ARCHIVE OF VRC CLINICAL TRIALS

STUDIES CLOSED TO ACCRUAL

These studies are recruiting.

VRC Clinical Trials Related to Development of Vaccines for Prevention of HIV

VRC 001 (01-I-0079):
"Evaluation of an HIV-1 DNA Vaccine Encoding a Modified Gag-Pol Protein in Uninfected Adult Volunteers"

VRC 004 (03-I-0022):
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV-1 DNA Plasmid Vaccine, VRC-HIVDNA009-00-VP, in Uninfected Adult Volunteers

VRC 006 (04-I-0172):
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Recombinant Multiclade HIV-1 Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Adult Volunteers

VRC 007 (04-I-0254):
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a 6-Plasmid Multiclade HIV-1 DNA Vaccine, VRC-HIVDNA016-00-VP, in Uninfected Adult Volunteers

VRC 008 (05-I-0148):
A Phase I Clinical Trial of a Prime-Boost HIV-1 Vaccination Schedule: Multiclade DNA Vaccine, VRC-HIVDNA016-00-VP, Followed by Multiclade Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Adult Volunteers

VRC 009 (05-I-0081):
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Booster Dose of a Recombinant Multiclade HIV-1 Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Subjects who were Previously Immunized with VRC-HIVDNA009-00-VP in VRC 004 (03-I-0022)

VRC 010 (05-I-0140):
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Booster Dose of a Recombinant Multiclade HIV-1 Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Subjects who were Previously Immunized with VRC-HIVDNA016-00-VP in VRC 007 (04-I-0254)

VRC 011 (06-I-0149):
A Phase I Clinical Trial of Intramuscular, Subcutaneous and Intradermal Administration of an HIV-1 Multiclade DNA Vaccine, VRC-HIVDNA016-00-VP, and an HIV-1 Multiclade Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in Uninfected Adult Volunteers

VRC Clinical Trials Related to Development of Vaccines for Treatment of HIV

VRC 101 (06-I-0056):
A Phase I/II Clinical Trial to Evaluate the Safety and Immunogenicity of a Prime-Boost Vaccination Schedule of a Multiclade HIV-1 DNA Plasmid Vaccine, VRC-HIVDNA016-00-VP, followed by a Recombinant Multiclade HIV-1 Adenoviral Vector Vaccine, VRC-HIVADV014-00-VP, in HIV-Infected Adult Volunteers

VRC Clinical Trials Related to Vaccines for Biodefense and Emerging Pathogens

Smallpox Vaccine Studies
VRC 201 (02-I-0316):
A Phase I/II Clinical Trial of Modified Vaccinia Virus Ankara (MVA) to Evaluate its Safety, Dosing Schedule, Immunogenicity and Protective Efficacy Against Dryvax Challenge in Vaccinia-Naive Individuals

VRC 203 (03-I-0087):
A Phase I/II Clinical Trial of Modified Vaccinia Virus Ankara (MVA) to Evaluate its Safety, Immunogenicity and Protective Efficacy Against Dryvax Challenge in Vaccinia-Immune Individuals

Ebola Vaccine Studies
VRC 204 (04-I-0028):
A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiple Strain Ebola DNA Plasmid Vaccine, VRC-EBODNA012-00-VP, in Adult Volunteers

SARS Vaccine Studies
VRC 301 (05-I-0056):
A Phase I Study of the Safety and Immunogenicity of a SARS Recombinant DNA Plasmid Vaccine, VRC-SRSDNA015-00-VP, in Healthy Adult Volunteers

West Nile Virus Vaccine Studies
VRC 302 (05-I-0126):
A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00-VP, in Healthy Adult Volunteers

VRC 303 (06-I-0110):
A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects

Influenza Vaccine Studies
VRC 304 (07-I-0042):
A Phase I Study of the Safety and Immunogenicity of a Recombinant DNA Plasmid Vaccine (VRC-AVIDNA036-00-VP), Encoding for the Influenza Virus H5 Hemagglutinin Protein in Healthy Adults

VRC 305 (07-I-0172):
A Phase I Open-Label Study of the Safety and Immunogenicity of a Recombinant DNA Plasmid Vaccine, VRC-AVIDNA036-00-VP, Encoding for the Influenza Virus H5 Hemagglutinin Protein Administered Intradermally in Healthy Adults