|
National Institutes of Health |
 |
 |
 |
 |
 |
 |
 |
|
|
|
Quick Links
|
PennsylvaniaClinical Research Resources Links ON THIS PAGE: Pennsylvania State University General Clinical Research Center Grant No. M01 RR10733 Special Assays, Services, or Tests Cytokine analyses Major Areas of InvestigationCardiovascular Metabolic Responses: Cardiovascular physiology and metabolic responses to congestive heart failure; pathophysiology of heart failure and the metabolic and neural control of sympathetic responses; normal physiology of the sympathetic nervous system; metabolic adaptations of the system to congestive heart failure and bedrest; impact of sex steroids on cardiovascular metabolic responses. Diabetes and Metabolism: Mechanisms of human insulin resistance in non-insulin-dependent diabetes mellitus and polycystic ovary syndrome; pathogenesis and treatment of diabetic retinopathy; posture and gait studies in the neuropathic diabetic elderly. Dermatology: Determination of mechanisms that regulate sebum production in order to identify target sites for alternative treatments for acne. Microdialysis: Measurement and quantification of compounds in interstitial space. The method, based on the principle of diffusion through a semipermeable membrane, allows investigation of discrete local tissue function directly at the cellular level. The microdialysis technique is well suited for research involving metabolism, endocrinology, toxicology, pharmacology, drug delivery, and neurotransmission. Pulmonary Medicine: Sleep apnea; allergies; respiratory distress syndrome. Sleep-Related Metabolic Responses: Sympathetic nervous system function and cardiac metabolic responses to obstructive sleep apnea; mechanisms of disorders of nocturnal respiration associated with the metabolic alkalosis of congestive heart failure; metabolic effects of exercise on sleep in insomniacs and the effects of benzodiazepines on the sympathetic nervous system and hypothalamic-pituitary-adrenal function in sleep disorders. Women's Health: Bone acquisition and density with calcium supplementation in teenage girls; relationship of bone density in mothers and teenage daughters; relationships of dietary caffeine, calcium intake, and bone density of postmenopausal women and infertility. Contact InformationFor information about this GCRC and how to access its resources, please contact: Administrative Manager Program Director Principal Investigator Associate Program Director Associate Program Director Research Subject Advocate GCRC Advisory Committee Chairperson Nurse Manager Core Laboratory Director— Microdialysis Core Laboratory Director—Immunomodulation Biostatistician Computer Systems Manager Pennsylvania State University General Clinical Research Center Satellite Grant No. M01 RR10732 Special Services, Tests, and Equipment Cytokine analyses Major Areas of InvestigationAdaptation to Physiological and Environmental Stresses: Human adaptation to different physiological and environmental stresses; dietary supplementation; application of information in chronic inflammatory diseases as well as age-related declines in immune functions. Environmental Physiology: Acute and chronic mechanisms of adaptation to heat, cold, and altitude; specifically, work has involved a systematic investigation of the effects of age, fitness, and gender on human thermoregulation and physiological effector responses to heat stress. Of primary interest is sweating and skin blood flow effector responses and their basic control mechanism, control of vascular fluid volume and hydration, and acclimation-related interactions. Immunomodulation Core Lab: This laboratory, located at the University Park facility, has the capability of assaying blood and other specimens. ELISAs are used to measure IL-B, IL-6, and tumor necrosis factor in biological fluids. The staff of the core laboratories provide training in a wide variety of laboratory methods to students, fellows, and faculty. Nutrition: Controlled feeding, nutrition counseling, and computerized diet record analyses. Study areas include the impact of nutrition on diabetes mellitus, obesity, anorexia, cancer, and the cardiovascular system; psychological and physiological controls of food intake and selection in normal weight and obese humans across the life span; nutritional strategies for weight management; food preference in children and regulation of food intake in children. Contact InformationFor information about this satellite and how to access its resources, please contact: Administrative Manager Assistant Administrative Manager Program Director Associate Program Director Research Subject Advocate Nurse Coordinator Core Laboratory Director—Microdialysis Core Laboratory Director—Immunomodulation Nutrition Research Manager Biostatistician Computer Systems Manager |
 |
National Institutes of Health (NIH) Bethesda, Maryland 20892 |
 |
Department of Health and Human Services |
 |
