Mascola JR, Broder CC, Haynes BF, Dimitrov DS.
J Virol. 2008 May 14. [Epub ahead of print]
Cell Host Microbe - 2008
HIV-1 assembly: viral glycoproteins segregate quantally to lipid rafts that associate individually with HIV-1 capsids and virions.
Leung K, Kim JO, Ganesh L, Kabat J, Schwartz O, Nabel GJ.
Cell Host Microbe. 2008 May 15;3(5):285-92.
Journal of Immunology - 2008
Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire.
Melenhorst JJ, Lay MD, Price DA, Adams SD, Zeilah J, Sosa E, Hensel NF, Follmann D, Douek DC, Davenport MP, Barrett AJ.
J Immunol. 2008 May 15;180(10):6484-9.
Journal of Virology - 2008
Limited maintenance of vaccine-induced SIV-specific CD8 T cell receptor clonotypes after virus challenge.
Smith MZ, Asher TE, Venturi V, Davenport MP, Douek DC, Price DA, Kent SJ.
J Virol. 2008 May 28. [Epub ahead of print]
April 2008
Journal of Virology - 2008
Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells.
Daucher M, Price DA, Brenchley JM, Lamoreaux L, Metcalf JA, Rehm C, Nies-Kraske E, Urban E, Yoder C, Rock D, Gumkowski J, Betts MR, Dybul MR, Douek DC.
J Virol. 2008 Apr;82(8):4102-14. Epub 2008 Jan 30.
Journal of Immunology - 2008
Immune activation driven by ctla-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
Cecchinato V, Tryniszewska E, Ma ZM, Vaccari M, Boasso A, Tsai WP, Petrovas C, Fuchs D, Heraud JM, Venzon D, Shearer GM, Koup RA, Lowy I, Miller CJ, Franchini G.
J Immunol. 2008 Apr 15;180(8):5439-47.
Journal of Immunology - 2008
CD127 and CD25 Expression Defines CD4+ T Cell Subsets That Are Differentially Depleted during HIV Infection.
Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G.
J Immunol. 2008 Apr 15;180(8):5582-92.
Journal of Virology - 2008
Comparative Efficacy of Neutralizing Antibodies Elicited by Recombinant Hemagglutinin Proteins from Avian H5N1 Influenza Virus.
Wei CJ, Xu L, Kong WP, Shi W, Canis K, Stevens J, Yang ZY, Dell A, Haslam SM, Wilson IA, Nabel GJ.
J Virol. 2008 Apr 16.
Journal of Virology - 2008
A Filovirus-unique Region of Ebola Virus Nucleoprotein Confers Aberrant Migration and Mediates Its Incorporation into Virions.
Shi W, Huang Y, Sutton-Smith M, Tissot B, Panico M, Morris HR, Dell A, Haslam SM, Boyington J, Graham BS, Yang ZY, Nabel GJ.
J Virol. 2008 Apr 16.
Current Opinion in HIV/AIDS - 2008
Mucosa and vaccine-induced immune protection in nonhuman primates.
Joseph J. Mattapallil and Mario Roederer
Current Opinion in HIV/AIDS 3(3):387-392.
*Currently no link
March 2008 Cytometry Part A, Journal of International Society for Analytical Cytometry - 2008
How many events is enough? Are you positive?
Roederer M.
Cytometry A.M. 2008 Feb 28.
Nature Review - Immunology - 2008
T-cell quality in memory and protection: implications for vaccine design.
Seder RA, Darrah PA, Roederer M.
Nat Rev Immunol. 2008 Apr;8(4):247-58. Epub 2008 Mar 7.
Cytometry Part A, Journal of International Society for Analytical Cytometry - 2008
Nine color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part I: Panel design by an empiric approach.
McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Oxford C, Evans TG, Asmuth DM.
Cytometry A. 2008 Mar 27.
Cytometry Part A, Journal of International Society for Analytical Cytometry - 2008
Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms.
McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Oxford C, Evans TG, Asmuth DM.
Cytometry A. 2008 Mar 27.
Nature Review - Immunology - 2008
The molecular basis for public T-cell responses?
Venturi V, Price DA, Douek DC, Davenport MP.
Nat Rev Immunol. 2008 Mar;8(3):231-8. Review.
Nature - 2008
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.
Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O'Shea J, Holland SM, Paul WE, Douek DC.
Nature. 2008 Mar 12.
Cytotherapy - 2008
Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture.
Melenhorst JJ, Scheinberg P, Lu J, Ambrozak DR, Sosa E, Zhao L, Hensel NF, Savani BN, Douek DC, Price DA, Barrett AJ.
Cytotherapy. 2008;10(2):152-64.
February 2008 February European Journal of Immunology - 2008
Polyfunctional T cell responses are a hallmark of HIV-2 infection.
Duvall MG, Precopio ML, Ambrozak DA, Jaye A, McMichael AJ, Whittle HC, Roederer M, Rowland-Jones SL, Koup RA.
Eur J Immunol. 2008 Feb;38(2):350-63.M
Nature Immunology - 2008
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
Karlsson Hedestam GB, Fouchier RA, Phogat S, Burton DR, Sodroski J, Wyatt RT.
Nat Rev Microbiol. 2008 Feb;6(2):143-55. Review.
2007 November 2007 European Journal of Immunology - 2007
Immunisation
with BCG and recombinant MVA85A induces long-lasting, polyfunctional
Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte
populations.
Precopio ML, Scheinberg P, Alder NC, Roederer M, Koup RA, Douek DC, Hill AV, McShane H.
Eur J Immunol. 2007. Nov;37(11):3089.
Nature Immunology - 2007
Immunopathology
of highly virulent pathogens: insights from Ebola virus.
Zampieri CA, Sullivan NJ, Nabel GJ.
Nat Immunol. 2007 Nov;8(11):1159-1164.
October 2007 Journal of General Virology - 2007
Persistent
memory CD4+ and CD8+ T-cell responses in recovered severe
acute respiratory syndrome (SARS) patients to SARS coronavirus
M antigen.
Yang L, Peng H, Zhu Z, Li G, Huang Z, Zhao Z, Koup RA, Bailer RT, Wu C.
J Gen Virol. 2007 Oct;88(Pt 10):2740-8.
Journal of Virology - 2007
Dendritic
Cells Are Less Susceptible to HIV-2 Than HIV-1 Infection.
Duvall MG, Loré K, Blaak H, Ambrozak DA, Adams WC, Santos K, Geldmacher C, Mascola JR, McMichael AJ, Whittle HC, Rowland-Jones SL, Koup RA.
J Virol. 2007 Oct 3.
Journal of Medicinal Chemistry - 2007
Structure-activity
relationships in the binding of chemically derivatized CD4
to gp120 from human immunodeficiency virus.
Xie H, Ng D, Savinov SN, Dey B, Kwong PD, Wyatt R, Smith AB 3rd, Hendrickson WA.
J Med Chem. 2007 Oct 4;50(20):4898-908.
Journal of Virology - 2007
Viral
and host factors in human respiratory syncytial virus pathogenesis.
Collins PL, Graham BS.
J Virol. 2007 Oct 10.
Journal of Virology - 2007
Comparison
of Plasma Viremia and Antibody Responses in Macaques Inoculated
with Envelope Variants of Single-Cycle SIV Differing in Infectivity
and Cellular Tropism.
Degottardi MQ, Lew SK, Piatak M Jr, Jia B, Feng Y, Lee SJ, Brenchley JM, Douek DC, Kodama T, Lifson JD, Evans DT.
J Virol. 2007 Oct 17.
September 2007 American Journal of Medicine - 2007
Q
fever in US military returning from Iraq.
Gleeson TD, Decker CF, Johnson MD, Hartzell JD, Mascola JR.
Am J Med. 2007 Sep;120(9):e11-2.
Nature- Medicine - 2007
Broad
HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.
Nat Med. 2007 Sep;13(9):1032-4. Epub 2007 Aug 26.
Journal of Immunology - 2007
Acute
Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian
Immunodeficiency Virus Virulence.
Pandrea IV, Gautam R, Ribeiro RM, Brenchley JM, Butler IF, Pattison M, Rasmussen T, Marx PA, Silvestri G, Lackner AA, Perelson AS, Douek DC, Veazey RS, Apetrei C.
J Immunol. 2007 Sep 1;179(5):3035-46.
Journal of Experimental Medicine - 2007
Progressive
CD4+ central memory T cell decline results in CD4+ effector
memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL,
Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
J Exp Med. 2007 Sep 3;204(9):2171-85. Epub 2007 Aug 27.
Nature - 2007
HIV/AIDS:
allied responses.
Mascola JR.
Nature. 2007 Sep 6;449(7158):29-30. No abstract available.
Journal of Immunology - 2007
Severe
Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency
Virus-Infected Sooty Mangabeys.
Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G.
J Immunol. 2007 Sep 1;179(5):3026-34.
Science - 2007
Structures
of the CCR5 N terminus and of a tyrosine-sulfated antibody
with HIV-1 gp120 and CD4.
Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J,Wilson IA, Wyatt R, Bewley CA, Kwong PD.
Science. 2007 Sep 28;317(5846):1930-4.
Journal of Immunological Methods - 2007
Validation
of RNA-based molecular clonotype analysis for virus-specific
CD8+ T-cells in formaldehyde-fixed specimens isolated from
peripheral blood.
van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD.
J Immunol Methods. 2007 Sep 30;326(1-2):127-38. Epub 2007 Aug 9.
August 2007 Journal of Immunology - 2007
Myeloid
and plasmacytoid dendritic cells are susceptible to recombinant
adenovirus vectors and stimulate polyfunctional memory T cell
responses.
Lore K, Adams WC, Havenga MJ, Precopio ML, Holterman L, Goudsmit J, Koup RA.
J Immunol. 2007 Aug 1;179(3):1721-9.
Blood - 2007
SIV-specific
CD8+ T cells express high levels of PD1 and cytokines but
have impaired proliferative capacity in acute and chronic
SIVmac251 infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA.
Blood. 2007 Aug 1;110(3):928-36. Epub 2007 Apr 17.
Journal of Virology - 2007
Estimating
the infectivity of CCR5-tropic simian immunodeficiency virus
SIV(mac251) in the gut.
Wilson DP, Mattapallil JJ, Lay MD, Zhang L, Roederer M, Davenport MP.
J Virol. 2007 Aug;81(15):8025-9. Epub 2007 May 16.
Journal of Virology - 2007
No
Evidence for Consistent Virus-specific Immunity in Simian
Immunodeficiency Virus Exposed, Uninfected Rhesus Monkeys.
Letvin NL, Rao SS, Dang V, Buzby AP, Korioth-Schmitz B, Dombagoda D, Parvani JG, Clarke RH, Bar L, Carlson KR, Kozlowski PA, Hirsch VM, Mascola JR, Nabel GJ.
J Virol. 2007 Aug 8; [Epub ahead of print]
Journal of Immunological Methods - 2007
Validation
of RNA-based molecular clonotype analysis for virus-specific
CD8+ T-cells in formaldehyde-fixed specimens isolated from
peripheral blood.
van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD.
J Immunol Methods. 2007 Aug 9; [Epub ahead of print]
Science - 2007
Immunization
by avian H5 influenza hemagglutinin mutants with altered receptor
binding specificity.
Yang ZY, Wei CJ, Kong WP, Wu L, Xu L, Smith DF, Nabel GJ.
Science. 2007 Aug 10;317(5839):825-8.
Nature- Medicine - 2007
Broad
HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.
Nat Med. 2007 Aug 26; [Epub ahead of print]
Journal of Experimental - Medicine 2007
Progressive
CD4+ central memory T cell decline results in CD4+ effector
memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
J Exp Med. 2007 Aug 27; [Epub ahead of print]
July 2007
Blood - 2007
Keratinocyte
growth factor augments immune reconstitution after autologous
hematopoietic progenitor cell transplantation in rhesus macaques.
Seggewiss R, Lore K, Guenaga FJ, Pittaluga S, Mattapallil
J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim
M, Donahue RE, Blazar BR, Dunbar CE, Douek DC.
Blood. 2007 Jul 1;110(1):441-9. Epub 2007 Mar 20.
Journal of Virology - 2007
Replication
competent variants of human immunodeficiency virus type-2
lacking the V3 loop exhibit resistance to chemokine receptor
antagonists.
Lin G, Bertolotti-Ciarlet A, Haggarty B, Romano J, McGeehan
K, Leslie G, d'Oliviere AP, Huang CC, Kwong PD, Doms RW, Hoxie
JA.
J Virol. 2007 Jul 3; [Epub ahead of print]
Proceedings of the Natural Academy of Sciences - 2007
Potent
cross-reactive neutralization of SARS coronavirus isolates
by human monoclonal antibodies.
Zhu Z, Chakraborti S, He Y, Roberts A, Sheahan T, Xiao X,
Hensley LE, Prabakaran P, Rockx B, Sidorov IA, Corti D, Vogel
L, Feng Y, Kim JO, Wang LF, Baric R, Lanzavecchia A, Curtis
KM, Nabel GJ, Subbarao K, Jiang S, Dimitrov DS.
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12123-8.
Epub 2007 Jul 9.
Nature Medicine - 2007
Multifunctional
T(H)1 cells define a correlate of vaccine-mediated protection
against Leishmania major.
Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, Flynn
BJ, Hoff ST, Andersen P, Reed SG, Morris SL, Roederer M, Seder
RA.
Nat Med. 2007 Jul;13(7):843-50. Epub 2007 Jun 10.
Nature Review - Microbiology 2007
Mapping
the future of HIV vaccines.
Nabel GJ
Nat Rev Microbiol. 2007 Jul; 262(1):26-43. not
yet available
Journal of Virology - 2007
Human
immunodeficiency virus type 1 protease cleaves procaspase
8 in vivo.
Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin
SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC,
Badley AD.
J Virol. 2007 Jul;81(13):6947-56. Epub 2007 Apr 18.
Journal of Internal Medicine - 2007
Inhibition
of HIV-1 entry by antibodies: potential viral and cellular
targets.
Phogat S, Wyatt RT, Karlsson Hedestam GB.
J Intern Med. 2007 Jul;262(1):26-43.
June 2007
Journal of Virology - 2007
Characterization
of human immunodeficiency virus type 1 monomeric and trimeric
gp120 glycoproteins stabilized in the CD4-bound state: antigenicity,
biophysics, and immunogenicity.
Dey B, Pancera M, Svehla K, Shu Y, Xiang SH, Vainshtein J,
Li Y, Sodroski J, Kwong PD, Mascola JR, Wyatt R.
J Virol. 2007 Jun;81(11):5579-93. Epub 2007 Mar 14.
Virology - 2007
Relative
dominance of epitope-specific CD8+ T cell responses in an
F1 hybrid mouse model of respiratory syncytial virus infection.
Rutigliano JA, Ruckwardt TJ, Martin JE, Graham BS.
Virology. 2007 Jun 5;362(2):314-9. Epub 2007 Feb
2.
Journal of Experimental Medicine - 2007
Immunization
with vaccinia virus induces polyfunctional and phenotypically
distinctive CD8+ T cell responses.
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak
DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham
BS, Roederer M, Koup RA.
J Exp Med. 2007 Jun 11;204(6):1405-1416. Epub 2007
May 29.
Journal of Immunology - 2007
Availability
of a diversely avid CD8+ T cell repertoire specific for the
subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Schaubert KL, Price DA, Frahm N, Li J, Ng HL, Joseph A, Paul
E, Majumder B, Ayyavoo V, Gostick E, Adams S, Marincola FM,
Sewell AK, Altfeld M, Brenchley JM, Douek DC, Yang OO, Brander
C, Goldstein H, Kan-Mitchell J.
J Immunol. 2007 Jun 15;178(12):7756-66.
Virology - 2007
Standardized
assessment of NAb responses elicited in rhesus monkeys immunized
with single- or multi-clade HIV-1 envelope immunogens.
Seaman MS, Leblanc DF, Grandpre LE, Bartman MT, Montefiori
DC, Letvin NL, Mascola JR.
Virology. 2007 Jun 26; [Epub ahead of print]
May 2007
Journal of Experimental Medicine - 2007
Immunization
with vaccinia virus induces polyfunctional and phenotypically
distinctive CD8+ T cell responses.
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak
DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham
BS, Roederer M, Koup RA.
J. Exp. Med. 2007 May 29; [Epub ahead of print]
Journal of Virology - 2007
Estimating
the infectivity of CCR5-tropic SIVmac251 in the gut.
Wilson DP, Mattapallil JJ, Lay M, Zhang L, Roederer M, Davenport
MP.
J Virol. 2007 May 16; [Epub ahead of print]
Blood - 2007
Graft-versus-leukemia
effects associated with detectable Wilms tumor-1 specific
T lymphocytes following allogeneic stem cell transplantation
for acute lymphoblastic leukemia (ALL).
Rezvani K, Yong AS, Savani BN, Mielke S, Keyvanfar K, Gostick
E, Price DA, Douek DC, Barrett AJ.
Blood. 2007 May 15; [Epub ahead of print]
Vaccine - 2007
Phase
I clinical evaluation of a six-plasmid multiclade HIV-1 DNA
candidate vaccine.
Catanzaro AT, Roederer M, Koup RA, Bailer RT, Enama ME, Nason
MC, Martin JE, Rucker S, Andrews CA, Gomez PL, Mascola JR,
Nabel GJ, Graham BS; The VRC 007 Study Team.
Vaccine. 2007 May 16;25(20):4085-92. Epub 2007 Mar
7.
April 2007
Journal of Immunological Methods - 2007
The
clonal composition of human CD4+CD25+Foxp3+ cells determined
by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements.
Scheinberg P, Melenhorst JJ, Hill BJ, Keyvanfar K, Barrett
AJ, Price DA, Douek DC.
J Immunol Methods. 2007 Apr 10;321(1-2):107-20. Epub
2007 Feb 2.
Journal of Acquired Immune Deficiency Syndrome - 2007
Safety
and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine
administered by a needle-free device in HIV-1-seronegative
subjects. Tavel JA, Martin JE, Kelly GG, Enama ME, Shen
JM, Gomez PL, Andrews CA, Koup RA, Bailer RT, Stein JA, Roederer
M, Nabel GJ, Graham BS.
J Acquir Immune Defic Syndr. 2007 Apr 15;44(5):601-5.
Blood - 2007
SIV-specific
CD8+T-cells express high levels of PD1 and cytokines but have
impaired proliferative capacity in acute and chronic SIVmac251
infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher
C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer
M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA.
Blood. 2007 Apr 17; [Epub ahead of print]
Journal of Virology - 2007
HIV-1
Protease Cleaves Procaspase 8 In Vivo
Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin
SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC,
Badley AD.
J Virol. 2007 Apr 18; PMID: 17442709 [PubMed - as
supplied by publisher]
February 2007
Public Library of Science Pathogens - 2007
Mechanism
of ad5 vaccine immunity and toxicity: fiber shaft targeting
of dendritic cells.
Cheng C, Gall JG, Kong WP, Sheets RL, Gomez PL, King CR, Nabel
GJ.
PLoS Pathog. 2007 Feb;3(2):e25.
Cytometry - 2007
Differential
susceptibility of leukocyte subsets to cytotoxic T cell killing:
Implications for HIV immunopathogenesis.
Liu J, Roederer M.
Cytometry A. 2007 Feb;71(2):94-104.
Journal of Virology - 2007
The
ERK mitogen-activated protein kinase pathway contributes to
Ebola virus glycoprotein-induced cytotoxicity.
Zampieri CA, Fortin JF, Nolan GP, Nabel GJ.
J Virol. 2007 Feb;81(3):1230-40. Epub 2006 Nov 15.
Journal of Virology - 2007
Lysis
of human immunodeficiency virus type 1 by a specific secreted
human phospholipase A2.
Kim JO, Chakrabarti BK, Guha-Niyogi A, Louder MK, Mascola
JR, Ganesh L, Nabel GJ.
J Virol. 2007 Feb;81(3):1444-50. Epub 2006 Nov 8.
Cytometry Part A - 2007
Increased
immunofluorescence sensitivity using 532 nm laser excitation.
Perfetto SP, Roederer M.
Cytometry A. 2007 Feb;71(2):73-9.
Journal of Acquired Immune Deficiency Syndrome - 2007
Phase
2 study of an HIV-1 canarypox vaccine (vCP1452) alone and
in combination with rgp120: negative results fail to trigger
a phase 3 correlates trial.
Russell ND, Graham BS, Keefer MC, McElrath MJ, Self SG, Weinhold
KJ, Montefiori DC, Ferrari G, Horton H, Tomaras GD, Gurunathan
S, Baglyos L, Frey SE, Mulligan MJ, Harro CD, Buchbinder SP,
Baden LR, Blattner WA, Koblin BA, Corey L; National Institute
of Allergy and Infectious Diseases HIV Vaccine Trials Network.
J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):203-12.
Virology - 2007
Relative
dominance of epitope-specific CD8+ T cell responses in an
F1 hybrid mouse model of respiratory syncytial virus infection.
Rutigliano JA, Ruckwardt TJ, Martin JE, Graham BS.
Virology. 2007 Feb 1; [Epub ahead of print]
Journal of Immunology Methods - 2007
The
clonal composition of human CD4+CD25+Foxp3+ cells determined
by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements.
Scheinberg P, Melenhorst JJ, Hill BJ, Keyvanfar K, Barrett
AJ, Price DA, Douek DC.
J Immunol Methods. 2007 Feb 2; [Epub ahead of print]
Vaccine - 2007
Efficient
protein boosting after plasmid DNA or recombinant adenovirus
immunization with HIV-1 vaccine constructs.
Shu Y, Winfrey S, Yang ZY, Xu L, Rao SS, Srivastava I, Barnett
SW, Nabel GJ, Mascola JR.
Vaccine. 2007 Feb 9;25(8):1398-408. Epub 2006 Nov
7.
Vaccine - 2007
Safety,
immunogenicity and efficacy of modified vaccinia Ankara (MVA)
against Dryvax challenge in vaccinia-naive and vaccinia-immune
individuals.
Parrino J, McCurdy LH, Larkin BD, Gordon IJ, Rucker SE, Enama
ME, Koup RA, Roederer M, Bailer RT, Moodie Z, Gu L, Yan L,
Graham BS; VRC 201/203 Study Team.
Vaccine. 2007 Feb 9;25(8):1513-25. Epub 2006 Nov
7.
Nature - 2007
Structural
definition of a conserved neutralization epitope on HIV-1
gp120.
Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang
X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski
J, Wyatt R, Nabel GJ, Kwong PD.
Nature. 2007 Feb 15;445(7129):732-7.
Journal of Experimental Medicine - 2007
Leukocyte-specific
protein 1 interacts with DC-SIGN and mediates transport of
HIV to the proteasome in dendritic cells.
Smith AL, Ganesh L, Leung K, Jongstra-Bilen J, Jongstra J,
Nabel GJ.
J Exp Med. 2007 Feb 19;204(2):421-30. Epub 2007 Feb
12.
January 2007
Virology - 2007
Changes
in the V3 region of gp120 contribute to unusually broad coreceptor
usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore
JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan
M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe
SM, Gabuzda D.
Virology. 2007 Jan 17; [Epub ahead of print]
Public Library of Science Pathogens - 2007
Neutralizing
Antibody Fails to Impact the Course of Ebola Virus Infection
in Monkeys.
Oswald WB, Geisbert TW, Davis KJ, Geisbert JB, Sullivan NJ,
Jahrling PB, Parren PW, Burton DR.
PLoS Pathog. 2007 Jan 19;3(1):e9 [Epub ahead of print]
Modern Pathology - 2007
The
histopathology of fatal untreated human respiratory syncytial
virus infection.
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS.
Mod Pathol. 2007 Jan;20(1):108-19. Epub 2006 Nov
24.
2006
December 2006
Journal of Allergy and Clinical Immunology - 2006
Smallpox
vaccines: Past, present, and future.
Parrino J, Graham BS.
J Allergy Clin Immunol. 2006 Dec;118(6):1320-6.
Proceedings of the National Academy of Sciences of
the United States of America - 2006
Delay
of T cell senescence by caloric restriction in aged long-lived
nonhuman primates.
Messaoudi I, Warner J, Fischer M, Park B, Hill B, Mattison
J, Lane MA, Roth GS, Ingram DK, Picker LJ, Douek DC, Mori
M, Nikolich-Zugich J.
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19448-53.
Epub 2006 Dec 11.
The Journal of Experimental Medicine - 2006
Acquisition
of direct antiviral effector functions by CMV-specific CD4+
T lymphocytes with cellular maturation.
Casazza JP, Betts MR, Price DA, Precopio ML, Ruff LE, Brenchley
JM, Hill BJ, Roederer M, Douek DC, Koup RA.
J Exp Med. 2006 Dec 25;203(13):2865-77. Epub 2006
Dec 11.
November 2006
Journal of Acquired Immune Deficiency Syndromes - 2006
Novel
approach for differential diagnosis of HIV infections in the
face of vaccine-generated antibodies: utility for detection
of diverse HIV-1 subtypes.
Khurana S, Needham J, Park S, Mathieson B, Busch MP, Nemo
G, Nyambi P, Zolla-Pazner S, Laal S, Mulenga J, Chomba E,
Hunter E, Allen S, McIntyre J, Hewlett I, Lee S, Tang S, Cowan
E, Beyrer C, Altfeld M, Yu XG, Tounkara A, Koita O, Kamali
A, Nguyen N, Graham BS, Todd D, Mugenyi P, Anzala O, Sanders
E, Ketter N, Fast P, Golding H.
J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):304-12.
Vaccine - 2006
Safety,
immunogenicity and efficacy of modified vaccinia Ankara (MVA)
against Dryvax((R)) challenge in vaccinia-naive and vaccinia-immune
individuals.
Parrino J, McCurdy LH, Larkin BD, Gordon IJ, Rucker SE, Enama
ME, Koup RA, Roederer M, Bailer RT, Moodie Z, Gu L, Yan L,
Graham BS; VRC 201/203 Study Team.
Vaccine. 2006 Nov 7; [Epub ahead of print]
Vaccine - 2006
Efficient
protein boosting after plasmid DNA or recombinant adenovirus
immunization with HIV-1 vaccine constructs.
Shu Y, Winfrey S, Yang ZY, Xu L, Rao SS, Srivastava I, Barnett
SW, Nabel GJ, Mascola JR.
Vaccine. 2006 Nov 7; [Epub ahead of print]
The Journal of Infectious Diseases - 2006
Phase
1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1
Candidate Vaccine Delivered by a Replication-Defective Recombinant
Adenovirus Vector.
Catanzaro AT, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie
Z, Gu L, Martin JE, Novik L, Chakrabarti BK, Butman BT, Gall
JG, King CR, Andrews CA, Sheets R, Gomez PL, Mascola JR, Nabel
GJ, Graham BS; Vaccine Research Center 006 Study Team.
J Infect Dis. 2006 Dec 15;194(12):1638-49. Epub 2006
Nov 8.
The Journal of Infectious Diseases - 2006
Phase
1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1
DNA Candidate Vaccine.
Graham BS, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie
Z, Martin JE, McCluskey MM, Chakrabarti BK, Lamoreaux L, Andrews
CA, Gomez PL, Mascola JR, Nabel GJ; Vaccine Research Center
004 Study Team.
J Infect Dis. 2006 Dec 15;194(12):1650-60. Epub 2006
Nov 8.
Journal of Virology - 2006
Lysis
of HIV-1 by a Specific Secreted Human Phospholipase A2.
Kim JO, Chakrabarti B, Guha-Niyogi A, Louder MK, Mascola JR,
Ganesh L, Nabel GJ.
J Virol. 2006 Nov 8; [Epub ahead of print]
Journal of Acquired Immune Deficiency Syndromes - 2006
Phase
2 Study of an HIV-1 Canarypox Vaccine (vCP1452) Alone and
in Combination With rgp120: Negative Results Fail to Trigger
a Phase 3 Correlates Trial.
Russell ND, Graham BS, Keefer MC, McElrath MJ, Self SG, Weinhold
KJ, Montefiori DC, Ferrari G, Horton H, Tomaras GD, Gurunathan
S, Baglyos L, Frey SE, Mulligan MJ, Harro CD, Buchbinder SP,
Baden LR, Blattner WA, Koblin BA, Corey L; the National Institute
of Allergy and Infectious Diseases HIV Vaccine Trials Network.
J Acquir Immune Defic Syndr. 2006 Nov 9; [Epub ahead
of print]
Proceedings of the National Academy of Sciences of
the United States of America - 2006
Gene
transfer in humans using a conditionally replicating lentiviral
vector.
Levine BL, Humeau LM, Boyer J, Macgregor RR, Rebello T, Lu
X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman
FD, Dropulic B, June CH.
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17372-7.
Epub 2006 Nov 7.
Journal of Virology - 2006
The
ERK Mitogen-Activated Protein Kinase Pathway Contributes to
Ebola Glycoprotein-Induced Cytotoxicity.
Zampieri CA, Fortin JF, Nolan GP, Nabel GJ.
J Virol. 2006 Nov 15; [Epub ahead of print]
Nature Medicine - 2006
Microbial
translocation is a cause of systemic immune activation in
chronic HIV infection.
Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G,
Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar
BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN,
Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC.
Nat Med. 2007 Jan;12(12):1365-1371. Epub 2006 Nov
19.
Modern Pathology - 2006
The
histopathology of fatal untreated human respiratory syncytial
virus infection.
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS.
Mod Pathol. 2006 Nov 24; [Epub ahead of print]
Proceedings of the National Academy of Sciences of
the United States of America - 2006
Sharing
of T cell receptors in antigen-specific responses is driven
by convergent recombination.
Venturi V, Kedzierska K, Price DA, Doherty PC, Douek DC, Turner
SJ, Davenport MP.
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18691-6.
Epub 2006 Nov 27.
October 2006
Antimicrobial Agents and Chemotherapy - 2006
Engineered
vaginal lactobacillus strain for mucosal delivery of the human
immunodeficiency virus inhibitor cyanovirin-N.
Liu X, Lagenaur LA, Simpson DA, Essenmacher KP, Frazier-Parker
CL, Liu Y, Tsai D, Rao SS, Hamer DH, Parks TP, Lee PP, Xu
Q.
Antimicrob Agents Chemother. 2006 Oct;50(10):3250-9.
The Journal of Immunology - 2006
Differential
Selection Pressure Exerted on HIV by CTL Targeting Identical
Epitopes but Restricted by Distinct HLA Alleles from the Same
HLA Supertype.
Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford
H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rosseau CM,
Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek
DC, Kiepiela P, Walker BD, Goulder PJ.
J Immunol. 2006 Oct 1;177(7):4699-708.
Proceedings of the National Academy of Sciences of
the United States of America - 2006
Protective
immunity to lethal challenge of the 1918 pandemic influenza
virus by vaccination.
Kong WP, Hood C, Yang ZY, Wei CJ, Xu L, Garcia-Sastre A, Tumpey
TM, Nabel GJ.
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15987-91.
Epub 2006 Oct 16.
September 2006
Clinical and Vaccine Immunology - 2006
A
DNA Vaccine for Ebola Virus is Safe and Immunogenic in a Phase
I Clinical Trial.
Martin JE, Sullivan NJ, Enama ME, Gordon IJ, Roederer M, Koup
RA, Bailer RT, Chakrabarti BK, Bailey MA, Gomez PL, Andrews
CA, Moodie Z, Gu L, Stein JA, Nabel GJ, Graham BS.
Clin Vaccine Immunol. 2006 Sep 20; [Epub ahead of
print]
The Journal of Experimental Medicine - 2006
PD-1
is a regulator of virus-specific CD8+ T cell survival in HIV
infection.
Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E,
Adams WC, Precopio ML, Schacker T, Roederer M, Douek DC, Koup
RA.
J Exp Med. 2006 Sep 5; [Epub ahead of print]
August 2006
Journal of Virology - 2006
Virus-specific
cellular immune correlates of survival in vaccinated monkeys
after simian immunodeficiency virus challenge.
Sun Y, Schmitz JE, Buzby AP, Barker BR, Rao SS, Xu L, Yang
ZY, Mascola JR, Nabel GJ, Letvin NL.
J Virol. 2006 Aug 30; [Epub ahead of print]
The Journal of Immunology - 2006
Subunit
recombinant vaccine protects against monkeypox.
Heraud JM, Edghill-Smith Y, Ayala V, Kalisz I, Parrino J,
Kalyanaraman VS, Manischewitz J, King LR, Hryniewicz A, Trindade
CJ, Hassett M, Tsai WP, Venzon D, Nalca A, Vaccari M, Silvera
P, Bray M, Graham BS, Golding H, Hooper JW, Franchini G.
J Immunol. 2006 Aug 15;177(4):2552-64.
The Journal of Immunology - 2006
IL-10
is required for optimal CD8 T cell memory following Listeria
monocytogenes infection.
Foulds KE, Rotte MJ, Seder RA.
J Immunol. 2006 Aug 15;177(4):2565-74.
July 2006
Journal of Virological Methods - 2006
Detection
of Ebola virus envelope using monoclonal and polyclonal antibodies
in ELISA, surface plasmon resonance and a quartz crystal microbalance
immunosensor.
Yu JS, Liao HX, Gerdon AE, Huffman B, Scearce RM, McAdams
M, Alam SM, Popernack PM, Sullivan NJ, Wright D, Cliffel DE,
Nabel GJ, Haynes BF.
J Virol Methods. 2006 Jul 18; [Epub ahead of print]
Journal of Virology - 2006
Cross-subtype
T-cell immune responses induced by a human immunodeficiency
virus type 1 group m consensus env immunogen.
Weaver EA, Lu Z, Camacho ZT, Moukdar F, Liao HX, Ma BJ, Muldoon
M, Theiler J, Nabel GJ, Letvin NL, Korber BT, Hahn BH, Haynes
BF, Gao F.
J Virol. 2006 Jul;80(14):6745-56.
Nature Medicine - 2006
Quantum
dot semiconductor nanocrystals for immunophenotyping by polychromatic
flow cytometry.
Chattopadhyay PK, Price DA, Harper TF, Betts MR, Yu J, Gostick
E, Perfetto SP, Goepfert P, Koup RA, De Rosa SC, Bruchez MP,
Roederer M.
Nat Med. 2006 Jul 23; [Epub ahead of print]
Journal of Immunological Methods - 2006
Amine
reactive dyes: An effective tool to discriminate live and
dead cells in polychromatic flow cytometry.
Perfetto SP, Chattopadhyay PK, Lamoreaux L, Nguyen R, Ambrozak
D, Koup RA, Roederer M.
J Immunol Methods. 2006 Jun 30;313(1-2):199-208.
Epub 2006 May 19.
Vaccine - 2006
HIV-1
Envgp140 trimers elicit neutralizing antibodies without efficient
induction of conformational antibodies.
Bower JF, Li Y, Wyatt R, Ross TM.
Vaccine. 2006 Jun 29;24(26):5442-51. Epub 2006 Apr
3
Journal of Virology - 2006
Preferential
infection shortens the life span of human immunodeficiency
virus-specific CD4+ T cells in vivo.
Brenchley JM, Ruff LE, Casazza JP, Koup RA, Price DA, Douek
DC.
J Virol. 2006 Jul;80(14):6801-9.
June 2006
Microbes and Infection - 2006
Human
memory T cell responses to SARS-CoV E protein.
Peng H, Yang LT, Li J, Lu ZQ, Wang LY, Koup RA, Bailer RT,
Wu CY.
Microbes Infect. 2006 Jun 30; [Epub ahead of print]
Vaccine - 2006
Cross-clade
recognition and neutralization by the V3 region from clade
C human immunodeficiency virus-1 envelope.
Wu L, Yang ZY, Xu L, Welcher B, Winfrey S, Shao Y, Mascola
JR, Nabel GJ.
Vaccine . 2006 Jun 5;24(23):4995-5002. Epub 2006
Apr 18.
Experimental Hematology - 2006
Alloreactive
T cell clonotype recruitment in a mixed lymphocyte reaction:
Implications for graft engineering.
Scheinberg P, Price DA, Ambrozak DR, Barrett AJ, Douek DC.
Exp Hematol . 2006 Jun;34(6):788-95.
Journal of Immunology - 2006
Maintenance
of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from
HIV-1 Infection.
Duvall MG, Jaye A, Dong T, Brenchley JM, Alabi AS, Jeffries
DJ, van der Sande M, Togun TO, McConkey SJ, Douek DC, McMichael
AJ, Whittle HC, Koup RA, Rowland-Jones SL.
J Immunol . 2006 Jun 1;176(11):6973-81.
Journal of Immunology - 2006
Degeneracy
and Repertoire of the Human HIV-1 Gag p1777-85 CTL Response.
Kan-Mitchell J, Bajcz M, Schaubert KL, Price DA, Brenchley
JM, Asher TE, Douek DC, Ng HL, Yang OO, Rinaldo CR Jr, Benito
JM, Bisikirska B, Hegde R, Marincola FM, Boggiano C, Wilson
D, Abrams J, Blondelle SE, Wilson DB.
J Immunol. 2006 Jun 1;176(11):6690-701
Current Opinion in HIV/AIDS - 2006
HIV vaccines: can mucosal CD4 T cells be protected?
Joseph J. Mattapallil* and Mario Roederer
Current Opinion in HIV/AIDS, 7 (1): 272-276.
Science - 2006
Preserved
CD4+ central memory T cells and survival in vaccinated SIV-challenged
monkeys.
Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L,
Yang ZY, Chakrabarti B, Rao SS, Schmitz JE, Montefiori DC,
Barker BR, Bookstein FL, Nabel GJ.
Science . 2006 Jun 9;312(5779):1530-3.
Clinical Immunology - 2006
Long-lived
effector/central memory T-cell responses to severe acute respiratory
syndrome coronavirus (SARS-CoV) S antigen in recovered SARS
patients.
Yang LT, Peng H, Zhu ZL, Li G, Huang ZT, Zhao ZX, Koup RA,
Bailer RT, Wu CY.
Clin Immunol . 2006 Jun 15; [Epub ahead of print]
AIDS Res Hum Retroviruses - 2006
Longitudinal
Assessment of de Novo T Cell Production in Relation to HIV-Associated
T Cell Homeostasis Failure.
Chattopadhyay PK, Douek DC, Gange SJ, Chadwick KR, Hellerstein
M, Margolick JB.
AIDS Res Hum Retroviruses . 2006 Jun;22(6):501-7.
Analytical Biochemistry - 2006
A
biosensor-based approach toward purification and crystallization
of G protein-coupled receptors.
Navratilova I, Pancera M, Wyatt RT, Myszka DG.
Anal Biochem. 2006 Jun 15;353(2):278-83. Epub 2006
Apr 18.
May
2006
Molecular and Cellular Biology - 2006
Protein
methyltransferase 2 inhibits NF-kappaB function and promotes
apoptosis.
Ganesh L, Yoshimoto T, Moorthy NC, Akahata W, Boehm M, Nabel
EG, Nabel GJ.
Mol Cell Biol. 2006 May;26(10):3864-74.
Journal of Experimental Medicine - 2006
Vaccination
preserves CD4 memory T cells during acute simian immunodeficiency
virus challenge.
Mattapallil JJ, Douek DC, Buckler-White A, Montefiori D, Letvin
NL, Nabel GJ, Roederer M.
J Exp Med. 2006 May 30; [Epub ahead of print]
PLoS Medicine - 2006
Immune
Protection of Nonhuman Primates against Ebola Virus with Single
Low-Dose Adenovirus Vectors Encoding Modified GPs.
Sullivan NJ, Geisbert TW, Geisbert JB, Shedlock DJ, Xu L,
Lamoreaux L, Custers JH, Popernack PM, Yang ZY, Pau MG, Roederer
M, Koup RA, Goudsmit J, Jahrling PB, Nabel GJ.
PLoS Med. 2006 May 16;3(6):e177 [Epub ahead of print]
Virology - 2006
Long-lived
memory T lymphocyte responses against SARS coronavirus nucleocapsid
protein in SARS-recovered patients.
Peng H, Yang LT, Wang LY, Li J, Huang J, Lu ZQ, Koup RA, Bailer
RT, Wu CY.
Virology. 2006 May 9; [Epub ahead of print]
Nature - 2006
Vaccines:
engineering immune evasion.
Mascola JR.
Nature. 2006 May 11;441(7090):161. No abstract available.
Journal of Immunology - 2006
Preservation
of Functional Virus-Specific Memory CD8+ T Lymphocytes in
Vaccinated, Simian Human Immunodeficiency Virus-Infected Rhesus
Monkeys.
Acierno PM, Schmitz JE, Gorgone DA, Sun Y, Santra S, Seaman
MS, Newberg MH, Mascola JR, Nabel GJ, Panicali D, Letvin NL.
J Immunol. 2006 May 1;176(9):5338-45.
Journal of Immunology - 2006
Alpha
and lambda interferon together mediate suppression of CD4
T cells induced by respiratory syncytial virus.
Chi B, Dickensheets HL, Spann KM, Alston MA, Luongo C, Dumoutier
L, Huang J, Renauld JC, Kotenko SV, Roederer M, Beeler JA,
Donnelly RP, Collins PL, Rabin RL.
J Virol. 2006 May;80(10):5032-40.
April 2006
Journal of Experimental Medicine - 2006
Toll-like
receptor agonists influence the magnitude and quality of memory
T cell responses after prime-boost immunization in nonhuman
primates.
Wille-Reece U, Flynn BJ, Lore K, Koup RA, Miles AP, Saul A,
Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA.
J Exp Med. 2006 Apr 24; [Epub ahead of print].
Virology - 2006
Polyvalent
HIV-1 Env vaccine formulations delivered by the DNA priming
plus protein boosting approach are effective in generating
neutralizing antibodies against primary human immunodeficiency
virus type 1 isolates from subtypes A, B, C, D and E.
Wang S, Pal R, Mascola JR, Chou TH, Mboudjeka I, Shen S, Liu
Q, Whitney S, Keen T, Nair BC, Kalyanaraman VS, Markham P,
Lu S.
Virology. 2006 Apr 6; [Epub ahead of print]
Cytometry - 2006
A
new "Logicle" display method avoids deceptive effects
of logarithmic scaling for low signals and compensated data.
Parks DR, Roederer M, Moore WA.
Cytometry A. 2006 Apr 7; [Epub ahead of print]
Vaccine - 2006
HIV-1
Env(gp140) trimers elicit neutralizing antibodies without
efficient induction of conformational antibodies.
Bower JF, Li Y, Wyatt R, Ross TM.
Vaccine. 2006 Apr 3; [Epub ahead of print]
March 2006
Toxicological Sciences - 2006
Biodistribution
of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute
Respiratory Syndrome, or West Nile Virus Is Similar, without
Integration, despite Differing Plasmid Backbones or Gene Inserts.
Sheets RL, Stein J, Manetz TS, Duffy C, Nason M, Andrews C,
Kong WP, Nabel GJ, Gomez PL.
Toxicol Sci. 2006 Jun;91(2):610-619. Epub 2006 Mar
28.
Toxicological Sciences - 2006
Toxicological
Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola,
Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar
Despite Differing Plasmid Backbones or Gene-Inserts.
Sheets RL, Stein J, Manetz TS, Andrews C, Bailer R, Rathmann
J, Gomez PL.
Toxicol Sci. 2006 Jun;91(2):620-630. Epub 2006 Mar
28.
Journal of Virology - 2006
Human
immunodeficiency virus (HIV) vaccine trials: a novel assay
for differential diagnosis of HIV infections in the face of
vaccine-generated antibodies.
Khurana S, Needham J, Mathieson B, Rodriguez-Chavez IR, Catanzaro
AT, Bailer RT, Kim J, Polonis V, Cooper DA, Guerin J, Peterson
ML, Gurwith M, Nguyen N, Graham BS, Golding H.
J Virol. 2006 Mar;80(5):2092-9.
Nature Immunology - 2006
HIV
disease: fallout from a mucosal catastrophe?
Brenchley JM, Price DA, Douek DC.
Nat Immunol. 2006 Mar;7(3):235-9.
February 2006
Current HIV/AIDS reports - 2006
Current
advances and challenges in HIV-1 vaccines.
Rodriguez-Chavez IR, Allen M, Hill EL, Sheets RL, Pensiero
M, Bradac JA, D'Souza MP.
Curr HIV/AIDS Rep. 2006 Feb;3(1):39-47. Review.
Cell - 2006
The
rational design of an AIDS vaccine.
Douek DC, Kwong PD, Nabel GJ.
Cell. 2006 Feb 24;124(4):677-81
Stem Cells - 2006
In
vitro culture during retroviral transduction improves thymic
repopulation and output after TBI and autologous PBPC transplantation
in rhesus macaques.
Lore K, Seggewiss R, Guenaga FJ, Pittaluga S, Donahue RE,
Krouse A, Metzger ME, Koup RA, Reilly C, Douek DC, Dunbar
CE.
Stem Cells. 2006 Feb 23; [Epub ahead of print]
Blood - 2006
HIV
nonprogressors preferentially maintain highly functional HIV-specific
CD8+ T-cells.
Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham
J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer
M, Koup RA.
Blood. 2006 Feb 7; [Epub ahead of print]
Journal of Virology - 2006
Characterization
of antibody responses elicited by human immunodeficiency virus
type 1 primary isolate trimeric and monomeric envelope glycoproteins
in selected adjuvants.
Li Y, Svehla K, Mathy NL, Voss G, Mascola JR, Wyatt R.
J Virol. 2006 Feb;80(3):1414-26.
Virology - 2006
Immunization
of rhesus macaques with a polyvalent DNA prime/protein boost
human immunodeficiency virus type 1 vaccine elicits protective
antibody response against simian human immunodeficiency virus
of R5 phenotype.
Pal R, Wang S, Kalyanaraman VS, Nair BC, Whitney S, Keen T,
Hocker L, Hudacik L, Rose N, Mboudjeka I, Shen S, Wu-Chou
TH, Montefiori D, Mascola J, Markham P, Lu S.
Virology. 2006 Feb 2; [Epub ahead of print]
Journal of Virology - 2006
Infectious
molecular clones from a simian immunodeficiency virus-infected
rapid-progressor (RP) macaque: evidence of differential selection
of RP-specific envelope mutations in vitro and in vivo.
Kuwata T, Dehghani H, Brown CR, Plishka R, Buckler-White A,
Igarashi T, Mattapallil J, Roederer M, Hirsch VM.
J Virol. 2006 Feb;80(3):1463-75.
January
2006
Current Opinion in HIV/AIDS - 2006
Acute HIV infection: it takes more
than guts!
Joseph Mattapallil* and Mario Roederer
Current Opinion in HIV/AIDS 2006, 1:10-15
Vaccine - 2006
Comparative
evaluation of three different intramuscular delivery methods
for DNA immunization in a nonhuman primate animal model.
Rao SS, Gomez P, Mascola JR, Dang V, Krivulka GR, Yu F, Lord
CI, Shen L, Bailer R, Nabel GJ, Letvin NL.
Vaccine. Jan 16;24(3):367-73.
Public Library of Science Medicine - 2006
New
approaches to vaccine adjuvants: inhibiting the inhibitor.
Graham BS.
PLoS Med. 2006 Jan;3(1):e57
Trends in Immunology - 2006
Renewing
the T cell repertoire to arrest autoimmune aggression.
Muraro PA, Douek DC.
Trends Immunol. 2006 Jan 4
Journal of Pathology - 2006
Infection
and disease: cause and cure.
Herrington CS, Douek DC.
J Pathol. 2006 Jan;208(2):131-3.
2005
December
2005
Journal of Immunology - 2005
Allergen-Induced
Airway Hyperresponsiveness Mediated by Cyclooxygenase Inhibition
Is Not Dependent on 5-Lipoxygenase or IL-5, but Is IL-13 Dependent.
Peebles RS Jr, Hashimoto K, Sheller JR, Moore ML, Morrow JD,
Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham
BS, Zhou W.
J Immunol. 2005 Dec 15;175(12):8253-9.
Vaccine - 2005
T-Cell
Responses Directed against Multiple HLA-A*0201-Restricted
Epitopes Derived from Wilms' Tumor 1 Protein in Patients with
Leukemia and Healthy Donors: Identification, Quantification,
and Characterization.
Rezvani K, Brenchley JM, Price DA, Kilical Y, Gostick E, Sewell
AK, Li J, Mielke S, Douek DC, Barrett AJ.
Clin Cancer Res. 2005 Dec 15;11(24):8799-8807.
November 2005
Journal of Virology - 2005
Modulation
of the immune response to the severe acute respiratory syndrome
spike glycoprotein by gene-based and inactivated virus immunization.
Kong WP, Xu L, Stadler K, Ulmer JB, Abrignani S, Rappuoli
R, Nabel GJ.
J Virol. 2005 Nov;79(22):13915-23.
Vaccine - 2005
Protection
against multiple influenza A subtypes by vaccination with
highly conserved nucleoprotein.
Epstein SL, Kong WP, Misplon JA, Lo CY, Tumpey TM, Xu L, Nabel
GJ.
Vaccine. 2005 Nov 16;23(46-47):5404-10.
Journal of Experimental Medicine - 2005
Avidity
for antigen shapes clonal dominance in CD8+ T cell populations
specific for persistent DNA viruses.
Price DA, Brenchley JM, Ruff LE, Betts MR, Hill BJ, Roederer
M, Koup RA, Migueles SA, Gostick E, Wooldridge L, Sewell AK,
Connors M, Douek DC.
J Exp Med. 2005 Nov 21;202(10):1349-61
Nature Medicine - 2005
Lymphopenia
and interleukin-2 therapy alter homeostasis of CD4(+)CD25(+)
regulatory T cells.
Zhang H, Chua KS, Guimond M, Kapoor V, Brown MV, Fleisher
TA, Long LM, Bernstein D, Hill BJ, Douek DC, Berzofsky JA,
Carter CS, Read EJ, Helman LJ, Mackall CL.
Nat Med. 2005 Nov;11(11):1238-43.
Science - 2005
Structure
of a V3-containing HIV-1 gp120 core.
Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield
RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R,
Kwong PD.
Science. 2005 Nov 11;310(5750):1025-8.
Journal of Virology - 2005
An
aptamer that neutralizes R5 strains of human immunodeficiency
virus type 1 blocks gp120-CCR5 interaction.
Dey AK, Khati M, Tang M, Wyatt R, Lea SM, James W.
J Virol. 2005 Nov;79(21):13806-10.
October 2005
Proceedings of the National Academy of Sciences -
2005
HIV
Gag protein conjugated to a Toll-like receptor 7/8 agonist
improves the magnitude and quality of Th1 and CD8+ T cell
responses in nonhuman primates.
Wille-Reece U, Flynn BJ, Lore K, Koup RA, Kedl RM, Mattapallil
JJ, Weiss WR, Roederer M, Seder RA.
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15190-4.
Nature Medicine - 2005
Lymphopenia
and interleukin-2 therapy alter homeostasis of CD4(+)CD25(+)
regulatory T cells.
Zhang H, Chua KS, Guimond M, Kapoor V, Brown MV, Fleisher
TA, Long LM, Bernstein D, Hill BJ, Douek DC, Berzofsky JA,
Carter CS, Read EJ, Helman LJ, Mackall CL.
Nat Med. 2005 Oct 16; [Epub ahead of print]
Proceedings of the National Academy of Sciences -
2005
Interfacial
metal and antibody recognition.
Zhou T, Hamer DH, Hendrickson WA, Sattentau QJ, Kwong PD.
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14575-80.
Journal of Medical Primatology - 2005
Polyvalent
DNA prime and envelope protein boost HIV-1 vaccine elicits
humoral and cellular responses and controls plasma viremia
in rhesus macaques following rectal challenge with an R5 SHIV
isolate..
Pal R, Wang S, Kalyanaraman VS, Nair BC, Whitney S, Keen T,
Hocker L, Hudacik L, Rose N, Cristillo A, Mboudjeka I, Shen
S, Wu-Chou TH, Montefiori D, Mascola J, Lu S, Markham P.
J Med Primatol. 2005 Oct;34(5-6):226-36.
Nature Medicine - 2005
A
live-cell assay to detect antigen-specific CD4(+) T cells
with diverse cytokine profiles.
Chattopadhyay PK, Yu J, Roederer M.
Nat Med . 2005 Oct;11(10):1113-7
September 2005
Journal of Antimicrobial Therapy - 2005
Successful
treatment of Acinetobacter meningitis with meropenem and rifampicin.
Gleeson T, Petersen K, Mascola J.
J Antimicrob Chemother. 2005 Sep;56(3):602-3.
Journal of Allergy and Clinical Immunology - 2005
Respiratory
syncytial virus infection in the absence of STAT1 results
in airway dysfunction, airway mucus, and augmented IL-17 levels.
Hashimoto K, Durbin JE, Zhou W, Collins RD, Ho SB, Kolls JK,
Dubin PJ, Sheller JR, Goleniewska K, O'neal JF, Olson SJ,
Mitchell D, Graham BS, Peebles RS Jr.
J Allergy Clin Immunol. 2005 Sep;116(3):550-7.
Blood - 2005
Antigen-specific
T-cell memory is preserved in children treated for acute lymphoblastic
leukemia.
Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S,
Gelman R, Rosenblatt HM, Shearer WT, Guenaga J, Douek DC,
Silverman LB, Sallan SE, Guinan EC, Nadler LM.
Blood. 2005 Sep 1;106(5):1749-54
Journal of Virology - 2005
Biochemical
and immunogenic characterization of soluble human immunodeficiency
virus type 1 envelope glycoprotein trimers expressed by semliki
forest virus.
Forsell MN, Li Y, Sundback M, Svehla K, Liljestrom P, Mascola
JR, Wyatt R, Karlsson Hedestam GB.
J Virol. 2005 Sep;79(17):10902-14.
Virology - 2005
Characterization
of antibody responses to purified HIV-1 gp120 glycoproteins
fused with the molecular adjuvant C3d.
Koch M, Frazier J, Sodroski J, Wyatt R.
Virology. 2005 Sep 30;340(2):277-284.
Virology - 2005
HIV-1
envelope pseudotyped viral vectors and infectious molecular
clones expressing the same envelope glycoprotein have a similar
neutralization phenotype, but culture in peripheral blood
mononuclear cells is associated with decreased neutralization
sensitivity.
Louder MK, Sambor A, Chertova E, Hunte T, Barrett S, Ojong
F, Sanders-Buell E, Zolla-Pazner S, McCutchan FE, Roser JD,
Gabuzda D, Lifson JD, Mascola JR.
Virology. 2005 Sep 1;339(2):226-38.
Nature Medicine - 2005
A
live-cell assay to detect antigen-specific CD4(+) T cells
with diverse cytokine profiles..
Chattopadhyay PK, Yu J, Roederer M.
Nat Med. 2005 Sep 25; [Epub ahead of print]
Trends in Immunology - 2005
Measuring
Ag-specific immune responses: understanding immunopathogenesis
and improving diagnostics in infectious disease, autoimmunity
and cancer.
Kern F, LiPira G, Gratama JW, Manca F, Roederer M.
Trends Immunol. 2005 Sep;26(9):477-84.
August 2005
Proceedings of the National Academy of Sciences -
2005
Toward
a live microbial microbicide for HIV: Commensal bacteria secreting
an HIV fusion inhibitor peptide.
Rao S, Hu S, McHugh L, Lueders K, Henry K, Zhao Q, Fekete
RA, Kar S, Adhya S, Hamer DH.
Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):11993-8.
Epub 2005 Jul 22.
International Immunology - 2005
Thymic
expression of peripheral tissue antigens in humans: a remarkable
variability among individuals.
Takase H, Yu CR, Mahdi RM, Douek DC, Dirusso GB, Midgley FM,
Dogra R, Allende G, Rosenkranz E, Pugliese A, Egwuagu CE,
Gery I.
Int Immunol. 2005 Aug;17(8):1131-40.
Infection and Immunity - 2005
Prevention
and treatment of cutaneous leishmaniasis in primates by using
synthetic type D/A oligodeoxynucleotides expressing CpG motifs.
Flynn B, Wang V, Sacks DL, Seder RA, Verthelyi D.
Infect Immun. 2005 Aug;73(8):4948-54.
Current Opinion in Immunology - 2005
Host-pathogen
interactions in the 21st century.
Pulendran B, Seder RA.
Curr Opin Immunol. 2005 Aug;17(4):335-7.
Journal of Virology - 2005
Soluble
mimetics of human immunodeficiency virus type 1 viral spikes
produced by replacement of the native trimerization domain
with a heterologous trimerization motif: characterization
and ligand binding analysis.
Pancera M, Lebowitz J, Schon A, Zhu P, Freire E, Kwong PD,
Roux KH, Sodroski J, Wyatt R.
J Virol. 2005 Aug;79(15):9954-69.
Journal of Virology - 2005
Human
immunodeficiency virus type 1 env clones from acute and early
subtype B infections for standardized assessments of vaccine-elicited
neutralizing antibodies.
Li M, Gao F, Mascola JR, Stamatatos L, Polonis VR, Koutsoukos
M, Voss G, Goepfert P, Gilbert P, Greene KM, Bilska M, Kothe
DL, Salazar-Gonzalez JF, Wei X, Decker JM, Hahn BH, Montefiori
DC.
J Virol. 2005 Aug;79(16):10108-25.
Journal of Virology - 2005
Recommendations
for the design and use of standard virus panels to assess
neutralizing antibody responses elicited by candidate human
immunodeficiency virus type 1 vaccines.
Mascola JR, D'Souza P, Gilbert P, Hahn BH, Haigwood NL, Morris
L, Petropoulos CJ, Polonis VR, Sarzotti M, Montefiori DC.
J Virol. 2005 Aug;79(16):10103-7.
July 2005
Contemporary Topics in Laboratory Animal Science -
2005
Mammary
ductal carcinoma with comedo pattern in a rhesus macaque.
Smith JM, Rao SS, Stump KC, Benazzi C, Sarli G, DeTolla LJ.
Contemp Top Lab Anim Sci. 2005 Jul;44(4):29-33.
Vaccine - 2005
Protection
against multiple influenza A subtypes by vaccination with
highly conserved nucleoprotein.
Epstein SL, Kong WP, Misplon JA, Lo CY, Tumpey TM, Xu L, Nabel
GJ.
Vaccine. 2005 Jul 9; [Epub ahead of print]
Journal of Virology - 2005
Pathogenicity
of simian-human immunodeficiency virus SHIV-89.6P and SIVmac
is attenuated in cynomolgus macaques and associated with early
T-lymphocyte responses.
Reimann KA, Parker RA, Seaman MS, Beaudry K, Beddall M, Peterson
L, Williams KC, Veazey RS, Montefiori DC, Mascola JR, Nabel
GJ, Letvin NL.
J Virol. 2005 Jul;79(14):8878-85.
Journal of Virology - 2005
A
human T-cell leukemia virus type 1 regulatory element enhances
the immunogenicity of human immunodeficiency virus type 1
DNA vaccines in mice and nonhuman primates.
Barouch DH, Yang ZY, Kong WP, Korioth-Schmitz B, Sumida SM,
Truitt DM, Kishko MG, Arthur JC, Miura A, Mascola JR, Letvin
NL, Nabel GJ.
J Virol. 2005 Jul;79(14):8828-34.
Molecular Therapy - 2005
Selective
survival of peripheral blood lymphocytes in children with
HIV-1 following delivery of an anti-HIV gene to bone marrow
CD34(+) cells.
Podsakoff GM, Engel BC, Carbonaro DA, Choi C, Smogorzewska
EM, Bauer G, Selander D, Csik S, Wilson K, Betts MR, Koup
RA, Nabel GJ, Bishop K, King S, Schmidt M, von Kalle C, Church
JA, Kohn DB.
Mol Ther. 2005 Jul;12(1):77-86.
Journal of Virology - 2005
Enhanced
breadth of CD4 T-cell immunity by DNA prime and adenovirus
boost immunization to human immunodeficiency virus Env and
Gag immunogens.
Wu L, Kong WP, Nabel GJ.
J Virol. 2005 Jul;79(13):8024-31.
Virology - 2005
Identification
of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope
in the matrix protein of respiratory syncytial virus.
Rutigliano JA, Rock MT, Johnson AK, Crowe JE Jr, Graham BS.
Virology. 2005 Jul 5;337(2):335-43.
Nature Medicine - 2005
Live
attenuated recombinant vaccine protects nonhuman primates
against Ebola and Marburg viruses.
Jones SM, Feldmann H, Stroher U, Geisbert JB, Fernando L,
Grolla A, Klenk HD, Sullivan NJ, Volchkov VE, Fritz EA, Daddario
KM, Hensley LE, Jahrling PB, Geisbert TW.
Nat Med. 2005 Jul;11(7):786-90.
Journal of Virology - 2005
Differential
susceptibility to human immunodeficiency virus type 1 infection
of myeloid and plasmacytoid dendritic cells.
Smed-Sorensen A, Lore K, Vasudevan J, Louder MK, Andersson
J, Mascola JR, Spetz AL, Koup RA.
J Virol. 2005 Jul;79(14):8861-9.
Journal of Biological Chemistry - 2005
Interaction
between the CD8 coreceptor and major histocompatibility complex
class I stabilizes T cell receptor-antigen complexes at the
cell surface.
Wooldridge L, van den Berg HA, Glick M, Gostick E, Laugel
B, Hutchinson SL, Milicic A, Brenchley JM, Douek DC, Price
DA, Sewell AK.
J Biol Chem. 2005 Jul 29;280(30):27491-501.
Virology - 2005
Characterization
of antibody responses to purified HIV-1 gp120 glycoproteins
fused with the molecular adjuvant C3d.
Koch M, Frazier J, Sodroski J, Wyatt R.
Virology. 2005 Jul 25; [Epub ahead of print]
June 2005
Science - 2005
Immunology.
Close to the edge: neutralizing the HIV-1 envelope.
Nabel GJ.
Science. 2005 Jun 24;308(5730):1878-9.
Journal of Experimental Medicine - 2005
Myeloid
and plasmacytoid dendritic cells transfer HIV-1 preferentially
to antigen-specific CD4+ T cells.
Lore K, Smed-Sorensen A, Vasudevan J, Mascola JR, Koup RA.
J Exp Med. 2005 Jun 20;201(12):2023-33.
Journal of Immunology - 2005
Immunization
with HIV-1 Gag Protein Conjugated to a TLR7/8 Agonist Results
in the Generation of HIV-1 Gag-Specific Th1 and CD8+ T Cell
Responses.
Wille-Reece U, Wu CY, Flynn BJ, Kedl RM, Seder RA.
J Immunol. 2005 Jun 15;174(12):7676-83.
Clinical Cancer Research - 2005
In
vitro induction of myeloid leukemia-specific CD4 and CD8 T
cells by CD40 ligand-activated B cells gene modified to express
primary granule proteins.
Fujiwara H, Melenhorst JJ, El Ouriaghli F, Kajigaya S, Grube
M, Sconocchia G, Rezvani K, Price DA, Hensel NF, Douek DC,
Barrett AJ.
Clin Cancer Res. 2005 Jun 15;11(12):4495-503.
BMC Immunology - 2005
Standardization
of cytokine flow cytometry assays.
Maecker HT, Rinfret A, D'Souza P, Darden J, Roig E, Landry
C, Hayes P, Birungi J, Anzala O, Garcia M, Harari A, Frank
I, Baydo R, Baker M, Holbrook J, Ottinger J, Lamoreaux L,
Epling CL, Sinclair E, Suni MA, Punt K, Calarota S, El-Bahi
S, Alter G, Maila H, Kuta E, Cox J, Gray C, Altfeld M, Nougarede
N, Boyer J, Tussey L, Tobery T, Bredt B, Roederer M, Koup
R, Maino VC, Weinhold K, Pantaleo G, Gilmour J, Horton H,
Sekaly RP.
BMC Immunol. 2005 Jun 24;6(1):13.
Journal of Immunology - 2005
Role
for innate IFNs in determining respiratory syncytial virus
immunopathology.
Johnson TR, Mertz SE, Gitiban N, Hammond S, Legallo R, Durbin
RK, Durbin JE.
J Immunol. 2005 Jun 1;174(11):7234-41.
Bioorganic & Medicinal Chemistry - 2005
Synthesis,
in vitro, and in vivo characterization of an integrin alpha(v)beta(3)-targeted
molecular probe for optical imaging of tumor.
WBurnett CA, Xie J, Quijano J, Shen Z, Hunter F, Bur M, Li
KC, Danthi SN.
Bioorg Med Chem. 2005 Jun 1;13(11):3763-71.
May 2005
Journal of Virology - 2005
Replication-defective
adenovirus serotype 5 vectors elicit durable cellular and
humoral immune responses in nonhuman primates.
Santra S, Seaman MS, Xu L, Barouch DH, Lord CI, Lifton MA,
Gorgone DA, Beaudry KR, Svehla K, Welcher B, Chakrabarti BK,
Huang Y, Yang ZY, Mascola JR, Nabel GJ, Letvin NL.
J Virol. 2005 May;79(10):6516-22.
Vaccine - 2005
Expanded
breadth of virus neutralization after immunization with a
multiclade envelope HIV vaccine candidate.
Chakrabarti BK, Ling X, Yang ZY, Montefiori DC, Panet A, Kong
WP, Welcher B, Louder MK, Mascola JR, Nabel GJ.
Vaccine. 2005 May 16;23(26):3434-45.
Virology - 2005
Identification
of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope
in the matrix protein of respiratory syncytial virus.
Rutigliano JA, Rock MT, Johnson AK, Crowe JE Jr, Graham BS.
Virology. 2005 May 22 [Epub ahead of print]
Journal of Virology - 2005
RhoA
signaling is required for respiratory syncytial virus-induced
syncytium formation and filamentous virion morphology.
Gower TL, Pastey MK, Peeples ME, Collins PL, McCurdy LH, Hart
TK, Guth A, Johnson TR, Graham BS.
J Virol. 2005 May;79(9):5326-36.
Blood - 2005
Antigen-specific
T cell memory is preserved in children treated for acute lymphoblastic
leukemia.
Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S,
Gelman R, Rosenblatt HM, Shearer WT, Guenaga J, Douek DC,
Silverman LB, Sallan SE, Guinan EC, Nadler LM.
Blood. 2005 May 26 [Epub ahead of print]
Proceedings of the National Academy of Sciences -
2005
Characterization
of subsets of CD4+ memory T cells reveals early branched pathways
of T cell differentiation in humans.
Song K, Rabin RL, Hill BJ, De Rosa SC, Perfetto SP, Zhang
HH, Foley JF, Reiner JS, Liu J, Mattapallil JJ, Douek DC,
Roederer M, Farber JM.
Proc Natl Acad Sci U S A. 2005 May 19; [Epub ahead
of print]
Structure - 2005
Scorpion-toxin
mimics of CD4 in complex with human immunodeficiency virus
gp120 crystal structures, molecular mimicry, and neutralization
breadth.
Huang CC, Stricher F, Martin L, Decker JM, Majeed S, Barthe
P, Hendrickson WA, Robinson J, Roumestand C, Sodroski J, Wyatt
R, Shaw GM, Vita C, Kwong PD.
Structure (Camb). 2005 May;13(5):755-68.
Journal of Experimental Medicine
Antigenic
conservation and immunogenicity of the HIV coreceptor binding
site.
Decker JM, Bibollet-Ruche F, Wei X, Wang S, Levy DN, Wang
W, Delaporte E, Peeters M, Derdeyn CA, Allen S, Hunter E,
Saag MS, Hoxie JA, Hahn BH, Kwong PD, Robinson JE, Shaw GM.
J Exp Med. 2005 May 2;201(9):1407-19.
Proceedings of the National Academy of Sciences -
2005
Resting
naive CD4+ T cells are massively infected and eliminated by
X4-tropic simian-human immunodeficiency viruses in macaques.
Nishimura Y, Brown CR, Mattapallil JJ, Igarashi T, Buckler-White
A, Lafont BA, Hirsch VM, Roederer M, Martin MA.
Proc Natl Acad Sci U S A. 2005 May 23; [Epub ahead
of print]
April 2005
Journal of Virology - 2005
Dysfunction
of simian immunodeficiency virus/simian human immunodeficiency
virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
Seaman MS, Xu L, Beaudry K, Martin KL, Beddall MH, Miura A,
Sambor A, Chakrabarti BK, Huang Y, Bailer R, Koup RA, Mascola
JR, Nabel GJ, Letvin NL.
J Immunol. 2005 Apr 15;174(8):4753-60.
Journal of Allergy and Clinical Immunology - 2005
VRC
004: Safety and Immunogenicity of a Multiclade HIV-1 DNA Vaccine
in Healthy Uninfected Adults (VRC-HIVDNA009-00-VP).
Martin JE, Enama ME, Koup RA, Bailer RT, Moodie Z, Roederer
M, Nabel GJ, Graham BS.
J Allergy Clin Immunol. 2005 Apr;115(4):892.
Journal of Virology - 2005
Vaccine-elicited
memory cytotoxic T lymphocytes contribute to Mamu-A*01-associated
control of simian/human immunodeficiency virus 89.6P replication
in rhesus monkeys.
Seaman MS, Santra S, Newberg MH, Philippon V, Manson K, Xu
L, Gelman RS, Panicali D, Mascola JR, Nabel GJ, Letvin NL.
J Virol. 2005 Apr;79(8):4580-8.
Journal of Biological Chemistry - 2005
Interaction
between the CD8 coreceptor and MHC class I stabilizes TCR-antigen
complexes at the cell surface.
Wooldridge L, van den Berg HA, Glick M, Gostick E, Laugel
B, Hutchinson SL, Milicic A, Brenchley JM, Douek DC, Price
DA, Sewell AK.
J Biol Chem. 2005 Apr 18; [Epub ahead of print]
Science - 2005
Endosomal
Proteolysis of the Ebola Virus Glycoprotein Is Necessary for
Infection.
Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM.
Science. 2005 Apr 14; [Epub ahead of print]
March 2005
Journal of Virology - 2005
Multiclade
human immunodeficiency virus type 1 envelope immunogens elicit
broad cellular and humoral immunity in rhesus monkeys.
Sun Y, Schmitz JE, Acierno PM, Santra S, Subbramanian RA, Barouch
DH, Gorgone DA, Lifton MA, Beaudry KR, Manson K, Philippon V,
Xu L, Maecker HT, Mascola JR, Panicali D, Nabel GJ, Letvin NL.
J Virol. 2005 Mar;79(5):2956-63.
Journal of Infectious Diseases - 2005
Lessons
from failure--preparing for future HIV-1 vaccine efficacy
trials.
Graham BS, Mascola JR.
J Infect Dis. 2005 Mar 1;191(5):647-9.
Nature - 2005
Massive
infection and loss of memory CD4(+) T cells in multiple tissues
during acute SIV infection.
Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer
M.
J Infect Dis. 2005 Mar 27; [Epub ahead of print]
Proceedings of the National Academy of Sciences -
2005
Characterization
of functional and phenotypic changes in anti-Gag vaccine-induced
T cell responses and their role in protection after HIV-1
infection.
Betts MR, Exley B, Price DA, Bansal A, Camacho ZT, Teaberry
V, West SM, Ambrozak DR, Tomaras G, Roederer M, Kilby JM,
Tartaglia J, Belshe R, Gao F, Douek DC, Weinhold KJ, Koup
RA, Goepfert P, Ferrari G.
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4512-7.
American Journal of Transplantation - 2005
Immunocompetent
T-cells with a memory-like phenotype are the dominant cell
type following antibody-mediated T-cell depletion.
Pearl JP, Parris J, Hale DA, Hoffmann SC, Bernstein WB, McCoy
KL, Swanson SJ, Mannon RB, Roederer M, Kirk AD.
Am J Transplant. 2005 Mar;5(3):465-74.
Journal of Virology - 2005
Immunologic
pressure within class I-restricted cognate human immunodeficiency
virus epitopes during highly active antiretroviral therapy.
Casazza JP, Betts MR, Hill BJ, Brenchley JM, Price DA, Douek
DC, Koup RA.
J Virol. 2005 Mar;79(6):3653-63.
Journal of Experimental Medicine - 2005
Thymic
output generates a new and diverse TCR repertoire after autologous
stem cell transplantation in multiple sclerosis patients.
Muraro PA, Douek DC, Packer A, Chung K, Guenaga FJ, Cassiani-Ingoni
R, Campbell C, Memon S, Nagle JW, Hakim FT, Gress RE, McFarland
HF, Burt RK, Martin R.
J Exp Med. 2005 Mar 7;201(5):805-16.
Blood - 2005
Imatinib
inhibits T-cell receptor-mediated T-cell proliferation and
activation in a dose-dependent manner.
Seggewiss R, Lore K, Greiner E, Magnusson MK, Price DA, Douek
DC, Dunbar CE, Wiestner A.
Blood. 2005 Mar 15;105(6):2473-9.
Vaccine - 2005
Antibody-dependent
cell-mediated cytotoxic responses in participants enrolled
in a phase I/II ALVAC-HIV/AIDSVAX B/E prime-boost HIV-1 vaccine
trial in Thailand.
Karnasuta C, Paris RM, Cox JH, Nitayaphan S, Pitisuttithum
P, Thongcharoen P, Brown AE, Gurunathan S, Tartaglia J, Heyward
WL, McNeil JG, Birx DL, de Souza MS; Thai AIDS Vaccine Evaluation
Group, Thailand.
Vaccine. 2005 Mar 31;23(19):2522-9.
February 2005
Nature - 2005
Human
immunodeficiency virus: refolding the envelope.
Kwong PD.
Nature. 2005 Feb 24;433(7028):815-6.
Virology - 2005
Selective
recognition of oligomeric HIV-1 primary isolate envelope glycoproteins
by potently neutralizing ligands requires efficient precursor
cleavage.
Pancera M, Wyatt R.
Virology. 2005 Feb 5;332(1):145-56.
January 2005
Proceeding of the National Academy of Sciences
Evasion
of antibody neutralization in emerging severe acute respiratory
syndrome coronaviruses.
Yang ZY, Werner HC, Kong WP, Leung K, Traggiai E, Lanzavecchia
A, Nabel GJ
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):797-801.
Epub 2005 Jan 10.
Journal of Virology - 2005
Neutralizing
antibodies elicited by immunization of monkeys with DNA plasmids
and recombinant adenoviral vectors expressing human immunodeficiency
virus type 1 proteins.
Mascola JR, Sambor A, Beaudry K, Santra S, Welcher B, Louder
MK, Vancott TC, Huang Y, Chakrabarti BK, Kong WP, Yang ZY,
Xu L, Montefiori DC, Nabel GJ, Letvin NL.
J Virol. 2005 Jan;79(2):771-9.
Journal of Virology - 2005
Comparative
immunogenicity of human immunodeficiency virus particles and
corresponding polypeptides in a DNA vaccine.
Akahata W, Yang ZY, Nabel GJ.
J Virol. 2005 Jan;79(1):626-31.
Journal of Virology - 2005
Ebola
virus glycoprotein toxicity is mediated by a dynamin-dependent
protein-trafficking pathway.
Sullivan NJ, Peterson M, Yang ZY, Kong WP, Duckers H, Nabel
E, Nabel GJ
J Virol. 2005 Jan;79(1):547-53.
Virology - 2005
Analysis
of the neutralizing antibody response elicited in rabbits
by repeated inoculation with trimeric HIV-1 envelope glycoproteins.
Grundner C, Li Y, Louder M, Mascola J, Yang X, Sodroski J,
Wyatt R.
Virology. 2005 Jan 5;331(1):33-46.
Journal of Biological Chemistry - 2005
Design
of soluble recombinant T cell receptors for antigen targeting
and T cell inhibition.
Laugel B, Boulter JM, Lissin N, Vuidepot A, Li Y, Gostick
E, Crotty LE, Douek DC, Hemelaar J, Price DA, Jakobsen BK,
Sewell AK.
J Biol Chem. 2005 Jan 21;280(3):1882-92. Epub 2004
Nov 04.
Journal of Immunology - 2005
Cyclooxygenase
inhibition augments allergic inflammation through CD4-dependent,
STAT6-independent mechanisms.
Hashimoto K, Sheller JR, Morrow JD, Collins RD, Goleniewska
K, O'Neal J, Zhou W, Ji S, Mitchell DB, Graham BS, Peebles
RS Jr.
J Immunol. 2005 Jan 1;174(1):525-32.
2004
December 2004
Immunity - 2004
T
Cell receptor recognition motifs govern immune escape patterns
in acute SIV Infection.
Price DA, West SM, Betts MR, Ruff LE, Brenchley JM, Ambrozak
DR, Edghill-Smith Y, Kuroda MJ, Bogdan D, Kunstman K, Letvin
NL, Franchini G, Wolinsky SM, Koup RA, Douek DC.
Immunity. 2004. Dec;21(6):793-803.
Immunity - 2004
T
Cell receptor recognition motifs govern immune escape patterns
in acute SIV Infection.
Price DA, West SM, Betts MR, Ruff LE, Brenchley JM, Ambrozak
DR, Edghill-Smith Y, Kuroda MJ, Bogdan D, Kunstman K, Letvin
NL, Franchini G, Wolinsky SM, Koup RA, Douek DC.
Immunity. 2004. Dec;21(6):793-803.
Immunity - 2004
Thymic
output and HIV infection: on the right TREC.
Douek D.
Immunity. 2004. Dec;21(6):744-5.
Journal of Experimental Medicine - 2004
T
cell cross-reactivity and conformational changes during TCR
engagement.
Lee JK, Stewart-Jones G, Dong T, Harlos K, Di Gleria K, Dorrell
L, Douek DC, van der Merwe PA, Jones EY, McMichael AJ.
J Exp Med. 2004. Dec 6;200(11):1455-66.
Immunology Reviews - 2004
The
role of cytokine DNAs as vaccine adjuvants for optimizing
cellular immune responses.
Barouch DH, Letvin NL, Seder RA.
Immunol Rev. 2004. Dec;202:266-74.
Virology - 2004
Factors
limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins.
Grundner C, Pancera M, Kang JM, Koch M, Sodroski J, Wyatt
R.
Virology. 2004. Dec 5;330(1):233-48.
Expert Review of Vaccines - 2004
Vaccine
cell substrates 2004.
Sheets R, Petricciani J.
Expert Rev Vaccines. 2004. Dec;3(6):633-8.
November 2004
Journal of Virology - 2004
Generation
of synthetic severe acute respiratory syndrome coronavirus
pseudoparticles: implications for assembly and vaccine production.
Huang Y, Yang ZY, Kong WP, Nabel GJ.
J Virol. 2004 Nov;78(22):12557-65.
Journal of Virology - 2004
Infection
of specific dendritic cells by CCR5-tropic human immunodeficiency
virus type 1 promotes cell-mediated transmission of virus
resistant to broadly neutralizing antibodies.
Ganesh L, Leung K, Lore K, Levin R, Panet A, Schwartz O, Koup
RA, Nabel GJ.
J Virol. 2004 Nov;78(21):11980-7.
Virus Research - 2004
Respiratory
syncytial virus and other pneumoviruses: a review of the international
symposium-RSV 2003.
Schmidt AC, Johnson TR, Openshaw PJ, Braciale TJ, Falsey AR,
Anderson LJ, Wertz GW, Groothuis JR, Prince GA, Melero JA,
Graham BS.
Virus Res. 2004 Nov;106(1):1-13.
Journal of Virology - 2004
Modified
vaccinia virus Ankara immunization protects against lethal
challenge with recombinant vaccinia virus expressing murine
interleukin-4.
McCurdy LH, Rutigliano JA, Johnson TR, Chen M, Graham BS.
J Virol. 2004 Nov;78(22):12471-9.
Journal of Biological Chemistry - 2004
Design
of soluble recombinant T cell receptors for antigen targeting
and T cell inhibition.
Laugel B, Boulter JM, Lisssin N, Vuidepot A, Li Y, Gostick
E, Crotty LA, Douek DC, Hemelaar J, Price DA, Jakobsen BK,
Sewell AK.
J Biol Chem. 2004 Nov 4; [Epub ahead of print]
Journal of Immunology - 2004
Vaccination
in humans generates broad T cell cytokine responses.
De Rosa SC, Lu FX, Yu J, Perfetto SP, Falloon J, Moser S,
Evans TG, Koup R, Miller CJ, Roederer M.
J Immunol. 2004 Nov 1;173(9):5372-80.
Virology - 2004
Factors
limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins.
Grundner C, Pancera M, Kang JM, Koch M, Sodroski J, Wyatt
R.
Virology. 2004 Dec 5;330(1):233-48.
October 2004
Journal of Virology - 2004
Signaling
through the prostaglandin I2 receptor IP protects against
respiratory syncytial virus-induced illness.
Hashimoto K, Graham BS, Geraci MW, FitzGerald GA, Egan K,
Zhou W, Goleniewska K, O'Neal JF, Morrow JD, Durbin RK, Wright
PF, Collins RD, Suzutani T, Peebles RS Jr.
J Virol. 2004 Oct;78(19):10303-9.
Nature Medicine - 2004
Memory
may not need reminding.
Seder RA, Sacks DL.
Nat Med. 2004 Oct;10(10):1045-7.
Blood - 2004
Unusual
immunophenotype of CD8+ T cells in familial hemophagocytic
lymphohistiocytosis.
Karandikar NJ, Kroft SH, Yegappan S, Rogers BB, Aquino VM,
Lee KM, Kumar V, Guenaga FJ, Jaffe ES, Douek DC, McKenna RW.
Blood. 2004 Oct 1;104(7):2007-9
Journal of Virology - 2004
Structure
and mechanistic analysis of the anti-human immunodeficiency
virus type 1 antibody 2F5 in complex with its gp41 epitope.
Ofek G, Tang M, Sambor A, Katinger H, Mascola JR, Wyatt R,
Kwong PD.
J Virol. 2004 Oct;78(19):10724-37
September 2004
Journal of Immunology - 2004
Prolonged
production of TNF-alpha exacerbates illness during respiratory
syncytial virus infection.
Rutigliano JA, Graham BS.
J Immunol. 2004 Sep 1;173(5):3408-17.
Journal of Infectious Diseases - 2004
Breakthrough
infections during phase 1 and 2 prime-boost HIV-1 vaccine
trials with canarypox vectors (ALVAC) and booster dose of
recombinant gp120 or gp160.
Lee D, Graham BS, Chiu YL, Gilbert PB, McElrath MJ, Belshe
RB, Buchbinder SP, Sheppard HW, Koblin BA, Mayer KH, Keefer
MC, Mulligan MJ, Celum CL.
J Infect Dis. 2004 Sep 1;190(5):903-7
Tissue Antigens - 2004
HLA
class I serotypes and cytotoxic T-lymphocyte responses among
human immunodeficiency virus-1-uninfected Thai volunteers
immunized with ALVAC-HIV in combination with monomeric gp120
or oligomeric gp160 protein boosting.
Paris R, Bejrachandra S, Karnasuta C, Chandanayingyong D,
Kunachiwa W, Leetrakool N, Prakalapakorn S, Thongcharoen P,
Nittayaphan S, Pitisuttithum P, Suriyanon V, Gurunathan S,
McNeil JG, Brown AE, Birx DL, de Souza M.
Tissue Antigens. 2004 Sep;64(3):251-6.
Journal of Experimental Medicine - 2004
CD4+
T Cell Depletion during all Stages of HIV Disease Occurs Predominantly
in the Gastrointestinal Tract.
Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman
GJ, Nguyen PL, Khoruts A, Larson M, Haase AT, Douek DC.
J Exp Med. 2004 Sep 20;200(6):749-59
American Journal of Pathology - 2004
Highly
tissue substructure-specific effects of human papilloma virus
in mucosa of HIV-infected patients revealed by laser-dissection
microscopy-assisted gene expression profiling.
Baumgarth N, Szubin R, Dolganov GM, Watnik MR, Greenspan D,
Da Costa M, Palefsky JM, Jordan R, Roederer M, Greenspan JS.
Am J Pathol. 2004 Sep;165(3):707-18.
August 2004
Nature Reviews Immunology - 2004
Seventeen-colour
flow cytometry: unravelling the immune system.
Perfetto SP, Chattopadhyay PK, Roederer M.
Nat Rev Immunol. 2004 Aug;4(8):648-55.
Journal of Virology - 2004
Vbeta14(+)
T cells mediate the vaccine-enhanced disease induced by immunization
with respiratory syncytial virus (RSV) G glycoprotein but
not with formalin-inactivated RSV.
Johnson TR, Varga SM, Braciale TJ, Graham BS
J Virol. 2004 Aug;78(16):8753-60.
Journal of Antimicrobial Chemotherapy - 2004
Inhibition
of respiratory syncytial virus by RhoA-derived peptides: implications
for the development of improved antiviral agents targeting
heparin-binding viruses.
Budge PJ, Graham BS.
J Antimicrob Chemother. 2004 Aug;54(2):299-302.
America Journal of Respiratory Critical Care Medicine
- 2004
Respiratory
syncytial virus in allergic lung inflammation increases Muc5ac
and gob-5.
Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson
SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF,
Peebles RS Jr.
Am J Respir Crit Care Med. 2004 Aug 1;170(3):306-12.
Nature Medicine - 2004
Correlates
of immune protection in HIV-1 infection: what we know, what
we don't know, what we should know.
Pantaleo G, Koup RA.
Nat Med. 2004 Aug;10(8):806-10.
Journal of Immunology - 2004
Absence
of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive,
HIV-uninfected vaccine recipients expressing the HLA-A*0201
allele.
Ferrari G, Neal W, Ottinger J, Jones AM, Edwards BH, Goepfert
P, Betts MR, Koup RA, Buchbinder S, McElrath MJ, Tartaglia
J, Weinhold KJ.
J Immunol. 2004 Aug 1;173(3):2126-33.
AIDS Research and Human Retroviruses - 2004
Macaque
Dendritic Cells Infected with SIV-Recombinant Canarypox ex
Vivo Induce SIV-Specific Immune Responses in Vivo.
Villamide-Herrera L, Ignatius R, Eller MA, Wilkinson K, Griffin
C, Mehlhop E, Jones J, Han SY, Lewis MG, Parrish S, Vancott
TC, Lifson JD, Schlesinger S, Mascola JR, Pope M.
AIDS Res Hum Retroviruses. 2004 Aug;20(8):871-84.
Journal of Infectious Diseases - 2004
Safety
and immunogenicity of an HIV subtype B and E prime-boost vaccine
combination in HIV-negative Thai adults.
Nitayaphan S, Pitisuttithum P, Karnasuta C, Eamsila C, de
Souza M, Morgan P, Polonis V, Benenson M, VanCott T, Ratto-Kim
S, Kim J, Thapinta D, Garner R, Bussaratid V, Singharaj P,
el-Habib R, Gurunathan S, Heyward W, Birx D, McNeil J, Brown
AE; Thai AIDS Vaccine Evaluation Group.
J Infect Dis. 2004 Aug 15;190(4):702-6.
July 2004
Journal of Antimicrobial Chemotherapy - 2004
Inhibition
of respiratory syncytial virus by RhoA-derived peptides: implications
for the development of improved antiviral agents targeting
heparin-binding viruses.
Budge PJ, Graham BS.
J Antimicrob ChemotherInfect Dis. 2004 Jul 14 [Epub
ahead of print]
Journal of Infectious Diseases - 2004
Safety
and Immunogenicity of an HIV Subtype B and E Prime-Boost Vaccine
Combination in HIV-Negative Thai Adults.
Nitayaphan S, Pitisuttithum P, Karnasuta C, Eamsila C, De
Souza M, Morgan P, Polonis V, Benenson M, VanCott T, Ratto-Kim
S, Kim J, Thapinta D, Garner R, Bussaratid V, Singharaj P,
El Habib R, Gurunathan S, Heyward W, Birx D, McNeil J, Brown
AE; Thai AIDS Vaccine Evaluation Group.
J Infect Dis. 2004 Aug 15;190(4):702-6.
Journal of Immunology - 2004
Absence
of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive,
HIV-uninfected vaccine recipients expressing the HLA-A*0201
allele.
Ferrari G, Neal W, Ottinger J, Jones AM, Edwards BH, Goepfert
P, Betts MR, Koup RA, Buchbinder S, McElrath MJ, Tartaglia
J, Weinhold KJ.
J Immunol. 2004 Aug 1;173(3):2126-33.
June 2004
Clinical Infectious Diseases - 2004
Modified
vaccinia ankara: potential as an alternative smallpox vaccine.
McCurdy LH, Larkin BD, Martin JE, Graham BS.
Clin Infect Dis. 2004 38(12):1749-53.
Journal of Virology - June 2004
pH-dependent
entry of severe acute respiratory syndrome coronavirus is
mediated by the spike glycoprotein and enhanced by dendritic
cell transfer through DC-SIGN.
Yang ZY, Huang Y, Ganesh L, Leung K, Kong WP, Schwartz O,
Subbarao K, Nabel GJ.
J Virol. 2004 Jun;78(11):5642-50.
Journal of Virology - June 2004
Respiratory
syncytial virus (RSV) G glycoprotein is not necessary for
vaccine-enhanced disease induced by immunization with formalin-inactivated
RSV.
Johnson TR, Teng MN, Collins PL, Graham BS.
J Virol. 2004 Jun;78(11):6024-32.
Blood - June 2004
High
prevalence of autoreactive, neuroantigen-specific CD8+ T cells
in multiple sclerosis revealed by novel flow cytometric assay.
Crawford MP, Yan SX, Ortega SB, Mehta RS, Hewitt RE, Price
DA, Stastny P, Douek DC, Koup RA, Racke MK, Karandikar NJ.
Blood. 2004 Jun 1;103(11):4222-31
Blood - June 2004
Unusual
Immunophenotype of CD8+ T-cells in Familial Hemophagocytic
Lymphohistiocytosis.
Karandikar NJ, Kroft SH, Yegappan S, Rogers BB, Aquino VM,
Lee KM, Kumar V, Guenaga FJ, Jaffe ES, Douek DC, McKenna RW.
Blood. 2004 Jun 17
May 2004
Journal of Immunology - May 2004
A
Immunogenicity of recombinant adenovirus serotype 35 vaccine
in the presence of pre-existing anti-Ad5 immunity.
Barouch DH, Pau MG, Custers JH, Koudstaal W, Kostense S, Havenga
MJ, Truitt DM, Sumida SM, Kishko MG, Arthur JC, Korioth-Schmitz
B, Newberg MH, Gorgone DA, Lifton MA, Panicali DL, Nabel GJ,
Letvin NL, Goudsmit J.
J Immunol. 2004 May 172(10):6290-7.
American Journal of Respiratory and Critical Care
Medicine - May 2004
Respiratory
Syncytial Virus in Allergic Lung Inflammation Increases Muc5ac
and gob-5.
A Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson
SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF,
Peebles Jr RS.
Am J Respir Crit Care Med. 2004 May 6 (Epub ahead
of print).
Journal of Virology - May 2004
RhoA-derived
peptide dimers share mechanistic properties with other polyanionic
inhibitors of respiratory syncytial virus (RSV), including
disruption of viral attachment and dependence on RSV G.
Budge PJ, Li Y, Beeler JA, Graham BS.
J Virol. 2004 May;78(10):5015-22.
Journal of Immunology - May 2004
The
functional profile of primary human antiviral CD8+ T cell
effector activity is dictated by cognate peptide concentration.
Betts MR, Price DA, Brenchley JM, Lore K, Guenaga FJ, Smed-Sorensen
A, Ambrozak DR, Migueles SA, Connors M, Roederer M, Douek
DC, Koup RA.
J Immunol. 2004 May 15;172(10):6407-17.
Journal of Immunology - May 2004
Adult
human liver contains CD8(pos) T cells with naive phenotype,
but is not a site for conventional alphabeta T cell development.
Golden-Mason L, Douek DC, Koup RA, Kelly J, Hegarty JE, O'Farrelly
C.
J Immunol. 2004 May 15;172(10):5980-5.
Journal of Virology - May 2004
Migration
of antigen-specific T cells away from CXCR4-binding human
immunodeficiency virus type 1 gp120.
Brainard DM, Tharp WG, Granado E, Miller N, Trocha AK, Ren
XH, Conrad B, Terwilliger EF, Wyatt R, Walker BD, Poznansky
MC.
J Virol. 2004 May;78(10):5184-93.
Journal of Virology - May 2004
Effects
of antibody on viral kinetics in simian/human immunodeficiency
virus infection: implications for vaccination.
Zhang L, Ribeiro RM, Mascola JR, Lewis MG, Stiegler G, Katinger
H, Perelson AS, Davenport MP.
J Virol. 2004 May;78(10):5520-2.
Journal of Virology - May 2004
Immunogenicity
of constrained monoclonal antibody A32-human immunodeficiency
virus (HIV) Env gp120 complexes compared to that of recombinant
HIV type 1 gp120 envelope glycoproteins.
Liao HX, Alam SM, Mascola JR, Robinson J, Ma B, Montefiori
DC, Rhein M, Sutherland LL, Scearce R, Haynes BF.
J Virol. 2004 May;78(10):5270-8.
April 2004
Nature - April 2004
DNA
vaccine induces SARS coronavirus neutralization and protective
immunity in mice.
Yang ZY, Kong WP, Huang Y, Roberts A, Murphy BR, Subbarao
K, Nabel GJ.
Nature. 2004 Apr 1;428(6982):561-4.
Journal of Virology - April 2004
Selective
modification of variable loops alters tropism and enhances
immunogenicity of human immunodeficiency virus type 1 envelope.
Yang ZY, Chakrabarti BK, Xu L, Welcher B, Kong WP, Leung K,
Panet A, Mascola JR, Nabel GJ.
J Virol. 2004 Apr;78(8):4029-36.
Journal of Experimental Medicine - April 2004
Immediate
Cytotoxicity But Not Degranulation Distinguishes Effector
and Memory Subsets of CD8+ T Cells.
Wolint P, Betts MR, Koup RA, Oxenius A.
J Exp Med. 2004 Apr 5;199(7):925-36
Blood - April 2004
Identification
and in vitro expansion of CD4+ and CD8+ T cells specific for
human neutrophil elastase.
Fujiwara H, El Ouriaghli F, Grube M, Price DA, Rezvani K,
Gostick E, Sconocchia G, Melenhorst J, Hensel N, Douek DC,
Barrett AJ.
Blood. 2004 Apr 15;103(8):3076-83.
Current HIV/AIDS Reports - April 2004
Current Advances in HIV Vaccines
D'Souza, MP, Allen M, Sheets R, Johnston MI
Current HIV/AIDS Reports 2004. April 1:18-24
March 2004
Journal of Virology - March 2004
The
V3 Loop Is Accessible on the Surface of Most Human Immunodeficiency
Virus Type 1 Primary Isolates and Serves as a Neutralization
Epitope.
Gorny MK, Revesz K, Williams C, Volsky B, Louder MK, Anyangwe
CA, Krachmarov C, Kayman SC, Pinter A, Nadas A, Nyambi PN,
Mascola JR, Zolla-Pazner S.
J Virol. 2004 Mar 1;78(5):2394-2404
Journal of Virology - March 2004
Treatment
with anti-LFA-1 delays the CD8+ cytotoxic-T-lymphocyte response
and viral clearance in mice with primary respiratory syncytial
virus infection.
Rutigliano JA, Johnson TR, Hollinger TN, Fischer JE, Aung
S, Graham BS.
J Virol. 2004 Mar;78(6):3014-3023.
Nature Immunology - March 2004
HIV
vaccine design and the neutralizing antibody problem.
Burton DR, Desrosiers RC, Doms RW, Koff WC, Kwong PD, Moore
JP, Nabel GJ, Sodroski J, Wilson IA, Wyatt RT.
Nat Immunol. 2004 Mar;5(3):233-6. No abstract available.
February 2004
Blood - February 2004
High
Prevalence of Autoreactive Neuroantigen-Specific CD8+ T Cells
in Multiple Sclerosis Revealed by Novel Flow Cytometric Assay.
Crawford MP, Yan SX, Ortega S, Mehta RS, Hewitt RE, Price
DA, Stastny P, Douek DC, Koup RA, Racke MK, Karandikar NJ.
Blood. 2004 Epub ahead of print
Journal of Immunology - February 2004
HIV-infected
Langerhans cells preferentially transmit virus to proliferating
autologous CD4(+) memory T cells located within Langerhans
cell-T cell clusters.
Sugaya M, Lore K, Koup RA, Douek DC, Blauvelt A.
J Immunol. 2004 Feb 15;172(4):2219-24.
Journal of Virology - February 2004
T-cell
subsets that harbor human immunodeficiency virus (HIV) in
vivo: implications for HIV pathogenesis.
Brenchley JM, Hill BJ, Ambrozak DR, Price DA, Guenaga FJ,
Casazza JP, Kuruppu J, Yazdani J, Migueles SA, Connors M,
Roederer M, Douek DC, Koup RA.
J Virol. 2004 Feb;78(3):1160-8
Journal of Immunology - February 2004
HLA
class II polymorphisms determine responses to bacterial superantigens.
Llewelyn M, Sriskandan S, Peakman M, Ambrozak DR, Douek DC,
Kwok WW, Cohen J, Altmann DM.
J Immunol. 2004 Feb 1;172(3):1719-26.
Journal of AIDS - February 2004
Immunoprophylaxis
to prevent mother-to-child transmission of HIV-1.
Safrit JT, Ruprecht R, Ferrantelli F, Xu W, Kitabwalla M,
Van Rompay K, Marthas M, Haigwood N, Mascola JR, Luzuriaga
K, Jones SA, Mathieson BJ, Newell ML; Ghent IAS Working Group
on HIV in Women Children.
J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):169-77
Journal of Immunology - February 2004
Ontogeny
of gammadelta T cells in humans.
De Rosa SC, Andrus JP, Perfetto SP, Mantovani JJ, Herzenberg
LA, Herzenberg LA, Roederer M.
J Immunol. 2004 Feb 1;172(3):1637-45
Nature Medicine - February 2004
Genetic,
cellular and immune approaches to disease therapy: past and
future.
Nabel GJ
Nat Med. 2004 Feb;10(2): 135-41.
Proceedings of the National Academy of Sciences -
February 2004
Structural
basis of tyrosine sulfation and VH-gene usage in antibodies
that recognize the HIV type 1 coreceptor-binding site on gp120.
Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY,
Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt
R, Choe H, Farzan M, Kwong PD.
Proc Natl Acad Sci U S A.M 2004 Feb 23 [Epub ahead
of print]
Structure - February 2004
The
447-52D Antibody: Hitting HIV-1.
Kwong PD.
Structure. 2004 Feb;12(2):173-4.
January 2004
EMBO Journal - January 2004
A
novel role for XIAP in copper homeostasis through regulation
of MURR1.
Burstein E, Ganesh L, Dick RD, Van De Sluis B, Wilkinson JC,
Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS
EMBO J. 23(1): 244-54.
Journal of Virology - January 2004
Incorporation
of pol into human immunodeficiency virus type 1 Gag virus-like
particles occurs independently of the upstream Gag domain
in Gag-pol.
Cen S, Niu M, Saadatmand J, Guo F, Huang Y, Nabel GJ, Kleiman
L.
J Virol. 2004 Jan; 78(2): 1042-9
Pediatric Infectious Disease Journal - January 2004
Contribution
of respiratory syncytial virus G antigenicity to vaccine-enhanced
illness and the implications for severe disease during primary
respiratory syncytial virus infection.
Johnson TR, Graham BS.
Pediatr Infect Dis J. 2004 Jan; 23(1): S46-S57.
AIDS - January 2004
T-cell
dynamics during acute SIV infection.
Mattapallil JJ, Letvin NL, Roederer M.
AIDS. 2004 Jan 2;18(1):13-23.
2003
December 2003
Journal of Virology - December 2003
Immunogenicity
of multiple gene and clade human immunodeficiency virus type
1 DNA vaccines.
Kong WP, Huang Y, Yang ZY, Chakrabarti BK, Moodie Z, Nabel
GJ.
J Virol. 77(23): 12764-72.
Nature - December 2003
The
gene product Murr1 restricts HIV-1 replication in resting
CD4+ lymphocytes.
Ganesh L, Burstein E, Guha-Niyogi A, Louder MK, Mascola JR,
Klomp LW, Wijmenga C, Duckett CS, Nabel GJ.
Nature. 426(6968): 853-7.
Blood - December 2003
Identification
and in vitro expansion of CD4+ and CD8+ T cells specific for
human neutrophil elastase.
Fujiwara H, El Ouriaghli F, Grube M, Price DA, Rezvani K,
Gostick E, Sconocchia G, Melenhorst J, Hensel N, Douek DC,
Barrett AJ.
Blood. 2003
November 2003
AIDS - November 2003
Diverse
HIV-1 subtypes and clinical, laboratory and behavioral factors
in a recently infected US military cohort.
Brodine SK, Starkey MJ, Shaffer RA, Ito SI, Tasker SA, Barile
AJ, Tamminga CL, Stephan KT, Aronson NE, Fraser SL, Wallace
MR, Wegner SA, Mascola JR, McCutchan FE.
AIDS. 17(17):2521-27.
Antimicrobial Agents and Chemotherapy - November
2003
Antiviral
activity of RhoA-derived peptides against respiratory syncytial
virus is dependent on formation of peptide dimers.
Budge PJ, Lebowitz J, Graham BS.
Antimicrobial Agents and Chemotherapy. (11):3470-7.
October 2003
Blood - October 2003
Functional
leukemia-associated antigen-specific memory CD8+ T cells exist
in healthy individuals and in patients with chronic myelogenous
leukemia before and after stem cell transplantation.
Rezvani K, Grube M, Brenchley JM, Sconocchia G, Fujiwara H,
Price DA, Gostick E, Yamada K, Melenhorst J, Childs R, Hensel
N, Douek DC, Barrett AJ.
Blood. 102 (8) 2892-900
Immunology Letters - October 2003
Low T cell receptor excision circle
levels in patients thymectomized 25-54 years ago.
Storek J, Douek DC, Keesey JC, Boehmer L, Storer B, Maloney
DG
Immunol Lett. 89(2-3):91-2.
Journal of Immunological Methods - October 2003
Sensitive and viable identification
of antigen-specific CD8+ T cells by a flow cytometric assay
for degranulation.
Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer
M, Koup RA.
Journal of Immunological Methods. 281 (1-2):65-78.
Journal of Immunology - October 2003
Toll-Like
Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus-
and HIV-1-Specific T Cell Responses.
Lore K, Betts MR, Brenchley JM, Kuruppu J, Khojasteh, Perfetto
S, Mario M, Seder RA, Koup RA
J Immunol. 171(8):4320-8.
Journal of Virology - October 2003
Access
of Antibody Molecules to the Conserved Coreceptor Binding
Site on Glycoprotein gp120 Is Sterically Restricted on Primary
Human Immunodeficiency Virus Type 1.
Labrijn AF, Poignard P, Raja A, Zwick MB, Delgado K, Franti
M, Binley J, Vivona V, Grundner C, Huang CC, Venturi M, Petropoulos
CJ, Wrin T, Dimitrov DS, Robinson J, Kwong PD, Wyatt RT, Sodroski
J, Burton DR.
J Virol. 2003 Oct 1;77(19):10557-10565.
Journal of Virology - October 2003
Cellular immunity elicited by human
immunodeficiency virus type 1/ simian immunodeficiency virus
DNA vaccination does not augment the sterile protection afforded
by passive infusion of neutralizing antibodies.
Mascola JR, Lewis MG, VanCott TC, Stiegler G, Katinger H,
Seaman M, Beaudry K, Barouch DH, Korioth-Schmitz B, Krivulka
G, Sambor A, Welcher B, Douek DC, Montefiori DC, Shiver JW,
Poignard P, Burton DR, Letvin NL.
J Virol. 77(19):10348-56.
Nature Medicine - October 2003
Ex
vivo identification, isolation and analysis of tumor-cytolytic
T cells.
Rubio V, Stuge TB, Singh N, Betts MR, Weber JS, Roederer M,
Lee PP.
Nat Med. 2003 Oct 5 [Epub ahead of print]
Virology - October 2003
Epitope
mapping and characterization of a novel CD4-induced human
monoclonal antibody capable of neutralizing primary HIV-1
strains.
Xiang S-H, Wang L, Abreu M, Huang C, Kwong PD, Rosenberg E,
Robinson JE and Sodroski J.
Virology. 325:124-134.
September 2003
British Journal of Haematology
- September 2003
Early
reconstitution of the T-cell repertoire after non-myeloablative
peripheral blood stem cell transplantation is from post-thymic
T-cell expansion and is unaffected by graft-versus-host disease
or mixed chimaerism.
Bahceci E, Epperson D, Douek DC, Melenhorst JJ, Childs RC,
Barrett AJ
Br J Haematol. 122(6):934-43.
Infectious Immunology - September 2003
Coinjection
with CpG-containing immunostimulatory oligodeoxynucleotides
reduces the pathogenicity of a live vaccine against cutaneous
Leishmaniasis but maintains its potency and durability.
Mendez S, Tabbara K, Belkaid Y, Bertholet S, Verthelyi D,
Klinman D, Seder RA, Sacks DL.
Infect Immun. 71(9):5121-9.
Journal of Immunology - September
2003
Prime-boost
vaccination with HIV-1 Gag protein and cytosine phosphate
guanosine oligodeoxynucleotide, followed by adenovirus, induces
sustained and robust humoral and cellular immune responses.
Tritel M, Stoddard AM, Flynn BJ, Darrah PA, Wu CY, Wille U,
Shah JA, Huang Y, Xu L, Betts MR, Nabel GJ, Seder RA.
J Immunol. 2003 Sep 1;171(5):2538-47.
Journal of Virology - September
2003
Ebola
virus pathogenesis: implications for vaccines and therapies.
Sullivan N, Yang ZY, Nabel GJ.
J Virol. 2003 Sep;77(18):9733-7.
Journal of Virology - September
2003
Enhanced
mucosal immunoglobulin a response of intranasal adenoviral
vector human immunodeficiency virus vaccine and localization
in the central nervous system.
Lemiale F, Kong WP, Akyurek LM, Ling X, Huang Y, Chakrabarti
BK, Eckhaus M, Nabel GJ.
J Virol. 2003 Sep;77(18):10078-87.
Nature Immunology - September 2003
Similarities
and differences in CD4+ and CD8+ effector and memory T cell
generation.
Seder RA, Ahmed R.
Nat Immunol. 4(9):835-42.
Structure - September 2003
Enhancing
Protein Crystallization through Precipitant Synergy.
Majeed S, Ofek G, Belachew A, Huang C, Zhou T, Kwong PD.
Structure (Camb). 2003 Sep;11(9):1061-70.
Virology - September 2003
Structure-based,
Targeted Deglycosylation of HIV-1 gp120 and Effects on Neutralization
Sensitivity and Antibody Recognition.
Kock M, Pancera M, Kwong PD, Kolchinsky P, Grundner C, Wang
L, Hendrickson WA, Sodroski J and Wyatt R. (2003)
Virology. 313: 387-400.
August 2003
Current Opinion in Immunology - August 2003
DNA vaccination: the answer to stable,
protective T-cell memory?
Kirman JR, Seder RA.
Curr Opin Immunol. 15(4):471-6.
Journal of Immunology Methods - August 2003
Optimized
lymphocyte isolation methods for analysis of chemokine receptor
expression.
Berhanu D, Mortari F, De Rosa SC, Roederer M.
J Immunol Methods. 279(1-2):199-207.
Nature - August 2003
Accelerated
vaccination for Ebola virus haemorrhagic fever in non-human
primates.
Sullivan NJ, Geisbert TW, Geisbert JB,
Xu L, Yang ZY, Roederer M, Koup RA, Jahrling PB, Nabel GJ.
Nature. 2003 Aug 7;424(6949):681-4.
July 2003
Cell - July 2003
Tyrosine
sulfation of human antibodies contributes to recognition of
the CCR5 binding region of HIV-1 gp120. Choe H, Li W,
Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman
T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson
JE, Sodroski JG, Farzan M.
Cell. 2003 Jul 25;114(2):161-70.
Journal of Experimental Medicine - July 2003
Dendritic
Cells Are Responsible for the Capacity of CpG Oligodeoxynucleotides
to Act as an Adjuvant for Protective Vaccine Immunity Against
Leishmania major in Mice.
Shah JA, Darrah PA, Ambrozak DR, Turon TN, Mendez S, Kirman
J, Wu CY, Glaichenhaus N, Seder RA.
J Exp Med. 2003 Jul 21;198(2):281-91.
June 2003
Journal of Clinical Microbiology - June 2003
Herpesvirus
DNA is consistently detected in lungs of patients with idiopathic
pulmonary fibrosis.
Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A,
Graham BS, Brigham KL, Oates JA Jr, Loyd JE, Stecenko AA.
J Clin Microbiol. 41(6):2633-40
May 2003
Current Molecular Medicine - May 2003
Defining
the protective antibody response for HIV-1.
Mascola JR.
Curr Mol Med. 2003 May;3(3):209-16.
April 2003
Cytometry - April 2003
Measuring
containment of viable infectious cell sorting in high velocity
cell sorters
Perfetto SP, DR Ambrozak, RA Koup, and M Roederer
Cytometry. 52A (2): 122-130
Nature Medicine - April, 2003
HIV-1:
nature's master of disguise.
Mascola JR, Montefiori DC.
Nat Med. 2003 9(4): 393-4.
Viral Immunology - April 2003
The
complex relationship between respiratory syncytial virus and
allergy in lung disease.
Peebles RS Jr, Hashimoto K, Graham BS.
Viral Immunol. 16(1):25-34
Virus Research - April 2003
Vaccine
for AIDS and Ebola virus infection.
Nabel GJ.
Virus Res. 2003 Apr;92(2):213-7. Review.
March 2003
Immunity - March 2003
Non-pathogenic
simian immunodeficiency virus infection of sooty mangabey
monkeys is characterized by limited bystander immunopathology
and preserved immune regenerative capacity despite chronic
high level virus replication.
Silvestri G, DL Sodora, RA Koup, SP O'Neil, HM McClure, SI
Staprans, and MB Feinberg.
Immunity. 18 (3): 441-52
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Methods - March 2003
Optimized
determination of T cell epitope responses
Roederer M, and RA Koup.
J. Immunol. Methods. 274 (1-2): 221-228
Nature - March 2003
Antibody
neutralization and escape by HIV-1.
Wei X, Decker JM, Wang S, Hui H, Kappes JC, Wu X, Salazar-Gonzalez
JF, Salazar MG, Kilby JM, Saag MS, Komarova NL, Nowak MA,
Hahn BH, Kwong PD, Shaw GM.
Nature. 2003 Mar 20;422(6929):307-12.
February 2003
Journal of Immunology - February 2003
IL-13
is sufficient for respiratory syncytial virus G glycoprotein-induced
eosinophilia after respiratory syncytial virus challenge.
Johnson TR, Parker RA, Johnson JE, Graham BS.
J Immunol. 2003 Feb 15;170(4):2037-45.
Journal of Virology - February 2003
Role
of plasma membrane lipid microdomains in respiratory syncytial
virus filament formation.
McCurdy LH, Graham BS.
J Virol. 2003 Feb;77(3):1747-56.
PNAS - February 2003
Definitive
separation of graft-versus-leukemia- and graft-versus-host-specific
CD4+ T cells by virtue of their receptor beta loci sequences.
J. Michálek, R. H. Collins, H. P. Durrani, P. Václavková,
L. E. Ruff, D. C. Douek, and E. S. Vitetta.
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1180-1184.
January 2003
Immunology - January 2003
T
Cell Dynamics in HIV-1 Infection.
Douek DC, Picker LJ, Koup RA.
Annu Rev Immunol. 2003 Jan 8.
Infection and Immunity - January 2003
Enhanced
Immunogenicity to Mycobacterium tuberculosis by Vaccination
with an Alphavirus Plasmid Replicon Expressing Antigen 85A
Kirman JR, Turon T, Su H, Li A, Kraus C, Polo JM, Belisle
J, Morris S, Seder RA.
Infect Immun. 2003 Jan;71(1):575-9.
Journal of Virology - January 2003
CD4
Binding Site Antibodies Inhibit Human Immunodeficiency Virus
gp120 Envelope Glycoprotein Interaction with CCR5.
Raja A, Venturi M, Kwong P, Sodroski J.
J Virol. 2003 Jan 1;77(1):713-718.
Journal of Virology - January 2003
Overcoming
Immunity to a Viral Vaccine by DNA Priming before Vector Boosting.
Yang ZY, Wyatt LS, Kong WP, Moodie Z, Moss B, Nabel GJ.
J Virol. 2003 Jan 1;77(1):799-803.
Nature Medicine - January 2003
Beyond
six colors: A new era in flow cytometry.
De Rosa SC, Brenchley JM, Roederer M.
Nat Med 2003 Jan;9(1):112-7.
2003
Handbook of Cell Signaling - 2003
HIV-1 Receptor Interactions.
Kwong PD.
Handbook of Cell Signaling, (Eds. Bradshaw RA and
Dennis EA, Elsevier Adademic Press).
2002
December 2002
Clinical & Experimental Immunology
- December 2002
Expansion
of activated human naive T-cells precedes effector function.
Brenchley JM, Douek DC, Ambrozak DR, Chatterji M, Betts MR,
Davis LS, Koup RA.
Clin Exp Immunol. 2002 Dec;130(3):432-40
Journal of Immunological Methods - December 2002
Quantification
of T-cell receptor excision circle DNA using fluorescence
resonance energy transfer and the LightCycler system.
Loeffler J, Bauer R, Hebart H, Douek DC, Rauser G, Bader P,
Einsele H.
J Immunol Methods. 2002 Dec 20;271(1-2):167-75.
Nature - December 2002
HIV-1
evades antibody-mediated neutralization through conformational
masking of receptor-binding sites.
Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed
S, Steenbeke TD, Venturi M, Chaiken I, Fung M, Katinger H,
Parren PW, Robinson J, Van Ryk D, Wang L, Burton DR, Freire
E, Wyatt R, Sodroski J, Hendrickson WA, Arthos J.
Nature. 2002 Dec 12;420(6916):678-82
November 2002
Blood - November 2002
Expression
of CD57 defines replicative senescence and antigen-induced
apoptotic death of CD8+ T cells.
Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ,
Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M,
Roederer M, Douek DC, Koup RA.
Blood. 2002 Nov 14
October 2002
Journal of Infectious Diseases - October 2002
Preparation
of Clinical-Grade Recombinant Canarypox-Human Immunodeficiency
Virus Vaccine-Loaded Human Dendritic Cells
Marovich MA, Mascola JR, Eller MA, Louder MK, Caudrelier PA,
El-Habib R, Ratto-Kim S, Cox JH, Currier JR, Levine BL, June
CH, Bernstein WB, Robb ML, Schuler-Thurner B, Steinman RM,
Birx DL, Schlesinger-Frankel S.
J Infect Dis. 2002 Nov; 186(9):1242-52
Journal of Virology - October 2002
Mutagenic
stabilization and/or disruption of a CD4-bound state reveals
distinct conformations of the human immunodeficiency virus
type 1 gp120 envelope glycoprotein.
Xiang SH, Kwong PD, Gupta R, Rizzuto CD, Casper DJ, Wyatt
R, Wang L, Hendrickson WA, Doyle ML, Sodroski J.
J Virol. 2002 Oct;76(19):9888-99
Journal of Virology
- October 2002
Decreased
levels of recent thymic emigrants in peripheral blood of simian
immunodeficiency virus-infected macaques correlate with alterations
within the thymus.
Sodora DL, JM Milush, F Ware, A Wozniakowski, L Montgomery,
HM McClure, AA Lackner, M Marthas, V Hirsch, RP Johnson, DC
Douek, and RA Koup.
J. Virol. 76 (19): 9981-9990
September 2002
DNA Cell Biology -
September 2002
Optimal
antigens for HIV vaccines based on CD8+ T response, protein
length, and sequence variability
Betts MR, K Yusim, and RA Koup
DNA Cell Biol. 21(9): 665-670
August 2002
Journal of Immunology - August 2002
Direct
ex vivo analysis of human CD4(+) memory T cell activation
requirements at the single clonotype level
Bitmansour AD, Douek DC, Maino VC, Picker LJ.
J Immunol. 169(3):1207-18
Molecular Cell - August 2002
The
Assembly of Ebola Virus Nucleocapsid Requires Virion-Associated
Proteins 35 and 24 and Posttranslational Modification of Nucleoprotein
Yue Huang, Ling Xu, Yongnian Sun, and Gary J. Nabel
Molecular Cell. 2002;10:307-316.
Nature Immunology - August 2002
Distinct
lineages of T(H)1 cells have differential capacities for memory
cell generation in vivo
Wu CY, Kirman JR, Rotte MJ, Davey DF, Perfetto SP, Rhee EG,
Freidag BL, Hill BJ, Douek DC, Seder RA.
Nat Immunol. 2002 Aug 12
New England Journal of Medicine - August 2002
Antiretroviral-drug
resistance among patients recently infected with HIV.
Little SJ, Holte S, Routy JP, Daar ES, Markowitz M, Collier
AC, Koup RA, Mellors JW, Connick E, Conway B, Kilby M, Wang
L, Whitcomb JM, Hellmann NS, Richman DD.
N Engl J Med. 347(6):385-94
July 2002
AIDS Research and Human Retroviruses - July 2002
Demonstration
of de novo HIV type 1 production by detection of multiply
spliced and unspliced HIV type 1 RNA in paraffin-embedded
tonsils.
Brachtel EF, Mascola JR, Wear DJ, Ehrenberg PK, Dayhoff DE,
Sanders-Buell E, Michael NL, Frankel SS
AIDS Res and Hum Retrovirsues. 18:785-790
European Molecular Biology Organization - July 2002
A
growth factor-dependent nuclear kinase phosphorylates p27Kip1
and regulates cell cycle progression
Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel
GJ, Nabel EG.
The EMBO Journal. 21;13:3390-3401.
Journal of Dermatological Science - July 2002
Injection
of human herpesvirus-8 in human skin engrafted on SCID mice
induces Kaposi's sarcoma-like lesions
Foreman KE, Friborg J, Chandran B, Katano H, Sata T, Mercader
M, Nabel GJ, Nickoloff BJ
J. Dermatol. Sci. 26(3):182-193
Journal of Virology - July 2002
The
mannose-dependent epitope for the neutralizing antibody 2G12
on human immunodeficiency virus type 1 glycoprotein gp120
Rogier W. Sanders, Miro Venturi, Linnea Schiffner, Roopa Kalyanaraman,
Hermann Katinger, Kenneth O. Lloyd, Peter D. Kwong, John P.
Moore.
J Virol. 2002 Jul;76(14):7293-305
June 2002
Journal of Experimental Medicine - June 2002
Vaccination
with heat-killed leishmania antigen or recombinant leishmanial
protein and CpG oligodeoxynucleotides induces long-term memory
CD4+ and CD8+ T cell responses and protection against leishmania
major infection
Rhee EG, Mendez S, Shah JA, Wu CY, Kirman JR, Turon TN, Davey
DF, Davis H, Klinman DM, Coler RN, Sacks DL, Seder RA.
J Exp Med. 2002 Jun 17;195(12):1565-73
Journal of Virology - June 2002
Modifications
of the human immunodeficiency virus envelope glycoprotein
enhance immunogenicity for genetic immunization
Chakrabarti BK, Kong WP, Wu BY, Yang ZY, Friborg J, Ling X,
King SR, Montefiori DC, Nabel GJ.
J Virol. 2002 Jun;76(11):5357-68.
Nature Immunology - June 2002
Role
of BCR affinity in T cell dependent antibody responses in
vivo
Yang Shih TA, Meffre E, Roederer M, Nussenzweig MC.
Nat Immunol. 3: 570-5.
Science - June 2002
HIV-1
diversity and vaccine development
Nabel G, Makgoba W, Esparza J.
Science. 2002 Jun 28;296(5577):2335
May 2002
Journal of the American Medical Association - May 2002
Hemorrhagic
Fever Viruses as Biological Weapons
Borio L, Inglesby T, Peters CJ, Schmaljohn AL, Hughes JM,
Jahrling PB, Ksiazek T, Johnson KM, Meyerhoff A, O'Toole T,
Ascher MS, Bartlett J, Breman JG, Eitzen EM Jr, Hamburg M,
Hauer J, Henderson DA, Johnson RT, Kwik G, Layton M, Lillibridge
S, Nabel GJ, Osterholm MT, Perl TM, Russell P, Tonat K; The
Working Group on Civilian Biodefense.
JAMA. 2002 287;(18):2391-405.
Journal of Virology - May 2002
Human
immunodeficiency virus type 1 neutralization measured by flow
cytometric quantitation of single-round infection of primary
human T cells
Mascola JR, Louder MK, Winter C, Prabhakara R, De Rosa SC,
Douek DC, Hill BJ, Gabuzda D, Roederer M.
J Virol. 2002;76:4810-21
Journal of Virology - May 2002
Highly
Stable Trimers Formed by Human Immunodeficiency Virus Type
1 Envelope Glycoproteins Fused with the Trimeric Motif of
T4 Bacteriophage Fibritin
Xinzhen Yang, Juliette Lee, Erin M. Mahony, Peter D. Kwong,
Richard Wyatt, and Joseph Sodroski
J. Virol. 2002 76: 4634-4642.
Journal of Virology - May 2002
NK
T cells contribute to expansion of CD8(+) T cells and amplification
of antiviral immune responses to respiratory syncytial virus
Johnson TR, Hong S, Van Kaer L, Altman JD, Koezuka Y, Graham
BS.
Journal of Virology. 2002; 76:4294-4303.
Nature - May 2002
HIV
preferentially infects HIV-specific CD4+ T cells
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto
Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman
Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA.
Nature. 2002 May 2;417(6884):95-8
Vaccine - May 2002
HIV
vaccine strategies
Nabel GJ.
Vaccine. 2002 May 6;20(15):1945-7.
Vaccine - May 2002
Passive
Transfer Studies to Elucidate the Role of Antibody-mediated
Protection Against HIV-1
Mascola JR.
Vaccine. 2002;20:1922-25
April
2002
American Journal of Respiratory and Critical Care Medicine
- April 2002
Selective
cyclooxygenase-1 and -2 inhibitors each increase allergic
inflammation and airway hyperresponsiveness in mice
Peebles RS, Hashimoto K, Morrow JD, Dworski R, Collins RD,
Jarzecka K, Mitchell DB, Graham BS, Sheller JR. American
Journal of Respiratory and Critical Care Medicine 2002;
165:1154-1160.
Accompanying editorial: Peters-Golden M. Open mind, open airways:
Broadening the paradigm of prostaglandins and allergic airway
inflammation. AJRCCM 2002; 165:1035-1036.
AIDS - April 2002
Immune
reconstitution in HIV-1-infected children on antiretroviral
therapy: role of thymic output and viral fitness
Ometto L, De Forni D, Patiri F, Trouplin V, Mammano F, Giacomet
V, Giaquinto C, Douek D, Koup R, De Rossi A.
AIDS. 2002 Apr 12;16(6):839-49
Blood - April 2002
Effects
of exogenous interleukin-7 on human thymus function
Okamoto Y, Douek DC, McFarland RD, Koup RA.
Blood. 2002 Apr 15;99(8):2851-8
Journal of Infectious Diseases
- April 2002
Illness
severity, virus shedding, and antibody responses in patients
hospitalized with bronchiolitis caused by respiratory syncytial
virus - Article in PDF format (PDF/Adobe
Acrobat Information and Help).
Wright PF, Gruber WC, Peters M, Reed G, Zhu YW, Robinson F,
Coleman-Dockery S, Graham BS.
Journal of Infectious Diseases. 2002; 185:1011-1018.
Journal of Virology - April 2002
Solid-phase
proteoliposomes containing human immunodeficiency virus envelope
glycoproteins.
Grundner C, Mirzabekov T, Sodroski J, Wyatt R.
J Virol. 2002 Apr;76(7):3511-21
Nature Immunology - April 2002
Role
of antigen receptor affinity in T cell-independent antibody
responses in vivo
Shih TA, Roederer M, Nussenzweig MC
Nat Immunol. 3: 399-406.
March 2002
Cancer Research - March 2002
Cellular
localization and function of Fas ligand (CD95L) in tumors
Kurooka M, Nuovo GJ, Caligiuri MA, Nabel GJ.
Cancer Res. 2002 Mar 1;62(5):1261-5.
Journal of Clinical Investigation - March 2002
Glatiramer
acetate (Copaxone) therapy induces CD8(+) T cell responses
in patients with multiple sclerosis
Karandikar NJ, Crawford MP, Yan X, Ratts RB, Brenchley JM,
Ambrozak DR, Lovett-Racke AE, Frohman EM, Stastny P, Douek
DC, Koup RA, Racke MK.
J Clin Invest. 2002 Mar;109(5):641-9
Journal of Acquired
Immune Deficiency Syndrome - March 2002
Safety
and immunogenicity of a high-titered canarypox vaccine in
combination with rgp120 in a diverse population of HIV-1-uninfected
adults: AIDS Vaccine Evaluation Group Protocol 022A
Gupta K, Hudgens M, Corey L, McElrath MJ, Weinhold K, Montefiori
DC, Gorse GJ, Frey SE, Keefer MC, Evans TG, Dolin R, Schwartz
DH, Harro C, Graham B, Spearman PW, Mulligan M, Goepfert P.
Journal of Acquired Immune Deficiency Syndrome. 2002;
29:254-261.
Journal of Immunology - March 2002
A
novel approach to the analysis of specificity, clonality,
and frequency of HIV-specific T cell responses reveals a potential
mechanism for control of viral escape
Douek DC, Betts MR, Brenchley JM, Hill BJ, Ambrozak DR, Ngai
KL, Karandikar NJ, Casazza JP, Koup RA.
J Immunol. 2002 Mar 15;168(6):3099-104
Journal of Immunology - March 2002
The
role of interferon in RSV pathogenesis
Durbin J, Johnson TR, Durbin RK, Mertz S, Peebles RS, Jr.,
Graham BS.
Journal of Immunology. 2002; 168:2944-2951.
February 2002
Blood - February 2002
A
broad T-cell repertoire diversity and an efficient thymic
function indicate a favorable long-term immune reconstitution
after cord blood stem cell transplantation.
Talvensaari K, Clave E, Douay C, Rabian C, Garderet L, Busson
M, Garnier F, Douek D, Gluckman E, Charron D, Toubert A.
Blood. 99(4):1458-64
Journal of Immunology - February 2002
CpG
oligodeoxynucleotides as vaccine adjuvants in primates
Verthelyi D, Kenney RT, Seder RA, Gam AA, Friedag B, Klinman
DM.
J Immunol. 2002 Feb 15;168(4):1659-63
Virology - February
2002
Respiratory
Syncytial Virus Immunobiology and Pathogenesis - Article
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Acrobat Information and Help).
Graham BS, Rutigliano JA, Johnson
TR.
Virology. 2002.
January 2002
Journal of Virology - January 2002
Effects
of antigen and genetic adjuvants on immune responses to human
immunodeficiency virus DNA vaccines in mice
Moore AC, Kong WP, Chakrabarti BK, Nabel GJ.
J Virol. 2002 Jan;76(1):243-50
Thorax
- January 2002
Suppression
of airway hyperresponsiveness induced by ovalbumin sensitisation
and RSV infection with Y-27632, a Rho kinase inhibitor
Hashimoto K, Peebles RS, Sheller JR, Jarzecka K, Furlong J,
Mitchell DB, Graham BS.
Thorax. 2002; (in press).
2002
Annual Review
Advances
in Experimental Biology and Medicine-2002
IL-7, the thymus and naïve T cells
Okamoto Y, Douek DC, McFarland RD, Koup RA
Adv Exp Med Biol. 512:81-90
Annual
Review of Medicine -2002
Clinical
Trials of HIV Vaccines
Graham BS.
Annual Review of Medicine. 2002; 53:207-221.
Current Protocols in Immunology
- 2002
Multiparameter FACS Analysis
Roederer, M., Coligan, J. E., Margulies, D. H., Shevach, E.
M., Strober, W., Coico, R. and Kruisbeek, A. (ed.),
John Wiley & Sons, Inc. New York, (in press).
2001
December 2001
Journal of Immunology
- December 2001
Evidence
for increased T cell turnover and decreased thymic output
in HIV infection
Douek DC, Betts MR, Hill BJ, Little SJ, Lempicki R, Metcalf
JA, Casazza J, Yoder C, Adelsberger JW, Stevens RA, Baseler
MW, Keiser P, Richman DD, Davey RT, Koup RA.
J Immunol. 2001 Dec 1;167(11):6663-8
Journal of Virology - December 2001
Analysis
of total human immunodeficiency virus (HIV)-specific CD4(+)
and CD8(+) T-cell responses: relationship to viral load in
untreated HIV infection.
Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM,
Casazza JP, Koup RA, Picker LJ.
J Virol. 75(24):11983-91
Cytometry - December
2001
Compensation
is not dependent on signal intensity nor on the number of
parameters (letter)
Roederer, M. (2001).
Cytometry. 46, 357.
Immunity - December
2001
Increased
CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells
Mueller, Y. M., Hutton, J. A., Rosa, S. D., Roederer, M.,
Witek, J., Altman, J. D. and Katsikis, P. D. (2001).
Immunity. 15, 871-882.
Journal of Investigative
Dermatology - December 2001
Human
Dendritic Cells as Targets of Dengue Virus Infection
Marovich, MM, Grouard-Vogel G, Louder M, Eller M, Sun W, Birx
D, Hayes C, Frankel S and Mascola JR.
J Invest Derm. 2001;6(3):219-24.
November 2001
Immunology Letters - November 2001
Monitoring
HIV-specific CD8+ T cell responses by intracellular cytokine
production.
Betts MR, Casazza JP, Koup RA.
Immunol Lett. 79:117-125.
October 2001
Cytometry - October 2001
Spectral
compensation for flow cytometry: visualization artifacts,
limitations and caveats
Roederer, M. (2001).
Cytometry. 45, 194-205.
Immunity - October 2001
HIV-1
actively replicates in naive CD4+ T cells residing within
human lymphoid tissues
Eckstein, D. A., Penn, M. L., Korin, Y. D., Scripture-Adams,
D. D., Zack, J. A., Kreisberg, M. P., Roederer, M., Sherman,
M. P., Chin, P. S. and Goldsmith, M. A. (2001).
Immunity. 15, 671-82.
Journal of Leukocyte Biology
- October 2001
Vdelta1
and Vdelta2 gammadelta T cells express distinct surface markers
and might be developmentally distinct lineages
DeRosa, S., Mitra, D., Watanabe, N., Herzenberg, L. A., Herzenberg,
L. A. and Roederer, M. (2001).
J. Leuk. Biol. 70, 518-26.
September 2001
AIDS - September 2001
Poor
CD4+ T cell restoration after suppression of HIV-1 replication
may reflect lower thymic function
Teixeira L, H Valdez, JM McCune, RA Koup, AD Badley, MK Hellerstein,
LA Napolitano, DC Douek, G Mbisa, S Deeks, JM Harris, JD Barbour,
BH Gross, IR Francis, R Halvorsen, R Asaad, and MM Lederman
AIDS. 15 (14):1749-1756
National Academy of Sciences
- September 2001
Naive
CD4 T cells inhibit CD28-costimulated R5-tropic HIV replication
in memory CD4 T cells
Mengozzi, M., Malipatlolla, M., De Rosa, S. C., Herzenberg,
L. A., Herzenberg, L. A. and Roederer, M. (2001).
Proc Natl Acad Sci. USA 98, 11644-9.
Virology - September
2001
Adaptation
to blockade of human immunodeficiency virus type 1 entry imposed
by the anti-CCR5 MAb 2D7
Aarons EJ, SA Beddows, T Willingham, L Wu, and RA Koup
Virology. 287 (2) :382-390
August 2001
Current Opinion in Immunology
- August 2001
Vaccines
for the prevention of HIV-1 disease
Mascola JR, Nabel GJ.
Curr Opin Immunol. 2001 Aug;13(4):489-95
Cytometry - August
2001
Frequency
Difference Gating: A Multivariate Method for Identifying Subsets
that Differ Between Samples
Roederer, M. and Hardy, R. R. (2001).
Cytometry. 45, 56-64.
Cytometry - August
2001
Probability
Binning Comparison: A Metric for Quantitating Multivariate
Distribution Differences
Roederer, M., Moore, W., Treister, A. S., Hardy, R. R. and
Herzenberg, L. A. (2001).
Cytometry. 45, 47-55.
Cytometry - August
2001
Probability
Binning Comparison: A Metric for Quantitating Univariate Distribution
Differences
Roederer, M., Treister, A., Moore, W. and Herzenberg, L. A.
(2001).
Cytometry. 45, 37-46.
Cytometry - August
2001
PE-APC:
A Resonance Energy Transfer Fluorochrome for Immunofluorescence
Tjioe, I., Legerton, T., Wegstein, J., Herzenberg, L. A. and
Roederer, M. (2001).
Cytometry. 44, 24-9.
Journal of Infectious Diseases
- 2001
Immune
interaction between respiratory syncytial virus infection
and allergen-sensitization critically depends on timing of
challenges
Peebles RS, Hashimoto K, Collins RD, Jarzecka K, Furlong J,
Mitchell DB, Sheller JR, Graham BS.
Journal of Infectious Diseases. 2001; 184: 1374-1379.
July 2001
Journal of Virology
- July 2001
Decay
kinetics of Human Immunodeficiency Virus-specific CD8+ T cells
in peripheral blood after initiation of highly active antiretroviral
therapy
Casazza JP, MR Betts, LJ Picker, and RA Koup
J. Virol. 75 (14): 6508-6516
June 2001
Journal of Infectious Diseases
- June 2001
RANTES
production from CD4+ lymphocytes correlates with host genotype
and rates of human immunodeficiency virus type 1 disease progression
Paxton WA, AU Neuman, S Kang, L Deutch, RC Brown, RA Koup,
and SM Wolinsky.
J. Infect. Dis. 183 (11):1678-1681
Nature Medicine - June 2001
Heme
oxygenase-1 protects against vascular constriction and proliferation
Duckers HJ, Boehm M, True AL, Yet SF, San H, Park JL, Clinton
Webb R, Lee ME,Nabel GJ, Nabel EG
Nat. Med. 7(6):693-698
Respiratory Research
- June 2001
Viruses,
dendritic cells, and the lung
Peebles RS, Graham BS
Respiratory Research. 2001; 2:245-249.
May 2001
Cytometry - May 2001
Phycoerythrin-allophycocyanin:
a resonance energy transfer fluorochrome for immunofluorescence
Tjioe I, Legerton T, Wegstein J, Herzenberg LA, Roederer M.
Cytometry. 44(1):24-9
Journal of Virology - May 2001
Human
immunodeficiency virus type 1-specific immunity after genetic
immunization is enhanced by modification of Gag and Pol expression
Huang Y, Kong WP, Nabel GJ.
J Virol. 2001 May;75(10):4947-51
Molecular Therapy - May 2001
Coexpression
of guanylate kinase with thymidine kinase enhances prodrug
cell killing in vitro and suppresses vascular smooth muscle
cell proliferation in vivo
Akyurek LM, Nallamshetty S, Aoki K, San H, Yang ZY, Nabel
GJ, Nabel EG.
Mol. Ther. 2001 3(5 Pt. 1):779-786
April 2001
Nature - April 2001
Challenges
and opportunities for development of an AIDS vaccine
Gary J. Nabel
Nature. Vol 410, 19 April 2001
Nature Immunology - April 2001
Extracellular
matrix interacts with soluble CD95L: retention and enhancement
of cytotoxicity
Aoki K, Kurooka M, Chen JJ, Petryniak J, Nabel EG, Nabel GJ
Nat Immunol. 2001 Apr; 2(4): 333-7
Nature Medicine - April 2001
A
new latent HIV reservoir
Koup RA
Nat Med. (4):404-5
March 2001
Blood - March 2001
Factors
affecting thymic function after allogeneic hematopoietic stem
cell transplantation
Weinberg K, Blazar BR, Wagner JE, Agura
E, Hill BJ, Smogorzewska M, Koup RA, Betts MR, Collins RH,
Douek DC.
Blood. 97 (5):1458-1466
Viral Immunology -
March 2001
Direct
functional analysis of epitope-specific CD8+ T cells in peripheral
blood
He, X. S., Rehermann, B., Boisvert, J., Mumm, J., Maecker,
H. T., Roederer, M., Wright, T. L., Maino, V. C., Davis, M.
M. and Greenberg, H. B. (2001).
Viral Immunol. 14, 59-69.
February 2001
Clinical Laboratory Medicine
- February 2001
11-color
Flow Cytometry: a Powerful Tool for Elucidation of the Complex
Immune System
DeRosa, S. and Roederer, M. (2001).
Clinical Laboratory Medicine. 2001; 21:697-712
Journal of Immunology
- February 2001
Effect
of thymectomy on human peripheral blood T cell pools in Myasthenia
Sempowski GD, JR Thomasch, ME Gooding, LP Hale, LJ Edwards,
E Ciafaloni, DB Sanders, JM Massey, DC Douek, RA Koup, and
BF Haynes Gravis.
J. Immunol. 166 (4) :2808-2817
Nature Medicine -
February 2001
11
color, 13 parameter Flow Cytometry: Identification of human
naive T cells by phenotype, function, and T cell receptor
diversity
DeRosa, S. C., Herzenberg, L. A., Herzenberg, L. A. and Roederer,
M. (2001).
Nature Medicine. 7, 245-8.
January 2001
Current Opinion in Investigational Drugs - January
2001
Vaccines:
Ideal drugs for the 21st Century?
Rappuoli R, Nabel GJ
Curr. Op. Invest. Drugs. 2001 2(1):45-46
Virology - January
2001
Direct
Measurement of CD4+ and CD8+ T Cell Responses to CMV in HIV-1-Infected
Subjects
Komanduri, K. V., Donahoe, S. M., Schmidt, D. K., Gillespie,
G., Ogg, G. S., Roederer, M., Nixon, D. F. and McCune, J.
M. (2001).
Virology. 279, 459-70.
2001 Annual Review
Trans Am Clin Climatol - 2001
The
Gordon Wilson lecture: viruses and human disease
Nabel GJ
Trans. Am. Clin. Climatol. Assoc. 112:79-84
2000
December 2000
Trends in Microbiology - December 2000
Viral
replication and the coactivators p300 and CBP
Hottiger MO, Nabel GJ
Trends Microbiol. 8(12):560-565
November 2000
Molecular Medicine - November 2000
SM22a
promoter targets gene expression to vascular smooth muscle
cells in vitro and in vivo
Akyurek LM, Yang Z-Y, Aoki K, San H, Nabel GJ, Parmacek MS,
Nabel EG
Mol. Med. 6:983-991
Nature - November
2000
Development
of a preventive vaccine for Ebola virus infection in primates
Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ.
Nature. 2000 Nov 30;408(6812):605-9.
Proceedings of the National
Academy of Science U S A - November 2000
Regulation
of beta -catenin transformation by the p300 transcriptional
coactivator
Sun Y, Kolligs FT, Hottiger MO, Mosavin R, Fearon ER, Nabel
GJ.
Proceedings of the National Academy of Science U S A.
2000 Nov 7;97(23):12613-8.
October 2000
European Journal of Clinical Investigation - October
2000
N-acetylcysteine
(NAC) replenishes glutathione in HIV infection
DeRosa, S. C., Zaretsky, M. D., Dubs, J. G., Roederer, M.,
Anderson, M., Green, A., Mitra, D., Watanabe, N., Nakamura,
H., Tjioe, I., Deresinski, S. C., Moore, W. A., Ela, S. W.,
Parks, D., Herzenberg, L. A. and Herzenberg, L. A. (2000).
Eur. J. Clin. Invest. 30, 915-29.
Science - October 2000
Control
of Viremia and prevention of clinical AIDS in Rhesus monkeys
by cytokine-augmented DNA vaccination
Barouch DH, Santra S, Schmitz J, Kuroda M, Fu T, Wagner W,
Bilska M, Craiu A, Zheng XX, Krivulka G, Beaudry K, Lifton
M, Nickerson C, Trigona W, Punt K, Freed D, Guan L, Dubey
S, Casimiro D, Simon A, Davies ME, Chastain M, Strom T, Gelman
R, Montefiori D, Lewis M, Emini E, Shiver J, and Letvin N.
Science. 2000 Oct;290:486-492.
New England Journal of Medicine - October 2000
Clinical
implications of basic research: Antibodies and resistance
to natural HIV infection
Nabel GJ and Sullivan NJ
N. Engl. J. Med. 343(17):1263-1265, 2000
September 2000
Journal of Immunological Methods - September 2000
A
practical approach to multicolor flow cytometry for immunophenotyping
Baumgarth, N. and Roederer, M. (2000).
J. Immunol. Meth 243, 77-97.
August
2000
Nature Medicine - August 2000
Identification
of the Ebola virus glycoprotein as the main viral determinant
of vascular cell cytotoxicity and injury
Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel
GJ.
Nature Medicine 2000 Aug;6(8):886-9.
June 2000
Molecular Therapy - June 2000
Restricted
expression of an adenoviral vector encoding Fas ligand (CD95L)
enhances safety for cancer gene therapy
Aoki K, Akyurek LM, San H, Leung K, Parmacek MS, Nabel EG,
Nabel GJ.
Molecular Therapy 2000 Jun;1(6):555-65
May 2000
Circulation - May 2000
Differential
effects of the cyclin-dependent kinase inhibitors p27 (Kip1),
p21 (Cip1),
and p16 (Ink4) on vascular smooth muscle cell proliferation
Tanner FC, Boehm M, Akyürek LM, San H, Yang Z-Y, Tashiro J,
Nabel GJ and Nabel EG
Circulation , 101(17):2022-2025
April 2000
Human Gene Therapy - April 2000
Human
gene marker/therapy clinical protocols
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley
FD, Lotze MT, Wilson
JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell
SR, Brenner M, Oldfield E,
Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA,
Crystal RG, Welsh MJ, Culver K,
Heslop HE, Simons J, Wilmott RW, Boucher RC, Siegler HF, Barranger
JA, Karlsson S, Kohn D,
Galpin JE, Raffel C, Hesdorffer C, Ilan J, Cassileth P, O'Shaughnessy
J, Kun LE, Das TK, Wong
Staal F, Sobol RE, Haubrich R, Sznol M, Rubin J, Sorcher EJ,
Rosenblatt J, Walker R, Brigham K,
Vogelzang N, Hersh E, Eck SL.
Hum. Gene Ther. 11(6):919-979
March 2000
Journal of Immunotherapy - March 2000
CD95-mediated
tumor recognition by CD4+ effector cells in a murine mammary
model
Aruga E, Tanigawa K, Aruga A, Arai H, Smith JW II, Nickoloff
BJ, Nabel GJ, and Chang AE
J. Immunother. 23(2):225-34
February 2000
Immunology Today - February 2000
How
much longer will tumour cells fool the immune system?
Ferrone S, Finerty JF, Jaffee EM, Nabel GJ.
Immunol. Today 21(2):70-72
January 2000
Journal of Immunology - January 2000
Ebola
virus secretory glycoprotein (sGP) diminishes FcgammaRIIIB-to-CR3
proximity on neutrophils
J. Immunol. 164: 953-958
2000
Annual Review
HIV Molecular Immunology Database - 2000
Clinical
Trials of HIV Vaccines in HIV Molecular Immunology Database
Compendium
Graham BS, Korber BTM, Moore JP, Brander C, Walker BD, Haynes
BF, Koup R, editors.
Los Alamos National Laboratory: Theoretical Biology and Biophysics,
Los Alamos, NM, 2000, pages I-20 - I-38.
1999
December 1999
Nature - December 1999
p53
inhibition by the LANA protein of KSHV protects against cell
death
Friborg J Jr, Kong W, Hottiger MO, and Nabel GJ.
Nature. 402(6764):889-894, 1999.
June 1999
New England Journal of Medicine - June 1999
Naturally
attenuated HIV-lessons for AIDS vaccines and treatment
Collins KL, Nabel GJ
N. Engl. J. Med. 340(22):1756-1757
April 1999
Nature Medicine - April 1999
Surviving
Ebola virus infection
Nabel GJ
Nat. Med. 5(4):373-374
February 1999
Nature - February 1999
A
transformed view of cyclosporine
Nabel GJ
Nature 397(6719):471-472
January 1999
Proceedings of the National Academies of Science -
January 1999
Development
of optimized vectors for gene therapy
Nabel GJ
Proc. Natl. Acad. Sci. U.S.A. 96(2):324-326
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