Texas

Baylor College of Medicine–Children

General Clinical Research Center
Texas Children's Hospital
Mail Station I-3420
6621 Fannin Street
Houston, TX 77030

Web site: http://www.bcm.edu/pediatrics/index.cfm

Grant No. M01 RR00188

Special Assays, Services, or Tests

Metabolic balances
Neurodevelopmental assessments

Special Resources, Instruments, or Services

Dual-energy X-ray absorptiometry
GC/IR/MS
GC/MS
Gene vector core laboratory
Indirect calorimetry (hood and room)
Instruments and skills for evaluation of health care outcomes and health services delivery
Total-body electrical conductivity analyzer
Whole-body ⁴⁰K counter

Major Areas of Investigation

Allergy and Immunology: AIDS Clinical Trials Group: vertical transmission of AIDS; heart and lung complications; audiologic function; oral manifestations; severe combined immunodeficiency disorders; asthma.

Critical Care: Long-term outcomes of pediatric intensive care unit (PICU) patients; work of breathing and mechanically ventilated patients: gastric intramucosal pH and predictor of cardiac output in children on mechanical ventilation; protein intake and nitrogen balance in PICU patients on total parenteral nutrition.

Endocrinology: Metabolic role of hormones in pubertal growth; effects of hormones on calcium metabolism; studies in clinical disorders of hypopituitarism, Turner's syndrome, diabetes mellitus.

Gene Therapy: Hepatic gene transplantation; gene therapy for pediatric AIDS; urea cycle disorders gene therapy; thymidine kinase gene therapy in children with brain tumors.

Genetic Diseases: Urea cycle disorders; contiguous gene deletion syndromes (Smith-Magenis, Prader-Willi, DiGeorge, Angelmann, Potocki-Shaffer, and Williams syndromes, and Fabry disease).

Infectious Diseases: Maternal-infant cytomegalovirus; Norwalk virus vaccine.

Neonatal Nutrition: Gluconeogenesis in very-low-birthweight infants; Ca and P metabolism and skeletal mineralization; early feeding strategies and development in low-birthweight infants; sulfur amino acid metabolism in low-birthweight infants; quality of energy intake in low-birthweight infants; essential fatty acid metabolism in very-low-birthweight and term infants.

Neurology: Hereditary ataxias; Rett syndrome.

Oncology: Pharmacokinetics of chemotherapy in CNS tumors.

Surgery: Islet cell transplantation.

Contact Information

For information about this GCRC and how to access its resources, please contact:

University of Texas Medical Branch at Galveston

General Clinical Research Center
John Sealy Hospital
5th Floor, A and B Units
301 University Boulevard
Galveston, TX 77555-0264

Web site: http://utsouthwestern.edu/utsw/home/research/gcrc

Grant No. M01 RR00073

Special Resources, Instruments, or Services

Metabolic control unit
Radiation biophysics laboratory for body composition
Sleep study facility
Volunteer database

Major areas of Investigation

Cancer: Genetic susceptibility to environmental carcinogens; hyperthermia for treatment of advanced cancer.

Cardiopulmonary Disorders: Hypertension; diabetes and cardiovascular disorders; dilated cardiomyopathy and growth hormone; obstructive sleep apnea; warfarin metabolism.

Endocrinology: Insulin resistance, obesity, and diabetes mellitus; growth hormone, androgens, and muscle function in elderly; bone density and hormonal contraception; endocrine complications of closed head injury; endocrine effects of soy diets.

Gastroenterology: Hepatitis C; hepatic steatosis; gastrointestinal myoelectric activity and motility; virtual colonoscopy.

Genetics and Rare Diseases: Human porphyrias; angioneurotic edema; genetic polymorphisms and drug metabolism.

Geriatrics: Androgen deficiency in elderly men; exercise, nutrition, and muscle function in the elderly.

Infectious Diseases: Virologic and immunologic progression in HIV infection; therapies for HIV infection; aging and neuroimmune modulation of viral resistance; genetic and viral influences on otitis media in children; hepatitis C; emerging infectious diseases.

Metabolism: Protein, fat, and carbohydrate metabolism; metabolic effects of burns and stress; effects of nutrition, exercise, and aging on muscle; insulin resistance; bed rest and microgravity; response to bolus intravenous infusions.

Neurology: Hyperglycemia in ischemic stroke; sleep disorders after stroke.

Nutrition: Soy diets, the endocrine system, and breast cancer; differential metabolism of dietary fatty acids.

Space Medicine: Effects of bed rest and microgravity on bone, muscle, and drug metabolism.

Women's Health: Bone density and hormonal contraception; assessment of uterine contractility and cervical ripening to predict delivery; ovarian steroids; diet and risk for breast cancer; effectiveness of pap smear follow-up.

Wound Healing: Metabolic stress and treatment of burned children; childhood psychosocial development, rehabilitation, and sleep abnormalities after burns.

Contact Information

For information about this GCRC and how to access its resources, please contact: