Laboratory of Molecular and Cellular Neurobiology
Forrest Weight
Education
Doctor of Medicine, 1962
College of Physicians and Surgeons (P+S)
Columbia University
New York, New York
Research Interests
Molecular and cellular physiology and pharmacology of the nervous system
Selected Publications
Akinshola BE. Straight-chain alcohols exhibit a cutoff in potency for the inhibition of recombinant glutamate receptor subunits. Br J Pharmacol 2001;133:651-8. pdf
Akinshola BE, Stewart RR, Karvonen L, Taylor RE, Liesi P. Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytes. Brain Res Mol Brain Res 2001;93:8-17. pdf
Ghazanfari FA, Stewart RR. Characteristics of endothelial cells derived from the blood-brain barrier and of astrocytes in culture. Brain Res 2001;890:49-65. pdf
Liesi P, Fried G, Stewart RR. Neurons and glial cells of the embryonic human brain and spinal cord express multiple and distinct isoforms of laminin. J Neurosci Res 2001;64:144-67.
Wassif CA, Zhu P, Kratz L, Krakowiak PA, Battaile KP, Weight FF, Grinberg A, Steiner RD, Nwokoro NA, Kelley RI, Stewart RR, Porter FD. Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome. Hum Mol Genet 2001;10:555-64. pdf
Li C, Xiong K, Weight FF: Ethanol inhibition of adenosine 5'-triphosphate-activated current in freshly isolated adult rat hippocampal CA1 neurons. Neurosci Lett. 2000;295:77-80. pdf
Xiong K, Li C, Weight FF: Inhibition by ethanol of rat P2X(4) receptors expressed in Xenopus oocytes. Br J Pharmacol. 2000;130:1394-8. pdf
Li C, Peoples RW, Lanthorn TH, Li Z, Weight FF: Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglion. Neuroscience Letters 1999;263:57-60.
Okada M, Zhang L, Russell JT, Holtzclaw L, Ozaki N, Weight FF, Linnoila M, Goldman D: Reduction of human 5HT2C receptor function by an abundant naturally occurring amino acid substitution Cys23Ser. Submitted
Peoples RW, Weight FF: Differential alcohol modulation of GABAA and NMDA receptors. NeuroReport 1999;10:97-101.
Weight FF, Li C, Peoples RW: Alcohol action on membrane ion channels gated by extracellular ATP (P2X receptors). Neurochem Intl; 1999 Aug;35:143-52. Review.
Xiong K, Peoples RW, Montgomery J, Chiang Y, Stewart RR, Weight FF, Li C: Differential modulation by copper and zinc of P2X2 and P2X4 receptor function. J Neurophysiol 1999;81:2088-2094. pdf
Li C, Peoples RW, Weight FF: Ethanol-induced inhibition of a neuronal P2X purinoceptor by an allosteric mechanism. Br J Pharmacol 1998;123:1-3.
Peoples RW, Weight FF: Inhibition of excitatory amino acid-activated currents by trichloroethanol and trifluoroethanol in mouse hippocampal neurones. Br J Pharmacol 1998;124:1159-1164, 1998.
Li C, Peoples RW, Weight FF: Enhancement of ATP-activated current by protons in dorsal root ganglion neurons. Pflügers Arch 1997;433:446-54
Li C, Peoples RW, Weight FF: Mg2+ inhibition of ATP-activated current in rat nodose ganglion neurons: evidence that Mg2+ decreases the agonist affinity of the receptor. J Neurophysiol 1997;77:3391-5.
Li C, Peoples RW, Weight FF: Inhibition of ATP-activated current by zinc in dorsal root ganglion neurons of bullfrog. J Physiol (Lond.) 1997;505:641-653.
Peoples RW, Weight FF: Anesthetic actions on excitatory amino acid receptors. In: Anesthesia: Biologic Foundations. Yaksh TL et al (eds) Philadelphia: Lippincott-Raven Publ. 1997; 239-258.
Peoples RW, White G, Lovinger DM, Weight FF: Ethanol inhibition of N-methyl-D-aspartate-activated current in mouse hippocampal neurones: whole-cell patch-clamp analysis. Br J Pharmacol 1997;122:1035-1042.
Zhang L, Oz M, Stewart RR, Peoples RW, Weight FF: Volatile general anaesthetic actions on recombinant nACHa7, 5HT3, and chimeric nACHa7-5HT3, receptors expressed in Xenopus oocytes. Br J Pharmacol 1997;120:353-4.
Zhang L, Peoples RW, Oz M, Harvey-White J, Weight FF, Brauneis U: Potentiation of NMDA receptor-mediated responses by dynorphin at low extracellular glycine concentrations. J Neurophysiol 1997;78:582-90.
Brauneis U, Oz M, Peoples RW, Weight FF, Zhang L: Differential sensitivity of recombinant N-methyl-D-aspartate receptor subunits to inhibition by dynorphin. J. Pharmacol. Exp Ther 1996;279:1063-1068.
Li C, Peoples RW, Weight FF: Acid pH augments excitatory action of ATP on a dissociated mammalian sensory neuron. NeuroReport 1996;7:2151-2154.
Li C, Peoples RW, Weight FF: Cu2+ potently enhances ATP-activated current in rat nodose ganglion neurons. Neurosci Lett 1996;219:45-48,.
Li C, Peoples RW, Weight, FF: Proton potentiation of ATP-gated ion channel responses to ATP and Zn2+ in rat nodose ganglion neurons. J Neurophysiol 1996; 76:3048-3058.
Matsuzawa M, Weight FF, Potember RS, Liesi P: Directional neurite outgrowth and axonal differentiation of embryonic hippocampal neurons are promoted by a neurite outgrowth domain of the B2-chain of laminin. Intl J Dev Neurosci 1996;14:283-295.
Peoples RW, Li C, Weight FF: Lipid vs protein theories of alcohol action in the nervous system. Annual Rev Pharmacol Toxicol 1996;36:185-201.
Wright JM, Peoples RW, Weight FF: Single-channel and whole-cell analysis of ethanol inhibition of NMDA-activated currents in cultured mouse cortical and hippocampal neurons. Brain Res 1996;738:249-256.
Yoshimura N, White G, Weight FF, de Groat WC: Different types of Na+ and A-type K+ currents in dorsal root ganglion neurones innverating the rat urinary bladder. J Physiol (Lond.) 1996;494:1-16.
Yu D, Zhang L, Eisele, J-L, Bertrand D, Changeux J-P, Weight FF: Ethanol inhibition of nicotinic acetylcholine type m7 receptor involves the amino-terminal domain of the receptor. Molecular Pharmacol 1996;50:1010-1016.
Zhang L, Yu Y, Mackin S, Weight FF, Uhl GR, Wang JB: Differential m opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. J Biol Chem 1996;271:11449-11454. pdf
Fan P, Oz M, Zhang L, Weight FF: Effect of cocaine on 5-HT3 receptor-mediated ion current in Xenopus oocytes. Brain Res 1995;673:181-184.
Peoples RW, Weight FF: Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol intoxication. Proc Natl Acad Sci USA 1995;92:2825-2829.
Zhang L, Oz M, Weight FF: Potentiation of 5-HT3 receptor-mediated responses by protein kinase C activation. NeuroReport 1995;6:1464-1468.
Laboratory of Molecular and Cellular Neurobiology
NIH/NIAAA
Park Bldg., Rm 158
Bethesda, MD 20892-8115