Minnesota

University of Minnesota

General Clinical Research Center
University of Minnesota
MMC 8504
420 Delaware Street, SE
Minneapolis, MN 55455

Web site: www.gcrc.umn.edu

Grant No. M01 RR00400

Special Assays, Services, or Tests

Biomedical Imaging Core

Body composition lab: DEXA, indirect calorimetry, anthropometric measures

Child and infant development core lab: Event-related potential, autonomic nervous system, neuropsychological batteries; consultation for selection of assessments for neurodevelopment

Developmental cell therapy core lab: Production of therapeutic cell products for immune-based therapies, laboratory analyses on clinical cell products for quality control and to analyze patient samples to evaluate the impact of novel experimental therapies GC/MS core lab: Analysis of stable isotope enrichment in plasma and urine samples

Magnetic resonance core lab: Magnetic resonance spectroscopy and imaging

Metabolic kitchen: Preparation and service of controlled research diets

Molecular genetics core lab: DNA extraction and storage, lymphocyte isolation and lymphoblastoid cell line production, genetic mapping using short tandem repeat polymorphism (STRP) markers, DNA sequencing and DNA polymorphism detection; consultation for study design, sample selection, and database analysis

Major Areas of Investigation

Allergy: Molecular genetics of asthma.

Cardiovascular Diseases: Lytic therapy of deep venous thrombosis; adolescent risk factors.

Genetic Diseases: Core laboratory determinations of RFLPs in immunogenetics of families with both insulin-dependent diabetes and non-insulin-dependent diabetes; diabetic neuropathy; molecular screening of distal X and Y chromosomes in children with familial and/or idiopathic short stature; epidemiology of chronic/recurrent otitis media.

Infectious Diseases: HIV infection.

Metabolic Disorders: Islet transplantation, intensive treatment of type 1 diabetes; dietary treatment of diabetes; cystic fibrosis and diabetes complications; effect of recurrent hypoglycemia on cerebral glucose metabolism; action to control cardiovascular risk in diabetes; renal and cellular studies in type 1 diabetic patients.

Nephrology: Structural-functional relationships in diabetic nephropathy; chronic allograft nephropathy.

Neurodevelopment: Effect of nutrition and stress on brain development and behavior.

NMR Studies: Nuclear magnetic resonance studies of glucose and glycogen metabolism in humans at 4 Tesla; diffusion tensor imaging in schizophrenia.

Nutrition: Omega-3 lipid supplementation; fatty acid flux in fasted and fed humans; resistance training to prevent increases in body fat; adolescent obesity.

Oncology: Treatment and prevention of relapse of leukemia after bone marrow transplant using donor peripheral blood mononuclear cells; continuous infusion taxol for refractory malignancies; vaccination with tetanus and keyhole limpet hemocyanin (KLH) to assess immune responses; metastatic colorectal cancer therapies.

Pharmacology: Epilepsy treatment; immunosuppressive therapy after transplant.

Psychiatry: Addiction medicine; eating disorders; schizophrenia.

Pulmonary Diseases: Treatment of cystic fibrosis.

Contact Information

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