Prepared for:

Agency for Healthcare Research and Quality

U.S. Department of Health and Human Services

540 Gaither Road

Rockville, MD 20850

www.ahrq.gov

Contract No. 290-97-0001, Task Order No. 06

Prepared by:

Southern California-RAND Evidence-based Practice Center, Santa Monica, California

Program Directors

Paul Shekelle, MD, PhD

Sally C. Morton, PhD

Project Directors

Mary Hardy, MD

Ian Coulter, PhD

Physician Reviewers

Jay Udani, MD

Myles Spar, MPH, MD

Karen Oda, MD

Programmer/Analyst

Lara K. Jungvig, BA

Statisticians

Wenli Tu, MS

Marika J. Suttorp, MS

Staff Assistants

Di Valentine, JD

Louis Ramirez, BA

Reference Librarian

Roberta Shanman, MLS

Editor

Sydne J. Newberry, PhD

AHRQ Publication No. 03-0043

July 2003

ISBN: 1-58763-090-7

ISSN: 1530-4396

U.S. Department of Health and Human Services

Tommy G. Thompson, Secretary

Office of Public Health and Science

Richard H. Carmona, M.D., M.P.H., F.A.C.S., Surgeon General of the United States

Agency for Healthcare Research and Quality

Carolyn M. Clancy, M.D., Director

This document is in the public domain and may be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders.

Suggested Citation:

Shekelle P, Morton S, Hardy M. Effect of Supplemental Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cardiovascular Disease. Evidence Report/Technology Assessment No. 83 (Prepared by Southern California-RAND Evidence-based Practice Center, under Contract No 290-97-0001). AHRQ Publication No. 03-E043. Rockville, MD: Agency for Healthcare Research and Quality. July 2003.

This report may be used, in whole or in part, as the basis for development of clinical practice guidelines and other quality enhancement tools, or a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

AHRQ is the lead Federal agency charged with supporting research designed to improve the quality of health care, reduce its cost, address patient safety and medical errors, and broaden access to essential services. AHRQ sponsors and conducts research that provides evidence-based information on health care outcomes; quality; and cost, use, and access. The information helps health care decisionmakerspatients and clinicians, health system leaders, and policymakersmake more informed decisions and improve the quality of health care services.