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Smallpox Vaccine Development
The Vaccine Research Center tested Modified Vaccinia Ankara (MVA) as an attenuated poxvirus with the potential to protect against vaccinia (the virus used to vaccinate against smallpox) or variola (the virus that causes smallpox). The vaccine was provided by Therion Biologics Corporation as part of a collaboration with the VRC. Two Phase I clinical trials testing MVA as a component of a safer smallpox vaccine in both vaccinia naïve and vaccinia immune populations have recently concluded.
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