Genetics of Late Onset Alzheimer’s Disease (LOAD) Case Control

The objectives of the Case Control Advisory Workshop were to:

• Determine the goals for a national case-control study for the genetics of LOAD
• Discuss the study design for a national case-control study for the genetics of LOAD
• Discuss inclusion/exclusion criteria for cases and controls

Participants included Alzheimer's disease geneticists, genetic epidemiologists, epidemiologists, and NIH/U.S. Department of Health and Human Services staff from five Institutes. Substantive interactions occurred during an open discussion of all participants on key issues.

The workshop participants generated suggestions for further research on the genetics of LOAD. Participants agreed the sample set could be partly comprised of a subset of representative cases participating in the family-based sample series. Controls could be provided by Alzheimer Disease Centers (ADCs) and be supplemented from existing epidemiology studies. One major consideration was the use of samples from properly informed and consented individuals participating in other NIH-funded studies. Also, a minority sample could be collected from a subset of ADCs and/or epidemiology studies.

Contact Information

Dr. Marilyn M. Miller, NNA
301-496-9350