Dix DJ, Allen JW, Collins BW, Mori C, Nakamura N, Poorman-Allen P, Goulding EH, Eddy EM. Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.Proc. Natl. Acad. Sci. USA 93: 3264-3268, 1996. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8622925)
Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubah DB, Korach KS. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.Endocrinology 137: 4796-4805, 1996.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8895349)
Cho C, Bunch DO, Faure J-E, Goulding EH, Eddy EM, Primakoff P, Myles DG. Fertilization defects in sperm from mice lacking fertilin beta.Science 281: 1857-1859, 1998. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9743500)
Cho C, Willis WD, Goulding EH, Jung-Ha H, Choi YC, Hecht NB, Eddy EM. Haploinsufficiency of protamine-1 or -2 causes infertility in mice.Nat. Genet. 28: 82-86, 2001.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11326282)
Mahato D, Goulding E H, Korach KS, Eddy EM. Estrogen receptor-alpha is required by the supporting somatic cells for spermatogenesis.Mol. Cell. Endocrinol. 178: 57-63, 2001.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11403895)
Miki K, Willis WE, Brown PR, Goulding EH, Fulcher KD, Eddy EM. Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.Develop. Biol. 248: 331-342, 2002.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12167408)
Cho C, Jung-Ha H, Willis WE, Goulding EH, Stein P, X, Z, Schultz RM, Hecht NB, Eddy EM. Protamine-2 deficiency leads to sperm DNA damage and embryo death in mice.Biol. Reprod. 69: 211-217, 2003.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12620939)
Goto M, Eddy EM. Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20.J. Biological Chem. 279: 42128-42138, 2004.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15280373)
Miki K, Qu W, Goulding EH, Willis, WD, Bunch DO, Strader LF, Perreault SD, Eddy EM, O’Brien DA. Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility.Proc. Natl. Acad. Sci. USA. 101: 16501-16506, 2004.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15546993)
Huang Z, Somanath PR, Chakrabarti R, Eddy EM, Vijayaraghavan S. Changes in intracellular distribution and activity of protein phosphatase PP1gamma2 and its regulating proteins in spermatozoa lacking AKAP4.Biol. Reprod. 72: 384-392, 2005.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15385410)
Hong S, Choi I, Woo JM, Oh J, Kim T, Choi E, Kim TW, Jung YK, Kim do H, Sun CH, Yi GS, Eddy EM, Cho C. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells.J. Biol. Chem. 280: 7685-7693, 2005.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15613475)
Rivkin E, Eddy EM, Willis WD, Goulding EH, Suganuma R, Yanagimachi R, Kierszenbaum AL. Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene. Mol. Reprod. Dev. 72:259-71, 2005. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16015579)
Eddy EM. The spermatozoon. In Neill, J. (ed): Knobil and Neill: The Physiology of Reproduction, 3rd Edition, San Diego, Elsevier Inc., pp. 3-54, 2006.
Nakamura N, Shibata H, O'Brien DA, Mori C, Eddy EM. Spermatogenic cell-specific Type 1 hexokinase is the predominant hexokinase in sperm. Molecular Reproduction and Development. 75(4):632-640, 2008.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17924400)
Kaneto M, Krisfalusi M, Eddy EM, O'Brien DA, Miki K. Bicarbonate-induced phosphorylation of p270 protein in mouse sperm by cAMP-dependent protein kinase. Molecular reproduction and development 75(6):1045-1053, 2008.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18357561)
O'Bryan MK, Takada S, Kennedy CL, Scott G, Harada S-i, Ray MK, Dai Q, Wilhelm D, de Kretser DM, Eddy EM, Koopman P, Mishina Y. Sox8 is a critical regulator of adult Sertoli cell funtion and male fertility. Developmental biology 316(2):359-370, 2008.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18342849)
Choi E, Lee J, Oh J, Park I, Han C, Yi C, Kim DH, Cho BN, Eddy EM, Cho C . Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. BMC genomics 28(8):256-, 2007.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17662146)
Baek N, Woo J-M, Choi E, Park I, Han C, Yi C, Kin DH, Eddy EM, Cho C. Characterization of eight novel proteins with male germ cell-specific expression in mouse. Reproductive biology and endocrinology : RB&E 6(1):32, 2008.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18652659)
da Ros VG, Maldera JA, Willis WD, Cohen DJ, Goulding EH, Gelman DM, Rubinstein M, Eddy EM, Cuasnicu PS. Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1
(CRISP1). Developmental biology 320(1):12-18, 2008.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18571638)
Nakamura N, Miranda-Vizuete A, Miki K, Mori C, Eddy EM. Cleavage of disulfide bonds in mouse spermatogenic cell-specific type 1 hexokinase isozyme is associated with increased hexokinase activity and initiation of sperm motility. Biology of reproduction 79(3):537-545, 2008.[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18509164)
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