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Zongli Xu, Ph.D.

Zongli Xu, Ph.D.
Zongli Xu, Ph.D.
Research Fellow



Tel (919) 541-1677
Fax (919) 541-2511
xuz@niehs.nih.gov

Curriculum Vitae (http://www.niehs.nih.gov/research/atniehs/labs/epi/molecular/staff/xu/xu_cv.pdf)  Download Adobe Reader
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Research Triangle Park, North Carolina 27709
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Zongli Xu, Ph.D., is a postdoctoral fellow under the mentorship of Jack Taylor, M.D., Ph.D. His research involves both application and methodology studies in genetic epidemiology. Xu's overall goal is to understand the interaction between genes and environmental exposures in human health and therefore deciphering the mechanisms underlying complex human diseases. Along with colleagues in the Laboratory of Molecular Carcinogenesis and Biostatistics Branch of NIEHS, his applied work is mainly focused on human carcinogenesis, while much of his methodological work is investigating the use of sets of haplotype or LD tagging single nucleotide polymorphisms (SNPs) for candidate gene or genome-wide gene scan association studies. The applied work helps to motivate methodological research, which involves issues surrounding the design and data analysis in genetic epidemiological studies.

Studies

  • Haplotypes in Environmental Genome Project

Selected Publications

  1. Xu ZL, Fang JQ. A method of Bayesian linkage analysis on complex binary traits in general pedigrees. Journal of Biomathematics 18:15-20, 2003.
  2. Xu ZL, Fang YJ, Fang JQ. A model for sibpair linkage analysis on multi-response traits and its application to gene mapping of essential hypertension. Journal of Biomathematics 18:176-181, 2003.
  3. Xu ZL, Zou F, Vision TJ. Improving QTL mapping resolution in experimental crosses by the use of genotypically selected samples. Genetics 170(1):401-8. 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15781710&query_hl=8&itool=pubmed_DocSum) Exit NIEHS
  4. Taylor JA, Xu ZL, Kaplan NL, Morris RW. How well do HapMap haplotypes identify common haplotypes of genes? A comparison with haplotypes of 334 genes resequenced in the environmental genome project. Cancer Epidemiol Biomarkers Prev. 15(1):133-7. 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16434598&query_hl=4&itool=pubmed_docsum) Exit NIEHS
  5. Zou F, Xu Z, Vision T. Assessing the significance of quantitative trait loci in replicable mapping populations. Genetics. 174(2):1063-8. 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16888335&query_hl=9&itool=pubmed_docsum) Exit NIEHS
  6. Xu Z, Kaplan NL, Taylor JA. Tag SNP selection for candidate gene association studies using HapMap and gene resequencing data. Eur J Hum Genet 2007;15:1063-70. Epub 2007 Jun 13.
  7. Xu Z, Kaplan NL, Taylor JA. TAGster: efficient selection of LD tag SNPs in single or multiple populations. Bioinformatics 2007;23:3254-5. Epub 2007 Sep 7.

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Last Reviewed: August 27, 2008