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Taconic Health Report - Quality Laboratory Animals and Services for Research 9/12/06 & 3/26/07

Production Site:	Germantown, New York
Health Report Group (HRG):	IBU3
Locations in HRG:	I01301
Date Location First Occupied:	Sep/12/2006
Taconic Health Standard:	Murine Pathogen Free
Date of Issue:	Nov/28/2007
Species and # Lines Present:	Mice: 4 Lines Rats: 1 Line
Transferred From:	Gnotobiotic Center
Animal Lines:	CONTRACT ANIMALS-MICE(4 LINES), CONTRACT ANIMALS-RATS(1 LINES)

Latest Test Date is the date animals are removed from the colony to begin the health testing process.
Compilation of all results for web posting may take several weeks.

Target Organism	Test Frequency	Testing Laboratory	Test Method	Species Tested M = Mice R = Rats	Latest Test Date	Latest Result #positive/ #tested	2008 Cumulative Results #positive/ #tested	Results #positive/ #tested	2006 Results #positive/ #tested
Viruses
Mouse Hepatitis Virus (MHV)	2 weeks	Taconic Anmed	ELISA	M	Oct/30/2007	0/2	0/59	0/7	-
Mouse Minute [parvo] Virus (MMV)	2 weeks	Taconic Anmed	ELISA	M	Oct/30/2007	0/2	0/59	0/7	-
Mouse Parvovirus (MPV)	2 weeks	Taconic Anmed	ELISA	M	Oct/30/2007	0/2	0/59	0/7	-
Mouse Rotavirus (EDIM)	2 weeks	Taconic Anmed	ELISA	M	Oct/30/2007	0/2	0/59	0/7	-
Kilham's Rat Virus (KRV)	2 weeks	Taconic Anmed	ELISA	R	Oct/30/2007	0/2	0/41	0/7	-
Rat Coronavirus (RCV)	2 weeks	Taconic Anmed	ELISA	R	Oct/30/2007	0/2	0/41	0/7	-
Rat Minutevirus (RMV)	2 weeks	Taconic Anmed	ELISA	R	Oct/30/2007	0/2	0/41	0/7	-
Rat Parvovirus (RPV)	2 weeks	Taconic Anmed	ELISA	R	Oct/30/2007	0/2	0/41	0/7	-
Sialodacryoadenitis Virus (SDAV)	2 weeks	Taconic Anmed	ELISA	R	Oct/30/2007	0/2	0/41	0/7	-
Toolan's H-1 Parvovirus (TH1)	2 weeks	Taconic Anmed	ELISA	R	Oct/30/2007	0/2	0/41	0/7	-
Encephalomyelitis Virus (GD7)	6 weeks	Taconic Anmed	ELISA	M, R	Oct/02/2007	0/6	0/42	0/10	-
Pneumonia Virus of Mice (PVM)	6 weeks	Taconic Anmed	ELISA	M, R	Oct/02/2007	0/6	0/42	0/10	-
Sendai Virus	6 weeks	Taconic Anmed	ELISA	M, R	Oct/02/2007	0/6	0/42	0/10	-
Lymphocytic Choriomeningitis Virus (LCM)	13 weeks	Taconic Anmed	ELISA	M	Oct/02/2007	0/4	0/17	0/5	-
Murine Norovirus (MNV)	13 weeks	RADIL	MFI	M	Oct/02/2007	0/4	0/17	0/5	-
Ectromelia Virus	26 weeks	Taconic Anmed	ELISA	M	Jun/19/2007	0/4	0/9	0/5	-
Hantaan Virus	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/4	0/14	0/10	-
Mouse Adenovirus (FL) (MAV1)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/4	0/14	0/10	-
Mouse Adenovirus (K87) (MAV2)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/4	0/14	0/10	-
Mouse Cytomegalovirus (MCMV)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/4	0/9	0/5	-
Respiratory Enteric Virus III (REO3)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/4	0/14	0/10	-
K Virus	52 weeks	Taconic Anmed	ELISA	M	Jan/23/2007	0/5	0/5	0/5	-
Lactic Dehydrogenase Elevating Virus (LDHV)	52 weeks	Taconic Anmed	CHEM	M	Jan/23/2007	0/5	0/5	0/5	-
Polyoma Virus	52 weeks	Taconic Anmed	ELISA	M	Jan/23/2007	0/5	0/5	0/5	-
Thymic Virus	52 weeks	Taconic Anmed	IFA	M	Jan/23/2007	0/5	0/5	0/5	-
Bacteria, Mycoplasma, Fungi
Beta hemolytic Streptococcus	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Bordetella bronchiseptica	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Citrobacter rodentium	6 weeks	Taconic Anmed	CULT	M	Oct/02/2007	0/4	0/29	0/5	-
Clostridium piliforme	6 weeks	Taconic Anmed	ELISA	M, R	Oct/02/2007	0/6	0/42	0/10	-
Corynebacterium kutscheri	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Klebsiella oxytoca	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Klebsiella pneumoniae	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Mycoplasma sp.	6 weeks	Taconic Anmed	ELISA	M, R	Oct/02/2007	0/6	0/42	0/10	-
Pasteurella pneumotropica	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Other Pasteurella sp.	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Pseudomonas aeruginosa	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Salmonella sp.	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Staphylococcus aureus	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Streptobacillus moniliformis	6 weeks	Taconic Anmed	PCR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Streptococcus pneumoniae	6 weeks	Taconic Anmed	CULT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Cilia Associated Respiratory Bacillus (CARB)	13 weeks	Taconic Anmed	ELISA	M, R	Oct/02/2007	0/6	0/26	0/10	-
Corynebacterium bovis **	13 weeks	Taconic Anmed	CULT	M, R	Apr/17/2007	0/6	0/6	-	-
Helicobacter hepaticus & H. bilis	13 weeks	Taconic Anmed	PCR	M, R	Oct/02/2007	0/6	0/26	0/10	-
Other Helicobacter sp.	13 weeks	Taconic Anmed	PCR	M, R	Oct/02/2007	0/6	0/26	0/10	-
Pneumocystis carinii	26 weeks	Taconic Anmed	PCR	R	Jan/23/2007	0/5	0/5	0/5	-
Pneumocystis murina	26 weeks	Taconic Anmed	PCR	M	Jun/19/2007	0/4	0/9	0/5	-
Parasites
Aspiculuris sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Eimeria sp.	6 weeks	Taconic Anmed	FLOT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Entamoeba muris	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Giardia muris	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Hymenolepis sp.	6 weeks	Taconic Anmed	FLOT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Liponyssus sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Myobia sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Myocoptes sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Notoedres sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Polyplax sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Psorergates sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Radfordia sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Rodentolepis sp.	6 weeks	Taconic Anmed	FLOT	M, R	Oct/02/2007	0/6	0/42	0/10	-
Spironucleus sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Syphacia sp.	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Trichomonads	6 weeks	Taconic Anmed	MICR	M, R	Oct/02/2007	0/6	0/42	0/10	-
Trichosomoides crassicauda	6 weeks	Taconic Anmed	MICR	R	Oct/02/2007	0/2	0/13	0/5	-
Klossiella muris	13 weeks	Taconic Anmed	HIST	M, R	Oct/02/2007	0/6	0/26	0/10	-
Encephalitozoon cuniculi	52 weeks	Taconic Anmed	ELISA	M, R	Jan/23/2007	0/10	0/10	0/10	-
Histopathology
Ileum	13 weeks	Taconic Anmed	HIST	M, R	Oct/02/2007	0/6	0/26	0/10	-
Kidney	13 weeks	Taconic Anmed	HIST	M, R	Oct/02/2007	0/6	0/26	1/10 f	-
Liver	13 weeks	Taconic Anmed	HIST	M, R	Oct/02/2007	0/6	0/26	1/10 f	-
Lung	13 weeks	Taconic Anmed	HIST	M, R	Oct/02/2007	1/6	1/26 f	1/10 f	-
Other	N/A	Taconic Anmed	N/A	M, R	Jul/26/2007	0/2	0/2	-	-
Gross Pathology
Necropsy Findings	6 weeks	Taconic Anmed	N/A	M, R	Oct/02/2007	0/6	0/42	0/10	-

** Corynebacterium bovis is tested in immunodeficient (mice with scid or nude mutation; rats with nude mutation) animals only

Rats Only
Chronic Nephrosis
Mineralization
Nephritis and/or Tubular Necrosis
Focal Hepatitis
Perivascular Lymphoid Aggregates
Pneumonitis
Tumor
Helicobacter bilis (only)
Helicobacter hepaticus (only)
Helicobacter bilis & hepaticus
Renal Cysts

Approved By:James G Geistfeld DVM, MBA, Dip. ACLAM (signature)

Do you have questions about this health report?
Taconic USA Operations: 1-518-537-5200 Taconic Europe Operations: +45-70-23-0405
VetServ@taconic.com
© Taconic 2006 All rights reserved

Production Site:	Germantown, New York
Health Report Group (HRG):	IBU15
Locations in HRG:	I01501, I01503
Date Location First Occupied:	Mar/26/2007
Taconic Health Standard:	Murine Pathogen Free
Date of Issue:	Nov/28/2007
Species and # Lines Present:	Mice: 5 Lines Rats: 1 Line
Transferred From:	Gnotobiotic Center, I00401
Animal Lines:	CONTRACT ANIMALS-MICE(5 LINES), CONTRACT ANIMALS-RATS(1 LINES)

Latest Test Date is the date animals are removed from the colony to begin the health testing process.
Compilation of all results for web posting may take several weeks.

Target Organism	Test Frequency	Testing Laboratory	Test Method	Species Tested M = Mice R = Rats	Latest Test Date	Latest Result #positive/ #tested	2008 Cumulative Results #positive/ #tested	Results #positive/ #tested	2006 Results #positive/ #tested
Viruses
Mouse Hepatitis Virus (MHV)	2 weeks	Taconic Anmed	ELISA	M	Nov/06/2007	0/1	0/27	-	-
Mouse Minute [parvo] Virus (MMV)	2 weeks	Taconic Anmed	ELISA	M	Nov/06/2007	0/1	0/27	-	-
Mouse Parvovirus (MPV)	2 weeks	Taconic Anmed	ELISA	M	Nov/06/2007	0/1	0/27	-	-
Mouse Rotavirus (EDIM)	2 weeks	Taconic Anmed	ELISA	M	Nov/06/2007	0/1	0/27	-	-
Kilham's Rat Virus (KRV)	2 weeks	Taconic Anmed	ELISA	R	Oct/23/2007	0/5	0/45	-	-
Rat Coronavirus (RCV)	2 weeks	Taconic Anmed	ELISA	R	Oct/23/2007	0/5	0/45	-	-
Rat Minutevirus (RMV)	2 weeks	Taconic Anmed	ELISA	R	Oct/23/2007	0/5	0/45	-	-
Rat Parvovirus (RPV)	2 weeks	Taconic Anmed	ELISA	R	Oct/23/2007	0/5	0/45	-	-
Sialodacryoadenitis Virus (SDAV)	2 weeks	Taconic Anmed	ELISA	R	Oct/23/2007	0/5	0/45	-	-
Toolan's H-1 Parvovirus (TH1)	2 weeks	Taconic Anmed	ELISA	R	Oct/23/2007	0/5	0/45	-	-
Encephalomyelitis Virus (GD7)	6 weeks	Taconic Anmed	ELISA	M, R	Nov/06/2007	0/1	0/28	-	-
Pneumonia Virus of Mice (PVM)	6 weeks	Taconic Anmed	ELISA	M, R	Nov/06/2007	0/1	0/28	-	-
Sendai Virus	6 weeks	Taconic Anmed	ELISA	M, R	Nov/062007	0/1	0/28	-	-
Lymphocytic Choriomeningitis Virus (LCM)	13 weeks	Taconic Anmed	ELISA	M	Jun/19/2007	0/3	0/8	-	-
Murine Norovirus (MNV)	13 weeks	RADIL	MFI	M	Jun/19/2007	0/3	0/8	-	-
Ectromelia Virus	26 weeks	Taconic Anmed	ELISA	M	Jun/19/2007	0/3	0/8	-	-
Hantaan Virus	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/8	0/18	-	-
Mouse Adenovirus (FL) (MAV1)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/8	0/18	-	-
Mouse Adenovirus (K87) (MAV2)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/8	0/18	-	-
Mouse Cytomegalovirus (MCMV)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/3	0/8	-	-
Respiratory Enteric Virus III (REO3)	26 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/8	0/18	-	-
K Virus	52 weeks	Taconic Anmed	ELISA	M	Jun/19/2007	0/3	0/8	-	-
Lactic Dehydrogenase Elevating Virus (LDHV)	52 weeks	Taconic Anmed	CHEM	M	Jun/19/2007	0/3	0/8	-	-
Polyoma Virus	52 weeks	Taconic Anmed	ELISA	M	Jun/19/2007	0/3	0/8	-	-
Thymic Virus	52 weeks	Taconic Anmed	IFA	M	Jun/19/2007	0/3	0/8	-	-
Bacteria, Mycoplasma, Fungi
Beta hemolytic Streptococcus	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Bordetella bronchiseptica	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Citrobacter rodentium	6 weeks	Taconic Anmed	CULT	M	Nov/06/2007	0/1	0/12	-	-
Clostridium piliforme	6 weeks	Taconic Anmed	ELISA	M, R	Nov/06/2007	0/1	0/28	-	-
Corynebacterium kutscheri	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Klebsiella oxytoca	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Klebsiella pneumoniae	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Mycoplasma sp.	6 weeks	Taconic Anmed	ELISA	M, R	Nov/06/2007	0/1	0/28	-	-
Pasteurella pneumotropica	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Other Pasteurella sp.	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Pseudomonas aeruginosa	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	5/28	-	-
Salmonella sp.	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Staphylococcus aureus	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Streptobacillus moniliformis	6 weeks	Taconic Anmed	PCR	M, R	Nov/06/2007	0/1	0/28	-	-
Streptococcus pneumoniae	6 weeks	Taconic Anmed	CULT	M, R	Nov/06/2007	0/1	0/28	-	-
Cilia Associated Respiratory Bacillus (CARB)	13 weeks	Taconic Anmed	ELISA	M, R	Jun/19/2007	0/8	0/18	-	-
Corynebacterium bovis **	13 weeks		CULT	M, R	-	-	-	-	-
Helicobacter hepaticus & H. bilis	13 weeks	Taconic Anmed	PCR	M, R	Jun/19/2007	0/8	0/18	-	-
Other Helicobacter sp.	13 weeks	Taconic Anmed	PCR	M, R	Jun/19/2007	0/8	0/18	-	-
Pneumocystis carinii	26 weeks	Taconic Anmed	PCR	R	Jun/19/2007	0/5	0/10	-	-
Pneumocystis murina	26 weeks	Taconic Anmed	PCR	M	Jun/19/2007	0/3	0/8	-	-
Parasites
Aspiculuris sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Eimeria sp.	6 weeks	Taconic Anmed	FLOT	M, R	Nov/06/2007	0/1	0/28	-	-
Entamoeba muris	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Giardia muris	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Hymenolepis sp.	6 weeks	Taconic Anmed	FLOT	M, R	Nov/06/2007	0/1	0/28	-	-
Liponyssus sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Myobia sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Myocoptes sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Notoedres sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Polyplax sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Psorergates sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Radfordia sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Rodentolepis sp.	6 weeks	Taconic Anmed	FLOT	M, R	Nov/06/2007	0/1	0/28	-	-
Spironucleus sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Syphacia sp.	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Trichomonads	6 weeks	Taconic Anmed	MICR	M, R	Nov/06/2007	0/1	0/28	-	-
Trichosomoides crassicauda	6 weeks	Taconic Anmed	MICR	R	Nov/06/2007	0/6	0/16	-	-
Klossiella muris	13 weeks	Taconic Anmed	HIST	M, R	Oct/02/2007	0/8	0/18	-	-
Encephalitozoon cuniculi	52 weeks	Taconic Anmed	ELISA	M, R	Jan/23/2007	0/8	0/18	-	-
Histopathology
Ileum	13 weeks	Taconic Anmed	HIST	M, R	Jun/19/2007	0/8	0/18	-	-
Kidney	13 weeks	Taconic Anmed	HIST	M, R	Jun/19/2007	3/8	3/18 c	-	c
Liver	13 weeks	Taconic Anmed	HIST	M, R	Jun/19/2007	0/8	0/18	-	-
Lung	13 weeks	Taconic Anmed	HIST	M, R	Jun/19/2007	0/8	0/18	-	c,f
Other	N/A	Taconic Anmed	N/A	M, R	Jul/24/2007	0/6	0/6	-	-
Gross Pathology
Middle Ear Exam	6 weeks		N/A	M, R	-	-	-	-	-
Necropsy Findings	6 weeks	Taconic Anmed	N/A	M, R	Nov/06/2007	0/1	0/28	-	-

** Corynebacterium bovis is tested in immunodeficient (mice with scid or nude mutation; rats with nude mutation) animals only

Rats Only
Chronic Nephrosis
Mineralization
Nephritis and/or Tubular Necrosis
Focal Hepatitis
Perivascular Lymphoid Aggregates
Pneumonitis
Tumor
Helicobacter bilis (only)
Helicobacter hepaticus (only)
Helicobacter bilis & hepaticus
Renal Cysts

Approved By: James G Geistfeld DVM, MBA, Dip. ACLAM (signature)

Page last updated Jun 20, 2008