Laboratory of Clinical and Translational Studies
Dan Rio
Education
B.A. in Mathematics/Physics, University of South Florida, 1976
M.A. in Physics, University of South Florida, 1981
Ph.D. in Biomedical Engineering/Medical Physics, University of Florida, 1984
Research Interests
Processing and analysis of 3D brain images involving MRI, fMRI, and PET.
Automated segmentation and mensuration of different brain tissues in MRI and PET.
Co-registration and warping of volumetric images from different subjects within the same modality, and from the same subject between different modalities.
Statistical Analysis of functional images (PET, fMRI) by random field methods, Fourier transform, and wavelet decomposition.
Time series analysis of fMRI volumes.
Selected Publications
Agartz I, Momenan R, Rawlings RR, Kerich MJ, Hommer DW. Hippocampal volume in patients with alcohol dependence. Arch Gen Psychiatry 1999;56:356-63. 
Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, Champoux M, Suomi SJ, Linnoila MV, Higley JD. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry. 2002;7:118-22.
Bennett AJ, Sponberg AC, Graham T, Suomi SJ, Higley JD, DePetrillo PB 2001. Initial ethanol exposure results in decreased heart rate variability in ethanol-naive rhesus monkeys. Eur J Pharmacol. 2001;433:169-172. pdf
Boyce T, Higley JD, Jemerin JJ, Champoux MB, Suomi SJ: Tympanic temperature asymmetry and stress behaviors in rhesus macaques and children. Arch Pediatr Adoles Med 1996;150:518-23.
Castellanos FX, Marvasti FF, Ducharme JL, Walter JM, Israel ME, Krain A, Pavlovsky C, Hommer DW. Executive function oculomotor tasks in girls with ADHD. J Am Acad Child Adolesc Psychiatry 2000;39:644-50. pdf
Champoux M, Hibbeln JR, Shannon C, Majchrzak S, Suomi SJ, Salem N Jr, Higley JD. Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates.
Pediatr Res. 2002;51:273-81.
Champoux M, Hibbeln JR, Higley J, Shannon C, Purple M, Salem N, Suomi S. Formula supplementation with DHA and AA and improvements in neonatal development in rhesus monkeys. Pediatrics Research 2001, in press.
Champoux MB, Higley JD, Suomi SJ: Behavioral and physiological characteristics of Indian and Chinese-Indian hybrid rhesus macaque infants. Dev Psychobiol 1997;31:49-63.
Champoux MB, Kriete MF, Higley JD, Suomi SJ: CBC and serum chemistry differences between Indian-derived and Chinese-Indian hybrid rhesus monkey infants. Am J Primatol 1996;39:79-84.
DePetrillo PB, Wan W. Methods of and compounds for inhibiting calpains. Patent number: 09/847,872. Pending. 2001.
DePetrillo PB. Determining the hurst exponent for time series data. Patent number: 6,144,877. Pending. 2000
DePetrillo PB, Bennett AJ, Speers d, Suomi SJ, Shoaf SE, Karimullah K, Dee Higley J: Ondansetron modulates pharmacodynamic effects of ketamine on electrocardiographic signals in rhesus monkeys. Eur J Pharmacol 2000;391:113-9. pdf
DePetrillo PB, Yang Q, Rackoff J, SanMiguel A, Karimullah K. Surface fractal computation and its application to immunofluorescent histochemical studies of calpain and calpastatin in PC12 cells. J Neurosci Methods. 2000;103:191-7. pdf
DePetrillo PB, Speers D, Ruttimann UE: Determining the Hurst exponent of fractal time series and its application to electrocardiographic analysis. Comput Biol Med 1999;29:393-406. pdf
DePetrillo PB, White KV, Liu M, Hommer D, Goldman D: Effects of alcohol use and gender on the dynamics of EKG time-series data. Alcohol Clin Exp Res 1999;23:745-50.
DePetrillo PB: Calcium-activated neutral protease activity is decreased in PC12 cells after ethanol exposure. J Neurochem 1997;68:1863-9.
Eckardt MJ, Rohrbaugh JW, Stapleton JM, Davis EZ, Martin PR, Weingartner HJ: Attention-related brain potential and cognition in alcoholism-associated organic brain disorders. Biol Psychiatry. 1996;39:143-6.
Eskay RL, Hamelink C, Martineau M, Torda M: Alcohol-induced activation of the stress axis and neurodegeneration in the hippocampal-entorhinal cortex circuit. ASAM, State of the Art Addiction Medicine Conference Proceedings (in press).
Eskay RL, Chautard T, Torda T, Daoud RI, Hamelink C. Alcohol, corticosteroids, energy utilization and hippocampal endangerment. Ann NY Acad Sci. 1995;771:105-14.
Fahlke C, Lorenz JG, Long J, Champoux M, Suomi SJ, Higley JD: Rearing experiences and stress-induced plasma cortisol as early risk factors for excessive alcohol consumption in nonhuman primates. Alcohol Clin Exp Res 2000;24:644-50.
Foley TD: The lipid peroxidation product 4-hydroxynonenal potently and selectively inhibits synaptic plasma membrane ecto-ATPase activity, a putative regulator of synaptic ATP and adenosine. Neurochem Res 1999:24:1241-8.
Foley TD: 5-HPETE is a potent inhibitor of neuronal Na+, K+-ATPase activity. Biomed Biophys Res Comm 1997;235:374-6.
Foley TD, Linnoila M: Nanomolar concentrations of ouabain block ethanol-inducible Na+,K(+)-ATPase activity in brain. Eur J Pharmacol. 1995;292(3-4):287-92.
George D, Umhau J, Phillips M, Emmela D, Ragan P, Shoaf S, Rawlings R. Serotonin, testosterone and alcohol in the etiology of domestic violence. Psychiatry Research
2001;104:27-37. pdf
George DT, Hibbeln JR, Ragan PW, Umhau JC, Phillips MJ, Doty L, Hommer D, Rawlings RR: Lactate-induced rage and panic in a select group of subjects who perpetrate acts of domestic violence. Biol Psychiatry 2000;47:804-12. pdf
George DT, Rawlings R, Eckardt MJ, Phillips MJ, Shoaf SE, Linnoila M. Buspirone treatment of alcoholism: age of onset, and cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid concentrations, but not medication treatment, predict return to drinking. Alcohol Clin Exp Res. 1999;23:272-8.
George DT, Benkelfat C, Rawlings R, Eckardt M, Phillips MJ, Nutt DJ, Wynne D, Murphy D, Linnoila M: Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects. Am J Psychiatry 1997;154:81-7.
George DT, Lindquist T, Ragan PW, Alim T, Eckardt MJ, Linnoila M: Effect of alcoholism on the incidence of lactate-induced panic attacks. Biol Psychiatry. 1997;42(11):992-9.
George DT, Nutt DJ, Rawlings RR, Phillips MJ, Eckardt MJ, Potter WZ, Linnoila M: Behavioral and endocrine responses to clomipramine in panic disorder patients with or without alcoholism. Biol Psychiatry. 1995;37(2):112-9.
George DT, Rawlings R, Eckardt MJ, Phillips MJ, Shoaf SE, Linnoila M: Buspirone treatment of alcoholism: age of onset, and cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid concentrations, but not medication treatment, predict return to drinking. Alcohol Clin Exp Res 1999;23(2):272-8.
Gerald MS, Higley JD. Evolutionary underpinnings of excessive alcohol consumption.
Addiction. 2002;97:415-25. Review.
Ghirardelli TG, Egeth HE: Goal-directed and stimulus-driven attention in cross-dimensional texture segregation. Percept Psychophys 1998;60(5):826-38.
Gould TD, Bastain TM, Israel ME, Hommer D, Castellanos FX. Altered performance on an ocular fixation task in attention-deficit/hyperactivity disorder. Biol Psychiatry 2001;50:633-5. pdf
Grasing K, Murphy G, Lin J, Swigar M, Freedholm D, Clark L, Wolkowitz O, Weingartner H: Human pharmacokinetics and tolerability of L-365,260, a novel cholecystokinin-ß-antagonist. J Clin Pharmacol 1996;36(4):292-300.
Gurguis GN, Turkka J, Laruelle M, Kleinman J, Linnoila M: Coupling efficiency of brain beta-adrenergic receptors to Gs protein in suicide, alcoholism and control subjects. Psychopharmacology (Berl) 1999;145:31-8.
Gurguis GN, Turkka J, Linnoila M: Effects of serotonin and metergoline on (125)[I]-iodocyanopindolol binding parameters to beta-adrenergic receptors in rat brain. Eur Neuropsychopharm 1998;8(2):131-40.
Gurguis G, Turkka J, George D, Linnoila M: ß-Adrenoreceptor coupling to GS protein in alcohol dependence, panic disorder and patients with both disorders. Neuropsychopharmacology 1997;16:69-76.
Habash T, Eskay R, Kuenzel W, Castonguay T. Interactions of glucocorticoids, NPY and hypothalamic serotonin. Nutritional Neuroscience 2000;3:183-192.
Habash T, Eskay R, Kuenzel W, Castonguay T. Interactions of glucocorticoids, NPY and hypothalamic serotonin. Nutritional Neuroscience 2000;3:183-192.
Habib KE, Higley JD, Rice KC, Cai J, Listwak SJ, Chrousos GP, Suomi SJ, Gold PW, Gold PW. CRH type-1 receptor antagonism attenuates behavioral, endocrine and autonomic responses to stress in primates. Hormones, Brain & Neuropsychopharmacol. 2000;2:119.
Habib KE, Listwak SJ, Cai J, Negrao A, Pushkas JG, Schulkin J, Cizza G, Champoux M, Chrousos GP, Suomi SJ, Higley JD, Gold PW. Sensitization of cerebrospinal fluid corticotropin-releasing hormone (CRH) with frequent exposure to psychosocial stress in infant primates. Endocrine Society 82nd Annual Meeting, Toronto, Canada 2000;82:238.
Habib KE, Listwak SJ, Negro PJ, Pushkas JG, Champoux M, Schulkin J, Chrousos GP, Suomi SJ, Higley JD, Gold PW, Gold PW. Dissociation of Cerebrospinal Fluid (CSF) Corticotropin-Releasing Hormone (CRH) and the Hypothalamic-Pituitary-Adrenal Axis (HPA) During the Process of Learning in Primates. Endocrine Society 82nd Annual Meeting, Toronto, Canada 2000;82:281.
Habib KE, Pushkas JG, Champoux M, Weld KP, Schulkin J, Chrousos GP, Suomi SJ, Higley JD, Gold PW, Rice KC. Sensitization of brain CRH after stress, abuse and emotional deprivation. Soc. Neurosci. Abstr. 2000;26:2023.
Habib KE, Weld KP, Rice KC, Pushkas J, Champoux M, Listwak S, Webster EL, Atkinson AJ, Schulkin J, Contoreggi C, Chrousos GP, McCann SM, Suomi SJ, Higley JD, Gold PW. Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc Natl Acad Sci U S A 2000;97:6079-84.
Hall FS, Devries AC, Fong GW, Huang S, Pert A: Effects of 5,7-dihydroxytryptamine depletion of tissue serotonin levels on extracellular serotonin in the striatum assessed with in vivo microdialysis: relationship to behavior. Synapse 1999;33:16-25.
Hall FS, Huang S, Fong GW, Pert A, Linnoila M: Effects of isolation-rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats. Psychopharmacology (Berl). 1998t;139(3):203-9.
Hall FS, Huang S, Fong GW, Pert A, Linnoila M: Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn Hooded and Wistar rats. Psychopharmacology (Berl). 1998; 139(3):210-6.
Hall FS, Huang S, Fong GF, Pert A: The effects of social isolation on the forced swim test in Fawn hooded and Wistar rats. J Neurosci Methods. 1998;79(1):47-51.
Hall FS: Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences. Crit Rev Neurobiol. 1998;12(1-2):129-62. Review.
Hall FS, Huang S, Fong G, Linnoila M: The effects of isolation-rearing on acoustic startle and pre-pulse inhibition in Wistar and Fawn hooded rats. Ann NY Acad Sci 1997;821:542-4.
Hall FS, Wilkinson LS, Humby T, et al.: Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacol Biochem Behav 1998;59(4):859-72.
Hall FS, Wilkinson LS, Humby T, et al.: Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacol Biochem Behav 1998;59(4):859-72.
Hall FS, Humby T, Wilkinson LS, et al.: The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiol Behav 1997;62(2):281-90.
Hall FS, Humby T, Wilkinson LS, et al.: The effects of isolation-rearing on sucrose consumption in rats. Physiol Behav 1997;62(2):291-7.
Hall FS, Humby T, Wilkinson LS, et al.: The effects of isolation-rearing on preference by rats for a novel environment. Physiol Behav 1997;62(2):299-303.
- Han L, Nielsen DA, Rosenthal NE, Jefferson K, Kaye W, Murphy D, Altemus M, Humphries J, Cassano G, Rotondo A, Virkkunen M, Linnoila M, Goldman D: No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biol Psychiatry 1999;45:615-9.
Harbluk JL, Weingartner HJ: Memory distortions in detoxified alcoholics. Brain Cognition 1997;35(3):328-30.
Heishman SJ, Weingartner HJ, Henningfield JE: Selective deficits in reflective cognition of polydrug abusers: Preliminary findings. Psychology of Addictive Behaviors 1999;13:227-31.
Heinz A, Goldman D, Jones DW, Palmour R, Hommer D, Gorey JG, Lee KS, Linnoila M, Weinberger DR. Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 2000;22:133-9.
Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, Linnoila M, Weinberger DR. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 2000;47:643-9.
Heinz A, Weingartner H, George D, Hommer D, Wolkowitz OM, Linnoila M: Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations. Psychiatry Res 1999;89:97-106.
Heinz A, Higley JD, Gorey JG, et al: In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. Am J Psychiatry 1998;155(8):1023-8.
Heinz A, Ragan P, Jones DW, Hommer D, Williams W, Knable MB, Gorey J, Dotyl L, Geyer C, Lee KS, Coppola R, Weinberger DR, Linnoila M: Reduced central serotonin transporters in alcoholism. Am J Psychiatry 1998;155(11):1544-9.
Hibbeln JR, Umhau JC, George DT, Shoaf SE, Linnoila M, Salem N Jr: Plasma total cholesterol concentrations do not predict cerebrospinal fluid neurotransmitter metabolites: implications for the biophysical role of highly unsaturated fatty acids. Am J Clin Nutr 2000;71:331S-8S.
Higley J. Individual differences in alcohol-induced aggression: A nonhuman primate model. Alcohol Research & Health 2001;25:12-9.
Higley JD, Bennett AJ: Central nervous system serotonin and personality as variables contributing to excessive alcohol consumption in non-human primates. Alcohol Alcohol 1999;34(3):402-18.
Higley JD, Hommer D, Lucas K, Shoaf S, Suomi SJ, Linnoila M: CNS serotonin turnover rate predicts innate tolerance, high alcohol consumption, and aggression during intoxication among rhesus monkeys. Am J Psychiatry (in press).
Higley JD, Suomi SF, Linnoila M. Progress toward developing a nonhuman primate model of alcohol abuse and alcoholism. Soc Sci Med (in press).
Higley JD, Suomi SJ, Linnoila M: Genetic and environmental influences on CSF 5-HIAA concentrations: Recent developments in suicide research. NY Acad Sci (in press).
Higley JD, Hasert MS, Suomi SJ, Linnoila M: The serotonin reuptake inhibitor sertraline reduces excessive alcohol consumption in nonhuman primates. Neuropsycho-pharmacology 1998;18(6):431-43.
Higley JD, Linnoila M: Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission. Ann N Y Acad Sci. 1997;836:39-56. Review.
Higley JD, Mehlman PT, Poland RE, Taub DT, Suomi SJ, Linnoila M: Aggression, social dominance, serotonin, and causal relationships. Biol Psychiatry 1997;42:306-7.
Higley JD, Linnoila M: A nonhuman primate model of excessive alcohol intake: personality and neurobiological parallels of type I- and type II-like alcoholism. In: Galanter M (ed). Recent Developments in Alcoholism. New York:Plenum: 1997, pp 191-219.
Higley JD, Suomi SJ, Linnoila M: Excessive alcohol consumption, inappropriate aggression, and serotonin: A nonhuman primate model of alcohol abuse. Recent Dev Alcohol 1997;13:191-219.
Higley JD: Juvenile primate behavior: Diversity, development, and evolutionary underpinnings. Am J Primatol 1996;37:77-82.
Higley JD, Suomi SJ, Linnoila M: A nonhuman primate model of Type II alcoholism? Part 2: Diminished social competence and excessive aggression correlates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Alcohol Clin Exp Res 1996;20:643-50.
Higley JD, Suomi SJ, Linnoila M: A nonhuman primate model of Type II excessive alcohol consumption? Part 1: Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption. Alcohol Clin Exp Res 1996;20:629-42.
Higley JD: Use of nonhuman primates in alcohol research. Alcohol, Health & Research World 1996;19:213-6.
Higley JD, Mehlman PT, Taub DT, Higley SB, Fernald B, Vickers J, Suomi SJ, Linnoila M: Excessive mortality in young male nonhuman primates with low CSF 5-HIAA concentrations. Arch Gen Psychiatry 1996;53:537-543.
Higley JD, Mehlman PT, Poland RE, Faucher I, Taub DT, Vickers J, Suomi SJ, Linnoila M: A nonhuman primate model of violence and assertiveness: CSF 5-HIAA and CSF testosterone correlate with different types of aggressive behaviors. Biol Psychiatry 1996;40:1067-82.
Higley JD, Suomi SF: Effect of reactivity and social competence on individual responses to severe stress in children: Investigations using nonhuman primates. In: Pfeffer CR (ed). Intense Stress and Mental Disturbance in Children. New York:APP:1996, pp 3-57.
Higley JD, King ST, Hasert MF, Champoux M, Suomi SJ, Linnoila M: Stability of interindividual differences in serotonin function and its relationship to aggressive wounding and competent social behavior in rhesus macaque females. Neuropsychopharmacology 1996;14:67-76.
Hommer D, Momenan R, Kaiser E, Rawlings R. Evidence for a gender-related effect of alcoholism on brain volumes. Am J Psychiatry 2001;158:198-204. pdf
Hommer, DW. Functional imaging of craving. Alcohol Res Health. 1999;23:187-96. Review.
Hommer D, Andreason P, Rio D, Williams W, Ruttimann U, Momenan R, Zametkin A, Rawlings R, Linnoila M: Effects of m-Chlorophenylpiperazine on the regional brain glucose utilization: a positron emission tomographic comparison of alcoholics and control subjects. J Neurosci 1997;17(8):2796-806. pdf
Hommer D, Momenan R, Rawlings R, Ragan P, Williams W, Rio D, Eckardt M: Decreased corpus callosum size among alcoholic women. Arch Neurol. 1996;53(4):359-63.
Hristova E, Rehak N, Cecco S, Ruddel, Herion D, Eckardt M, Linnoila M, Elin R: Serum ionized magnesium in chronic alcoholism: is it really decreased? Clin Chem. 1997;43:394-9.
Kamara K, Eskay R, Castonguay T: High fat diets and stress responsivity. Physiol Behav. 1998;64(1):1-6.
Kapcala L, Chautard T, Eskay RL. The protective role of the hypothalamic pituitary-adrenal axis against lethality produced by immune, infectious and inflammatory stress. Ann NY Acad Sci 1995;771:419-37. Review.
Kittles RA, Bergen AW, Urbanek M, Virkkunen M, Linnoila M, Goldman D, Long JC: Autosomal, mitochondrial, and Y chromosome DNA variation in Finland: evidence for a male-specific bottleneck. Am J Phys Anthropol 1999;108:381-99. pdf
Kittles RA, Long JC, Bergen AW, Eggert M, Virkkunen M, Linnoila M, Goldman D: Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits. Proc Natl Acad Sci U S A 1999;96:4204-9. pdf
Knutson B, Adams CM, Fong GW, Hommer D. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 2001;21:RC159. pdf
Knutson B, Fong GW, Adams CM, Varner JL, Hommer D. Dissociation of reward anticipation and outcome with event-related fMRI. Neuroreport 2001;12:3683-7. pdf
Knutson B, Momenan R, Rawlings RR, Fong GW, Hommer D. Negative association of neuroticism with brain volume ratio in healthy humans. Biol Psychiatry 2001;50:685-90. pdf
Knutson B, Westdorp A, Kaiser E, Hommer D. FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage. 2000 Jul;12(1):20-7. pdf
Knutson B, Burgdorf J, Panksepp J: High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats. Physiol Behav 1999 Jun;66:639-43.
Knutson B, Burgdorf J, Panksepp J: Anticipation of play elicits high-frequency ultrasonic vocalizations in young rats. J Comp Psychol 1998;112:65-73.
Knutson B, Wolkowitz OM, Cole SW, et al.: Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 1998;55:373-9.
Knutson B, Cole S, Wolkowitz O, Reus V, Chan T, Moore E: Serotonergic intervention increases affiliative behavior in humans. Ann NY Acad Sci 1998;807:492-3.
Knutson B, Panksepp J: Effects of serotonin depletion on the play of juvenile rats. Ann NY Acad Sci 1997;807:475-7.
Karimullah K, George DT, DePetrillo PB 2001. The time-course of electrocardiographic interbeat interval dynamics in alcoholic subjects after short-term abstinence. Eur J Pharmacol. 2001;427:227-233. pdf
Knutson B, Burgdorf J, Panksepp J: High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats. Physiol Behav 1999 Jun;66(4):639-43.
Knutson B, Burgdorf J, Panksepp J: Anticipation of play elicits high-frequency ultrasonic vocalizations in young rats. J Comp Psychol 1998;112(1):65-73.
Knutson B, Cole S, Wolkowitz O, Reus V, Chan T, Moore E: Serotonergic intervention increases affiliative behavior in humans. Ann NY Acad Sci 1998;807:492-3.
Knutson B, Wolkowitz OM, Cole SW, et al.: Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 1998;55(3):373-9.
Knutson B, Panksepp J: Effects of serotonin depletion on the play of juvenile rats. Ann NY Acad Sci 1997;807:475-7.
Kumra S, Sporn A, Hommer DW, Nicolson R, Thaker G, Israel E, Lenane M, Bedwell J, Jacobsen LK, Gochman P, Rapoport JL. Smooth pursuit eye-tracking impairment in childhood-onset psychotic disorders. Am J Psychiatry 2001;158:1291-8.
Lappalainen J, Long JC, Virkkunen M, Ozaki N, Goldman D, Linnoila M: HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses. Biol Psychiatry 1999;46:821-6.
Lilly AA, Mehlman PT, Higley JD: Trait-like immunological and hematological measures in female rhesus across varied environmental conditions. American Journal of Primatology 1999;48:197-223.
Lombardi WJ, Andreason PJ, Sirocco KY, Rio DE, Gross RE, Umhau JC, Hommer DW: Wisconsin card sorting test performance following head injury: dorsolateral fronto-striatal circuit activity predicts perseveration. J Clin Exp Neuropsychol 1999;21:2-16.
Linnoila M: On the psychobiology of antisocial behavior. In: Stoff DM, Breiling J, Maser J (eds). Handbook on Antisocial Behavior. New York:Wiley:1997, pp. 336-40.
Linnoila M, Higley JD, Virkkunen M: Serotonin, impulse control and alcoholism. In: Montgomery SA, Briley M (eds). Antidepressant Therapy at the Dawn of the 3Rd Millennium (in press).
Linnoila M, Virkkunen M, Tokola R, Nielsen D, Goldman D: Alcoholic violent offenders: Behavioral, endocrine, diurnal rhythm and genetic correlates of low CSF 5-HIAA concentrations. In: Paoletti R, Vanhouttem P, Saxena P (eds). Serotonin from Cell Biology to Pharmacology and Therapeutics. Milan:Kluwer (in press).
Little JT, Johnson D, Minichiello M, Weingartner HJ: Combined nicotinic and muscarinic blockade in elderly normal volunteers: cognitive, behavioral, and physiological responses. Neuropsychopharmacology 1998;19(1):60-9.
Lombardi WJ, Andreason PJ, Sirocco KY, Rio DE, Gross RE, Umhau JC, Hommer DW: Wisconsin card sorting test performance following head injury:dorsolateral fronto-striatal circuit activity predicts perseveration. J Clin Exp Neuropsychol 1999 Feb;21(1):2-16.
Lombardi WJ; Sirocco, KY; Andreason, PJ; George, DT: Effects of triazolam and ethanol on proactive interference: Evidence for an impairment in retrieval inhibition. J Clin Exp Neuropsychology 1997;19(5):698-712.
Maki PM, Zonderman AB, Weingartner H: Age differences in implicit memory: Fragmented object identification and category exemplar generation. Psychology and Aging 1999;14:284-94.
Mann K, Agartz I, Harper C, Shoaf S, Rawlings RR, Momenan R, Hommer DW, Pfefferbaum A, Sullivan EV, Anton RF, Drobes DJ, George MS, Bares R, Machulla HJ, Mundle G, Reimold M, Heinz A. Neuroimaging in alcoholism ethanol and brain damage. Alcohol Clin Exp Res 2001;25:104S-109S.
Martinez R, Molchan SE, Lawlor B, Thompson K, Martinson H, Latham G, Weingartner HJ, Sunderland T: Minimal effects of dextroamphetamine on scoplomaine-induced cognitive impairments in humans. Biol Psychiatry 1997;41:50-7.
Mehlman P, Westergaard G, Hoos B, Sallee F, Marsh S, Suomi SJ, Linnoila M, Higley J. CSF 5-HIAA and nighttime activity in free-ranging primates. Neuropsychopharmacology 2000;22:210-218.
Mehlman PT, Higley JD, Fernald BJ, Sallee FR, Suomi SJ, Linnoila M: CSF 5-HIAA, testosterone, and sociosexual behaviors in free-ranging male rhesus macaques in the mating season. Psychiatry Res 1997;72(2):89-102.
Mele A, Wozniak KM, Hall FS, et al.: The role of striatal dopaminergic mechanisms in rotational behavior induced by phencyclidine and phencyclidine-like drugs. Psychopharmacology 1998;135(2):107-18.
Momenan R, Hommer D, Rawlings R, Ruttimann U, Kehrich M, Rio D: Intensity adaptive segmentation of single echo T1-weighted magnetic resonance images. Human Brain Mapping 1997;5:194-205.
Murphy DL, Sims K, Eisenhofer G, Greenberg BD, George T, Berlin F, Zametkin A, Ernst M, Breakefield XO: Are MAO-A deficiency states in the general population and in putative high-risk populations highly uncommon? J Neural Transm 1998;Supp (52):29-38.
Nicolson R, Lenane M, Singaracharlu S, Malaspina D, Giedd JN, Hamburger SD, Gochman P, Bedwell J, Thaker GK, Fernandez T, Wudarsky M, Hommer DW, Rapoport JL. Premorbid speech and language impairments in childhood-onset schizophrenia: association with risk factors. Am J Psychiatry 2000;157:794-800.
Repo E, Virkkunen M, Rawlings R, Linnoila M: Suicidal behavior among Finnish fire setters. Eur Arch Psychiatry Clin Neurosci 1997;247(6):303-7.
Repo E, Virkkunen M, Rawlings R, Linnoila M:Criminal and psychiatric histories of Finnish arsonists. Acta Psychiatr Scand 1997;95:318-23.
Rissanen A, Naukkarinen H, Virkkunen M, Rawlings RR and Linnoila M: Fluoxetine normalizes increased cardiac vagal tone in bulimia nervosa. J Clin Psychopharmacol 1998;18(1):26-32.
Roberts BJ: Evidence of proteosome-mediated cytochrome P-450 degradation. J Biol Chem 1997;272:9771-8.
Rackoff J, Yang Q, DePetrillo PB 2001. Inhibition of rat PC12 cell calpain activity by glutathione, oxidized glutathione and nitric oxide. Neurosci Lett. 2001; 311:129-32. pdf
Ruttimann UE, Unser M, Rawlings RR, Rio D, Ramsey NF, Mattay VS, Hommer DW, Frank JA, Weinberger DR: Statistical analysis of functional MRI data in the wavelet domain. IEEE Trans Med Imaging. 1998;17(2):142-54.
Ruttimann UE, Patel KM, Pollack MM: Length of stay and efficiency in pediatric intensive care units. J Pediatr 1998;133(1):79-85.
Ruttimann UE, Ramsey NF, Hommer DW, Thevenaz P, Lee CH, Unser M. Analysis of functional magnetic resonance images by wavelet decomposition. IEEE Proceedings ICIP-95 1995;1: 633-6.
Ruttimann UE, Rio DE, Rawlings RR, Andreason P, Hommer DW: PET analysis using a variance stabilizing transom. In: Carson RE, Daube-Witherspoon ME, Herscovitch P (eds), Quantitative Functional Brain Imaging with Positron Emission Tomography. San Diego:Academic Press, 1998.
Ruttimann UE, Unser M, Rio DE: Statistical analysis of image differences by wavelet decomposition. In: Aldroubi A, Under M (eds). Wavelets in Biology and Medicine. Boca Raton:CRC Press:1996, 115-44.
Shoaf SE, Carson RE, Hommer D, Williams WA, Higley JD, Schmall B, Herscovitch P, Eckelman WC, Linnoila M. The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: studies with dual administration of [11C] and [14C] labeled tracer. J Cereb Blood Flow Metab 2000;20:244-52.
Shoaf SE, Carson R, Hommer D, Williams W, Higley JD, Schmall B, Herscovitch P, Eckelman W, Linnoila M: Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations. Neuropsychopharmacology. 1998;19(5):345-53.
Shoaf SE, Carson RE, Hommer D, Williams WA, Higley JD, Schmall B, Herscovitch P, Eckelman WC, Linnoila M: The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: studies with dual administration of [11C] and [14C] labeled tracer. J Cereb Blood Flow Metab 2000;20:244-52.
Shoaf SC, Hommer D, Williams W, Higley JD, Carson R, Herscovitch P, Eckelman W: The validity of the PET/alpha-[C-11]methyl-L-tryptophan method for measuring rates of serotonin synthesis in the human brain. Neuropsychopharmacology (Letter) 1999:21:156-7.
Shoaf SE: Pharmacokinetics of intravenous alcohol: two compartment, dual Michaelis-Menten elimination. Alcohol Clin Exp Res 2000;24:424-5.
Slonim AD, Patel KM, Ruttimann UE, Pollack MM: The impact of prematurity: a perspective of pediatric intensive care units. Crit Care Med 2000;28:848-53.
Sunderland T, Lawlor BA, Grafman J, Molchan SE, Thompson KE, Weingartner HJ: Memory impairments in Alzheimer’s disease: Clinical use of the Wechsler Memory Scale. In: Howe ML, Stone MJ, Brainerd CJ (eds.), Cognitive and Behavioral Performance Factors in Atypical Aging. New York, Springer-Verlag (in press).
Sunderland T, Molchan SE, Little JT, Bahro M, Putnam KT, Weingartner H: Pharmacologic challenges in Alzheimer disease and normal controls: Cognitive modeling in humans. Alzheimer Disease & Associated Disorders 1997;11(4):S23-6.
Sunderland T, Molchan S, Martinez R, Vitiello B, Putnam K, Martin A, Weingartner HJ. Functional cholinergic receptor sensitivity: the role of drug probes, pharmacological basis of cholinergic therapy in Alzheimer's disease. Biol Psychiatry (in press).
Szostak C, Lister RG, Weingartner H. Implicit memory functions in depression. Biol Psychiatry (in press).
Thevenaz P, Ruttimann UE, Unser M: A pyramid approach to subpixel registration based on intensity. IEEE Transactions on Image Processing 1998;7(1):27-41.
Tsai GCE, Ragan P, Chang R, et al: Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal. Am J Psychiatry 1998;155(6):726-32.
Umhau J, George D, Reed S, Petrulis S, Rawlings R, Porges S . Atypical autonomic regulation in perpetrators of violent domestic abuse. Psychophysiology 2001, in press.
Unser M, Thevenaz P, Lee C, Ruttimann UE: Registration and statistical analysis of PET images using the wavelet transform. IEEE Eng Med Biol Mag 1995;14:603-11.
Virkkunen M, Linnoila M: Serotonin in early-onset alcoholism. In: Recent Developments in Alcoholism (Vol 13). Galanter M (ed). New York:Plenum:1997, pp. 173-90.
Vivian JA, Highley JD, Linnoila M, Woods JH: Oral ethanol self-administration in rhesus monkeys: Behavioral and neurochemical correlates. Alcoholism-Clinical and Experimental Research 1999;23:1352-61.
Vivian JA, Liang YJ, Highley JD, Linnoila M, Woods JH: Oral self-administration of ethanol, phencyclidine, methadone, pentobarbital and quinine in rhesus monkeys. Psychopharmacology 1999;147:113-24.
Wan W, DePetrillo PB. Ritonavir inhibition of calcium-activated neutral proteases.
Biochem Pharmacol. 2002;63:1481-4. pdf
Weingartner HJ, Rawlings R, George DT, Eckardt M: Triazolam-induced changes in alcoholic thought processes. Psychopharmacology (Berl). 1998;138:311-7. pdf
Weingartner HJ: Evaluating the cognitive response to drug treatments in cognitive function measures: applications in patient studies. In: Eldin M, Fleishaker J, Garzone P (eds). Pharmacodynamics and Pharmacokinetics: Drug Treatments of Memory Impairments. Cincinnati:Witney (in press).
Weingartner HJ: Experiencing the Holocaust: a cognitive perspective. In: Suedfeld P (ed). Light from the Ashes: How Surviving the Holocaust Affected the Life and Research of Social Scientists (in press).
Weingartner HJ, Rawlings R, George DT, Eckardt M: Halcion-induced changes in alcoholic thought processes. Psychopharmacology (in press).
Weingartner HJ, Andreason PJ, Hommer DW, Sirocco KY, Rio DE, Ruttimann UE, Rawlings RR, Eckardt MJ: Monitoring the source of memory in detoxified alcoholics. Biol Psychiatry. 1996;40(1):43-53.
Weingartner HJ, Sirocco K, Rawlings R, Joyce E, Hommer D: Dissociations in the expression of the sedative effects of triazolam. Psychopharmacology (Berl). 1995;119(1):27-33.
Weld KP, Mench JA, Woodward RA, Bolesta MS, Suomi SJ, Higley JD: Effect of tryptophan treatment on self-biting and central nervous system serotonin metabolism in rhesus monkeys (Macaca mulatta). Neuropsychopharmacology. 1998;19(4):314-21.
Westergaard GC, Lussier ID, Higley JD. Between-species variation in the development of hand preference among macaques. Neuropsychologia 2001;39:1373-8.
Westergaard GC, Lussier ID, Suomi SJ, Higley JD. Stress correlates of hand preference in rhesus macaques. Dev Psychobiol 2001;38:110-5.
Westergaard GC, Chavanne TJ, Lussier ID, Suomi SJ, Higley JD. Hormonal correlates of hand preference in free-ranging primates. Neuropsychopharmacology 2000;23:502-7.
Westergaard GC, Isard MK, Drake JH, Suomi SJ, Highley JD: Rhesus macaque (Macaca mulatta) group formation and housing: Wounding and reproduction in a specific pathogen free (SPF) colony. American Journal of Primatology 1999;49:339-47.
Westergaard GC, Suomi SJ, Highley JD, Mehlman PT: CSF5-HIAAA and aggression in female macaque monkeys: species and interindividual differences. Psychopharmacology 1999; 146:440-6.
Williams WA, Shoaf SE, Hommer D, Rawlings R, Linnoila M: Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers. J Neurochem 1999;72:1641-7.
Wolkowitz OM, Reus VI, Roberts E, Chan T, Raum WJ, Ormiston S, Johnson R, Canick J, Brizendine L, Weingartner HJ: Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry 1997;41(3):311-8.
Wolkowitz OM, Reus VI, Roberts E, Manfredi F, Chan T, Ormiston S, Johnson R, Canick J, Brizendine L, Weingartner HJ: Antidepressant and cognition-enhancing effects of DHEA in major depression. Ann NY Acad Sci 1995;774:337-40.
Ye FQ, Yang Y, Duyn J, Mattay VS, Frank JA, Weinberger DR, McLaughlin AC: Quantitation of regional cerebral blood flow increases during motor activation: A multislice, steady-state, arterial spin tagging study. Magn Reson Med 1999;42(2):404-7
Ye FQ, Smith AM, Mattay VS, Ruttimann UE, Frank JA, Weinberger DR, McLaughlin AC: Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: A steady-state arterial spin-tagging study (Part 2). Neuroimage 1998;8(1):44-9.
Ye FQ, Smith AM, Yang Y, Duyn J, Mattay VS, Ruttimann UE, Frank JA, Weinberger DR, McLaughlin AC: Quantitation of regional cerebral blood flow increases during motor activation: a steady-state arterial spin tagging study. Neuroimage 1997;6:104-12.
Zajicek KB, Price CS, Shoaf SE, Mehlman PT, Suomi SJ, Linnoila M, Higley JD . Seasonal variation in CSF 5-HIAA concentrations in male rhesus macaques. Neuropsychopharmacology 2000;22:240-50. pdf
Zajicek K, Higley JD, Suomi SJ, Linnoila M: Rhesus macaques with high CSF 5-HIAA concentrations exhibit early sleep onset. Psychiatry Res. 1997;73(1-2):15-25.
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