Statistical and Mathematical Methods
Christopher J. Portier, Ph.D.
Tel (919) 541-3484
Fax (919) 541-1994
P.O. Box 12233
Mail Drop B2-08
Research Triangle Park, North Carolina 27709
The Environmental Systems Biology Group (ESBG) conducts a broad range of research into the development, understanding and implementation of statistical and mathematical methods for evaluating exposures and estimating risks, provides technical support to scientists and staff at NIEHS on methods and procedures in risk assessment, and provides risk assessment expertise to a large number of national and international agencies. The long-term objective is the development of methodology to facilitate the appropriate translation of "cutting-edge" research findings into future public health decisions.
Providing the highest quality scientific methods for the evaluation of health risks from environmental exposures is a high priority research area for the NIEHS. The ESBG uses a combination of laboratory research and mechanism-based mathematical modeling to develop methods intended to expedite the use of "cutting edge" basic research into the identification and quantification of health risks resulting from environmental exposures.
The group's mechanism-based modeling research efforts focus in three general areas: toxicokinetics/biochemistry, toxicogenomics and morbidity/mortality endpoints. In each focused research area, approaches are directly linked to activities within the National Toxicology Program (NTP)(http://ntp.niehs.nih.gov/) to ensure that they have both practical utility and an avenue for broader inclusion into public health decisions.
Major areas of research:
Christopher J. Portier, Ph.D., heads the Environmental Systems Biology Group within the Laboratory of Molecular Toxicology. He is also Associate Director of the NIEHS, and Director of the Office of Risk Assessment Research. Previously he was Director of the Environmental Toxicology Program at the NIEHS, and Associate Director of the National Toxicology Program. He received his Ph.D. in biostatistics from the University of North Carolina in 1981. He has published over 150 peer-reviewed articles in leading biomedical journals, as well as more than 50 book chapters and reports. For more information about Dr. Portier, please see.