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Rewiring Pathways and Networks by Environmental PerturbationsMarc Vidal, Ph.D. Project DescriptionThe project will use a model system of viral infections as an environmental stressor to study how cellular networks and pathways are altered. The grant will attempt to profile all binary viral-host protein-protein interactions for a group of viruses with related biological properties and systematically test each viral protein for its ability to disrupt or alter host-host protein interactions. The resulting interactions and perturbation data will be integrated with diverse genomic data sources to derive dynamic cellular network models. |
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