Slide 10:
Recombinant DNA Technology and Vaccine Development
It is key to note that vaccines made with recombinant
DNA technology do not use whole virus in the manufacturing
process. The genes used to express the antigenic structure
of interest are modified and resynthesized in the final
product, so it is not possible for any of the vaccines
being tested to cause HIV infection. The other major
point to make is about the value of in vivo antigen
production referring back to the concepts illustrated
in slides 2, 3, and 4, and indicating that when the
vaccine antigen is made inside the cell, there is a
much more potent induction of the CD8+ T cell response,
thought to be associated with control of HIV infection.
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