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Jane A. Hoppin, Sc.D.

Chronic Disease Epidemiology Group

Jane A. Hoppin, Sc.D.
Jane A. Hoppin, Sc.D.
Staff Scientist



Tel (919) 541-7622
Fax (919) 541-2511
hoppin1@niehs.nih.gov

Curriculum Vitae (Hoppin-cv.pdf)  Download Adobe Reader
P.O. Box 12233
Mail Drop A3-05
Research Triangle Park, North Carolina 27709
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Jane Hoppin, Sc.D., is an environmental epidemiologist interested in developing and improving exposure assessment methods for common environmental contaminants and applying these in epidemiology studies. Hoppin's research focuses on the health effects of pesticides and phthalates, common environmental contaminants.

Since joining NIEHS in 1999, Hoppin has been an integral part of the Agricultural Health Study, a large cohort study of approximately 60,000 farmers and their families in North Carolina and Iowa. She is one of the co-principal investigators for the study being conducted in collaboration with the National Cancer Institute (NCI), the Environmental Protection Agency (EPA) and the National Institute for Occupational Safety and Health (NIOSH). Her research interests in the cohort have focused on two areas, respiratory health and exposure assessment. Hoppin has taken the lead on respiratory analyses in the cohort, focusing on respiratory symptoms in applicators and respiratory disease among farmers and their wives. Using the power of this large cohort, researchers have been able to identify individual pesticides associated with respiratory symptoms as well as identify diesel exhaust exposure as a potential respiratory hazard among farmers.

Hoppin continues to assess factors influencing respiratory health in the cohort and is planning a longitudinal study of lung function to obtain objective measures of respiratory outcomes. She is also a co-investigator, providing exposure assessment expertise, on the Farming and Movement Evaluation (FAME) study, a nested case-control study of Parkinson’s disease in the Agricultural Health Study.

Phthalates are commonly used as plasticizers and in cosmetics. Human exposure to phthalates is widespread, and yet little is known about their human health consequences. Some phthalate esters act as endocrine disruptors in animals. Hoppin has focused on understanding patterns of phthalate exposure and assessing the respiratory consequences of these exposures.

Studies

  • Agricultural Health Study (AHS) (http://www.niehs.nih.gov/research/atniehs/labs/epi/studies/ahs/index.cfm)
    The AHS explores potential causes of cancer and other diseases among farmers, their families and commercial pesticide applicators.
  • Norwegian Mother and Child Cohort Study (MoBa) (http://www.niehs.nih.gov/research/atniehs/labs/epi/studies/moba/index.cfm)
    The Norwegian Mother & Child Cohort Study or MoBa is an ongoing long-term prospective cohort study of 100,000 pregnant women and their babies. In collaboration with the Norwegian National Public Health Institute, NIEHS is supporting the collection of additional biologic specimens from the pregnant women.
  • Farming and Movement Evaluation (FAME) Study (http://www.niehs.nih.gov/research/atniehs/labs/epi/studies/fame/index.cfm)
    The FAME Study examines the relationship between Parkinson's disease and exposure to pesticides, other neurotoxicants and soil pathogens. The study also examines the connection between the illness and lifestyle factors, skin melanin and polymorphisms in genes involved in xenobiotic metabolism, dopaminergic neurotransmission or xenobiotic-specific membrane transport.
  • AHS Neurobehavioral Study
    This is an extramurally-funded study (Frederic Gerr, Ph.D., principal investigator, University of Iowa) in collaboration with investigators from AHS. Based on lifetime pesticide use history, a subset of 800 cohort participants will receive neurobehavioral tests and provide biological samples to evaluate whether long-term, low-level exposures to pesticides have neurological consequences.

Selected Publications

  1. Hoppin JA, Umbach DM, London SJ, Alavanja MCR, Sandler DP. Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study. Am J Resp Crit Care Med 165:683-689, 2002. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11874814&dopt=Abstract) Exit NIEHS Website [Full Text] (http://ajrccm.atsjournals.org/cgi/content/full/165/5/683) Exit NIEHS Website [PDF] (http://ajrccm.atsjournals.org/cgi/reprint/165/5/683.pdf)  Download Adobe Reader Exit NIEHS Website
  2. Hoppin JA, Umbach DM, London SJ, Alavanja MCR, Sandler DP. Animal production and wheeze in the Agricultural Health Study: Impact of atopy, asthma, and smoking. Occup Environ Med 60:3e1-7, 2003. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=12883030&dopt=Abstract) Exit NIEHS Website [Full Text] (http://oem.bmj.com/cgi/content/full/60/8/e3) Exit NIEHS Website [PDF] (http://oem.bmj.com/cgi/reprint/60/8/e3.pdf)  Download Adobe Reader Exit NIEHS Website
  3. Hoppin JA, Ulmer R, London SJ. Phthalate exposure and pulmonary function. Environ Health Perspect 112:571-574, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15064163&dopt=Citation) Exit NIEHS Website [Full Text] ( http://www.ehponline.org/members/2004/6564/6564.html) Exit NIEHS Website [PDF] (http://www.ehponline.org/members/2004/6564/6564.pdf)  Download Adobe Reader Exit NIEHS Website
  4. Hoppin JA, Umbach DM, London SJ, Alavanja MCR, Sandler DP. Diesel exhaust, solvents, and other occupational exposures as risk factors for wheeze among farmers. Am J Resp Critical Care Med 169:1308-1313, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=15070818&dopt=Abstract) Exit NIEHS Website [Full Text] (http://ajrccm.atsjournals.org/cgi/content/full/169/12/1308) Exit NIEHS Website [PDF] (http://ajrccm.atsjournals.org/cgi/reprint/169/12/1308.pdf)  Download Adobe Reader Exit NIEHS Website
  5. Kirrane EF, Hoppin JA, Umbach DM, Samanic C, Sandler DP. Patterns of pesticide use and their determinants among wives of farmer pesticide applicators in the Agricultural Health Study. J Occup Environ Med 46:856-865, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15300138) Exit NIEHS Website [Full Text] (http://gateway.ut.ovid.com/gw2/ovidweb.cgi?QS=WgQLi8kH1Y44UIriHTiC6w4%2fI4EEt4XLYZ%2frWY9t6nDO6e2t6GPo%2fMhLXW9OtmQtkPY8DPirBr9BmSq%2fLM5qJzBe1kQvI95G5uNDH48iMrgCrrFlflceLRBHQ38ZnU7KNSo05AwN2a5L9kj6zjnmrNU%2bO91rxQCF_jFx1O406brtNJdDB) Exit NIEHS Website [download the PDF] (http://gateway.ut.ovid.com/gw2/ovidweb.cgi?WebLinkFrameset=1&S=FPDDNCCKOCAPMK00D&returnUrl=ovidweb.cgi%3f%26Full%2bText%3dL%257cS.sh.15.16%257c0%257c00043764-200408000-00015%26S%3dFPDDNCCKOCAPMK00D&directlink=http%3a%2f%2fgraphics.tx.ovid.com%2fovftpdfs%2fFPDDNCCKOCAPMK00D%2ffs047%2fovft%2flive%2fgv024%2f00043764%2f00043764-200408000-00015.pdf) Exit NIEHS Website
  6. Hoppin JA, Umbach DM, Henneberger PK, Kullman GJ, London SJ, Alavanja MCR. Sandler DP. Pesticides and other agricultural factors associated with self-reported Farmer’s Lung among farm residents in the Agricultural Health Study. Occup Environ Medicine, Dec 20, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17182642&query_hl=8&itool=pubmed_docsum) Exit NIEHS Website
  7. Hoppin JA, Umbach DM, London SJ, Lynch CF, Alavanja MCR, Sandler DP. Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study. Am J Epidemiol. 163:1129-37, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16611668&query_hl=4&itool=pubmed_docsum) Exit NIEHS Website
  8. Flower KB, Hoppin JA, Shore DL, Lynch CF, Blair A, Knott C, Alavanja MCR, Sandler DP. Causes of mortality and risk factors for injury mortality among children in the Agricultural Health Study. Journal of Agromedicine 3/4:47-59, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=) Exit NIEHS
  9. Mahajan R , Blair A , Coble J , Lynch CF , Hoppin JA , Sandler DP , Alavanja MCR. Carbaryl exposure and incident cancer in the Agricultural Health Study. International journal of cancer. Journal International du Cancer 8:1799-1805, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17534892) Exit NIEHS
  10. Hoppin JA, Valcin M, Henneberger PK, Kullman GJ, Umbach DM, London SJ, Alavanja MCR, Sandler DP. Pesticide use and chronic bronchitis among farmers in the Agricultural Health Study. American journal of industrial medicine 50(12):969-979, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17975796) Exit NIEHS
  11. Koutros S, Cross AJ, Sandler DP, Hoppin JA, Ma X, Zheng T, Alavanja MCR, Sinha R. Meat and meat mutagens and risk of prostate cancer in the Agricultural Health Study. Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 17(1):80-87, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18199713) Exit NIEHS
  12. Koutros S, Mahajan R , Zheng T , Hoppin JA, Ma X , Lynch CF , Blair A , Alavanja MCR. Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study. Cancer Causes & Control : CCC 19(1):59-65, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17943454) Exit NIEHS
  13. Hoppin JA, Umbach DM, London SJ, Henneberger PK, Kullman GJ, Alavanja MCR, Sandler DP. Pesticide and atopic and non-atopic asthma among farm women in the Agricultural Health Study. American journal of respiratory and critical care medicine 2008 177(1):11-18. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17932376) Exit NIEHS
  14. Kang D, Park SK, Beane-Freeman L, Lynch CF, Knott CE, Sandler DP, Hoppin JA, Dosemeci M, Coble J, Jay Lubin J, Blair A, Alavanja M. Cancer incidence among pesticide applicators exposed to trifluralin in the Agricultural Health Study. Environmental health perspectives 107:271-276, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18342850) Exit NIEHS
  15. Crawford JM, Hoppin JA, Alavanja MCR, Blair A, Sandler DP, Kamel F. Hearing loss in licensed pesticide applicators. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 50(7):817-826, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18617838) Exit NIEHS
  16. Longnecker MP, Smith CS, Kissling GE, Hoppin JA, Butenhoff JL, Decker E, Ehresman DJ, Ellefson ME, Flaherty J, Gardner MS, Langlois E, LeBlanc A, Lindstrom AB, Reagen WK, Strynar MJ, Studabaker WB. An interlaboratory study of perfluorinated alkyl compound levels in human plasma. Environmental Science and Technology 107(2):152-159, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18295197) Exit NIEHS

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Last Reviewed: September 08, 2008