TS32, 5625 Fishers Lane, Rockville, MD, 20852

Phone: 301-443-3748

Fax: 301-480-0466

Email: onof@mail.nih.gov

Education

04/1991 M.D., Faculty of Medicine, University of Tokyo

06/1991-05/1992 Resident, Internal Medicine, National Medical Center Hospital

07/1996 Ph.D., Faculty of Medicine, University of Tokyo

Research Experience

01/1996- 11/1998 Postdoctoral Fellow of the Japan Society for the Promotion of Science

11/1998- 08/2000 Postdoctoral Fellow, SUNY at Stony Brook

09/2000- 10/2003 Research Assistant Professor, SUNY at Stony Brook

11/2003- 5/28/2007 Assistant Professor, the Whitney Laboratory & Department of Neuroscience, University of Florida

5/29/2007- Chief, Section on Model Synaptic Systems, Laboratory of Molecular Physiology, NIAAA/NIH

License and Certification

1991 American Medical License Registration (Foreign Medical Graduates Examination)

1991 Japanese Medical License Registration

Awards and Grants

Fellowship (Japan Society for the Promotion of Science)   1996-1998

Muscular Dystrophy Association, Research Grant   07/2004– 06/2007       $297,000

NIH 1 R01 NS050388-01A1   07/01/2005 - 06/30/2009      $942,112

Publications

Ono, F. (2008) An emerging picture of synapse formation: A balance of two opposing pathways. Science Signaling 1, pe3.

Ibanez-Tallon, I., Wen, H., Miwa, J.M., Xing, J., Tekinay, AB., Ono, F., Brehm, P.,  and Heintz, N. (2004) Tethering naturally occurring Peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo. Neuron 43:305-11.

Luna, V., Wang, M., Ono, F., Gleason, M., Dallman, J., Mandel, G., and Brehm, P. (2004) Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. Journal of Neurophysiology 92:2003-2009.

Ono, F., Mandel, G., and Brehm, P. (2004) Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish. Journal of Neuroscience 24:5475-5481.

Lefebvre, J.L., Ono, F., Puglielli, C., Saidner, G., Franzini-Armstrong, C., Brehm, P., and Granato, M. (2004) Increased neuromuscular activity causes axonal defects and muscle degeneration. Development 31:2605-2618.

Li, W., Ono, F., and Brehm, P. (2003) Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors. Journal of Neuroscience 23:10467 - 10474.

Nakajo, K., Katsuyama, Y., Ono, F., Ohtsuka, Y., and Okamura, Y. (2003) Primary structure, functional characterization and developmental expression of the ascidian Kv4-class potassium channel. Neuroscience Research 45:59-70.

Ono, F., Shcherbatko, A., Higashijima, S., Mandel, G.,  and Brehm, P. (2002) The zebrafish motility mutant "twitch once" reveals new roles for rapsyn in synaptic function. Journal of Neuroscience 22:6491-8.

Okada, T., Katsuyama, Y., Ono, F., and Okamura, Y. (2002) The development of three identified motor neurons in ascidian embryo. Developmental Biology 244:278-92.

Ono, F., Higashijima, S., Shcherbatko, A., Fetcho, J.R., and Brehm, P. (2001) Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. Journal of Neuroscience 21:5439-5448.

Shchberbatko, A., Ono, F., Mandel, G., and Brehm, P. (1999) Voltage-dependent sodium channel function is regulated through membrane mechanics. Biophysical Journal 77:1945-1959.

Ono, F., Katsuyama, Y., Nakajo, K., and Okamura, Y. (1999) Subfamily-specific posttranscriptional mechanism underlies K+ channel expression in a developing neuronal blastomere. Journal of Neuroscience 19:6874-6886.

Okamura, Y., Ono, F. and Okagaki, R. (1997) Regulation of voltage-gated ion channels during ascidian embryogenesis. Developmental Neuroscience 19:23-24.

Okamura, Y., Ono, F. and Okagaki, R. (1996) Regulation of sodium channel gene expression by cell-specific interactions in the Ascidian embryo. Basic Neuroscience in Invertebrates 21-30.

Okamura, Y.,  Ono, F., Okagaki, R., Chong, J.A., and Mandel, G. (1994) Neural expression of a sodium channel gene requires cell-specific interactions. Neuron 13:937-948.

Invited Talks

Neuroscience Research Institute, Tsukuba, Japan, June 2002

University of Connecticut Health Center, Farmington CT, December 2002

University of Florida, St Augustine & Gainesville FL, March 2003

FASEB summer conference "Ion Channel Regulation", Tucson, AZ, June 2003

Neuroscience Research Institute, Tsukuba, Japan, June 2004

National Institute of Physiological Sciences, Okazaki, Japan, June2004

NIH/NIAAA, Rockville, MD, September 2005

Kobe University, Kobe, Japan, July 2006

Review Services

Ad hoc reviewer for Journal of Neuroscience, Developmental Biology, Canadian Journal of Zoology, NSF,  The Netherlands Organisation for Health Research and Development,  American Journal of Physiology, etc