Fumihito Ono, M.D., Ph.D.
TS32, 5625 Fishers Lane, Rockville, MD, 20852
Phone: 301-443-3748
Fax: 301-480-0466
Email: onof@mail.nih.gov
Education
04/1991 M.D., Faculty of Medicine, University of Tokyo
06/1991-05/1992 Resident, Internal Medicine, National Medical Center Hospital
07/1996 Ph.D., Faculty of Medicine, University of Tokyo
Research Experience
01/1996- 11/1998 Postdoctoral Fellow of the Japan Society for the Promotion of Science
11/1998- 08/2000 Postdoctoral Fellow, SUNY at Stony Brook
09/2000- 10/2003 Research Assistant Professor, SUNY at Stony Brook
11/2003- 5/28/2007 Assistant Professor, the Whitney Laboratory & Department of Neuroscience, University of Florida
5/29/2007- Chief, Section on Model Synaptic Systems, Laboratory of Molecular Physiology, NIAAA/NIH
License and Certification
1991 American Medical License Registration (Foreign Medical Graduates Examination)
1991 Japanese Medical License Registration
Awards and Grants
Fellowship (Japan Society for the Promotion of Science) 1996-1998
Muscular Dystrophy Association, Research Grant 07/2004– 06/2007 $297,000
NIH 1 R01 NS050388-01A1 07/01/2005 - 06/30/2009 $942,112
Publications
Ono, F. (2008) An emerging picture of synapse formation: A balance of two opposing pathways. Science Signaling 1, pe3.
Ibanez-Tallon, I., Wen, H., Miwa, J.M., Xing, J., Tekinay, AB., Ono, F., Brehm, P., and Heintz, N. (2004) Tethering naturally occurring Peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo. Neuron 43:305-11.
Luna, V., Wang, M., Ono, F., Gleason, M., Dallman, J., Mandel, G., and Brehm, P. (2004) Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. Journal of Neurophysiology 92:2003-2009.
Ono, F., Mandel, G., and Brehm, P. (2004) Acetylcholine receptors direct rapsyn clusters to the neuromuscular synapse in zebrafish. Journal of Neuroscience 24:5475-5481.
Lefebvre, J.L., Ono, F., Puglielli, C., Saidner, G., Franzini-Armstrong, C., Brehm, P., and Granato, M. (2004) Increased neuromuscular activity causes axonal defects and muscle degeneration. Development 31:2605-2618.
Li, W., Ono, F., and Brehm, P. (2003) Optical measurements of presynaptic release in mutant zebrafish lacking postsynaptic receptors. Journal of Neuroscience 23:10467 - 10474.
Nakajo, K., Katsuyama, Y., Ono, F., Ohtsuka, Y., and Okamura, Y. (2003) Primary structure, functional characterization and developmental expression of the ascidian Kv4-class potassium channel. Neuroscience Research 45:59-70.
Ono, F., Shcherbatko, A., Higashijima, S., Mandel, G., and Brehm, P. (2002) The zebrafish motility mutant "twitch once" reveals new roles for rapsyn in synaptic function. Journal of Neuroscience 22:6491-8.
Okada, T., Katsuyama, Y., Ono, F., and Okamura, Y. (2002) The development of three identified motor neurons in ascidian embryo. Developmental Biology 244:278-92.
Ono, F., Higashijima, S., Shcherbatko, A., Fetcho, J.R., and Brehm, P. (2001) Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. Journal of Neuroscience 21:5439-5448.
Shchberbatko, A., Ono, F., Mandel, G., and Brehm, P. (1999) Voltage-dependent sodium channel function is regulated through membrane mechanics. Biophysical Journal 77:1945-1959.
Ono, F., Katsuyama, Y., Nakajo, K., and Okamura, Y. (1999) Subfamily-specific posttranscriptional mechanism underlies K+ channel expression in a developing neuronal blastomere. Journal of Neuroscience 19:6874-6886.
Okamura, Y., Ono, F. and Okagaki, R. (1997) Regulation of voltage-gated ion channels during ascidian embryogenesis. Developmental Neuroscience 19:23-24.
Okamura, Y., Ono, F. and Okagaki, R. (1996) Regulation of sodium channel gene expression by cell-specific interactions in the Ascidian embryo. Basic Neuroscience in Invertebrates 21-30.
Okamura, Y., Ono, F., Okagaki, R., Chong, J.A., and Mandel, G. (1994) Neural expression of a sodium channel gene requires cell-specific interactions. Neuron 13:937-948.
Invited Talks
Neuroscience Research Institute, Tsukuba, Japan, June 2002
University of Connecticut Health Center, Farmington CT, December 2002
University of Florida, St Augustine & Gainesville FL, March 2003
FASEB summer conference "Ion Channel Regulation", Tucson, AZ, June 2003
Neuroscience Research Institute, Tsukuba, Japan, June 2004
National Institute of Physiological Sciences, Okazaki, Japan, June2004
NIH/NIAAA, Rockville, MD, September 2005
Kobe University, Kobe, Japan, July 2006
Review Services
Ad hoc reviewer for Journal of Neuroscience, Developmental Biology, Canadian Journal of Zoology, NSF, The Netherlands Organisation for Health Research and Development, American Journal of Physiology, etc