Contact: Dr. Lillian Shum, (301) 594-0618, Lillian.Shum@nih.gov
The Developmental Biology and Genetics program supports basic and translational research to understand the development of tooth and bone and to identify the genetic and environmental contributions to craniofacial disorders. The objective of this scientific program is to elucidate the underlying causes of craniofacial disorders, thereby advancing the fields of diagnosis, treatment, and prevention. In addition, the program encourages research that is responsive to the NIH Roadmap Initiatives.
Craniofacial Development
The Craniofacial Development Program supports basic and clinical research on normal and abnormal craniofacial development that relates to the causes, diagnosis, treatment and prevention of craniofacial disorders and diseases. Research support is focused on studies elucidating the cellular and molecular mechanisms that regulate craniofacial development. The program includes studies using a wide variety of mammalian and nonmammalian models.
The program supports studies of:
- Craniofacial neural crest induction
- Cell migration
- Pattern specification
- Cell fate determination
- Differentiation
- Interactions between cells and extracellular matrix components
Genetics
The Genetics Program supports research designed to identify the genetic and molecular mechanisms underlying craniofacial disorders. Craniofacial abnormalities such as cleft lip and cleft palate, ectodermal dysplasia, craniosynostosis, amelogenesis and dentinogenesis imperfecta are the result of spontaneous or inherited genetic mutations. Craniofacial disorders are often complex birth defects in which gene-gene and gene-environment interactions play a critical role in determining the developmental outcome.
The program supports research on:
- Gene discovery studies using genome-wide high-throughput technologies and epidemiologic studies
- Clinical studies of genotype/phenotypic correlation
- Identification of biomarkers
- Studies examining mechanisms that regulate developmental gene expression
- Studies of prenatal nutrition and environmental exposures
- Studies of genetically engineered animal models to identify genes and analyze regulatory mechanisms and the effects of genetic mutations on developmental processes
The NIDCR encourages studies on the diagnosis of genetic disorders, prevention strategies to decrease environmental risks, and improved treatments including gene and stem cell-based therapies.
Development of Tooth and Bone
Studies focusing on the development of hard tissues in the craniofacial region also are supported by this program. Basic research is being done to understand the development of tooth and bone structure, as well as to elucidate the signaling mechanisms that are needed to initiate mineralization. Research includes areas such as tooth formation and eruption, and growth and remodeling of calcified dense tissues. The program encourages the application of microarray technology and proteomics to understand global changes in gene and protein profiles that are associated with tooth and bone development.
Additional Information
Lillian Shum, PhD
Acting Director
Developmental Biology and Genetics Program
Integrative Biology and Infectious Diseases Branch
Division of Extramural Research
National Institute of Dental and Craniofacial Research
6701 Democracy Blvd.
Room 624, Mail Stop 4878
Bethesda, MD 20892-4878
(Courier please use: MD 20817)
Phone: 301-594-0618
Fax: 301-480-8319
Email: Lillian.Shum@nih.gov