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Questions and Answers Table of Contents

What types of grants do NIH and NIAID support?
How do I know what grant type to apply for?
What forms do I use to apply for different award types?
Does NIAID accept applications with multiple PIs?
For a new investigator, is it better to start with a small grant, such as an R21 or an R03, rather than an R01?
Should I apply for a small grant under a broad NIH PA or an IC-specific one?
How do I know if I can resubmit an application that responded to a PA?
Does NIAID use R21 grants only for biodefense or emerging infectious diseases?
Where can I find out more about multiproject awards?
Are fellowships a kind of grant?
Are supplements a kind of grant?
What are training grants?
Where can I find out about NIAID's investigator-initiated clinical trials awards?
When does NIAID award a cooperative agreement?
Are cooperative agreements a kind of grant?
Are small business awards always grants?
How does NIH define investigator-initiated research?
What's the difference between a mechanism and activity code and how are these terms used?
Where can I find information about other award types?
What if my question wasn't answered here, or I'd like to suggest a question?

What types of grants do NIH and NIAID support?

NIH supports many award types, and NIAID supports a subset of them, including research project grants, training and fellowship awards, and career development grants. This list can change; check NIAID Extramural Activity Codes for the latest information.

How do I know what grant type to apply for?

Talk to your program officer and experienced investigators in your institution. Go to Contact Staff for Help in the NIH Grant Cycle: Application to Renewal for program officer contact information.

Most investigators seeking a research grant try for an R01. Read Which Award Type Suits You Best? in the NIH Grant Cycle: Application to Renewal for advice.

If you are looking for a training or career development award, see our Support by Career Stage -- Ph.D. Track and Support by Career Stage -- M.D. Track to determine which award is right for you. For general information on training and career grants, go to Training and Career Awards.

What forms do I use to apply for different award types?

While NIH moves to electronic applications through Grants.gov, you use either the PHS 398 or grant application package depending on whether the grant type you are applying for has made that transition.

See the dates in NIH's Transition Plan on the Electronic Submission page. Also see Which form do I use to apply for an NIH research grant? in Quick Facts on Research Grant Applications.

Does NIAID accept applications with multiple PIs?

Yes, NIH allows multiple PIs for most research project grant applications, such as the R01, Exploratory/Developmental Research Grants, Phase I (R21), and Small Research Grants (R03). For initiatives, check the NIH Guide announcement to confirm.

Before you proceed, read Take Heed -- You Might Want to Avoid a Multiple PI Application in the NIH Grant Cycle: Application to Renewal, and go to NIH's Multiple Principal Investigators Web site.

For a new investigator, is it better to start with a small grant, such as an R21 or an R03, rather than an R01?

You should request the amount appropriate to your research and career level. Talk to your institution and a program officer for advice. Do not choose the award type yourself.

For more information and links to program officer contact information, go to Which Award Type Suits You Best? in the NIH Grant Cycle: Application to Renewal. You may also want to read our New Investigator Guide to NIH Funding.

Should I apply for a small grant under a broad NIH PA or an IC-specific one?

See Is it better to apply under one of the broad NIH PAs or an Institute-specific one? in our Small and Exploratory/Developmental Research Grants questions and answers.

How do I know if I can resubmit an application that responded to a PA?

To figure out whether you can resubmit an application that responded to a program announcement, go to the NIAID Funding Opportunities List and look for your PA on the list. If it's not there, it's no longer open.

If it is, you can find the expiration date by clicking on the title to access the Guide notice. You can resubmit until that time unless NIAID decides to extend the PA.

To learn more about resubmitting, go to How to Revise and Resubmit in the NIH Grant Cycle: Application to Renewal.

Does NIAID use R21 grants only for biodefense or emerging infectious diseases?

No. NIAID uses R21s for various initiatives. Use the filter on the NIAID Funding Opportunities List to find NIAID-relevant R21 funding opportunity announcements.

Where can I find out more about multiproject awards?

Read Instructions for Preparing a Multiproject Grant Application.

Are fellowships a kind of grant?

Yes. Fellowships and career development awards are grants. Learn more at Fellowships (F) and Career Development Awards (K) on the Training and Career Awards page.

Are supplements a kind of grant?

No. Supplements add money to existing grants. Learn more at Supplements.

What are training grants?

Training grants provide support for institutions to pay stipends and benefits to candidates they select for pre- and postdoctoral research training. PIs on training grants are senior-level investigators. Go to Training Grants (T) for more information.

Where can I find out about NIAID's investigator-initiated clinical trials awards?

For information on R34 planning grants and U01 implementation cooperative agreements, go to Investigator-Initiated Clinical Trials Resources. The site has information on NIAID's required process for investigator-initiated clinical trials, including SOPs, instructions, Guide notices, and questions and answers.

Are cooperative agreements a kind of grant?

Yes.

When does NIAID award a cooperative agreement?

NIAID awards a cooperative agreement when it expects substantial involvement of NIAID program officers. See the Cooperative Agreements (U) SOP and the Conversion of Grants to Cooperative Agreements SOP.

Are small business awards always grants?

At NIAID, they are.

How does NIH define investigator-initiated research?

Investigator-initiated research results from an investigator's submitting an application to NIH usually on a topic of his or her choice. It differs from targeted research in which investigators respond to an institute's call for applications in research topics specified in requests for applications or requests for proposals.

However, NIH considers applications responding to program announcements to be investigator-initiated research. This can be confusing because RFAs, RFPs, and program announcements are all types of initiatives issued by institutes. Also see Compare FOAs.

What's the difference between a mechanism and activity code and how are these terms used?

Though these terms are sometimes used interchangeably to describe a grant type, our Glossary gives the correct definitions for mechanism and activity code.

Where can I find information about other award types?

Here are sites for some other award types:

What if my question wasn't answered here, or I'd like to suggest a question?

Email deaweb@niaid.nih.gov with the title of this page or its URL and your question or comment. We answer questions by email and post them here. Thanks for helping us clarify and expand our knowledge base.

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