Due to a Continuing Resolution, the NIA is currently operating under last year's funding levels. At this time, we have not received the FY 2004 appropriation. Therefore, the information below reflects the FY 2004 submission for the President's budget.
The FY 2004 President's Budget for NIH (including AIDS) increases from $27,074,982,000 in FY 2003 to $27,892,765,000 in FY 2004, an increase of 3.0 percent. AIDS funding increases by 5.6 percent, from $2,718,213,000 in FY 2003 to $2,869,858,000 in FY 2004.
The FY 2004 President's Budget for NIA (including AIDS) is $994,411,000, an increase of 0.8 percent over the FY 2003 budget authority of $993,598,000. Funding for AIDS related research increases from $5,344,000 in FY 2003 to $5,519,000 in FY 2004, an increase of 3.3 percent.
One of NIH's highest priorities is the funding of medical research through research project grants (RPGs). Support for RPGs allows NIH to sustain the scientific momentum of investigator-initiated research while providing new research opportunities. The FY 2004 NIA request provides an aggregate average cost increase of 3.6 percent for RPGs. In FY 2004, it is estimated that 1,409 RPG awards will be funded, an increase of 48 awards over the FY 2003 actuals.
The FY 2004 request includes funding for 1,409 research project grants, compared to 1,361 in FY 2003 and 1,315 in FY 2002. Of these 1,409 awards, 403 will be competing research project grants and 1,006 will be noncompeting awards. In addition, the request includes funding for 74 SBIR/STTR grants.
Funding for the Centers mechanism increases by 2.6 percent over the FY 2003 level.
The FY 2004 request includes a decrease of 1.6 percent below the FY 2003 level for Other Research due to the completion of the Human Subjects Research Enhancement Program.
Funding for Contracts in FY 2004 decreases by 11.1 percent below the FY 2003 level.
Promises for advancement in medical research are dependent on a continuing supply of new investigators with new ideas. In the FY 2004 request, NIA will support 571 pre- and postdoctoral trainees in full-time training positions. An increase of 3.5 percent over FY 2003 levels is provided for stipends and training-related expenses (e.g., health insurance, research supplies and equipment, and travel to scientific meetings).
The FY 2004 request includes a 1.4 percent increase over the FY 2003 level for Intramural Research and a 1.3 percent increase over the FY 2003 level for Research, Management, and Support (RMS).
The President is required to submit a Fiscal Year 2005 President's Budget to Congress during the first week in February 2004.(Contact: Mr. Kevin Laser, FMB, 301-496-9147)
In Sec.3(f), NIH is directed to:
NIA coordinated the NIH submission for the Senate Special Committee on Aging's Developments in Aging Report for calendar years 2001-2002. This biannual report outlines the activities taken by Federal agencies on behalf of older Americans.
On September 29, 2003, Dr. John Hardy presented a recent NIA Parkinson's finding published in Science (October 2003) at the NIH Parkinson's disease briefing, Past Success and Future Promise, to Senate and House staff. Dr. Richard Hodes also attended the event with Dr. Elias Zerhouni, NIH Director, and NINDS Director, Dr. Story Landis.
(Contact: Dr. Tamara Jones, NIA/OD, Ph: 401-451-8835)
Ms. Anneliese Hahn-Ebersole joined the Behavioral and Social Research (BSR) Program in October 2003 as a Research Program Analyst to provide scientific and administrative assistance to the Individual Behavioral Processes Branch. She received her undergraduate degree in Psychology and Master's degree in Biology from the University of Notre Dame. She has spent the last four years at the University of Chicago managing three NIH-funded research projects, including an NIA-funded project on Social Isolation, Health, and Aging .
Ms. Rachel Permuth , formerly a Program Analyst in the Population and Social Processes Branch, left BSR on October 17, 2003. She has accepted a position at the National Cancer Institute.
Ms. Stephanie Whittier, from the Administration on Aging, joined NIH as part of this year's Emerging Leaders Program with the Department of Health and Human Services (DHHS). Her first rotation is in NIA with the BSR Program.
Stephanie received her M.S.W. from the University of California, Berkeley in 2002, focusing on Management, Planning, and Policy. She has experience working with aging, children and families, and substance abuse. She has advocated for elder rights on issues such as nursing homes, assisted living facilities, elder inmates, and palliative care with California Advocates for Nursing Home Reform (CANHR) and as a post-graduate intern with the California State Senate Subcommittee on Aging and Long Term Care. She has participated on a number of research projects on aging.
Susan Nayfield, M.D. M.S., M. Sc., has joined GCG as Chief of the Geriatrics Branch. Dr. Nayfield's prior position was in the Clinical and Genetic Epidemiology Branch of the National Cancer Institute's (NCI) Division of Cancer Control and Population Sciences, where she also chaired their Special Studies Institutional Review Board (IRB). Dr. Nayfield completed her fellowship training in hematology; her two Master's degrees are in pathology and epidemiology.
Dr. Jon Rolf joined the NIA Scientific Review Office December 31, 2003 as a Scientific Review Administrator. He is a clinical/community psychologist with over 30 years experience in public health research, practice, policy development, and technology transfer. As PI and co-investigator, he has conducted over 30 research projects on persons at-risk across the lifespan and has published more than 40 articles and books. Most recently, Dr. Rolf served in the Substance Abuse and Mental Health Services Administration (SAMHSA)/Center for Substance Abuse Prevention (CSAP) as both the leader of CSAP's web-based decision support enterprise system and as the Senior Advisor for CSAP's Centers for the Application of Prevention Technologies program. Previously, he was a Distinguished Professor in Community Health at Kansas State University and on the faculties of The Johns Hopkins School of Public Health, and The University of Vermont. Dr. Rolf received his BA degree Cum Laude from Amherst College and earned his Ph.D. in Clinical Psychology from the University of Minnesota-Minneapolis.
1st U.S.-E.U. DNA Repair Meeting: Endogenous Stress. The Biology of Aging Program (BAP) and the Intramural Research Program (IRP) co-sponsored an exploratory meeting in October with the National Institute of Environmental Health Sciences (NIEHS). It was organized by Dr. Vilhelm Bohr (IRP), Dr. Huber Warner (BAP) and Dr. Sam Wilson (NIEHS). The meeting emphasized interaction between American and European scientists and focused on DNA damage as a risk factor in aging. (BAP Contact: Dr. Huber Warner, BAP, Ph: 301-496-4996)
Small Interventions with Large Effects: Psychological Foundations of Effective Policies. An exploratory meeting was held on November 14, 2003 at Harvard University in Cambridge, MA. Behavioral interventions in areas such as nutrition, exercise, education, safety, medical compliance, saving for retirement, poverty abatement, and crime reduction are costly and produce disappointing results. In many domains, coercive interventions--like withholding for Social Security--seem more effective.
BSR contracted with the Center for Basic Research in the Social Sciences (CBRSS) at Harvard University to organize this workshop exploring several small, inexpensive and non-coercive psychological and sociological interventions that affect human behavior. The potential impact of this research on individual and group behavior, as well as public policy, was discussed. (Contact: Dr. Richard Suzman, BSR, Ph: 301-496-3131)
Whitehall in Washington, D.C., an advisory meeting, was held in Bethesda, MD, on November 19, 2003. At NIA/BSR's request, the National Academy of Sciences reviewed the concept of a proposal to conduct a large, prospective study in the U.S. modeled after the Whitehall II Study of British Civil Servants. The British study has found strong relationships between occupational class gradients and mortality among British civil servants. A similar U.S. study is proposed to understand if there is a similar social gradient among U.S. federal workers for health outcomes and, if so, if similar factors contribute to this gradient, e.g., job characteristics, behavioral and psychosocial factors. Following this meeting, at which the concept was approved, BSR is developing a more detailed initiative. (Contact: Dr. Richard Suzman, BSR, Ph: 301-496-3131)
Workshop on Response Errors in Economic Surveys of the Elderly, an exploratory meeting, was held on January 8, 2004, in Santa Monica, CA. Dr. Daniel L. McFadden (Department of Economics, University of California at Berkeley), in conjunction with BSR, organized a workshop of leading experts to address issues associated with identifying, testing, and correcting survey response effects in economic surveys of the elderly. Emphasis was on experiments currently completed, in process, or proposed in several surveys, including the Health and Retirement Study, and on econometric methods for analyzing the results of these experiments. (Contact: Dr. Richard Suzman, BSR, Ph: 301-496-3131)
NIA Training of the Aging Mind Exploratory Meeting. This exploratory meeting will be held on March 1, 2004, in Bethesda. Public and scientific interest in cognitive training for older adults indicates a need for reliable information and advancement of the area. This need is particularly important within the context of the aging worker, advances in technology, and use of non-work time. The purpose of this meeting will be for the leading researchers who are studying training processes to develop an advisory document on use of training to benefit cognitive processes of the elderly. (Contact: Dr. Jeffrey Elias, BSR, Ph: 301-594-5942)
Different Patterns of Extended Life Span: Uses of Survival Curve Data . An exploratory working group meeting, “Different Patterns of Extended Life Span: Uses of Survival Curve Data,” is planned for May 2004. This workshop, jointly sponsored by the Geriatrics and Clinical Gerontology (GCG) Program, the Biology of Aging Program (BAP), and the Behavioral and Social Research Program, will bring together biologists, epidemiologists, gerontologists and demographers to discuss methods of characterizing effects of factors on survival properties in experimental animal studies, and in epidemiologic and demographic studies. Issues to be covered include: a review of existing data on the effects on these survival properties produced by specific mutations and interventions that extend life span in experimental animals and differences among human populations; and consideration of how such effects might best be reported in the scientific literature to enhance interpretability and comparability of studies on factors affecting survival. The workshop will explore ways in which this information might be used to guide hypothesis-based testing of mechanisms responsible for extending life span or health span. It also will consider needs for new methods for use in experimental, epidemiologic, and demographic studies. ( Contact: Dr. Evan Hadley, GCG, Ph: 301-435-3044)
The Biology of Premenopausal Protection Workshop. This advisory workshop will be held in Bethesda on May 26-27, 2004. It plans to explore gaps in knowledge of the role of the steroid and peptide reproductive hormone levels across the menstrual cycle within the premenopausal hypothalamic-pituitary-ovarian (H-P-O) axis that may serve to protect premenopausal women, relative to age-matched postmenopausal women and men, from various health problems associated with menopause. The workshop will feature speakers on the topics of (1) overview of the problem, (2) a review of the currently known biology of steroid and peptide reproductive hormones within the H-P-O axis, their biologic mechanisms of action and intracellular signaling pathways, as well as their biosynthesis and metabolism, (3) changes in hormonal dynamics within the H-P-O axis from pre- through post-menopause and the interactions of those hormonal dynamics with somatic tissues involved in post-menopausal health problems, and (4) the role of aging, age-changes in non-reproductive hormones, and tissue responses to hormones. Separate discussion sessions will address how these premenopausal hormone dynamics change across the menopause and how they affect the following somatic organ systems: bone, CNS, immune, cardiovascular, adipose. Finally, the workshop will examine appropriate animal and human models to address important gaps in knowledge. (Contacts: BAP – Dr. Frank Bellino, BAP, Ph: 301-496-6402; Dr. Sherry Sherman, GCG, Ph: 301-435-3048; Dr. Marilyn Miller, Dr. Andrew Monjan, NNA, Ph: 301-496-9350)
When Does Aging Begin? an exploratory workshop, planned for spring, 2004, is being organized by the Biology of Aging Program in collaboration with other NIA programs. The workshop is part of a series to bring together junior and senior grantees and additional experts on important questions in aging tissue biology. Workshops were held in 2002 (GH/IGF and Aging Tissues) and 2003 (Apoptosis and Aging Tissues). Research on early changes in aging tissues will be featured. Discussions will center on the feasibility, potential productivity, and approaches to studying aging changes in tissues at the earliest detectable times in order to determine early steps in aging changes and their causes. (Contact: Dr. Jill Carrington, BAP, Ph: 301-496-6402)
Sex Steroid Studies: Bench to Bedside – What Is Right? What Is Wrong?
The focus of the workshop will be on the basic science, epidemiologic, and clinical trial data that are presently available, and examine what data are still needed for decisions to be made on designing appropriate clinical trials on the use of sex steroids for prevention of cognitive decline in aging women. This workshop will bring together scientists in the fields of basic science, reproductive epidemiology, and clinical trials. A number of NIA-supported investigators, NIA staff, and NIH/DHHS staff will be participants. (Contact: Dr. Marilyn Miller, NNA, Ph: 301- 496-9350)
Performance Measures/Vignettes in Large Scale Surveys, an exploratory workshop, will be held in June 2004. BSR funds demographic and epidemiological population-based studies that have historically relied on self-report measures of disability (e.g., traditional ADL and IADL scales) to assess physical functioning. BSR is planning a workshop to develop a set of recommended performance tests that staff might encourage researchers to use, when appropriate, in BSR-funded studies. (Contact: Ms. Angie Chon-Lee, BSR, Ph: 301-594-5943)
Aging and Bioimaging/Biosensor Research. An exploratory meeting focusing on applications of imaging and sensor technology to measure age-related physiologic and morphologic changes across the life span is planned for mid-June 2004. This meeting co-sponsored by the NIA Geriatrics and Clinical Gerontology (GCG) Program and the Neuroscience and Neuropsychology of Aging (NNA) Program, and the National Institute of Bioimaging and Bioengineering (NIBIB) will identify key longitudinal changes that are best measured with imaging and/or sensor technologies; determine whether and how existing imaging and/or sensor technologies are appropriate to measure these changes; identify needs for the development and validation of new or improved technologies to measure these changes, and identify ways to integrate these measures into existing studies of aging. (Contact: Ms. Winnie Rossi, GCG, Ph: 301-496-3836)
Neuroimaging in the Diagnosis of Alzheimer's Disease and MCI. The NNA is planning this exploratory meeting in conjunction with the Center for Medicaid and Medicare Services (CMS) to explore the status of neuroimaging technologies (magnetic resonance imaging [MRI], positron emission tomograph [PET], and single photon emission spectroscopy [SPECT]) in the diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The sensitivity/specificity of each will be compared at various stages of illness, as well as cost vs. benefit over clinical diagnosis alone, given the state of therapeutics today. How these parameters may change with the introduction of a disease-modifying drug will also be discussed. (Contact: Dr. Susan Molchan, NNA, Ph: 301-496-9350)
The National Institutes of Health (NIH) has modified its policy on mentored career development awards (K Awards) to allow award recipients to hold concurrent salary support from their career award and a competing research grant when recognized as a Principal Investigator or subproject Director. Thus mentored career award recipients in the last two years of their support period will be permitted to reduce the level of effort required for the career award and replace that effort with an NIH research grant or subproject provided they remain in a mentored situation. This policy will permit those candidates who are ready to apply for and receive NIH research support to continue to benefit from the period of protected time offered by the career development award. http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-04-007.html
Previously mentored career award recipients who received independent research grant support were not permitted to draw salary from the research grant. That policy particularly restricted clinical investigators whose institutions were forced to subsidize their salaries while they continued on the career award. The impetus for this policy change arose from recommendations from NACA that were developed by the Clinical Investigators Working Group of NACA.
In FY 2003 NIA received 57 clinical loan repayment applications of which two were withdrawn prior to award. Forty-five of the remaining applications were paid, representing a success rate of 82%. Among those individuals receiving awards the majority (25) listed their final degree as an MD.
NIH overall in FY 2003 awarded 1,197 loan repayment contracts, 65.6% more than in FY 2002. The success rate was 63 percent. More than 50 percent of awards went to MDs, over a third to PhDs, and 8 percent to MD/PhDs.
The NIA television Public Service Announcement, Madame Eterno , won a 25 th Anniversary Classic Telly Award. This competition honors outstanding non-network television, film, and video production. (For more information about OCPL public service announcements, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
The Alzheimer's Disease Education and Referral Center (ADEAR) website (www.nia.nih.gov/Alzheimers) received an Award of Excellence in the 2003 Aesculapius Awards for excellence in health communications. Aesculapius Awards are sponsored by the Health Improvement Institute and given to producers of health-related radio and television public service announcements and websites that the judges consider excellent in communicating health information to the public. (For more information about the ADEAR website, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
On October 23, 2003, the NIHSeniorHealth website (www.nihseniorhealth.gov) was launched on Capitol Hill at a briefing chaired by Senator Tom Harkin (D, Iowa). This website makes aging-related health information easily accessible for older people, family members, and friends seeking reliable, easy-to-understand online health information. Approximately 150 people from the Hill, senior centers and residences, NIH, and other interested organizations attended the briefing. Press coverage of the launch included a pick-up by the Associated Press as well as articles in more than 200 online and print outlets. During the month of November the website had 361,361 visitors. There are currently 10 topics available – more will be added in 2004. The current most popular topics are exercise, Alzheimer's disease, arthritis, and balance problems. (For more information on NIH SeniorHealth, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
In support of recruitment efforts for the NIA Alzheimer's Disease Genetics Study (sponsored by NIA, supported by the Alzheimer's Association, and conducted by the National Cell Repository for Alzheimer's Disease and the Alzheimer's Disease Centers nationwide), the Office of Communications and Public Liaison (OCPL) and the Alzheimer's Association conducted seven focus groups. Participants in the groups offered insight into family reactions to genetic research. Focus group members identified perceived benefits and barriers to participation in a genetics study as well as testing selected messages and communications channels. Based on findings from these groups a recruitment tool kit was developed. The kit includes brochure and talking points flyer, power point presentation, templates for materials to be used at local recruitment sites, and background materials on the study. The kit also includes a CD with electronic versions of all the materials. (For more information on recruitment for the NIA Alzheimer's Disease Genetics Initiative, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
Gary Ruvkun, Ph.D., Professor of Genetics at Harvard Medical School, presented the Florence Mahoney Lecture on Aging on Dec. 3 in Masur Auditorium. His title “Genetic and RNAi Analysis of C. elegans Aging” reflects his use of the nematode C. elegans to study problems in aging, longevity and developmental biology. This lecture is part of the NIH Director's Wednesday Afternoon Lecture Series. NIA's lecture is named after the late Florence Mahoney who was instrumental in the development of NIA as a world-renowned biomedical research institute.
NIA and ADEAR health publications were distributed at a variety of meetings and exhibits including the National Medical Association, Stone Soul Picnic, Meals on Wheels Association of America, National Council of Negro Women Black Family Reunion, AARP Life @ 50+, National Association of County & City Health Officials, Geriatric Care Managers 19 th Annual Conference, AoA Caring Communities Summit, American Academy of Family Physicians, ADCS (in conjunction with American Neurological Association), Maryland Respite Care Coalition, White House Faith-Based and Community Initiatives Conference, American College of Nurse Practitioners, WPGC For Sisters Only, PrimeTime Expo, Society for Neuroscience, American Academy of Nursing, and Gerontological Society of America . ( For more information on the OCPL exhibit schedule, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
NIA and the American Visionary Museum announced their Vital Visionaries Collaboration to pair Baltimore elders with medical students to explore creativity as an aspect of healthy aging. (For more information on the Vital Visionary project, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
New publications:
Updated/Reprinted publications:
(For more information on NIA publications, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
Over 10 news releases were distributed on research findings ranging from recognition of a link between exceptional longevity and lipoprotein molecule size, to pinpointing a gene that influences age-at-onset of Alzheimer's and Parkinson's diseases. The most current NIA press releases can be found online at www.nia.nih.gov/NewsAndEvents/WhatsNew.htm (For more information on NIA press releases, contact Jane E. Shure, OCPL, Ph: 301-496-1752.)
From the NIH Guide - From August 20, 2003 – December 23, 2003Published since the last National Advisory Council on Aging Meeting.Also check our NIA website for “Current Funding Opportunities”(Shown here are selected Notices relevant to NIA and selected Initiatives)
Workshop on Technology for Adaptive Aging: A Prepublication Report to Assist Applicants for RFA AG-04-007 Release Date: December 16, 2003Notice: NOT-AG-04-001http://grants1.nih.gov/grants/guide/notice-files/NOT-AG-04-001.html This notice is to inform applicants for NIA's RFA Number AG-04-007 (http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-04-007.html) entitled “Roybal Centers for Translational Research on Aging” about a prepublication report of the Workshop on Technology for Adaptive Aging from the National Research Council of National Academy of Sciences that is now available via the internet at http://books.nap.edu/catalog/10857.html. This url will be helpful to applicants applying for this initiative. The long-range objectives of the Roybal Centers are to improve the health, quality of life, and productivity of middle-aged and older people.
Human Embryonic Stem Cell Research Resource Infrastructure Enhancement Award - Addendum to Par-03-177 Release Date: December 16, 2003Notice: NOT-AI-04-012http://grants1.nih.gov/grants/guide/notice-files/NOT-AI-04-012.htmlApplication Receipt Dates: January 14, 2004 and January 12, 2005This addendum is to inform potential applicants for human embryonic stem cell research resource infrastructure enhancement awards (http://grants.nih.gov/grants/guide/notice-files/NOT-HL-04-102.html) that the National Institute of Allergy and Infectious Diseases (NIAID) (http://www.niaid.nih.gov) is participating in this program announcement.
Addendum to RFA-DK-03-022: Ancillary Studies to Obesity Related Clinical Trials Release Date: December 10, 2003Notice: NOT-DK-04-002http://grants.nih.gov/grants/guide/notice-files/NOT-DK-04-002.htmlThis addendum is to inform potential applicants of two changes in RFA-DK-03-022: a change in the name and receipt dates of one of the networks. The name of the “Weight Reduction for Incontinence Network (WIN)”, one of the seven cooperative clinical trials/networks listed in the RFA has been changed to “Program to Reduce Incontinence by Diet and Exercise (PRIDE)”. Applications for ancillary studies to PRIDE (formerly known as WIN), may be accepted for all receipt dates (March 19, 2004, November 19, 2004, and July 19, 2005).
Mentored Career Development Awards: Change in NIH Policy Concerning Concurrent Support from Career Development Award and A Research Grant Release Date: November 14, 2003Notice: NOT-OD-04-007http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-04-007.htmlWith this notice, the National Institutes of Health (NIH) modifies its policy on mentored career development awards (K Awards) to allow award recipients to hold concurrent support from their career award and a competing research grant when recognized as a Principal Investigator or subproject Director. Thus mentored career award recipients in the last two years of their support period will be permitted to reduce the level of effort required for the career award and replace that effort with an NIH research grant or subproject provided they remain in a mentored situation. This policy will permit those candidates who are ready to apply for and receive NIH research support to continue to benefit from the period of protected time offered by the career development award.
Guidelines for Inclusion of Women, Minorities, and Persons With Disabilities in Nih-Supported Conference Grants Release Date: September 26, 2003Notice: NOT-OD-03-066 http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-03-066.html This Notice provides updated policy regarding the inclusion of women, minorities, and persons with disabilities in conference grants supported by the National Institutes of Health (NIH). It also provides updated Institute and Center (IC) contact information. The previous guidelines were issued in the NIH Guide on April 28, 1995, at http://grants.nih.gov/grants/guide/notice-files/NOT95-123.html . These guidelines apply to both intramural and extramural programs.
This notice is intended to correct and clarify the instructions for page limitations and appendix information for R21 applications. Applications for an R01 application must conform to the standard PHS 398 instructions.
In response to comments and suggestions from the research community on how NIH can continue to improve the application forms to make them more user-friendly, NIH has made several formatting enhancements to the PHS 398, 2590 and 416 forms.
Small Business Innovation Research Program Release Date: August 28, 2003Notice: NOT-OD-03-060 (Note: Although this notice involved a past due date it also has information of interest to perspective grantees interested in SBIRs.) http://grants2.nih.gov/grants/guide/notice-files/NOT-OD-03-060.htmlThe purpose of this notice is to (1) announce the issuance of the Solicitation of the Public Health Service for Small Business Innovation Research Contract Proposals (PHS 2004-1) with a due date of November 14, 2003 for receipt of SBIR Contract proposals; and (2) inform the public about the opportunities that the SBIR program offers to small business concerns as well as to scientists at research institutions.
(Sorted by most recent release date)
Nathan Shock Centers of Excellence in Basic Biology of AgingRelease Date: December 23, 2003RFA Number: RFA-AG-04-010http://grants2.nih.gov/grants/guide/rfa-files/RFA-AG-04-010.htmlApplication Receipt Dates: May 20, 2004Purpose of This RFAThe National Institute on Aging (NIA) invites applications for support of centers, known as Nathan Shock Centers of Excellence in Basic Biology of Aging. These Center grants will provide funding for research and training activities related to basic biology of aging. They are intended for institutions with a substantial investment in and commitment to aging research, but they are not intended to directly support clinical research or clinical trials. Direct your questions about scientific/research issues to:Huber R. Warner, Ph.D., Associate DirectorBiology of Aging ProgramNational Institute on Aging7201 Wisconsin AvenueGateway Building, Suite 2C231Bethesda, MD 20892-9205Telephone: 301/496-4996FAX: 301/402-0010Email: warnerh@nia.nih.gov
Occupational Health and Safety Research (R01) Release Date: December 12, 2003PA Number: PA-04-038 http://grants2.nih.gov/grants/guide/pa-files/PA-04-038.html Purpose of This PA This initiative invites grant applications for research related to occupational safety and health. NIOSH research programs support priority areas identified in the National Occupational Research Agenda (NORA) and other significant programs related to occupational safety and health. Direct your questions about scientific/research issues to: Jeffrey Elias, PhD Behavioral and Social Research Program National Institute on Aging Gateway Building, Suite 533 Bethesda, MD 20892-9205 Telephone: (301) 402-4156 Email: eliasj@nia.nih.gov
Diet Composition and Energy Balance Release Date: December 10, 2003 PA Number: PA-04-033 http://grants1.nih.gov/grants/guide/pa-files/PA-04-033.html Application Receipt Dates: Standard NIH Receipt Dates http://grants1.nih.gov/grants/funding/submissionschedule.htm Purpose of This PA The goal of this program announcement is to invite research applications investigating the role of diet composition in energy balance, including studies in both animals and humans. Both short and longer-term studies would be encouraged, ranging from basic studies investigating the impact of micro-or macronutrient composition on appetite, metabolism, and energy expenditure through clinical studies evaluating the efficacy of diets differing in micro- or macronutrient composition, absorption, dietary variety, or energy density for weight loss or weight maintenance. Direct your questions about scientific/research issues to:Chhanda Dutta, Ph.D.Geriatrics and Clinical Gerontology ProgramNational Institute on Aging Gateway Building, Suite 3C-3077201 Wisconsin AvenueBethesda, MD 20892-9205Phone: (301) 435-3048Fax: (301) 402-1784Email: duttac@nia.nih.gov
Oral Health of Special Needs and Older PopulationsRelease Date: December 8, 2003PA Number: PA-04-031http://grants1.nih.gov/grants/guide/pa-files/PA-04-031.html Application Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThis initiative is to encourage investigator-initiated clinical research focused on the oral health of special needs populations, including those with developmental or acquired physical or mental disabilities, people with mental retardation (MR), people living with HIV/AIDS, and frail or functionally dependent elders. The types of clinical research welcomed are epidemiologic, behavioral/social sciences, health care, patient-oriented and community-based studies aimed at understanding and improving the oral, dental and craniofacial health status, quality of life and health outcomes among elders and other special needs populations. For questions related to cognitive changes and aging, or decision making and dental health planning in older individuals contact:Jeffrey Elias, PhDBehavioral and Social Research Program National Institute on Aging Gateway Building, Suite 533 Bethesda, MD 20892-9205 Telephone: (301) 402-4156 Email: eliasj@nia.nih.gov
Research on Crystal Deposition ArthropathiesRelease Date: December 5, 2003RFA Number: RFA-AR-04-006http://grants.nih.gov/grants/guide/rfa-files/RFA-AR-04-006.htmlApplication Receipt Dates: August 19, 2004Purpose of This RFAThis initiative invites applications for research on improved diagnosis and treatment of the major crystal deposition arthropathies including gout, calcium pyrophosphate dihydrate (CPPD) crystal deposition disease and hydroxyapatite crystal deposition disease (also known as basic calcium phosphate crystallopathy). The applications may be for individual research projects (R01) or for exploratory/developmental grants (R21). Direct your questions about scientific/research issues to: Jill L. Carrington, Ph.D.Director, Musculoskeletal BiologyBiology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231Bethesda, MD 20892Telephone: (301) 496-6402FAX: (301) 402-0010Email: Carringtonj@nia.nih.gov
Acute Coronary Syndromes in Old AgeRelease Date: November 21, 2003 PA Number: PA-04-026 http://grants1.nih.gov/grants/guide/pa-files/PA-04-026.html Application Receipt Dates: Standard NIH Receipt Dates http://grants1.nih.gov/grants/funding/submissionschedule.htm Purpose of This PA The goal of this program is to foster biomedical research that will lead to a better understanding of the biology, pathophysiology, clinical presentation, and medical management of the acute coronary syndromes (ACS) in old age. This PA is intended to foster clinical research, including integrative biomedical research, some of which will incorporate the tools of molecular and cellular biology in the study of function and clinical outcome. A long-term goal is to provide the necessary framework for the development of effective prevention and/or new treatment strategies for ACS in old age. Direct your questions about scientific/research issues to: Andre J. Premen, Ph.D. Geriatrics & Clinical Gerontology Program National Institute on Aging Gateway Building, Room 3C-307 Bethesda, MD 20892-9205 Telephone: (301) 496-6761 FAX: (301) 402-1784 Email: PremenA@nia.nih.gov
Bioengineering Research PartnershipsRelease Date: November 18, 2003PA Number: PAR-04-023http://grants1.nih.gov/grants/guide/pa-files/PAR-04-023.html Application Receipt Dates: January 21, 2004; August 20, 2004; January 20,2005; August 19, 2005; January 20, 2006; and August 22, 2006 Purpose of This PAParticipating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic, applied, and translational multi- disciplinary research that addresses important biological or medical research problems. In the context of this program, a partnership is a multi- disciplinary research team that applies an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. Direct your questions about scientific/research issues to:Winifred K. Rossi, M.A.Geriatrics and Clinical Gerontology Program National Institute on Aging7201 Wisconsin Avenue - Suite 3E327Bethesda, MD 20892-9205 TEL: 301-496-3836 FAX: 301-402-1784 Email: rossiw@nia.nih.gov
Roybal Centers for Translational Research on Aging Release Date: November 3, 2003RFA Number: RFA-AG-04-007 (see NOT-AG-04-001 )http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-007.htmlApplication Receipt Dates: January 22, 2004Purpose of This RFAThe National Institute on Aging (NIA) invites applications from qualified institutions for Edward R. Roybal Centers for Translational Research in the Behavioral and Social Sciences. The long-range objectives of the Roybal Centers are to improve the health, quality of life, and productivity of middle-aged and older people, through: (1) facilitating the translation from the basic behavioral and social sciences (including human factors) to practical outcomes, including new technologies, for the benefit of the aged, and 2) if possible also stimulating new "use-inspired" basic research in the behavioral and social sciences. Direct your questions about scientific/research issues to:Jeffrey W. Elias, Ph.D.Behavioral and Social Research Program National Institute on AgingGateway Building, Suite 533Bethesda, MD 20892-9205Telephone: (301) 402-4156E-mail: eliasj@nia.nih.gov
Genetic Studies of Obesity-Related Traits In Model OrganismsRelease Date: October 29, 2003RFA Number: RFA-DK-03-018 http://grants1.nih.gov/grants/guide/rfa-files/RFA-DK-03-018.htmlApplication Receipt Dates: March 17, 2004 and March 17, 2005Purpose of This RFAThe National Institutes of Diabetes and Digestive and Kidney Diseases(NIDDK), the National Institute on Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI) invite investigator-initiated research projects (R01 and R21) designed to identify and characterize genes influencing obesity-related phenotypes in fruit flies (Drosophila melanogaster), soil nematodes (Caenorhabditis elegans), and zebrafish (Danio rerio). Animals bearing alterations in these genes will be indispensable tools for understanding the pathogenesis of obesity and lipodystrophies, for testing therapeutics, and for discovering genes that can be tested in human studies for association with obesity and related co-morbidities such as cardiovascular disease. Direct your questions about scientific/research issues to:David Finkelstein, Ph. D.Biology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231Bethesda, MD 20892-9205Telephone: (301) 496-7847FAX: (301) 402-0010E-Mail: finkelsd@nia.nih.gov
Assays of Stem Cell Function In Clinical Aging ResearchRelease Date: October 28, 2003RFA Number: RFA-AG-04-009http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-009.htmlApplication Receipt Dates: January 21, 2004Purpose of This RFAThis Request for Applications (RFA) is to solicit proposals for: a) clinical and epidemiologic studies to increase knowledge about the role in humans of stem cell deficits, and of variation in stem cell numbers and function, on health and functional outcomes in old age, and on age- related physiologic changes and progression of chronic diseases, and/or b) research to develop or improve assays of human stem cell number and/or function that could be used in the types of studies indicated above. Direct your questions about scientific/research issues to:Chhanda Dutta, Ph.DGeriatrics and Clinical Gerontology ProgramNational Institute on Aging7201 Wisconsin Avenue, Room 3C307 MSC 9205Bethesda, MD 20892-9205Telephone: 301-435-3048E-mail: cd23z@nih.gov
Biology of Stem Cells In AgingRelease Date: October 27, 2003RFA Number: RFA-AG-04-008http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-008.htmlApplication Receipt Dates: January 22, 2004Purpose of This RFAThis Request for Applications (RFA) is to solicit applications that address the basic biology of stem cells in tissue maintenance and disease in aging. Research to elucidate the role of stem cells in tissue turnover, maintenance and repair, and how stem cells and their environment change with age, will be important to understanding why tissues, organs and organisms experience declining function with age. As well, this research will be critical to development of stem-cell based therapies for age-related diseases and conditions in the growing population of elderly patients. Applications are encouraged for projects that significantly advance research to characterize stem cells as a function of aging, characterize the tissue environment and the interaction of stem cells with that environment during aging, understand stem cell involvement in tissue and organ health with age, examine how stem cells may integrate into aged tissues for maintenance and repair, and examine the role of stem cells in degenerative disorders of aging. Applications may focus on various aging tissues or physiological systems, including cardiovascular, musculoskeletal, immune, urogenital, endocrine, and nervous systems. Direct your questions about scientific/research issues to:Jill L. Carrington, Ph.D.Chief, Systems Branch Biology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402 FAX: (301) 402-0010Email: carringtonj@nia.nih.govDirect your questions about scientific/research issues to:Bradley C. Wise, Ph.D.Program Director, Fundamental NeuroscienceNeuroscience and Neuropsychology of Aging ProgramNational Institute on Aging 7201 Wisconsin Avenue, Suite 350 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Ancillary Studies to Obesity-Related Clinical TrialsRelease Date: October 22, 2003RFA Number: RFA DK-03-022 (see addendum NOT-DK-04-002 )http://grants1.nih.gov/grants/guide/rfa-files/RFA-DK-03-022.htmlApplication Receipt Dates: March 19, 2004; November 19, 2004; July 19, 2005.Purpose of This RFAThe goal of this initiative is to solicit research grant applications for ancillary studies investigating obesity-related research questions in conjunction with six NIDDK-sponsored cooperative agreement clinical trials and consortia and one NIA-sponsored cooperative agreement. Direct your questions about scientific/research issues to:Chhanda Dutta, PhDGeriatrics and Clinical Gerontology ProgramNational Institute on AgingGateway Building, Suite 3C-3077201 Wisconsin AvenueBethesda, MD 20892-9205Telephone: (301)435-3048FAX: (301)402-1784E-mail: cd23z@nih.gov
NIH Clinical Trial Planning Grant (R34) ProgramRelease Date: October 16, 2003PA Number: PA-04-008http://grants1.nih.gov/grants/guide/pa-files/PA-04-008.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThe purpose of the NIH Clinical Trial Planning Grant (R34) is to provide support for the development of a Phase III clinical trial, including the establishment of the research team, the development of tools for data management and oversight of the research, the definition of recruitment strategies, and the finalization of the protocol and other essential elements of the study included in a manual of operations/procedures. The Clinical Trial Planning Grant is not designed for the collection of preliminary data or the conduct of pilot studies to support the rationale for a clinical trial. Direct your questions about scientific/research issues to: Ms. Joanna BadinelliGeriatrics and Clinical Gerontology ProgramNational Institute on AgingGateway Building, Suite 3C-3077201 Wisconsin AvenueBethesda, MD 20892-9205Phone: (301) 435-3046Fax: (301) 402-1784Email: BadinelJ@mail.nih.gov
Neurotechnology Research, Development, and EnhancementRelease Date: October 08, 2003PA Number: PA-04-006 http://grants1.nih.gov/grants/guide/pa-files/PA-04-006.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PA This Program Announcement replaces PA-02-003. The purpose of this Program Announcement (PA) is to encourage submission of new research project grant (R01) and exploratory/developmental grant (R21) applications to research and develop innovative technologies, methodologies, or instrumentation for basic or clinical studies of the brain or behavior in human or non-human animals. Also solicited are applications for support to research, develop, and significantly enhance existing technologies that are important to understanding the brain or behavior. Direct your questions about scientific/research issues to:Bradley C. Wise, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on Aging 7201 Wisconsin Avenue, Suite 350, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Proteomics In Aging and Age-Related DisordersRelease Date: October 07, 2003RFA Number: RFA-AG-04-006http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-006.htmlApplication Receipt Dates: February 23, 2004Purpose of This RFAThe National Institute on Aging (NIA) is soliciting applications that use proteomic approaches to study age-related changes in protein structure and function. Proteomics research is expected to provide significant insights into the cellular and molecular mechanisms of aging and age-associated disease processes. This Request for Applications (RFA) encourages projects that advance research to identify and quantitate protein expression patterns, post-translational modification of proteins, and protein-protein interactions which may change in cells or tissues as a direct result of the aging process or age-related pathology. Research projects that take advantage of various animal models of aging and of age-related human disease, and that focus on cells or tissues of aging physiological systems, such as the cardiovascular, musculoskeletal, immune, endocrine and nervous systems, are encouraged. Direct your questions about scientific/research issues regarding projects focused on the nervous system to: Bradley C. Wise, Ph.DNeuroscience and Neuropsychology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 350 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Direct your questions about scientific/research issues regarding projects focused on non-neural tissues to:Felipe Sierra, Ph.D.Biology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205|Telephone: (301) 496-6402FAX: (301) 402-0010Email: sierraf@nia.nih.gov
The Alzheimer's Disease Neuroimaging InitiativeRelease Date: October 2, 2003 RFA Number: RFA-AG-04-005 http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-005.html Application Receipt Dates: January 16, 2004 Purpose of This RFA The National Institute on Aging (NIA) invites applications from qualified institutions for a Cooperative agreement (UO1) to establish a Coordinating Center (CC) together with a Neuroimaging Center (NC) and a consortium of clinical sites for the NIA Neuroimaging Initiative. The purpose of this Initiative, planned as a public-private partnership, is to develop a multi-site, longitudinal, prospective, naturalistic study of normal cognitive aging, mild cognitive impairment (MCI), and early Alzheimer's disease (AD) as a public domain research resource to facilitate the scientific evaluation of neuroimaging (magnetic resonance imaging [MRI], positron emission tomography [PET]), and other biomarkers for the onset and progression of MCI and AD. A primary goal is to identify the biomarkers of disease progression that are most promising for use as surrogate endpoints in phase 2 and 3 clinical trials for the prevention and treatment of AD. Direct inquiries regarding programmatic issues to:Susan Molchan, M.D. Program Director, Alzheimer's Disease Clinical Trials Neuroscience and Neuropsychology of Aging Program National Institute on Aging Gateway Bldg., Suite 350 7201 Wisconsin Ave.Bethesda, MD 20892-9205 Telephone:(301)496-9350; FAX:(301)496-1494E-mail: molchans@mail.nih.gov
Human Embryonic Stem Cell Research Resource Infrastructure Enhancement AwardRelease Date: September 26, 2003 PAR Number: PAR-03-177 (see addenda NOT-AI-04-012 and NOT-HL-04-102)http://grants1.nih.gov/grants/guide/pa-files/PAR-03-177.html Application Receipt Dates: January 14, 2004, January 12, 2005 Purpose of This PAR The purpose of this initiative is to enhance the availability of human embryonic stem cells (hESC) for research. The research projects proposed under this Program Announcement (PAR) will address the expansion, testing, quality assurance, cryopreservation and distribution of existing hESC lines that are in compliance with criteria for federal funding of research on existing hESC as described in http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-005.html. Direct your questions about scientific/research issues to: Jill L. Carrington, Ph.D.Director, Musculoskeletal Biology Biology of Aging Program National Institute on Aging 7201 Wisconsin Avenue, Suite 2C231 Bethesda, MD 20892 Telephone: (301) 496-6402 FAX: (301) 402-2210Email: Carringtonj@nia.nih.gov
Interactions Between Stem Cells and The Microenvironment in VivoRelease Date: September 16, 2003PA Number: PAS-03-172http://grants1.nih.gov/grants/guide/pa-files/PAS-03-172.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThis initiative invites applications for studies on the cellular and molecular signaling between the local environment within organisms and stem and progenitor cells that are either introduced as transplants or are normally resident within host tissues and organs. The objective of this initiative is to promote a thorough exploration and characterization of the bi-directional communication between multipotent cells and the three-dimensional local milieu or niche that they encounter in vivo under normal and compromised states, such as with aging or following injury, disease or drug exposure. Direct your questions about scientific/research issues to:Bradley C. Wise, Ph.D.Program Director, Fundamental NeuroscienceNeuroscience and Neuropsychology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 350 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Paul B. Beeson Career Development Awards in Aging Release Date: September 8, 2003 RFA Number: RFA-AG-04-004 http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-004.html Application Receipt Dates: December 17, 2003 Purpose of This RFAThe National Institute on Aging (NIA), the John A. Hartford Foundation, Atlantic Philanthropies, and the Starr Foundation are collaborating on this initiative to sustain and promote the research careers of clinically trained individuals who are pursuing research careers in aging. The program is named after Dr. Paul B. Beeson. Dr. Beeson was Chairman of Medicine at Emory and Yale Medical Schools, Nuffield Professor at Oxford University and Professor and distinguished VA Physician at the University of Washington. He chaired the first Institute of Medicine study on "Aging and Medical Education" in 1978. His leadership as an editor of the Cecil Textbook of Medicine greatly influenced medical education. From his research and patient care base, he grew increasingly interested in the process of aging, and this interest led to a commitment that included his editorship of the Journal of the American Geriatrics Society. Direct your questions about scientific/research issues to:Robin A. Barr, D. Phil.Office of Extramural AffairsNational Institute on Aging7201 Wisconsin Avenue, Room 2C218, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9322FAX: (301) 402-2945Email: BarrR@nia.nih.gov
Health Promotion Among Racial and Ethnic Minority MalesRelease Date: September 8, 2003PA Number: PA-03-170 (see addendum NOT-CA-03-041) http://grants1.nih.gov/grants/guide/pa-files/PA-03-170.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThe purpose of this initiative is to stimulate and expand research in the health of minority men. Specifically, this initiative is intended to: 1) enhance our understanding of the numerous factors (e.g., sociodemographic, community, societal, personal) influencing the health promoting behaviors of racial and ethnic minority males and their subpopulations across the life cycle, and 2) solicit applications focusing on the development and testing of culturally and linguistically appropriate health-promoting interventions designed to reduce health disparities among racially and ethnically diverse males and their subpopulations age 21 and older. Direct your questions about scientific/research issues to: Dr. Sidney M. StahlBehavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Ave., Room 533Bethesda, MD 20892-9205Telephone: (301) 402-4156FAX: (301) 402-0051Email: Sidney_Stahl@nih.gov
Aging Musculoskeletal and Skin Extracellular MatrixRelease Date: September 4, 2003PA Number: PA-03-167http://grants1.nih.gov/grants/guide/pa-files/PA-03-167.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThe purpose of this PA is to solicit grant applications for basic research projects to investigate how changes in the extracellular matrix with age affect the function of the tissues of the musculoskeletal system and skin. Projects are encouraged that determine how cellular aging processes lead to altered matrix production and maintenance, and how aging-related altered matrix composition and organization affect the function of these issues. Direct your questions about scientific/research issues to:Jill L. Carrington, Ph.D.Director, Musculoskeletal BiologyBiology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231Bethesda, MD 20892Telephone: (301) 496-6402FAX: (301) 402-2210Email: Carringtonj@nia.nih.gov
Basic and Translational Research in EmotionRelease Date: September 4, 2003PA Number: PA-03-169http://grants1.nih.gov/grants/guide/pa-files/PA-03-169.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThis initiative invites research grant applications to expand basic and translational research on the processes and mechanisms involved in the experience and expression of emotion. Direct your questions about scientific/research issues to:Jeffrey W. Elias, Ph.D.Behavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Avenue, Room 533Bethesda, MD 20892Telephone: (301) 496-3136FAX: (301) 402-0051Email: Eliasj@nia.nih.gov
Neuroprotective CNS Barriers in Neurological DiseasesRelease Date: August 28, 2003PA Number: PAS-03-165http://grants1.nih.gov/grants/guide/pa-files/PAS-03-165.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThe goal of this Program Announcement with set-aside funds (PAS) is to invite applications for studying the neurobiological and cerebrovascular mechanisms through which the neuroprotective blood-brain and blood-csf barriers function in the healthy and diseased adult, aged and pediatric brain. Blood-Brain Barrier (BBB) research embodies the true meaning of a "translational model" of neuroscience wherein breakthroughs in basic neuroscience are delivered to the clinic and require an agent delivery strategy and/or the ability to target specific areas of the brain. This PAS encourages studies focused on improving our understanding of the neuroprotective CNS barriers and enhancing the effectiveness of drug and gene delivery strategies for treatment of neurological diseases. Chief among the challenges to be addressed is the need to increase our knowledge about the molecular and cellular biology, cells of origin, gene and protein expression, and the regional differences of brain microvascular endothelial cells and pericytes and their interactions with adjacent brain cells. Direct your questions about scientific/research issues to:Dr. Bradley C. WiseNational Institute on Aging7201 Wisconsin Avenue, Suite 350Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Claude D. Pepper Older Americans Independence CentersRelease Date: August 21, 2003RFA Number: RFA-AG-04-002http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-002.htmlApplication Receipt Dates: December 17, 2003Purpose of This RFAThe general goal of the Claude D. Pepper Older Americans Independence Centers (OAIC) program is to increase scientific knowledge that will lead to better ways to maintain or restore independence in older persons. Specifically, NIA's goal for the OAIC program is to develop or strengthen awardee institutions' programs that focus, and sustain progress, on a key aging research area. The means by which the OAIC program seeks to achieve this goal is provision of resources to institutions to help them address key research problems, technologic limitations, and needs for trained researchers, on issues in which progress could contribute to greater independence for older persons. Direct your questions about scientific/research issues to:Susan G. Nayfield, M.D., M.ScChief, Geriatrics BranchGeriatrics and Clinical Gerontology ProgramNational Institute on AgingGateway Building, Suite 3C-3077201 Wisconsin AvenueBethesda, MD 20892-9205Phone: (301) 496-6761Fax: (301) 402-1784E-mail: nayfiels@mail.nih.gov
Initiatives under the NIH Roadmap will help enable the agency to sustain its historic record of cutting-edge contributions that are central to extending the quality of healthy life for people in this country and around the world.
Building Blocks, Biological Pathways, and NetworksMetabolomics Technology DevelopmentNational Technology Centers for Networks and PathwaysMolecular Libraries and Imaging
Molecular Libraries Small Molecule Repository – RFP-RM-04-001Development of High Resolution Probes for Cellular ImagingRequest for Information (Rfi) Molecular Libraries High Throughput Screening CentersStructural BiologyCenters for Innovation in Membrane Protein ProductionBioinformatics and Computational BiologyNational Centers for Biomedical ComputingNanomedicine(No RFAs released yet in this area)
High-Risk Research(No RFAs released yet in this area)Interdisciplinary ResearchTraining for a New Interdisciplinary Research WorkforceSupplements for Methodological Innovations in the Behavioral and Social SciencesInterdisciplinary Health Research Training: Behavior, Environment and BiologyShort Programs for Interdisciplinary Research TrainingCurriculum Development Award in Interdisciplinary ResearchExploratory Centers (P20) for Interdisciplinary ResearchPublic-Private Partnerships(No RFAs released yet in this area)
Re-engineering the Clinical Research Enterprise
Re-Engineering the Clinical Research EnterpriseFeasibility of Integrating and Expanding Clinical Research Networks
Dynamic Assessment of Patient-Reported Chronic Disease OutcomesMultidisciplinary Clinical Research Career Development Programs
December 2003
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