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OhioClinical Research Resources Links ON THIS PAGE: Children's Hospital Medical Center General Clinical Research Center Web site: www.cincinnatichildrens.org/gcrc Grant No. M01 RR08084 Special Assays, Services, or Tests Bone-specific alkaline phosphatase Nutrition services: Indirect calorimetry, anthropometry,
computerized dietary analysis Major Areas of InvestigationAllergy and Immunology: Allergen elimination diets and severity of asthma; effect of intravenous mepolizumab on the outcome and management of hypereosinophilic syndromes. Cardiology: Cardiovascular risk tracking study; blood pressure divergence in adolescent females; vitamin E intake and oxidized low-density lipoprotein; effect of pre-operative methylprednisolone on inflammatory response following cardiopulmonary bypass; body mass index rebound epidemiology; genetic epidemiology of energy metabolism; neurohormonal activation in single ventricular physiology. Critical Care Medicine: Adrenal dysfunction in children with septic shock; nitric oxide in infants with respiratory failure. Developmental Disorders: Human synthetic secretin in children with autism; effect of oral baclofen on function in cerebral palsy. Endocrinology: Glucagon-like peptide-1 in diabetic and nondiabetic humans, including effects on insulin secretion; mechanisms and implications of discordant hemoglobin A1c; rhIGF-1 in children with short stature and growth hormone insensitivity syndrome; coronary atherosclerosis in early insulin-dependent diabetes mellitus; sulfonylurea therapy in patients with mutations in the Delta F508 CF transmembrane conductance regulator gene; IGF-1 receptor mutations in human uterine growth retardation; effects of ketogenic diet on body weight/cardiovascular risk factors. Gastroenterology and Nutrition: Cholera challenge trial; bile acid therapy in treatment of childhood liver disease, including cystic fibrosis, total parenteral nutrition-related cholestasis, and peroxisomal diseases; inborn errors of bile acid metabolism; analysis and physiology of soy isoflavones; cholesterol supplementation and synthesis rates in infants; regulation of plasma cholesterol levels by cholesterol absorption, synthesis, and LDL-receptors; intranasal vitamin B12 dosing interval; rectal bleeding in infants; borderline pancreatic function assessment in cystic fibrosis; role of magnesium in pathogenesis of childhood cholestatic liver disease; reduced bone mass in nonambulatory children and adults; intravenous methylprednisolone versus oral prednisolone in treatment of acute rejection in liver transplant patients; effect of fat ingestion on serum apolipoprotein A-IV levels; pharmacokinetics of the supplement, secoisolariciresinol diglycoside. General Pediatrics: Melatonin metabolism studies looking at shift work and effects on blood pressure in type 1 diabetes; suckling and PTHrP secretion and renal activity; bone mass tracking studies; bone density and forearm fractures in injured children. Hematology: Sickle cell disease, including biotinylated erythrocyte studies and causes for thrombophilia. Hepatology: Response of hepatitis C virus to pegylated interferon and ribavirin in hemophilic patients with/without coinfection with HIV. Human Genetics: Phenotype and genetics of Gaucher's disease; enzyme therapy for Gaucher's disease; antiresorptive therapy for osteopenia in Gaucher's disease; bone densitometry in subjects with neurofibromatosis. Infectious Disease: Indinavir/ritonavir therapy in HIV-affected subjects; efavirenz/nelfinavir pharmacokinetic study; pharmacokinetic interactions between HIV protease inhibitors and calcium channel blockers. Neonatology: Hypothermia trial in term infants; parenteral glutamine supplementation in low-birthweight infants. Nephrology: Renal tubular function in Bartter syndrome; immunosuppressive therapy after renal transplant in children; treatment of childhood nephrotic syndrome; urea kinetic modeling in hemodialysis patients; vascular abnormalities in children and adolescents with chronic renal disease; normalization of hematocrit in patients with chronic renal disease. Psychiatry: Clomipramine treatment trials in depression and obsessive-compulsive disorder; fibromyalgia genetic studies. Psychology: Behavioral nutrition studies involving weight gain in cystic fibrosis, feeding preterm infants, increasing dietary calcium in juvenile rheumatoid arthritis, and young children with chronic illness and their families; neuropsychological functioning in adolescents with spina bifida; Children's Health and Natural Growth Evaluation Study; depression and nutrition in pediatric sickle cell disease. Pulmonary Medicine: Aerosolized tobramycin in young children with cystic fibrosis; dose cohort studies in cystic fibrosis subjects; effect of obstructive sleep apnea on cardiac function and structure in children. Rheumatology: Calcium supplementation for bone mineralization in juvenile rheumatoid arthritis; genetic juvenile rheumatoid arthritis studies. Contact InformationFor information about this GCRC and how to access its resources, please contact: Administrative Manager Program Director Principal Investigator Associate Program Director Associate Program Director Research Subject Advocate GCRC Advisory Committee Chairperson Nurse Manager Core Laboratory Director Nutrition Research Manager Biostatistician |
National Institutes of Health (NIH) Bethesda, Maryland 20892 |
Department of Health and Human Services |