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Bimodal action of ethanol on HUVEC. AT, adenosine transporter; A1 R, adenosine A1 receptor.


The illustration below is from Vol 277 pp. 20927-33, 2002 of Journal of Biological Chemistry

Bimodal action of ethanol on HUVEC. AT, adenosine transporter; A1 R, adenosine A1 receptor.

Treatment with low concentrations of EtOH activates the cell survival promoting PI3K/Akt pathway in endothelial cells by an adenosine receptor-dependent mechanism, and activation of the proapoptotic caspase pathway by higher concentrations of EtOH via an adenosine-independent mechanism can mask or counteract such effects



Updated: August 2002
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