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Laboratory Animal Medicine
Srinivas S. Rao D.V.M., Ph.D, M.B.A., Diplomate, ACVP
Laboratory Animal Medicine, VRC
Srinivas S. Rao, D.V.M., Ph.D., MBA, Diplomate, ACVP
301-594-8465
Address: VRC, NIH
40 Convent Dr., Room 1407
Bethesda, MD 20892-3015
Laboratory Personnel:
Dr. Srinivas S. Rao, Chief, Laboratory Animal Medicine. Ph. 301-594-8465.
srao1@mail.nih.gov
Vi Dang, Animal Resources Program Coordinator. Ph. 301-594-8464.
vidang@mail.nih.gov
Laboratory Animal Medicine Program provides all aspects
of oversight and programmatic assistance to support teaching, training
and research involving laboratory animals. The Program is fully
AAALAC accredited an d adheres to the following of the Federal regulations
as published in the Animal Welfare Act (AWA); the Guide for the
Care and Use of Laboratory Animals (Guide); the Public Health Service
Policy; and the U.S. Government Principles Regarding the Care and
Use of Animals and NIH Manual 3040-2. Dr. Rao also serves as the
Animal Program Director of VRC, NIH and helps coordinate the laboratory
animal activities with the policies of NIH including Office
of Animal Care and Use (OACU).
In assuring that the letter and the spirit of these
regulatory requirements are met, the LAM provides a contemporary
program that includes:
Veterinary Medical Care
- State-of-the-art husbandry, veterinary care, and management
support of our colony animals,
- Routine surveillance and quality assurance of vendor-and colony-
produced animals
- Preventative medical care; surveillance, diagnosis, treatment
and control of disease.
- Anesthesia and analgesia.
- Assistance with breeding colony development and maintenance
- Training of faculty and staff in the handling, humane care,
and manipulation of research animals,
- Consultation, collaboration, and professional assistance in
animal model development.
- Monitoring of in vivo maintained tumor and hybridoma tissues,
- Assisting in the review process of the Animal Care and Use Protocol
development
Veterinary Technical Services
- The Veterinary Care Unit can provide technical services to support
the research needs of individuals who use animal models.
- These services include: parenteral injection or oral administration
of pharmaceutical agents and other experimental materials; blood
and/or serum collection; surgical manipulations; anesthetic administration
and other procedures as needed.
- For those who wish to perform the procedures themselves but
are inexperienced, training in these techniques is available from
the Veterinary Care Unit at no charge
Husbandry Technical Services
- provide a range of technical services including: mouse breeding
management (mating, sex identification, weaning, pregnancy determination);
mouse rederivation assistance
- autoclaved rodent caging and supplies
- Irradiation assistance to rodents and cells.
- housing facilities for infectious animals (restrictions apply)
- rodent isolators (limited space);
- quarantine services
- procedure rooms for animal manipulations
- special feeding and/or watering requests; and animal transportation.
Veterinary Pathology Consultation
Selected Publications
- Jeffrey D. Hasday, Allen Garrison, Ishwar S. Singh,
Theodore Standiford, Garrettson S. Ellis, Srinivas Rao, Ju-Ren
He, Penny Rice, Mariah Frank, Simeon E. Goldblum, and Rose M.
Viscardi.
Febrile-Range
Hyperthermia Augments Pulmonary Neutrophil Recruitment and Amplifies
Pulmonary Oxygen Toxicity
Am J Pathol. 2003 Jun;162(6):2005-17.
- Viscardi RM, Kaplan J, Lovchik JC, He JR,
Hester L, Rao S, Hasday JD.
Characterization
of a murine model of Ureaplasma urealyticum pneumonia.
Infect Immun. 2002 Oct; 70(10):5721-9.
- Vigneulle RM, Rao S, Fasano A, MacVittie
TJ.
Structural
and functional alterations of the gastrointestinal tract following
radiation-induced injury in the rhesus monkey.
Dig Dis Sci. 2002 Jul;47(7):1480-91.
- Reid W, Sadowska M, Denaro F, Rao S, Foulke
J Jr, Hayes N, Jones O, Doodnauth D, Davis H, Sill A, O'Driscoll
P, Huso D, Fouts T, Lewis G, Hill M, Kamin-Lewis R, Wei C, Ray
P, Gallo RC, Reitz M, Bryant J.
An
HIV-1 transgenic rat that develops HIV-related pathology and immunologic
dysfunction.
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9271-6.
- Reid WC, Carmichael KP, Srinivas S, Bryant
JL.
Pathologic
changes associated with use of tribromoethanol (avertin) in the
Sprague Dawley rat.
Lab Anim Sci. 1999 Dec;49(6):665-7. No abstract available.
- Bunnell JE, Trigiani ER, Srinivas SR, Dumler
JS.
Development
and distribution of pathologic lesions are related to immune status
and tissue deposition of human granulocytic ehrlichiosis agent-infected
cells in a murine model system.
J Infect Dis. 1999 Aug;180(2):546-50.
- Navarro-Garcia F, Eslava C, Villaseca JM,
Lopez-Revilla R, Czeczulin JR, Srinivas S, Nataro JP, Cravioto
A.
In
vitro effects of a high-molecular-weight heat-labile enterotoxin
from enteroaggregative Escherichia coli.
Infect Immun. 1998 Jul;66(7):3149-54.
- Elliott SJ, Srinivas S, Albert MJ, Alam
K, Robins-Browne RM, Gunzburg ST, Mee BJ, Chang BJ.
Characterization
of the roles of hemolysin and other toxins in enteropathy caused
by alpha-hemolytic Escherichia coli linked to human diarrhea.
Infect Immun. 1998 May;66(5):2040-51.
- Xu M, Kumar D, Srinivas S, Detolla LJ,
Yu SF, Stass SA, Mixson AJ.
Parenteral
gene therapy with p53 inhibits human breast tumors in vivo through
a bystander mechanism without evidence of toxicity.
Hum Gene Ther. 1997 Jan 20;8(2):177-85.
- DeTolla LJ, Srinivas S, Whitaker BR, Andrews
C, Hecker B, Kane AS, Reimschuessel R.
Guidelines
for the Care and Use of Fish in Research.
ILAR J. 1995;37(4):159-173. No abstract available.
Note: Srinivas S. Rao was previously S. Srinivas
Vi
Dang reports to Dr. Rao and serves currently as the
Animal Resources Program Coordinator. In addition to coordinating
several activities of the LAM program, Mr. Dang also serves as the
ACUC coordinator. He also is the Facility Manager of the LAM, VRC
and helps in the oversight of the contract operating the LAM vivarium.
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