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'IN VITRO' MICROBIOLOGICAL MUTAGENICITY AND UNSCHEDULED DNA SYNTHESIS STUDIES OF EIGHTEEN PESTICIDES |
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Eighteen pesticides being reviewed as a part of the EPA Substitute Chemical Program were tested for mutagenic activity by the following in vitro procedures: (1) Reverse mutation in...
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2,4,5-TRICHLOROPHENOXYACETIC ACID INFLUENCE ON 2,6-DINITROTOLUENE-INDUCED URINE GENOTOXICITY IN FISCHER 344 RATS: EFFECT ON G.I. MICROFLORA AND ENZYME ACTIVITY |
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2,4,5-Trichlorophenoxyacetic acid and 2,6-dinitrotoluene are hazardous chemicals that have potential harmful effects 2,6-DNT is recognized as a hepatoxicant while 2,4,5-T, a compon...
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A COMPARATIVE ASSESSMENT OF BOISE, IDAHO, AMBIENT AIR FINE PARTICLE SAMPLES USING THE PLATE AND MICROSUSPENSION SALMONELLA MUTAGENICITY ASSAYS |
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The primary objective of this study is to characterize the genotoxic potential of the ambient air aerosols collected within an air shed impacted primarily by wood smoke and automot...
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A COMPARATIVE REVIEW OF THE GENOTOXICANTS FOUND IN AMBIENT AIR |
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Although research efforts have associated the induction of cancer in man and in experimental animals with exposure to airborne substances for a long time, major insights into the s...
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A GENOTOXIC ASSESSMENT OF ENVIRONMENTAL TOBACCO SMOKE USING BACTERIAL BIOASSAYS |
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Recently, the National Research Council in the U.S.A. stated that labOratory studies of environmental tobacco smoke (ETS) should be important in identifying ETS carcinogens and the...
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A MASS BALANCE OF SURFACE WATER GENOTOXICITY IN PROVIDENCE RIVER (RHODE ISLAND USA) |
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White and Rasmussen (Mutation Res. 410:223-236) used a mass balance approach to demonstrate that over 85% of the total genotoxic loading to the St. Lawrence River at Montreal is no...
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A Novel Approach: Chemical Relational Databases, and the Role of the ISSCAN Database on Assessing Chemical Carcinogenity |
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Mutagenicity and carcinogenicity databases are crucial resources for toxicologists and regulators involved in chemicals risk assessment. Until recently, existing public toxicity d...
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A REVIEW OF THE GENETIC AND RELATED EFFECTS OF 1,3-BUTADIENE IN RODENTS AND HUMANS |
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In this paper, the metabolism and genetic toxicity of 1,3-butadiene (BD) and its oxidative metabolites in humans and rodents is reviewed with attention to newer data that have been...
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A REVIEW OF THE RODENT CARCINOGENICTY AND MUTAGENICITY OF AMBIENT AIR |
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This is a review of the information known about the carcinogenicity and mutagenicity of urban outdoor air including volatile pollutants and particulate organic material.
The e...
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A STUDY OF 2,4,6-TRINITROTOLUENE INHIBITION OF BENZO[A]PYRENE UPTAKE AND ACTIVATION IN A MICROBIAL MUTAGENICITY ASSAY |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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A SURVEY OF EPA/OPP AND OPEN LITERATURE ON SELECTED PESTICIDE CHEMICALS III. MUTAGENICITY AND CARCINOGENICITY OF BENOMYL AND CARBENDAZIM |
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Abstract
The known aneuploidogens, benomyl and its metabolite, carbendazim (methyl 2- benzimidazole carbamate or MBC), were selected for the third in a series of ongoing proje...
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ABSENCE OF MUTAGENICITY IN THE URINE OF AUTOPSY SERVICE WORKERS EXPOSED TO FORMALDEHYDE: FACTORS INFLUENCING MUTAGENICITY TESTING OF URINE |
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The study examined the effect of exposure to autopsy workers to formaldehyde using urinary mutagenicity testing with Salmonella typhimurium. A matched control group was also studie...
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ADDITIVITY OF IN VIVO MUTATION INDUCTION BY CUMULATIVE EXPOSURES TO BENZO[A]PYRENE OR DIBENZO[A,L]PYRENE |
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Dibenzo[a,l]pyrene (DB[a,l]P) and benzo[a]pyrene (B[a]P) are polycyclic aromatic hydrocarbons (PAH) found in cigarette smoke condensate, coal combustion processes and in some envir...
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AEROSOL FORMATION FROM DIESEL EXHAUST AND SO2. A CHAMBER STUDY |
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Dilute diesel emission systems were studied in a 600 cu m indoor smog chamber under various conditions likely to be encountered in an urban environment. Aerosol formation and growt...
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ALIPHATIC HALOGENATED HYDROCARBONS PRODUCE VOLATILE 'SALMONELLA' MUTAGENS |
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Production of volatile mutagenic metabolites from 5 halogenated promutagens was examined by a simple modification of the conventional Salmonella/microsome mutagenicity assay. This ...
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ALTERNATIVE DISINFECTANTS FOR DRINKING WATER TREATMENT |
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During a one-year study at Jefferson Parish, Louisiana the chemical, microbiological, and mutagenic effects of using the major drinking water disinfectants (chlorine, chlorine diox...
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AMES SALMONELLA MUTAGENICITY ASSAY PROCEDURE FOR WATER SAMPLES |
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This report describes methods for water and wastewater sample collection and processing for the Ames Salmonella mutagenicity assay. uidelines are provided for sampling equipment, c...
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AN APPROACH TO THE DESIGN OF NONMUTAGENIC AZO DYES: PART III. ANALOGS OF THE MUTAGEN 4-AMINO-3-METHOXYAZOBENZENE |
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A series of analogs of the known mutagen 4-amino-3-methoxyazobenzene has been synthesized in which the size of the alkoxy group has been varied to determine the effect of this kind...
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AN EVALUATION OF THE MUTAGENICITY, METABOLIC ACTIVATION AND DNA ADDUCT FORMATION OF 5-NITROBENZO[B]NAPHTHO[2,1-D] THIOPHENE |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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AN EVALUATION OF THE MUTAGENICITY, METABOLISM AND DNA ADDUCT FORMATION OF 5-NITROBENZO[B]NAPHTHO[2,1-D]THIOPHENE |
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An Evaluation of the Mutagenicity, Metabolism and DNA Adduct Formation of 5-Nitrobenzo[b ]naphtho[2, I-d]thiophene
Thioarenes, sulfur containing polycyclic aromatic compoun...
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ANALYSIS BY CHEMICAL CLASS OF SALMONELLA MUTAGENICITY TESTS AS PREDICTORS OF ANIMAL CARCINOGENICITY (JOURNAL VERSION) |
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For a number of years, investigators have recognized that humans potentially are exposed to large numbers of genotoxicants. Many efforts have attempted to validate various short-te...
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ANALYSIS OF ALKYL PHOSPHATES BY EXTRACTIVE ALKYLATION |
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The development of suitable methods for analysis of the alkyl phosphate metabolites of organophosphorus pesticides in urine has been a rather difficult and persistent problem. Curr...
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ANALYSIS OF EMISSIONS FROM RESIDENTIAL NATURAL GAS FURNACES |
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The paper gives emissions data from residential natural-gas furnaces and compares selected data to emissions data from residential oil furnaces and woodstoves. atural-gas furnace e...
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ANALYSIS OF EMISSIONS FROM RESIDENTIAL OIL FURNACES AND COMPARISON WITH WOODSTOVE EMISSIONS |
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The paper gives results of a series of emission tests on a residential oil furnace to determine emissions from two types of burners. A number of analyses were performed on the emis...
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ANALYSIS OF THE CYTOTOXICITY AND MUTAGENICITY OF DRINKING WATER DISINFECTION BY-PRODUCTS IN SALMONELLA TYPHIMURIUM. (R825956) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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ANALYSIS OF THE GENOTOXICITY OF ANTHRAQUINONE DYES IN THE MOUSE LYMPHOMA ASSAY |
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Despite their widespread use and potential for significant human exposure, genotoxicity data on anthraquinones and other dyes are generally limited. n this study, 16 anthraquinones...
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ANALYTICAL ISOLATION, SEPARATION AND IDENTIFICATION OF MUTAGENS FROM NONVOLATILE ORGANICS OF DRINKING WATER |
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A general procedure has been developed for the concentration/fractionation of mutagenic residue organics from small, <50L, and large, to 1200L, volumes of drinking water obtained f...
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ANTIMUTAGENICITY OF CINNAMALDEHYDE AND VANILLIN IN HUMAN CELLS: GLOBAL GENE EXPRESSION AND POSSIBLE ROLE OF DNA DAMAGE AND REPAIR |
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This study investigated the possibility that chemicals identified as antimutagens may, in fact, operate through a mechanism involving DNA damage. We addressed this question by usin...
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ANTIMUTAGENICITY PROFILES FOR SOME MODEL COMPOUNDS |
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The concept of activity profile listings and plots, already applied successfully to the display of mutagenicity data, has been modified for the application to antimutagenicity data...
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ANTIMUTAGENICITY PROFILES OF SYNTHETIC AND NATURAL ANTIMUTAGENS |
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The concept of activity profile listings and plots, already applied successfully to the display of mutagenicity data, has been modified for application to antimutagenicity data. he...
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APPLICATION OF A SIMPLE SHORT-TERM BIOASSAY FOR THE IDENTIFICATION OF GENOTOXINS FROM HAZARDOUS WASTES |
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The proper disposal of hazardous wastes currently generated and clean up of waste disposal sites of the past are challenges facing regulatory agencies in the industrialized nations...
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APPLICATION OF SAR METHODS TO NON-CONGENERIC DATA BASES ASSOCIATED WITH CARCINOGENICITY AND MUTAGENICITY: ISSUES AND APPROACHES |
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Structure-activity relationships (SAR) are potentially useful for estimating the mutagenicity or carcinogenicity of chemicals for-which bioassay test results are unavailable. radit...
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APPLICATION OF THE MICRO-FORWARD MUTATION ASSAY TO ASSESS MUTAGENICITY OF AIRBORNE PARTICULATES IN INDOOR |
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Validity test of the micro-forward mutation assay using Salmonella typhimurium strain TM677 was carried out using benzene-ethanol extracts from airborne particulates as test materi...
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APPROACH OF THE DESIGN OF NONMUTAGENIC AZO DYES: ANALOGS OF THE MUTAGENS CI DIRECT BLACK 17 |
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The effect on mutagenicity caused by incorporating an alkoxy substitutent into the structure of a disazo hydrophilic dye has been investigated. he results of this study indicate th...
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APPROACHING THE TOXICITY OF DISINFECTION BY-PRODUCTS IN DRINKING WATER AS A MIXTURE PROBLEM |
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Abstract
Assessment of human health risk from exposure to disinfection by-products (DBPs) in drinking water is of concern because of the wide spread exposure of persons who u...
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ASBESTOS AND GASTRO-INTESTINAL CANCER: CELL CULTURE STUDIES |
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Three forms of asbestos: amosite, crocidolite, and chrysotile, were assayed for their cytotoxicity and mutagenicity in cell clture. Using embjryonic human intestine derived and adu...
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ASCORBIC ACID REDUCTION OF ACTIVE CHLORINE PRIOR TO DETERMINING AMES MUTAGENICITY OF CHLORINATED NATURAL ORGANIC MATTER (NOM) |
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Many potable water disinfection byproducts (DBPs) that result from the reaction of natural organic matter (NOM) with oxidizing chlorine are known or suspected to be carcinogenic an...
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ASSESSING DETOXIFICATION AND DEGRADATION OF WOOD PRESERVING AND PETROLEUM WASTES IN CONTAMINATED SOIL |
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This study was undertaken to evaluate in-situ soil bioremediation processes, including degradation and detoxification, for wood preserving and petroleum refining wastes at high con...
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ASSESSMENT OF BACTERIAL MUTAGENICITY METHODS FOR VOLATILE AND SEMI-VOLATILE COMPOUNDS AND MIXTURES |
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Extensive effort has been given to identifying and quantitating the organic genotoxins associated with airborne particles; however, very little is known about the mutagenicity of v...
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ASSESSMENT OF GENOTOXICITY OF HAZARDOUS WASTES WITH THE ARABIDOPSIS EMBRYO ASSAY |
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The paper summarizes the results of evaluating the genetic effects of five samples obtained from a mercuric acetate plant in New Jersey. The samples were tested in Arabidopsis thal...
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ASSESSMENT OF HAZARDOUS WASTES FOR GENOTOXICITY |
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The authors have evaluated a group of short-term bioassays to identify those that may be suitable for screening large numbers of diverse hazardous industrial wastes for genotoxicit...
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ASSESSMENT OF HEALTH EFFECTS OF BENZENE GERMANE TO LOW-LEVEL EXPOSURE |
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The report on the health effects of benzene assesses the teratogenicity, mutagenicity, carcinogenicity, and hematopoietic effects from benzene germane to low level exposure. Epidem...
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ASSESSMENT OF STANDARD REFERENCE COMPOUNDS FOR COMPARATIVE STUDIES USING THE SALMONELLA TYPHIMURIUM MUTAGENICITY ASSAY: I. WITHOUT EXOGENOUS ACTIVATION |
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Finney (1978) described a bioassay as an experiment for estimating the nature, constitution, or potency of a material by means of the eaction that follows its application to living...
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ASSESSMENT OF STANDARD REFERENCE COMPOUNDS FOR COMPARATIVE STUDIES USING THE SALMONELLA TYPHIMURIUM MUTAGENICITY ASSAY: II. WITH EXOGENOUS ACTIVATION |
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The purpose of this project was to evaluate the variability in the mutagenic response of potential standard reference chemicals that require exogenous metabolic activation in the s...
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ASSESSMENT OF THE CARCINOGENICITY OF DICOFOL (KELTHANE (TRADE NAME)), DDT, DDE, AND DDD (TDE) |
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The carcinogenic activity of the pesticides dicofol and associated pesticide compounds DDT, DDE, and DDD are reviewed. All of these compounds exhibit carcinogenic activity in surro...
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ASSESSMENT OF THE MUTAGENIC POTENTIAL OF CARBON DISULFIDE, CARBON TETRACHLORIDE, DICHLOROMETHANE, ETHYLENE DICHLORIDE, AND METHYL BROMIDE: A COMPARATIVE ANALYSIS IN RELATION TO ETHYLENE DIBROMIDE |
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The document provides an evaluation of the mutagenic potential of five alternative fumigants to ethylene dibromide(EDB). These include carbon disulfide(CS2), carbon tetrachloride(C...
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ASSESSMENT OF THE MUTAGENICITY OF ORGANIC AIR POLLUTANTS BEFORE AND AFTER ATMOSPHERIC TRANSFORMATION |
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During the past decade, there has been renewed effort examining the extent to which hazardous compounds (particularly mutagens and carcinogens) are found in the urban atmosphere. o...
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ASSESSMENT OF THE TLC/SALMONELLA ASSAY FOR SCREENING HAZARDOUS WASTES |
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Using a modified version of the TLC/Salmonella assay developed by Bjorseth et al. (1982), 10 complex hazardous wastes were tested for mutagenic activity. The method couples thin la...
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ASSOCIATION BETWEEN MUTATION SPECTRUM AND PERSISTENT DNA ADDUCT PROFILE IN SALMONELLA FOR BENZO[A]PYRENE AND DIBENZO[A]PYRENE |
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Dibenzo[a,l]pyrene (DB[a1]P) is less prevalent in the environment but 100-200X more carcinogenic in rodents than benzo[a]pyrene (B[a]P) .B[a]P induces most of its adducts on G, whe...
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ASSOCIATION BETWEEN URINARY MUTAGENICITY AND RISK OF COLORECTAL ADENOMAS IN A CLINIC-BASED CASE-CONTROL STUDY |
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ASSOCIATION BETWEEN URINARY MUTAGENICITY AND RISK OF COLORECTAL ADENOMAS IN A CLINIC-BASED CASE-CONTROL STUDY
Humans are exposed to a variety of mutagens from diet, smoking...
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AZO DYES ARE MAJOR CONTRIBUTORS TO THE MUTAGENIC ACTIVITY DETECTED IN THE CRISTAIS RIVER WATERS |
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To determine if compounds from a dye processing plant were contributing to the mutagenicity repeatedly found in the Cristais River, Sao Paulo, Brazil, we chemically characterized t...
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BACTERIAL MUTAGENICITY OF ACEANTHRYLENE: A NOVEL CYCLOPENTA-FUSED POLYCYCLIC AROMATIC HYDROCARBON OF LOW MOLECULAR WEIGHT |
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Aceanthrylene, a novel non-alternant cyclopenta-fused hydrocarbon, was shown to be a potent S9-dependent mutagen in the Ames Salmonella plate incorporation assay. The mutagenic pot...
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BACTERIAL MUTAGENICITY OF NEW CYCLOPENTA-FUSED CATA-ANNELATED POLYCYCLIC AROMATIC HYDROCARBONS, AND IDENTIFICATION OF THE MAJOR METABOLITES OF BENZ(J)ACEPHENANTHRYLENE FORMED BY AROCLOR-TREATED RAT LIVER MICROSOMES |
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Three novel cyclopenta-fused polycyclic aromatic hydrocarbons were synthesized, benz(d)aceanthrylene, benz(k)aceanthrylene, and benz(j)acephenanthrylene, and evaluated for mutageni...
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BASIS OF THE INSENSITIVITY OF 'SALMONELLA TYPHIMURIUM' STRAIN TA98/1,8-DNP6 TO THE MUTAGENIC ACTION OF NITROARENES |
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Salmonella typhimurium tester strain TA98/1,8-DNP6 is resistant to the mutagenicity of 1,8-dinitropyrene because it lacks an esterification enzyme which is needed for the formation...
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BENZ(J)ACEANTHRYLENE: A NOVEL POLYCYCLIC AROMATIC HYDROCARBON WITH BACTERIAL MUTAGENIC ACTIVITY |
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Initial studies on the mutagenicity and metabolism of a novel cyclopenta-PAH, benz(j) aceanthrylene, are reported in the Salmonella bacterial system. The spectrum of activity of be...
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BIOASSAY AND CHEMICAL ANALYSIS FOR HAZARDOUS MATERIALS IN RESIDUAL OILS. VOLUME 1. NARRATIVE |
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The report gives results of an examination, including mutagenic screening, of the chemical composition of residual fuel oils and their column chromatography prefractions. A degree ...
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BIOASSAY AND CHEMICAL ANALYSIS FOR HAZARDOUS MATERIALS IN RESIDUAL OILS. VOLUME 2. APPENDICES |
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The report gives results of an examination, including mutagenic screening, of the chemical composition of residual fuel oils and their column chromatography pre-fractions. A degree...
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BIOASSAY AND CHEMICAL ANALYSIS OF AMBIENT AIR PARTICULATE EXTRACTS FRACTIONATED BY USING NONAQUEOUS ANION-EXCHANGE SOLID PHASE EXTRACTION |
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A nonaqueous anion-exchange solid-phase extraction technique has been developed for analyzing particulate extracts of ambient air samples and combustion source samples. he techniqu...
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BIOASSAY OF COMPLEX MIXTURES OF INDOOR AIR POLLUTANTS |
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Indoor air pollution is a complex mixture of chemicals originating from outdoor air and indoor sources. oxicology studies of these mixtures are limited by difficulties in obtaining...
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BIOASSAY-DIRECT FRACTIONATION OF 1-NITROPYRENE METABOLITES: GENERATION OF MUTAGRAMS BY COUPLING REVERSE-PHASE HPLC WITH MICROSUSPENSION MUTAGENICITY ASSAYS |
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We have performed bioassay-direct fractionation of a model complex mixture (rabbit lung S9-generated metabolites of 14 C-radiolabeled 1-nitropyrene) by assaying reverse-phase HPLC ...
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BIOASSAY-DIRECTED FRACTIONAL AND SALMONELLA MUTAGENICITY OF AUTOMOBILE AND FORKLIFT DIESEL EXHAUST PARTICLES |
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Abstract
Many pulmonary toxicity studies of diesel exhaust particles (DEP) have used an
automobile-generated sample (A-DEP) whose mutagenicity has not been repo...
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BIOAVAILABILITY OF 1-NITROPYRENE FROM MODEL COAL FLY ASH AND ITS UPTAKE BY ALVEOLAR MACROPHAGES |
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Alveolar macrophage cultures exposed to coal fly ash vapor-coated with 1-nitropyrene were used as a model system to study the bioavailability and the uptake of a nitroaromatic hydr...
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BIODEGRADATION OF SIMPLE CHEMICAL MIXTURES IN SOILS |
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Exogenous cultures of microorganisms are often utilized to enhance bioremediation. The purpose of this study was to compare the capabilities of two exogenous microbial cultures, Ps...
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BIODIESEL EXHAUST: THE NEED FOR HUMAN HEALTH EFFECTS RESEARCH |
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Biodiesel is a diesel fuel alternative that has shown potential of becoming a commercially accepted part of the United States energy infrastructure. In November of 2004, the signin...
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BIOMARKER ASSAYS IN NIPPLE APIRATE FLUID |
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ABSTRACT
The noninvasive technique of nipple aspiration as a potential source of biomarkers of breast cancer risk was evaluated. The feasibility of performing mutagenesis a...
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BIOMARKERS OF EXPOSURE, EFFECT AND SUSCEPTIBILITY IN WORKERS EXPOSED TO NITROTOLUENES |
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Nitrotoluenes, such as 2-nitrotoluene, 2,4-dinitrotoluene (24DNT), and 2,6-dinitrotoluene (26DNT), are carcinogenic in animal experiments. Humans are exposed to such chemicals in t...
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BROMODICHLOROMETHANE TOXICOKINETICS: LINKING METABOLISM TO EFFECT |
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Bromodichloromethane (BDCM), a trihalomethane (THM), is among the most prevalent disinfection byproducts found in chlorinated drinking water. Weak associations between THM expo...
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CARCINOGEN ASSESSMENT OF COKE OVEN EMISSIONS |
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Coke oven workers in Allegheny County, Pennsylvania and at 10 non-Allegheny County coke plants in the United States and Canada were found to be at an excess risk of mortality from ...
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CARCINOGENIC N-HYDROXYLAMINOPURINE DERIVATIVES DO NOT ACT AS BASE ANALOG MUTAGENS IN 'SALMONELLA TYPHIMURIUM' |
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N-hydroxylaminopurines are highly mutagenic for growing as well as resting Salmonella typhimurium strain TA100 and to a lesser extent for strain TA98. Aminopurines, under similar c...
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CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE |
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Evidence pertaining to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide is reviewed and evaluated. The report covers studies completed before 1985. Case reports a...
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CAUSES OF PAPILLOMAS ON FISH EXPOSED TO CHLORINATED SEWAGE EFFLUENT |
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This research was initiated to determine the cause of oral papillomas in black bullheads (Ictalurus melas) from the final oxidation pond of the Tuskegee, Alabama, sewage treatment ...
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CAUSES OF PAPILLOMAS ON FISH LIVING IN CHLORINATED SEWAGE EFFLUENT |
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This research was initiated to determine the cause of the oral papillomas on black bullheads (Ictalurus melas) from the final oxidation pond of the Tuskegee, Alabama, sewage treatm...
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CHANGES IN MUTAGENICITY DURING CRUDE OIL DEGRADATION BY FUNGI |
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NO ABSTRACT PROVIDED...
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CHARACTERISTICS OF THE USEPA'S OFFICE OF PESTICIDE PROGRAMS' TOXICITY INFORMATION DATA BASES |
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The United States Environmental Protection Agency's (USEPA's) Office of Pesticide Programs (OPP) requires that data from toxicity testing be submitted to the OPP to support the reg...
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CHARACTERIZATION OF AUTOMOTIVE EMISSIONS BY BACTERIAL MUTAGENESIS BIOASSAY: A REVIEW |
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Due to the growing numbers of diesel passenger automobiles in the United States, there has been an expanded effort to understand the health effects of airborne pollutants arising f...
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CHARACTERIZATION OF CONDENSIBLE AND SEMIVOLATILE ORGANIC MATERIALS FROM BOISE WOODSTOVE SAMPLES |
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The paper gives results from woodstove spurce and ambient sampling in Boise, ID. ata are presented for the total chromatographable organic, gravimetric, and gas chromatograph/mass ...
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CHARACTERIZATION OF EMISSIONS AND FUEL ECONOMY OF IN-USE DIESEL AUTOMOBILES |
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Exhaust emissions from twenty 1977-1980 in-use light-duty diesel vehicles were measured to determine the effects of driving cycle, mileage accumulation, and test conditions. Hydroc...
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CHEMICAL ACTIVATION OF NON-MUTAGENIC NITRATED POLYCYCLIC AROMATIC HYDROCARBONS TO MUTAGENS |
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Nitrated polycyclic aromatic hydrocarbons, including carcinogens, may be non-mutagenic in microorganisms because bacterial nitroreductases are unable to reduce their nitro function...
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CHEMICAL ANALYSIS OF REVERSE OSMOSIS MEMBRANE AND XAD RESIN ADSORPTION CONCENTRATES OF WATER DISINFECTED BY CHLORINATION OR OZONATION/CHLORINATION PROCESSES |
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Chemical Analysis of Reverse Osmosis Membrane and XAD Resin Adsorption Concentrates of Water Disinfected by Chlorination or Ozonation/Chlorination Processes.
J. E. Simmo...
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CHEMICAL CHARACTERIZATION OF EXTRACTABLE ORGANIC MATTER FROM AMBIENT AEROSOLS COLLECTED IN BOISE, ID |
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Fine fraction (2.5 micron) ambient air aerosols were collected in Boise, ID between November, 1986, and February, 1987. wo composite samples of extractable organic matter (EOM) wer...
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CHEMICAL EVALUATION AND TOXICOLOGICAL TESTING OF CONCENTRATED DISINFECTED WATERS |
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Raw water pumped from the Mississippi River was clarified and fluoridated. A portion was taken through a high pressure and filter and split into five parallel streams at a pilot sc...
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CHEMICAL OF CURRENT INTEREST PROPYLENE OXIDE: HEALTH AND ENVIRONMENTAL EFFECTS PROFILE |
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This article reviews all of the relevant information on propylene oxide including physical and chemical properties, environmental fate and transport processes, exposure (water, foo...
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CHEMICAL REACTIVITY, CYTOTOXICITY, AND MUTAGENICITY OF CHLOROPROPANONES |
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Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP) and 1,3-dichloropropanone (1,3-DCP). Ch...
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CHEMICAL SEPARATION AND IN SITU MUTAGENICITY TESTING |
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The traditional way to characterize a complex sample has been by chemical analysis to identify the individual components. However, unknown or overlooked mutagens or carcinogens may...
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COLLECTION, CHEMICAL FRACTIONATION, AND MUTAGENICITY BIOASSAY OF AMBIENT AIR PARTICULATE |
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The influence of industrialization and consequent increased concentration of urban particulate matter on the incidence of cancer has long been a concern. The first bioassays used t...
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COMPARATIVE APPROACH TO EVALUATING RELATIVE CANCER RISKS FROM ENERGY SOURCES USING SHORT-TERM GENETIC BIOASSAYS |
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The evaluation of emissions from new energy sources has stimulated the development of new comparative approaches to health assessment studies. All energy sources that result in inc...
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COMPARATIVE MUTAGENICITY OF HALOGENATED PYRIDINES IN THE 'SALMONELLA TYPHIMURIUM'/MAMMALIAN MICROSOME TEST |
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The Salmonella/microsome assay with strains TA97, TA98, TA100, and TA102 was used to examine the potential mutagenicity and structure-activity of 16 mono- and dihalogenated pyridin...
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COMPARATIVE MUTAGENICITY OF HALOMETHANES AND HALONITROMETHANES IN SALMONELLA TA100: STRUCTURE-ACTIVITY ANALYSIS AND MUTATION SPECTRA |
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Halonitromethanes (HNMs) are a recently identified class of disinfection by-products (DPBs) in drinking water that are mutagenic in Salmonella and potent inducers of DNA strand bre...
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COMPARATIVE MUTAGENICITY OF HALOMETHANES AND HALONITROMETHANES IN SALMONELLA TA100: STRUCTURE-ACTIVITY ANALYSIS AND MUTATION SPECTRA. (ERD) |
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Halonitromethanes (HNMs) are a recently identified class of disinfection by-products (DPBs) in drinking water that are mutagenic in Salmonella and potent inducers of DNA strand br...
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COMPARATIVE POTENCY OF COMPLEX MIXTURES: USE OF SHORT-TERM GENETIC BIOASSAYS IN CANCER RISK ASSESSMENT |
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The primary problem regarding the introduction of new energy sources is whether they will alter the mutagenicity, carcinogenicity and potential human cancer risk from combustion em...
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COMPARATIVE YIELDS OF MUTAGENS FROM CIGARETTE SMOKERS' URINE OBTAINED BY USING SOLID-PHASE EXTRACTION TECHNIQUES |
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Urine from cigarette smokers was prepared for mutagenicity testing by extracting mutagens with solid phase extraction columns. ommercially available prepacked bonded silicas (cotad...
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COMPARISON OF BIOINIDICATORS OF EXPOSURE TO GENOTOXIC INDOOR AIR POLLUTANTS |
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Human exposure to complex mixtures of genotoxic indoor air pollutants can be assessed using several different bioanalytical methods. xternal exposure can be assessed using micromut...
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COMPARISON OF BIOMARKERS IN WORKERS EXPOSED TO 2,4,6-TRINITROTOLUENE |
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2,4,6-Trinitrotoluene (TNT) is an important occupational and environmental pollutant. In TNT-exposed humans, the notable toxic manifestations have included aplastic anemia, toxic h...
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COMPARISON OF MUTAGENICITY RESULTS FOR NINE COMPOUNDS EVALUATED AT THE HGPRT LOCUS IN THE STANDARD AND SUSPENSION CHO ASSAYS |
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The Chinese hamster ovary (CHO) assay which measures newly induced mutations at the hypoxanthine-guanine phosphoribosyltransferase (hgprt) locus has been widely used for mutagenesi...
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COMPARISON OF NITRO-AROMATIC CONTENT AND DIRECT-ACTING MUTAGENICITY OF PASSENGER CAR ENGINE EMISSIONS |
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This paper describes a study to identify and quantify 23 nitroaromatic compounds in the extracts of particulate material from three light-duty passenger car diesel engines and one ...
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COMPARISON OF THE MUTAGENICITY OF SEWAGE SLUDGES |
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Samples of five municipal sewage sludges from Illinois cities have been subjected to a multiorganism testing program to determine the presence or absence of mutagenic activity. Chi...
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COMPLEX MIXTURES OF URBAN AIR POLLUTANTS: IDENTIFICATION AND COMPARATIVE ASSESSMENT OF MUTAGENIC AND TUMORIGENIC CHEMICALS AND EMISSION SOURCES |
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Advances in the cancer risk assessment of complex mixtures of urban air pollutants requires the development of new methods to advance our understanding of low dose and inter-specie...
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COMPONENT-BASED AND WHOLE-MIXTURE ASSESSMENTS IN ADDRESSING THE UNIDENTIFIED FRACTION OF COMPLEX MIXTURES: DRINKING WATER AS AN EXAMPLE |
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Component-Based and Whole-Mixtures Assessments in Addressing the Unidentified Fraction of Complex Mixtures: Drinking Water as an Example
J. E. Simmons; L. K. Teuschler; ...
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COMPUTATIONAL AND SAR STUDIES OF MX AND ITS STRUCTURAL ANALOGUES: REACTIVITY AND MUTAGENICITY |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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COMPUTATIONAL TOXICOLOGY ADVANCES: EMERGING CAPABILITIES FOR DATA EXPLORATION AND SAR MODEL DEVELOPMENT |
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Computational Toxicology Advances: Emerging capabilities for data exploration and SAR model development
Ann M. Richard and ClarLynda R. Williams, National Health & Environmental...
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COMPUTER AUTOMATED EVALUATION OF MUTAGENICITY AND CARCINOGENICITY OF SELECTED POLYCYCLIC AROMATIC HYDROCARBONS |
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The mechanisms by which polycyclic aromatic hydrocarbons (PAHs) induce mutations and cancer have been the subject of considerable attention for several years. arious theoretical an...
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COMPUTER AUTOMATED STUDY OF THE STRUCTURE-MUTAGENICITY RELATIONSHIPS OF NON-FUSED-RING NITROARENES AND RELATED COMPOUNDS |
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A quantitative structure-activity analysis of the mutagenicity of non-fused ring nitroaromatic compounds is reported. The analysis is performed on the basis of substructural fragme...
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COMPUTER-ASSISTED STRUCTURE ACTIVITY RELATIONSHIPS OF NITROGENOUS CYCLIC COMPOUNDS TESTED IN SALMONELLA ASSAYS FOR MUTAGENICITY |
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Study of the relationship between mutagenicity and molecular structure for a data set of nitrogenous cyclic compounds is reported. A computerized SAR system (ADAPT) was utilized to...
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CONSIDERATIONS IN THE U.S. ENVIRONMENTAL PROTECTION AGENCY'S TESTING APPROACH FOR MUTAGENICITY |
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Historically the U.S. Environmental Protection Agency has used mutagenicity information as part of its weight-of-evidence approach to discern the potential for human carcinogenicit...
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CONTRIBUTION OF WOODSMOKE AND MOTOR VEHICLE EMISSIONS TO AMBIENT AEROSOL MUTAGENICITY (JOURNAL VERSION) |
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Mutagenicity is frequently considered as a screening test for the carcinogenicity of compounds to which humans are exposed. Past estimates of the mutagenicity of ambient aerosol ha...
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CORRELATION BETWEEN BENZO(A)PYRENE-INDUCED MUTAGENICITY AND DNA ADDUCT FORMATION IN 'SALMONELLA TYPHIMURIUM' TA100 |
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In an attempt to stabilize the dose response in the Salmonella typhimurium test (STT), the use of DNA-bound products from BP was evaluated as a measure of the biologically effectiv...
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CYCLOPENTA-FUSED ISOMERS OF BENZ(A)ANTHRACENE IDENTIFICATION OF MAJOR MICROSOMAL METABOLITES |
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The microsomal metabolism of a variety of polycyclic systems has been investigated as part of an interest in structure-activity relationships governing cytochrome P-450 mediated bi...
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CYTOTOXICITY AND EFFECT ON MUTAGENICITY OF BUFFERS IN A MICROSUSPENSION ASSAY |
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We have examined the effects of three buffers, Vogel-Bonner minimal E (VBM), and 0.15 and 0.015 M sodium phosphate, pH 7.4; and two concentrations of overnight cells (5X and 10X) o...
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CYTOTOXICITY AND MUTAGENESIS METHODS FOR EVALUATING TOXICITY REMOVAL FROM WASTEWATERS |
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This project was a feasibility study of the effectiveness of a mammalian cell cytotoxicity assay and a mammalian cell mutagenesis assay for monitoring the toxicity and mutagenicity...
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Carcinogenicity and Mutagenicity Data: New Initiatives to Improve Access and Utility for Modeling |
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Currents models for prediction of chemical carcinogenicity and mutagenicity rely upon a relatively small number of publicly available data resources, where the data being modeled a...
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Chemical Analysis of Drinking Water Concentrates in the Four Lab Study |
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The purpose of the Four Lab study was to evaluate potential health effects from exposure to disinfection by-products (DBPs). Unchlorinated water taken from a full-scale drinking w...
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DESIGN AND IMPLEMENTATION OF A COLLABORATIVE STUDY ON THE MUTAGENICITY OF COMPLEX MIXTURES IN SALMONELLA TYPHIMURIUM |
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In 1987, the International Programme on Chemical Safety (IPCS) in collaboration with the U.S. Environmental Protection Agency (U.S. EPA) and the U.S. National Institute of Standard...
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DESIGNING STUDIES AND COLLECTING DATA USEFUL FOR CUMULATIVE RISK ASSESSMENT |
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DESIGNING STUDIES AND COLLECTING DATA USEFUL FOR CUMULATIVE RISK ASSESSMENT. J E Simmons1, C Gennings2, M Casey2, M J Plewa3, E D Wagner3, W H Carter, Jr.2, A McDonald1,Y M Sey1...
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DETECTION OF CARCINOGENICITY BASED ON MUTAGENICITY IN ARABIDOPSIS |
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Thirty-seven synthetic chemicals plus two mycotoxins were tested for mutagenicity in an Arabidopsis embryo system. The results of this test, prokaryotic repair tests, bacterial mut...
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DETECTION OF DIRECTOR-ACTING MUTAGENS IN AMBIENT AIR - A COMPARISON OF TWO HIGHLY SENSITIVE MUTAGENICITY ASSAYS |
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Ambient air has been shown to contain numerous hazardous pollutants, many of which are carcinogens and mutagens. n this study, 2 Salmonella test methods (the spiral an preincubatio...
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DETECTION OF GENETIC HAZARDS FROM ENVIRONMENTAL CHEMICALS WITH PLANT TEST SYSTEMS |
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This book chapter reviews the methodology and utility of five plant bioassays for detecting the mutagenicity of environmental chemicals. he bioassays described in this chapter are ...
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DETERMINATION OF A CHLORINATED FURANONE (MX) IN TREATED WATER |
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A potent mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy2(5H)-furanone (MX) has been identified in three chlorinated drinking waters in the United States. It has also been identifie...
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DETERMINING THE STRUCTURE-ACTIVITY RELATIONSHIPS OF AMINOBIPHENYL AND BENZIDINE ANALOGS |
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Determining the structure-activity relationships of aminobiphenyl and benzidine analogues
Benzidine is a confirmed human carcinogen causing bladder and other types of cancer...
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DEVELOPING AZO AND FORMAZAN DYES BASED ON ENVIRONMENTAL CONSIDERATIONS: SALMONELLA MUTAGENICITY |
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Abstract
In previous papers, the synthesis and chemical properties of iron-complexed azo and formazan dyes were reported. In this regard, it was shown that in certain cases iron...
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DEVELOPMENT AND ASSESSMENT OF PROCEDURES FOR COLLECTION, CHEMICAL CHARACTERIZATION AND MUTAGENICITY TESTING OF AMBIENT AIR |
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The overall objective of this Research Triangle Institute pilot study was to develop and evaluate a minimal testing protocol which could detect and quantify the mutagenic potential...
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DEVELOPMENT AND VALIDATION OF THE SPIRAL SALMONELLA ASSAY: AN AUTOMATED APPROACH TO BACTERIAL MUTAGENICITY TESTING |
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Several automated approaches to Salmonella mutagenicity testing have been proposed in recent years but have failed to gain acceptance in the scientific community due to poor perfor...
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DEVELOPMENT OF SOURCE TESTING, ANALYTICAL AND MUTAGENICITY BIOASSAY PROCEDURES FOR EVALUATING EMISSIONS FROM MUNICIPAL AND HOSPITAL WASTE COMBUSTORS |
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These U.S. EPA Laboratories are cooperatively conducting research aimed at developing new testing equipment and procedures that will allow a more comprehensive assessment of the co...
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DEVELOPMENT OF SOURCE TESTING, ANALYTICAL, AND MUTAGENICITY BIOASSAY PROCEDURES FOR EVALUATING EMISSIONS FROM MUNICIPAL AND HOSPITAL WASTE COMBUSTORS |
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The paper discusses researched aimed at developing new testing equipment and procedures that will allow a more comprehensive assessment of the complex mixture of organics that is p...
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DIETARY FOLATE DEFICIENCY ENHANCES ARSENIC-INDUCED MICRONUCLEUS FORMATION IN MICE |
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Dietary folate deficiency enhances arsenic-induced micronucleus formation in mice.
Folate deficiency increases background levels ofDNA damage and can enhance the mutage...
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DIFFERENTIAL RECOVERY OF 'TK' AND 'HGPRT' INDUCED MUTANTS IN MAMMALIAN CELLS |
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Human genetic disease is known to result from both point mutations and chromosomal aberrations. It is therefore critical that short-term in vitro mammalian tests be evaluated as to...
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DIRECT MUTAGEN RISK ASSESSMENT: THE DEVELOPMENT OF METHODS TO MEASURE IMMUNOLOGIC AND GENETIC RESPONSES TO MUTAGENS |
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The review puts forward the concept of Direct Mutagen Risk Assessment through a discussion of the development of methods with which to measure immunologic and genetic responses to ...
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DISINFECTION BYPRODUCTS: THE NEXT GENERATION |
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Disinfection of drinking water is rightly hailed as a major public health triumph of the 20th Century. Before widespread disinfection of drinking water in the U.S. and Europe, mil...
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DNA-DAMAGING EFFECTS OF GENOTOXINS IN MIXTURE: NONADDITIVE EFFECTS OF AFLATOXIN B-1 AND N-ACETYLAMINOFLUORENE ON THEIR MUTAGENICITY IN SALMONELLA TYPHIMURIUM. (R825809) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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DNA-REACTIVE CARCINOGENS: MODE OF ACTION AND HUMAN CANCER HAZARD |
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It has been known for decades that mutagenicity plays an important role in the activity of most carcinogens. This mutagenicity can result from direct damage to DNA through a chemic...
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DOSE RELATED DIFFERENCES IN DNA ADDUCT LEVELS IN RODENT TISSUES FOLLOWING SKIN APPLICATIONS OF COMPLEX MIXTURES FROM AIR POLLUTION SOURCES |
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Dose-related differences in the binding of DNA reactive intermediates for three environmentally important complex particulate extracts and a well studied carcinogen Benzo(a)Pyrene ...
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DROWNING IN DISINFECTION BY-PRODUCTS? ASSESSING SWIMMING POOL WATER |
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The development of treated water for swimming pools has made swimming a year round activity, widely enjoyed for leisure as well as exercise. Swimming pools can be found in differen...
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DROWNING IN DISINFECTION BY-PRODUCTS? SWIMMING POOL WATER QUALITY RECONSIDERED. |
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The development of treated water for swimming pools has made swimming a year ¬round activity, widely enjoyed for leisure as well as exercise. Swimming pools can be found in differe...
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EFFECT OF A BASE-CATALYZED DECHLORINATION PROCESS ON THE GENOTOXICITY OF PCB-CONTAMINATED SOIL |
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We evaluated the genotoxicity of dichloromethane (DCM) extracts of PCB-contaminated soil before and after the soil had been treated by a base-catalyzed dechlorination process, whic...
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EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME AMINOAZOBENZENE DYES AND THEIR REDUCTIVE-CLEAVAGE PRODUCTS |
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Fifteen aminoazobenzene dyes and seven of their reductive-cleavage products were examined in the Salmonella/microsome assay with strains TA98, TA100, TA1535, TA1537 and TA1S38. yes...
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EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME PHENYLENEDIAMINE-BASED DISZAO DYES |
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Sixteen phenylenediamine based disazo dyes were exaimined in the Salmonella/mammalian microsome assay with strains TA98, TAl00, and TA1538. ll of the dyes contain an alkoxy group o...
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EFFECT OF DIETARY CASEIN LEVELS ON ACTIVATION OF PROMUTAGENS IN THE SPIRAL SALMONELLA MUTAGENICITY ASSAY II. STUDIES WITH INDUCED RAT LIVER S9 |
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NO ABSTRACT PROVIDED...
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EFFECT OF LAND TREATMENT ON THE MUTAGENICITY OF MILWAUKEE HARBOR SEDIMENT [POSTER PRESENTATION] |
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Sediment from the Milwaukee harbor is known to be contaminated with PAHs and PCBs. A pilot-scale study was conducted to evaluate the potential of land treatment to detoxify these ...
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EFFECT OF SOLVENT AND EXTRACTION METHODS ON THE BACTERIAL MUTAGENICITY OF SIDESTREAM CIGARETTE SMOKE |
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The mutagenic activity of sidestream cigarette smoke particles was estimated by testing sidestream cigarette smoke particles which had been collected under controlled burning condi...
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EFFECT OF THE DECHLORINATING AGENT, ASCORBIC ACID, ON THE MUTAGENICITY OF CHLORINATED WATER SAMPLES |
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XAD resin adsorption has been widely used to concentrate the organic compounds present in chlorinated drinking waters prior to mutagenicity testing. Previous work has shown that mu...
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EFFECTS OF OPERATING VARIABLES ON PAH EMISSIONS AND MUTAGENICITY OF EMISSIONS FROM WOODSTOVES |
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The paper discusses studies in instrumented woodstove test laboratories to quantify woodstove emissions during operations typical of in-house usage. (The studies parallel field sou...
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EFFECTS OF OPERATING VARIABLES ON PAH EMISSIONS AND MUTAGENICITY OFEMISSIONS FROM WOODSTOVES |
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The paper discusses studies in instrumented woodstove testlaboratories to quantify woodstove emissions during operationstypical of in-house usage. The studies parallel field source...
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ENHANCEMENT OF BENZO(A)PYRENE MUTAGENICITY BY CHRYSOTILE ASBESTOS IN RAT LIVER EPITHELIAL CELLS |
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The co-mutagenicity of chrysotile asbestos and benzo(a)pyrene (B(a)P) was studied in adult rat liver (ARL-18) epithelial cells. Exposure to chrysotile alone did not increase the mu...
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ENU MUTAGENESIS IN THE MOUSE ELECTROPHORETIC SPECIFIC-LOCUS TEST 2. MUTATIONAL STUDIES OF MATURE OOCYTES |
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Experiments were conducted using the biochemical specific locus test to assess the mutagenicity of N-ethyl-N-nitrosourea (ENU) in mature oocytes of mice. 57Bl/6J females were treat...
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ENVIRONMENTAL ASSESSMENT OF A LOW-EMISSION OIL-FIRED RESIDENTIAL HOT WATER CONDENSING HEATING SYSTEM. VOLUME I: TECHNICAL RESULTS |
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The report gives results of a test program measuring air and water emissions from a high-efficiency hot-water residential heating system of European design, utilizing a condensing ...
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ENVIRONMENTAL ASSESSMENT: SOURCE TEST AND EVALUATION REPORT - B AND W/ALLIANCE ATMOSPHERIC FLUIDIZED-BED COMBUSTOR |
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The report gives results of a comprehensive emission sampling and analysis of a pilot-scale, atmospheric-pressure, coal-fired, fluidized-bed combustor (AFBC). Screening data on org...
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ENVIRONMENTAL ASSESSMENT: SOURCE TEST AND EVALUATION REPORT--EXXON MINIPLANT PRESSURIZED FLUIDIZED-BED COMBUSTOR WITH SORBENT REGENERATION |
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The report gives results of a comprehensive emission sampling and analysis of the EPA-sponsored, Exxon Miniplant, pressurized, coal-fired, fluidized-bed combustor (PFBC) and sorben...
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ENVIRONMENTAL CHARACTERIZATION OF GEOKINETICS' IN-SITU OIL SHALE RETORTING TECHNOLOGY |
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Air emissions and water effluents from true in-situ oil shale retorting were physically, chemically and biologically characterized by sampling of Geokinetics Retort No. 17, a pilot...
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ENVIRONMENTAL CHARACTERIZATION OF GEOKINETICS' IN-SITU OIL SHALE RETORTING TECHNOLOGY: FIELD AND ANALYTICAL DATA APPENDICES |
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Air emissions and water effluents from true in-situ oil shale retorting were physically, chemically and biologically characterized by sampling of Geokinetics Retort No. 17, a pilot...
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ENVIRONMENTAL TOBACCO SMOKE: MUTAGENIC EMISSION RATES AND THEIR RELATIONSHIP TO OTHER EMISSION FACTORS |
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The objective of this study was to evaluate the emission rates and exposure concentrations of mutagens, nicotine, and particles from cigarettes. Studies were conducted under contro...
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EPA SCIENTISTS PARTICIPATE IN THE SRA 2005 ANNUAL MEETING |
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Several NCEA Scientists will be presenting at this years Society For Risk Analysis (SRA) Annual Meeting (see other sources for the SRA meeting agenda). The meet...
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EPA'S (ENVIRONMENTAL PROTECTION AGENCY'S) INTEGRATED AIR CANCER PROGRAM |
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The Integrated Air Cancer Project (IACP) is an interdisciplinary research program designed to develop the scientific methods and data sets needed to identify the major carcinogenic...
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ESTERIFICATION OF ARYLHYDROXYLAMINES: EVIDENCE FOR A SPECIFIC GENE PRODUCT IN MUTAGENESIS |
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Characterization of a Salmonella typhimurium mutant strain (TA98/1,8-DNP6) resistant to the mutagenicity of nitrated polycyclic aromatic hydrocarbons (nitroarenes) revealed that it...
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ESTIMATING THE POTENCY OF MUTAGENS: CYTOTOXICITY AS AN OBLIGATORY CONSEQUENCE OF MUTAGENICITY |
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Rapid and reliable screening methods are required for identifying environmental mutagens and estimating their mutagenic potency in preparation for use of more elaborate tests to as...
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EVALUATING THE HUMAN HEALTH EFFECTS OF HAZARDOUS WASTES: REPRODUCTION AND DEVELOPMENT, NEUROTOXICITY, GENETIC TOXICITY AND CANCER |
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Several approaches are available for characterizing potential toxicity of wastes. his paper describes biological tests which are appropriate for identifying waste as neurotoxic, ge...
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EVALUATION OF CHEMICAL AND BIOLOGICAL METHODS FOR THE IDENTIFICATION OF MUTAGENIC AND CYTOTOXIC HAZARDOUS WASTE SAMPLES |
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To assist in the development of methods for identifying potentially hazardous wastes, the authors have conducted studies on the extraction of toxicants from several solid waste sam...
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EVALUATION OF CONVENTIONAL TREATMENT PROCESSES FOR REMOVAL OF MUTAGENIC ACTIVITY FROM MUNICIPAL WASTEWATERS |
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The present study was conducted to evaluate the mutagenicity of a domestic wastewater and a combined domestic/industrial wastewater at various stages of conventional treatment. Inf...
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EVALUATION OF HIGH VOLUME PARTICLE SAMPLING AND SAMPLE HANDLING PROTOCOLS FOR AMBIENT URBAN AIR MUTAGENICITY DETERMINATIONS |
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An investigation of high volume particle sampling and sample handling procedures was undertaken to evaluate variations of protocols being used by the U.S Environmental Protection A...
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EVALUATION OF HYPERFILTRATION FOR SEPARATION OF TOXIC SUBSTANCES IN TEXTILE PROCESS WATER |
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The report gives results of an evaluation of hyperfiltration for separation of toxic substances in textile process water. Three membranes (cellulose acetate, polyether/amide, and d...
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EVALUATION OF NEW 2,2-DIMETHYL-5,5-DIPROPOXYBENZIDINE- AND 3,3-DIPROPOXYBENZIDINE-BASED DIRECT DYE ANALOGS FOR MUTAGENIC ACTIVITY BY USE OF THE SALMONELLA/MAMMALIAN MUTAGENICITY ASSAY |
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A series of new metallized and unmetallized direct dyes based on benzidine analogs, 2,2'dimethyl-5,5'-dipropoxybenzidine and 3,3'-dipropoxybenzidine, were evaluated for mutagenicit...
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EVALUATION OF RELATIVE ENVIRONMENTAL HAZARDS FROM A COAL GASIFIER |
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The report gives results of an evaluation of relative environmental hazards from a laboratory-scale coal gasifier. Detailed chemical analyses of four effluent streams (gas, aqueous...
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EVALUATION OF TECHNIQUES USED IN THE PREPARATION OF DIESEL EXTRACT SAMPLES FOR MUTAGENICITY STUDIES |
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Diesel exhaust particles were used to compare methods and techniques used in the preparation of particulate samples for microbial mutagenesis testing. Investigated in the study wer...
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EVALUATION OF THE MUTAGENIC ACTIVITY OF 3-NBA (3-NITROABENZANTHRONE) USING STRAINS OF SALMONELLA TYPHIMURIUM WITH DIFFERENT LEVELS OF THE ENZYMES NITROREDUCTASE AND ACETYLTRANSFERASE |
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The 3-NBA (3-nitro-7H- benz[d,e]antracen-7-one) is extremely potent in the Ames test an useful test for mutagenicity, being a possible inducer of tumors in animals and possible car...
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EVALUATION OF THE MUTAGENICITY AND CARCINOGENICITY OF MOTOR VEHICLE EMISSIONS IN SHORT-TERM BIOASSAYS |
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Incomplete combustion of fuel in motor vehicles results in the emission of submicron carbonaceous particles which, after cooling and dilution, contain varying quantities of extract...
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EVALUATION OF THE MUTAGENICITY OF MUNICIPAL SEWAGE SLUDGE |
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Samples of five municipal sewage sludges from Illinois cities have been subjected to a multiorganism testing program to determine the presence or absence of mutagenic activity. Chi...
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EVALUATION OF THE RELEASE OF MUTAGENS FROM DIESEL PARTICLES IN THE PRESENCE OF PHYSIOLOGICAL FLUIDS |
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The Ames Salmonella typhimurium plate incorporation assay was used to evaluate the mutagenicity of organics extracted from diesel exhaust particles. Organic solvents were more effi...
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EVALUATION OF TOXIC EFFECTS OF ORGANIC CONTAMINANTS IN RECYCLED WATER |
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The report represents the results of a comprehensive series of toxicological studies designed to evaluate the health effects of the application of recycled water for drinking purpo...
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EVALUATION OF URBAN RUNOFF AND COMBINED SEWER OVERFLOW MUTAGENICITY |
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The introduction of potential mutagens to the human environment may serve to increase the rate of contact with substances that contribute to cancer incidence in the general populat...
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EVIDENCE FOR THE EXISTENCE OF DISTINCT NITROREDUCTASES IN 'SALMONELLA TYPHIMURIUM': ROLES IN MUTAGENESIS |
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Previous studies on the mutagenicity of nitroheterocyclics and nitrated polycyclic aromatic hydrocarbons had indicated the probable existence in Salmonella typhimurium of a multipl...
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EVIDENCE FOR THE PRESENCE OF MUTAGENIC ARYL AMINES IN HUMAN BREAST MILK AND DNA ADDUCTS IN EXFOLIATED BREAST-DUCT EPITHELIAL CELLS |
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Aromatic (AA) and heterocyclic amines (HAA) are ubiquitous environmental mutagens present in combustions emissions, fried meats, tobacco smoke, etc., and are suspect human mammary ...
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EXAMINATION OF THE ADDITIVITY ASSUMPTION USING THE SPIRAL AND STANDARD SALMONELLA ASSAYS TO EVALUATE BINARY COMBINATIONS OF MUTAGENS |
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Binary combinations of pure chemicals and complex mixtures were evaluated for their ability to produce additive mutagenicity responses in the spiral and standard Salmonella mutagen...
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Emerging Issues in Genotoxicity and Carcinogenicity with Implications for Structure Activity Analyses |
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In silico systems for the prediction of the ability of chemicals to induce carcinogenicity in rodents have generally relied on knowledge of the structure and physical-chemical feat...
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FEASIBILITY OF USING BACTERIAL STRAINS (MUTAGENESIS) TO TEST FOR ENVIRONMENTAL CARCINOGENS |
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A literature review was undertaken to assess feasibility of using bacteria as screening agents to detect environmental carcinogens. Mutagenicity data were included in the study bec...
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FOLATE DEFICIENCY ENHANCES ARSENIC-INDUCED GENOTOXICITY IN MICE |
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Folate deficiency increases background levels of DNA damage and can enhance the mutagenicity of chemical agents. Duplicate experiments were performed to investigate the effect of d...
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FORMATION OF MUTAGENIC URINARY METABOLITES FROM 1-NITROPYRENE IN GERM-FREE AND CONVENTIONAL RATS: ROLE OF THE GUT FLORA |
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1-Nitropyrene (NP), an environmental pollutant, a potent mutagen and an animal carcinogen, undergoes reduction, acetylation, ring hydroxylation and conjugation in the rat in vivo t...
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FRACTIONATION OF COMPLEX MIXTURES USING AND ION-EXCHANGE METHODOLOGY |
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Fractionation of particle emission extracts captured from complex combustion mixtures gas performed upon environmental samples using an ion-exchange technique. aptured emissions fr...
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GC/MS (GAS CHROMATOGRAPHY-MASS SPECTROMETRY) ANALYSIS OF ORGANICS IN DRINKING WATER CONCENTRATES AND ADVANCED WASTE TREATMENT CONCENTRATES. VOLUME 1. ANALYSIS RESULTS FOR 17 DRINKING WATER, 16 ADVANCED WASTE TREATMENT AND 3 PROCESS BLANK CONCENTRATES |
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The goal of this research program was to provide a detailed chemical characterization of organic material concentrated from large volumes (1,500 liters to 15,000 liters) of finishe...
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GENERAL ENHANCEMENT OF MUTAGENIC POTENCY OF VARIOUS MUTAGENS DUE TO DELETED GENES IN THE ΔuvrB STRAINS TA 98 AND TA 100 OF SALMONELLA COMPARED WITH STRAINS CONTAINING ONLY A POINT MUTATION IN uvrB |
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The two most common strains used in Ames mutagenicity assays, TA98 and TA 100, contain a �uvrB mutation designed to enhance the mutagenicity of compounds, presumably due to the los...
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GENERATION OF MUTAGENIC TRANSFORMATION PRODUCTS DURING THE IRRADIATION OF SIMULATED URBAN ATMOSPHERES |
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Mixtures of air pollutants simulating urban atmospheres were irradiated in a smog chamber, and the resultant products were monitored for the production of mutagenic and other hazar...
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GENETIC BASIS FOR USING 'TRADESCANTIA' CLONE 4430 AS AN ENVIRONMENTAL MONITOR OF MUTAGENS |
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The Tradescantia stamen hair system developed by the late Dr. Arnold H. Sparrow has been used in a wide variety of radiobiological studies, and more recently as an environmental mo...
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GENETOX MANAGER SYSTEM (GENETOX) - PROGRAMMER'S GUIDE - VAX COMPONENT |
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This programmer's guide is the reference manual explaining how the EPA GeneTox Manager System operates on the VAX. t is intended for use by anyone who has to perform program mainte...
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GENETOX MANAGER SYSTEM (GENETOX) - USER'S GUIDE VAX COMPONENT |
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This User's Guide is the reference manual describing use of the GeneTox application under the VAX/VMS operating system. eneTox Manager is a data capture, data management, and stati...
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GENETOX MANAGER SYSTEM - BACTERIAL MUTAGENESIS ASSAYS: USER'S GUIDE |
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This user's guide is the reference manual describing use of the EPA Genetox Manager System. eneTox Manager is a data capture, data management, and statistical analysis program used...
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GENETOX MANAGER SYSTEM - PERSONAL COMPUTER SOFTWARE PROGRAMMER'S GUIDE |
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This programmer's guide is the reference manual for describing software system and programs used in constructing personal computer portion of the EPA Genetox Manager System. eneTox...
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GENOTOXIC ACTIVITY OF ORGANIC CHEMICALS IN DRINKING WATER |
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The information summarized in this review provides substantial evidence for the widespread presence of genotoxins in drinking water. In many, if not most cases, the genotoxic activ...
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GENOTOXIC AND CARCINOGENIC PROPERTIES OF CHLORINATED FURANONES - IMPORTANT BY-PRODUCTS OF WATER CHLORINATION |
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The widespread presence of genotoxins in drinking water can be directly linked to the chlorination stage of water treatment. ecent studies in Finland, the United States and Great B...
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GENOTOXIC PROPERTIES OF MUNICIPAL WASTEWATERS IN OHIO |
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Wastewaters from six municipal wastewater treatment plants in Ohio were tested at different stages of treatment for mutagenicity in the Ames/Salmonella assay. The chlorinated secon...
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GENOTOXICITY AND METABOLISM OF THE SOURCE-WATER CONTAMINANT 1,1-DICHLOROPROPENE: ACTIVATION BY GSTT1-1 AND STRUCTURE-ACTIVITY CONSIDERATIONS |
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1, 1 -Dichloropropene (1,1-DCPe) is a contaminant of some source waters used to make drinking water. Because of this and the fact that no toxicological data were available for this...
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GENOTOXICITY OF 1,3-DICHLOROPROPANE, 2,2-DICHLOROPROPANE, AND 1,1-DICHLOROPROPENE IN SALMONELLA, THE E. COLI PROPHAGE-INDUCTION ASSAY, AND HUMAN HEPH2 CELLS |
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Genotoxicity of 1,3-Dichloropropane, 2,2-Dichloropropane, and 1,1-Dichloropropene in Salmonella, the E. coli Prophage-Induction Assay and Human HepG2 Cells
1,3-Dichloroprop...
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GENOTOXICITY OF 2,4,5-TRICHLOROPHENOXYACETIC ACID BIODEGRADATION PRODUCTS IN THE SALMONELLA REVERSION AND LAMBDA PROPHAGE-INDUCTION BIOASSAYS |
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The herbicide, 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), is still an environmental hazard because of its persistent nature even though its use was outlawed in this country in th...
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GENOTOXICITY OF BIOREMEDIATED SOILS FROM THE REILLY TARSITE, ST. LOUIS PARK, MINNESOTA |
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An in vitro approach was used to measure the genotoxicity of creosote-contaminated soil before and after four bioremediation processes. The soil was taken from the Reilly Tar site,...
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GENOTOXICITY OF COMPLEX MIXTURES: STRATEGIES FOR THE IDENTIFICATION AND COMPARATIVE ASSESSMENT OF AIRBORNE MUTAGENS AND CARCINOGENS FROM COMBUSTION SOURCES (JOURNAL VERSION) |
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Two strategies for assessment of the toxicity of complex mixtures are described and illustrated with examples from genotoxicity studies of complex combustion mixtures. The first is...
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GENOTOXICITY OF GAMMA IRRADIATION IN L5178Y MOUSE LYMPHOMA CELLS |
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The L5178Y mouse lymphoma assay has been widely used in short-term mutagenicity testing. Research into the types of genetic damage detected at the thymidine kinase locus indicates ...
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GENOTOXICITY OF TEN CIGARETTE SMOKE CONDENSATES IN FOUR TEST SYSTEMS: COMPARISONS AMONG ASSAYS AND CONDENSATES |
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The particulate fraction of cigarette smoke, cigarette smoke condensate (CSC), is genotoxic in many short-term in vitro tests and carcinogenic in rodents. However, no study has eva...
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GENOTOXICITY OF TEN CIGARETTE SMOKE CONDENSATES IN FOUR TEST SYSTEMS: COMPARISONS BETWEEN ASSAYS AND CONDENSATES |
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What is the study?
This the first assessment of a set of cigarette smoke condensates from a range of cigarette types in a variety (4) of short-term genotoxicity assays.
...
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GENOTOXICITY OF THREE PYRIDINE COMPOUNDS TO L5178Y MOUSE LYMPHOMA CELLS |
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The L5l78Y mouse lymphoma assay was used to examine the potential mutagenicity of three halogenated pyridine compounds. Position effects of the halogen moiety and role of metabolic...
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GENOTOXICITY STUDIES OF BENZ(1)ACEANTHRYLENE |
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The genotoxicity of the cyclopenta-fused polycyclic aromatic hydrocarbon, benz(1)aceanthrylene (B(1)A),was evaluated in vitro using the L5178Y/T (K sup +/-) mouse lymphoma assay an...
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GENOTOXICITY STUDIES OF SODIUM DICHLOROACETATE AND SODIUM TRICHLOROACETATE |
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The genotoxic properties of sodium dichloroacetate (DCA) and sodium trichloroacetate (TCA)were evaluated in several short-term in vitro and in vivo assays. Neither compound was mut...
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GLUTATHIONE S-TRANSFERASE M1 (GSTM1) NULL GENOTYPE AND BENZIDINE-ASSOCIATED BLADDER CANCER, URINE MUTAGENICITY, AND EXFOLIATED UROTHELIAL CELL DNA ADDUCTS |
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NO ABSTRACT PROVIDED...
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GLUTATHIONE S-TRANSFERASE-MEDIATED MUTAGENICITY OF TRIHALOMETHANES IN SALMONELLA TYPHIMURIUM: CONTRASTING RESULTS WITH BROMODICHLOROMETHANE AND CHLOROFORM |
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NO ABSTRACT PROVIDED...
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GUIDE FOR THE 'SALMONELLA TYPHIMURIUM'/MAMMALIAN MICROSOME TESTS FOR BACTERIAL MUTAGENICITY |
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Since its development by Dr. Bruce Ames and his coworkers, the Salmonella typhimurium/mammalian microsome mutagenicity assay has been used widely throughout the world. Many authors...
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GUIDELINES FOR MUTAGENICITY RISK ASSESSMENT |
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The guidelines published today are products of a two-year Agency-wide effort, which has included many scientists from the larger scientific community. These guidelines set forth pr...
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GUIDELINES FOR PREPARING ENVIRONMENTAL AND WASTE SAMPLES FOR MUTAGENICITY (AMES) TESTING: INTERIM PROCEDURES AND PANEL MEETING PROCEEDINGS |
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The User's Guide presents review papers and interim protocols for the preparation of waste and environmental samples for testing with the Salmonella reverse-mutation assay (Ames te...
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HAZARD IDENTIFICATION: EFFICIENCY OF SHORT-TERM TESTS IN IDENTIFYING GERM CELL MUTAGENS AND PUTATIVE NONGENOTOXIC CARCINOGENS |
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For more than a decade, mutagenicity tests have had a clearly defined role in the identification of potential human mutagens and an ancillary role in the identification of potentia...
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HEALTH ASSESSMENT DOCUMENT FOR 1,2-DICHLOROETHANE (ETHYLENE DICHLORIDE). EXTERNAL REVIEW DRAFT. PARTS 1 AND 2 |
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Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indic...
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HEALTH ASSESSMENT DOCUMENT FOR 1,2-DICHLOROETHANE (ETHYLENE DICHLORIDE). FINAL REPORT |
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Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indic...
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HEALTH ASSESSMENT DOCUMENT FOR ACROLEIN. EXTERNAL REVIEW DRAFT |
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Acrolein is an unsaturated aldehyde which is highly toxic by the inhalation and oral routes and is a strong irritant. The reactivity and toxicity of acrolein is seen at the princip...
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HEALTH ASSESSMENT DOCUMENT FOR CHLOROFORM. FINAL REPORT |
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Chloroform is ubiquitous in the environment. The northern hemisphere background average has been determined to be approximately 14 ppt and the global average is 8 ppt. After inhala...
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HEALTH ASSESSMENT DOCUMENT FOR DICHLOROMETHANE (METHYLENE CHLORIDE), EXTERNAL REVIEW DRAFT |
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Dichloromethane (DCM) is a solvent widely used for a variety of purposes. It has been detected in the ambient air of urban and non-urban areas of the United States and also in natu...
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HEALTH ASSESSMENT DOCUMENT FOR DIESEL EMISSIONS (1994) |
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This report on the health effects of diesel combustion emissions, includes a quantitative cancer risk assessment, and a reference concentration (non-cancer) for lifetime exposure; ...
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HEALTH ASSESSMENT DOCUMENT FOR DIESEL EMISSIONS - VOLUME II OF II |
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This document reports on the health effects of diesel combustion emissions, including a quantitative cancer risk assessment, and a reference concentration (non-cancer) for lifetime...
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HEALTH ASSESSMENT DOCUMENT FOR HEXACHLOROCYCLOPENTADIENE (EXTERNAL REVIEW DRAFT) |
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The Office of Health and Environmental Assessment of the Office of Research and Development has prepared this health assessment document (HAD) at the request of the Office of Air Q...
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HEALTH ASSESSMENT DOCUMENT FOR HEXACHLOROCYCLOPENTADIENE. FINAL REPORT |
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The Office of Health and Environmental Assessment of the Office of Research and Development has prepared this health assessment document (HAD) at the request of the Office of Air Q...
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HEALTH ASSESSMENT DOCUMENT FOR MANGANESE. EXTERNAL REVIEW DRAFT |
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The Office of Research and Development of U.S. EPA has prepared this health assessment document for the program office to determine whether manganese should be regulated as a hazar...
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HEALTH ASSESSMENT DOCUMENT FOR NICKEL AND NICKEL COMPOUNDS. FINAL REPORT |
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The predominant atmospheric forms of nickel are as sulfate, oxides, and complex oxides. Nickel also occurs in ambient and drinking waters and soils. Routes of intake for man are in...
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HEALTH ASSESSMENT DOCUMENT FOR POLYCHLORINATED DIBENZO-P-DIOXINS |
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The health assessment document on polychlorinated dibenzo-p-dioxins discusses multimedia environmental issues pertaining to the most toxic chlorinated dioxins, namely, 2,3,7,8-tetr...
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HEALTH ASSESSMENT DOCUMENT FOR TETRACHLOROETHYLENE (PERCHLOROETHYLENE). FINAL REPORT |
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Tetrachloroethylene (PCE) is a volatile solvent with important commercial applications. It has been detected in the ambient air of a variety of urban and nonurban areas of the Unit...
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HEALTH EFFECTS ASSESSMENT FOR ACENAPHTHENE |
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Because of the lack of data for the carcinogenicity and threshold toxicity of acenaphthene risk assessment values cannot be derived. The ambient water quality criterion of 0.2 mg/l...
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HEALTH EFFECTS ASSOCIATED WITH INDOOR AIR POLLUTANTS |
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A state-of-information survey concerning health effects of indoor air pollutants in the categories of formaldehyde, volatile organics, radon, particulates, and combustion products ...
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HEALTH EFFECTS OF CONSUMPTION OF RENOVATED WATER: CHEMISTRY AND CYTOTOXICITY |
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The objective of the research has been to develop methods to separate, identify, and measure volatile and non-volatile compounds found in secondary wastewater effluent, and to test...
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HEALTH EFFECTS OF DIESEL ENGINE EMISSIONS: PROCEEDINGS OF AN INTERNATIONAL SYMPOSIUM HELD AT CINCINNATI, OHIO ON DECEMBER 3-5, 1979. VOLUME II |
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The Proceedings are organized into eight main sections corresponding to the format of the Symposium and addressing Toxicological Effects of Inhaled Diesel Emissions, Mutagenic and ...
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HIGH CONCENTRATIONS OF SODIUM CHLORIDE INDUCE A 'POSITIVE' RESPONSE AT THE TK LOCUS OF L5178Y/TK(+)/(-)MOUSE LYMPHOMA CELLS (JOURNAL VERSION) |
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The experiment with sodium chloride demonstrates the importance of carefully evaluating weak mutagenic responses observed with high concentrations of test compounds. The positive m...
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HIGHLY SENSITIVE BIOASSAYS FOR EVALUATING AIRBORNE MUTAGENS INDOORS |
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The standard mutagenicity bioassays that are readily applied to the valuation of outdoor air samples collected by high volume samplers are not efficiently sensitive to measure the ...
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HUMAN HEPATOCYTE-MEDIATED MUTAGENESIS AND DNA REPAIR ACTIVITY |
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Combined cultures of human hepatocytes and human fibroblasts constitute a system composed entirely of normal human cells that can be used to investigate the mutagenicity of chemica...
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IACP (INTEGRATED AIR CANCER PROJECT) EMISSIONS: TRANSFORMATIONS AND FATE |
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As part of the Integrated Air Cancer Project (IACP), diluted emissions from wood stoves and automobiles were injected into a Teflon smog chamber and irradiated to simulate their ph...
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IDENTIFICATION AND COMPARATIVE RISK ASSESSMENT OF AIRBORNE CARCINOGENS FROM COMBUSTION SOURCES |
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The identification and assessment of airborne carcinogens has been significantly advanced by the use of short-term genetic bioassays. Bioassay-directed fractionation coupled with n...
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IDENTIFICATION OF MUTAGENIC COMPOUNDS FORMED DURING CHLORINATION OF HUMIC ACID |
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Humic acid chlorination products are being studied in an effort to identify the chemicals responsible for the mutagenicity formed during water chlorination. In the present report, ...
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IMPORTANCE OF SAMPLE PH ON RECOVERY OF MUTAGENICITY FROM DRINKING WATER BY XAD RESINS |
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Sample pH and the presence of a chlorine residual were evaluated for their effects on the recovery of mutagenicity in drinking water following concentration by XAD resins. The leve...
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IN SILICO MODELLING OF HAZARDOUS ENDPOINTS: CURRENT PROBLEMS AND PROSPECTIVES |
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The primary hurdles for Quantitative Structure-Activity Relationships (QSARs) to overcome their acceptance for regulatory purposes will be discussed. They include (a) the developm...
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IN VITRO AND IN VIVO MUTAGENICITY STUDIES OF ENVIRONMENTAL CHEMICALS |
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The objectives of this project were to evaluate the mutagenicity of various compounds, mostly pesticides, using microbial and mammalian cell in vitro techniques, as well as in vivo...
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IN VITRO MICROBIOLOGICAL MUTAGENICITY AND UNSCHEDULED DNA SYNTHESIS STUDIES OF FIFTEEN PESTICIDES |
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Fifteen pesticides being reviewed as part of the EPA Substitute Chemical Program were examined by SRI International by several in vitro test procedures, for the following: Reverse ...
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INDOOR AIR EXPOSURE TO COAL AND WOOD COMBUSTION EMISSIONS IN XUAN WEI, CHINA, WITH A HIGH LUNG CANCER RATE |
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Residents of Xuan Wei County in China have unusually high lung cancer mortality that cannot be attributed to tobacco use or occupational exposure. hey are exposed to smoke from unv...
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INDOOR AIR SAMPLING AND MUTAGENICITY STUDIES OF EMISSIONS FROM UNVENTED COAL COMBUSTION (JOURNAL VERSION) |
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The purpose of the study is to develop sampling strategies and bioassay methods for indoor air in homes, the authors developed a medium-volume sampler to collect the <10 - micromet...
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INDOOR AIR SAMPLING AND MUTAGENICITY STUDIES RELATED TO EMISSIONS FROM UNVENTED COAL COMBUSTION |
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The purpose of the study is to develop sampling strategies and bioassay methods for indoor air in homes. The work reported here was conducted to prepare for a joint U.S.-China fiel...
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INDUCED HEPATOCYTES AS A METABOLIC ACTIVATION SYSTEM FOR THE MOUSE-LYMPHOMA ASSAY |
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We have developed methods for the coculture of hepatocytes and mouse lymphoma cells and have shown the utility of this system for testing promutagens from several chemical classes ...
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INDUCTION OF GASTROINTESTINAL TRACT NUCLEAR ANOMALIES IN B6C3F1 MICE BY 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2-(5H)-FURANONE, MUTAGENIC BYPRODUCTS OF CHLORINE DISINFECTION |
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Two chlorinated hydroxylated furanones, 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) and 3,4-(dichloro)-5-hydroxy-2[5H]-furanone (MA), potent bacterial mutagens and by...
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INDUSTRIAL BOILER COMBUSTION MODIFICATION NOX CONTROLS. VOLUME III: STOKER-COAL-FIRED BOILER FIELD TEST - SITE B |
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The report gives methods and results of an environmental assessment test program at an industrial site. The aim of the program was to measure multimedia emissions changes as a resu...
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INFLUENCE OF ENVIRONMENTAL CHANGES ON DEGRADATION OF CHIRAL POLLUTANTS IN SOILS |
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Numerous anthropogenic chemicals of environmental concern- including some phenoxy acid herbicides, organophosphorus insecticides, polychlorinated biphenyls, phthalates, freon subst...
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INHIBITION OF FRIED MEAT-INDUCED DNA DAMAGE: A DIETARY INTERVENTION STUDY IN HUMANS |
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Dietary exposures have been implicated as risk factors in colorectal cancer. Such agents may act by causing DNA damage or may be protective against DNA damage. The effects of dieta...
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INTER-LABORATORY VARIABILITY IN AMES ASSAY RESULTS |
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The Ames test is widely used in the screening of chemicals and compounds for potential carcinogenic effect. here is, however, considerable inter-laboratory variability in results f...
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INTERIM PROCEDURES FOR CONDUCTING THE 'SALMONELLA'/MICROSOMAL MUTAGENICITY ASSAY (AMES TEST) |
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The Ames assay is a rapid-screening procedure for determining the presence of mutagenic and carcinogenic pure chemicals, complex environmental mixtures, and commercial products. Th...
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INVESTIGATING THE SOURCES OF THE MUTAGENIC ACTIVITY FOUND IN A RIVER USING THE SALMONELLA ASSAY AND DIFFERENT WATER EXTRACTION PROCEDURES |
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Abstract
As a consequence of the routine surface water quality-monitoring program of Sao Paulo State (Brazil), which includes the Salmonella microsome mutagenicity assay as one ...
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INVESTIGATION OF THE MUTAGENIC POTENTIAL OF EMISSIONS FROM ASPHALT FORMULATIONS WITH AND WITHOUT CRUMB-RUBBER MODIFICATION |
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INVESTIGATION OF THE MUTAGENIC POTENTIAL OF EMISSIONS FROM ASPHALT FORMULATIONS WITH AND WITHOUT CRUMB-RUBBER MODIFICATION
Larry D. Olsen', Virginia S. Houk2, Sarah H. Warre...
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IPCS COLLABORATIVE STUDY ON THE UTILITY OF PLANT TEST SYSTEMS IN GENETIC TOXICOLOGY: ARABIDOPSIS ASSAY FOR MUTAGENICITY |
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Four laboratories, two in Czechoslovakia (Brno and Prague) and two in USSR (Moscow and Duschanbe), participated in the International Program On Chemical Safety's (IPCS) Collaborati...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR ACROLEIN (EXTERNAL REVIEW DRAFT) |
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Acrolein is a colorless to yellowish flammable liquid with a disagreeable, choking odor. The principal use of acrolein is as an intermediate in the synthesis of acrylic acid, whic...
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ISSUES IN RISK ASSESSMENT IN MALE REPRODUCTIVE TOXICOLOGY |
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Efforts in the area of risk assessment have concentrated primarily on cancer as an outcome. However, attention is now being directed toward the development of strategies for assess...
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In vivo mutagenicity of conazole fungicides correlates with tumorigenicity |
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Triadimefon, propiconazole, and myclobutanil are conazoles, an important class of agricultural and therapeutic fungicides. Triadimefon and propiconazole are mouse liver tumorigens,...
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LACK OF LIVER MUTATIONS IN MEDAKA EXPOSED TO MX |
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Mutagenicity assays with Salmonella have shown that 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX), a drinking water disinfection by-product is a potent mutagen, account...
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LAND TREATMENT OF PAH-CONTAMINATED SOIL: PERFORMANCE MEASURED BY CHEMICAL AND TOXICITY ASSAYS |
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The performance of a soil remediation process can be determined by measuring the reduction in target soil contaminant concentrations and by assessing the treatment's ability to low...
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LAND TREATMENT OF PAH-CONTAMINATED SOIL: PERFORMANCE MEASURED BY CHEMICAL AND TOXICITY ASSAYS |
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The performance of a soil remediation process can be determined by measuring the reduction in target soil contaminant concentrations and by assessing the treatment's ability to low...
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LEVEL 1 BIOASSAY SENSITIVITY |
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The report, based on a survey of published literature, establishes a set of sensitivity estimates for the Level 1 environmental assessment (EA) bioassays recommended by EPA's IERL-...
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LONG-RANGE RESEARCH AGENDA FOR THE PERIOD 1986-1991 (ENVIRONMENTAL PROTECTION AGENCY, OFFICE OF RESEARCH AND DEVELOPMENT) |
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The framework for the document is based on scientific issues identified by EPA's Research Committees composed of representatives of the Office of Research Development (ORD), Agency...
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LUNG CANCER AND INDOOR AIR POLLUTION IN XUAN WEI, CHINA |
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Xuan Wei County, China has an unusually high lung cancer mortality rate that cannot be attributed to tobacco use or occupational exposure. Most Xuan Wei residents, especially women...
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LUNG CANCER AND INDOOR EXPOSURE OF UNVENTED COAL AND WOOD COMBUSTION EMISSIONS IN XUAN WEI, CHINA |
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Residents of Xuan Wei County in China have unusually high lung cancer mortality that cannot be attributed to tobacco use or occupational exposure. They are exposed to smoke from un...
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MEASUREMENT OF MUTAGENIC EMISSIONS FROM THE INCINERATION OF THE PESTICIDES DINOSEB DURING APPLICATION OF COMBUSTION MODIFICATIONS |
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The incineration of the pesticide dinoseb with staged combustion and reburning reduced not only the NOx by 96% compared to the absence of these two control technologies, but also t...
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MECHANISMS OF CARCINOGENICITY AND ANTICARCINOGENICITY: ROLE OF DIETARY COMPONENTS |
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The role of nutrition in the etiology of human disease, including cancer, has been recognized for a very long time. This knowledge and, perhaps, personal preference are reflected b...
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MEETING REPORT ASSESSING HUMAN GERM-CELL MUTAGENESIS IN THE POST-GENOME ERA: A CELEBRATION OF THE LEGACY OF WILLIAM LAWSON (BILL) RUSSELL |
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Although numerous germ-cell mutagens have been identified in animal model systems, to date, no human germ-cell mutagens have been confirmed. Because the genomic integrity of our g...
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METABOLISM AND MUTAGENICITY OF SOURCE WATER CONTAMINANTS 1, 3-DICHLOROPROPANE AND 2,2-DICHLOROPROPANE |
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Abstract
Cytochrome P450-dependent oxidation and glutathione (GSH)-dependent conjugation are the primary routes of metabolism of haloalkanes. Using rat liver microsomes and cyt...
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METABOLISM OF 1-NITROPYRENE BY HUMAN, RAT, AND MOUSE INTESTINAL FLORA: NYTAGENICITY OF ISOLATED METABOLITES BY DIRECT ANALYSIS OF HPLC FRACTIONS WITH A MICROSUSPENSION REVERSE MUTATION ASSAY |
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Among the nitro-substituted polycyclic aromatic hydrocarbons identified in environmental samples and known to be genotoxic, 1-nitropyrene is one of the most abundant. he biotransfo...
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METABOLISM, MICROFLORA EFFECTS, AND GENOTOXICITY IN HALOACETIC ACID-TREATED CULTURES OF RAT CECAL MICROBIOTA |
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Haloacetic acids are by-products of drinking water disinfection. Several compounds in this class are genotoxic and have been identified as rodent hepatocarcinogens. Enzymes produ...
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METABOLISM, MUTAGENICITY, AND ACTIVATION OF 1-NITROPYRENE IN VIVO AND IN VITRO |
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The genotoxic air pollutant 1-nitropyrene (NP) labelled with 14C was administered to rats as the pure compound (6 micromole) by intraperitoneal injection, and vapor-phase-coated on...
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METHODS FOR THE SPIRAL SALMONELLA MUTAGENICITY ASSAY INCLUDING SPECIALIZED APPLICATIONS |
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ABSTRACT
An automated approach to bacterial mutagenicity testing--the spiral Salmonella assay--was developed to simplify testing and to reduce the labor and materials requir...
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METHYLATED TRIVALENT ARSENICALS AS CANDIDATE ULTIMATE GENOTOXIC FORMS OF ARSENIC: INDUCTION OF CHROMOSOMAL MUTATIONS BUT NOT GENE MUTATIONS |
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ABSTRACT
Arsenic is a prevalent human carcinogen whose mutagenicity has not been characterized fully. Exposure to either form of inorganic arsenic, AsIII or AsV, can result in...
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MICROBIOLOGICALLY-MEDIATED MUTAGENIC ACTIVITY OF CRUDE OIL |
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Crude oil was incubated with raw and sterile river water samples and assayed for mutagenic activity by the Ames test to determine the ability of naturally-occurring freshwater micr...
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MODULATION OF THE CYTOTOXICITY AND GENOTOXICITY OF THE DRINKING WATER DBP IODOACETIC ACID BY SUPPRESSORS OF OXIDATIVE STRESS |
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Drinking water disinfection by-products (DBPs) are generated by the chemical disinfection of water and may pose a hazard to the public health. Previously we demonstrated that iodoa...
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MOLECULAR ANALYSIS OF MUTATIONS INDUCED AT THE HISD3052 ALLELE OF SALMONELLA BY SINGLE CHEMICALS AND COMPLEX MIXTURES |
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More single chemicals and complex environmental mixtures have been evaluated for mutagenicity at the hisD3052 allele of Salmonella, primarily in strain TA98, than in any other muta...
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MONITORING FOR MUTAGENICITY WITH PLANTS |
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Although plants have historically been important in the development of genetic principles and the illustration of the hazards of ionizing radiation, plants have not been adequately...
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MUTAGENIC ACTIVITY OF AEROSOL SIZE FRACTIONS |
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Several investigators in diverse geographical locations have detected airborne mutagens with the Ames' Salmonella typhimurium bioassay. Yet to be established is the aerodynamic dia...
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MUTAGENIC ACTIVITY OF PARTICULATE MATTER FROM WOOD SMOKE |
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The formation of mutagenic products through combustion and by atmospheric processes has become an area of increased interest. eries of experiments to evaluate the formation of muta...
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MUTAGENIC AGENTS |
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A description of some chemicals that are used in chemotherapy and pyschotherapy is presented in relation to their mutagenic activity. A comparison of the mutagenic activity of thes...
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MUTAGENIC AND CLASTOGENIC PROPERTIES OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE: A POTENT BACTERIAL MUTAGEN IN DRINKING WATER |
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3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was found to be a direct-acting mutagen in the Ames test for strains TA1535, TA1538, TA92, TA97, TA98, TA100 and TA102. Th...
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MUTAGENIC ATMOSPHERIC AEROSOL SOURCES APPORTIONED BY RECEPTOR MODELING |
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During the winter of 1985, the U.S. Environmental Protection Agency (EPA) collected air quality data and samples in residential locations in Albuquerque. ew Mexico and Raleigh, Nor...
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MUTAGENIC CHARACTERISTICS OF RIVER WATERS FLOWING THROUGH LARGE METROPOLITAN AREAS IN NORTH AMERICA |
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Mutagenic characteristics of river waters flowing through large metropolitan areas in North America
The hanging technique using blue rayon, which specifically adsorbs mutage...
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MUTAGENIC COMPOUNDS GENERATED FROM THE CHLORINATION OF DISPERSE AZO-DYES AND THEIR PRESENCE IN DRINKING WATER |
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Although the disinfection of water for human usage is necessary, the formation of toxic disinfection by-products (DBPs) does occur. Recent discovery of a novel class of mutagenic D...
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MUTAGENIC DETERMINATION OF PASSIVE SMOKING (JOURNAL VERSION) |
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The mutagenic activity of tobacco smoke has been further investigated with the plate incorporation method and a microsuspension technique of the Ames Salmonella assay. The microsus...
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MUTAGENIC PROPERTIES OF RIVER WATERS FLOWING THROUGH BIG CITY AREAS IN NORTH AMERICA |
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The hanging technique using Blue rayon, which specifically adsorbs mutagens with multicyclic planer structures, has advantages over the conventional method of bringing-large volume...
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MUTAGENIC RESIDUES RECOVERED FROM GRANULAR ACTIVATED CARBON AFTER ITS USE IN DRINKING WATER TREATMENT |
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In addition to its use in removal of compounds which cause taste, odor or color problems in drinking water, granular activated carbon (GAC) has received increasing attention as a t...
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MUTAGENIC SCREENING OF THREE DYES FOR MARKER GRENADES IN THE SALMONELLA REVERSION ASSAY AND THE L5178Y/TK+/-MOUSE LYMPHOMA ASSAY |
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Dyes are used by the military in M18 marker signaling grenades. The U.S. Army is concerned with evaluating any potential health hazards that might result from personal contact with...
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MUTAGENIC SPECIFICITY AND THE PREDICTION OF MECHANISMS AND BIOACTIVATION PATHWAYS OF GENOTOXICANTS: THE MUTAGENICITY OF 5-NITROACENAPHTHENE AS AN EXAMPLE |
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5-Nitroacenaphthlene induces primarily mutations of the frameshift type in Salmonella typhimurium (i.e., strains TA98 and TA1538). Addition of activation mixtures (S9) results in a...
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MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1,3-BUTADIENE |
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1,3-Butadiene has been shown to be an indirect mutage in bacteria. Two of its potential metabolites, 3,4- epoxybutene and diepoxybutane, are genotoxic in prokaryote as well as euka...
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MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1,3-BUTADIENE. REVIEW DRAFT |
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The Mutagenicity and Carcinogenicity Assessment of 1,3-Butadiene was prepared to serve as a source document for Agency-wide use. In the development of this assessment document, the...
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MUTAGENICITY AND CARCINOGENICITY OF COMPLEX COMBUSTION EMISSIONS:EMERGING MOLECULAR DATA TO IMPROVE RISK ASSESSMENT |
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The dichloromethane-extractable particulate organics of various combustion emissions, as well as urban air, have been evaluated for their ability to induce mutations in Salmonella ...
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MUTAGENICITY AND CHEMICAL ANALYSIS OF EMISSIONS FROM THE OPEN BURNING OF SCRAP RUBBER TIRES |
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The paper discusses the use of the Salmonella mutagenicity assay to perform bioassay-directed chemical analysis of emissions from the open burning of scrap rubber tires in both a s...
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MUTAGENICITY AND CHEMICAL CHARACTERISTICS OF CARBONACEOUS PARTICULATE MATTER FROM VEHICLES ON THE ROAD. (JOURNAL VERSION) |
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Experiments were conducted in the Allegheny Mountain Tunnel of the Pennsylvania Turnpike in the summer of 1979 to evaluate the Ames-assay bacterial mutagenicity of the solvent extr...
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MUTAGENICITY AND CLASTOGENICITY OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) IN L5178Y/TK +/- -3.7.2C MOUSE LYMPHOMA CELLS |
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3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) is a chlorohydroxyfuranone compound produced by the chlorine disinfection of humic-containing drinking water and the chlor...
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MUTAGENICITY AND CLASTOGENICITY OF ACRYLAMIDE IN L5178Y MOUSE LYMPHOMA CELLS |
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Acrylamide was tested without exogenous activation in L5178Y/TK+/- 3.7.2C cells for mutation at the thymidine kinase locus and for clastogenicity. Acrylamide gave a positive induce...
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MUTAGENICITY AND CLASTOGENICITY OF ADRIAMYCIN IN L5178Y/TK+/- 3.7.2C MOUSE LYMPHOMA CELLS |
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Adriamycin was a potent mutagen at the tk locus of L5178Y/TK+/- -3.7.2C mouse lymphoma cells. A dose of 5 ng/ml gave total mutant frequencies of 417/ten to the 6th power survivors ...
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MUTAGENICITY AND CLASTOGENICITY OF PROFLAVIN IN L5178Y/TK(+/-)-3.7.2.C CELLS |
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The paper evaluated the ability of proflavin to induce specific-locus mutations at the heterozygous thymidine kinase (tk) locus of L5178Y/TK+/- -3.7.2.C mouse lymphoma cells, which...
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MUTAGENICITY AND CLASTOGENICITY OF TENIPOSIDE (VM-26) IN L5178Y/TK(+/-)-3.7.2C MOUSE LYMPHOMA CELLS |
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The antitumor drug teniposide (VM-26) is a potent inducer of DNA breaks (Long et al., Cancer Res., 45:3106, 1985), but it is only weakly mutagenic at the hprt locus in CHO cells (S...
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MUTAGENICITY AND CYTOTOXICITY OF COAL FLY ASH FROM FLUIDIZED-BED AND CONVENTIONAL COMBUSTION |
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Two respirable coal fly-ash samples (3 micrometers) were evaluated for physical properties chemical composition, and biological activity, including cytotoxicity and mutagenicity. T...
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MUTAGENICITY AND DISINFECTION BY-PRODUCTS IN SURFACE DRINKING WATER DISINFECTED WITH PERACETIC ACID |
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The aims of this research were to study the influence of peracetic acid (PAA) on the formation of mutagens in surface waters used for human consumption and to assess its potential ...
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MUTAGENICITY AND DNA ADDUCT FORMATION OF PAH, NITRO-PAH, AND OXY-PAH FRACTIONS OF ATMOSPHERIC PARTICULATE MATTER FROM SAO PAULO, BRAZIL |
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Summary
What is the study?
Near roadway and immediate roadway exposures to transportation emissions gave very similar results in the Salmonella mutagenicity assay and in ...
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MUTAGENICITY AND MUTATION SPECTRA OF 2-ACETYLAMINOFLUORENE AT FRAMESHIFT AND BASE-SUBSTITUTION ALLELES IN FOUR DNA REPAIR BACKGROUNDS OF SALMONELLA |
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We used colony probe hybridization procedures-to determine the mutations in 600 revertants of the -1 frameshift allele hisD3052 and 200 revertants of the base substitution allele h...
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MUTAGENICITY AND MUTATION SPECTRA OF AIR AND WATER: ROLE OF GSST1-1 AND AKR GENOTYPES |
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Recent molecular epidemiology research confirms that an increased risk for bladder cancer is associated with dermal/inhalation exposure to chlorinated water (from bathing/showering...
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MUTAGENICITY ASSESSMENT OF ACETALDEHYDE |
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Acetaldehyde has been shown in studies by several different laboratories to be a clastogen and inducer of sister chromatid exchanges in cultured mammalian cells. Although there hav...
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MUTAGENICITY EVALUATION OF THE COMMERCIAL PRODUCT CI DISPERSE BLUE 291 USING DIFFERENT PROTOCOLS OF THE SALMONELLA ASSAY |
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Textile dyes can enter the water ecosystem through wastewater discharges potentially exposing humans through the consumption of water and food. The commercial disperse dye product ...
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MUTAGENICITY IN LUNG OF BIG BLUE ((R) MICE AND INDUCTION OF TANDEM-BASE SUBSTITUTIONS IN SALMONELLA BY THE AIR POLLUTANT PEROXYACETYL NITRATE (PAN): PREDICTED FORMATION OF INTRASTRAND CROSS-LINKS |
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Peroxyacetyl nitrate (PAN) is a ubiquitous air pollutant formed from N02 reacting with acetoxy radicals generated from ambient aldehydes in the presence of sunlight and ozone. It ...
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MUTAGENICITY IN SALMONELLA AND DNA DAMAGE IN THE CHO/COMET ASSAY INDUCED BY NITROHALOMETHANES, A NOVEL CLASS OF DRINKING WATER DISINFECTION BY-PRODUCTS |
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Mutagenicity in Salmonella and DNA Damage in the CHO/Comet Assay Induced by Nitrohalomethanes, a Novel Class of Drinking Water Disinfection By-Products.
Halomethanes are a...
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MUTAGENICITY IN SALMONELLA OF HALONITROMETHANES: A RECENTLY RECOGNIZED CLASS OF DISINFECTION BY-PRODUCTS IN DRINKING WATER |
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Halonitromethanes (HNMs) are a recently identified class of disinfection by-products in drinking water. They include chloronitromethane (CHN), dichloronitromethane (DCNM), trichlor...
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MUTAGENICITY IN SALMONELLA OF HALONITROMETHANES: A RECENTLY RECOGNIZED CLASS OF DISINFECTION BYPRODUCTS IN DRINKING WATERS. |
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Halonitromethanes(HNMs)are a recently identified class of disinfection by-products (DBPs) in drinking water.They include chloronitromethane (CHN), dichloronitromethane (DCNM), tric...
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MUTAGENICITY IN SALMONELLA OF HAZARDOUS WASTES AND URINE FROM RATS FED THESE WASTES |
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15 hazardous industrial waste samples were evaluated for mutagenicity in the Salmonella plate-incorporation assay using strains TA98 and TA100 in the presence and absence of Aroclo...
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MUTAGENICITY IN SALMONELLA OF SULFUR-CONTAINING POLYCYCLIC AROMATIC HETEROCYCLES AND THEIR DIHYDRODIOL DERIVATIVES |
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Polycyclic aromatic sulfur heterocycles (PASH) are common constituents of cigarette smoke, fossil fuel-derived materials, and their combustion byproducts. Many PASH are known mutag...
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MUTAGENICITY OF 'M'-AMSA AND 'O'-AMSA IN MAMMALIAN CELLS DUE TO CLASTOGENIC MECHANISM: POSSIBLE ROLE OF TOPOISOMERASE |
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4-(9-Acridinylamino)methanesulfon-m-anisidide (m-AMSA), an antitumor agent, is a potent clastogen in a variety of mammalian cell lines, but it is only weakly mutagenic at the hprt ...
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MUTAGENICITY OF 1-NITROPYRENE METABOLITES FROM LUNG S9 |
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The mutagenicity of 1-nitropyrene metabolites from rabbit lung S9 incubates was evaluated using the Salmonella typhimurium plate incorporation assay with strain TA98, with and with...
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MUTAGENICITY OF 7H-DIBENZO(C,G)CARBAZOLE AND METABOLITES IN SALMONELLA TYPHIMURIUM |
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7H-Dibenzo(c,g)carbazole (DBC) is a potent carcinogen of environmental import. Reverse-mutation plate-incorporation assays for mutagenicity were undertaken in Salmonella typhimuriu...
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MUTAGENICITY OF ACTINOMYCIN D IN MAMMALIAN CELLS DUE TO CLASTOGENIC EFFECTS |
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Actinomycin D was clastogenic and mutagenic in L5178Y/TK+/- -3.7.2C mouse lymphoma cells. The majority of the mutants were small colonies, indicating that actinomycin D acts primar...
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MUTAGENICITY OF ALASKAN OIL SPILL ORGANICS DURING EPA BIOREMEDIATION EFFORTS |
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On 24 March 1989 approximately 11 million gallons of Prudhoe Bay crude oil spilled into the waters of Prince William Sound, Alaska ultimately contaminating nearly 1000 miles of sho...
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MUTAGENICITY OF BENZO(A)PYRENE METABOLITES GENERATED ON THE ISOLATED PERFUSED LUNG FOLLOWING PARTICULATE EXPOSURE (JOURNAL VERSION) |
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The isolated perfused rabbit lung (IPL) is being used to study the effects of particulate exposure on the pulmonary metabolism of benzo(a)pyrene (BaP). Pasturealla-free New Zealand...
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MUTAGENICITY OF COAL TAR PAINTS USED IN DRINKING WATER DISTRIBUTION SYSTEMS |
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The aim of this study was to evaluate the mutagenicity of coal tar paints used for coating drinking water tanks and pipes, as a preliminary screening for potential genotoxic hazard...
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MUTAGENICITY OF COMBUSTION EMISSIONS FROM A BIOMEDICAL WASTER INCINERATOR |
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The Ames Salmonella typhimurium (TA98) assay was used to determine the mutagenicity of stack fly ash from a medical/pathological waste incinerator. tack fly ash also collected from...
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MUTAGENICITY OF CYCLOPENTA-FUSED ISOMERS OF BENZ(A)ANTHRACENE IN BACTERIAL AND RODENT CELLS AND IDENTIFICATION OF THE MAJOR RAT LIVER MICROSOMAL METABOLITES |
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The microsomal metabolites and mutagenic activity of four cyclopenta-fused benz(a)anthracenes; benz(j)aceanthrylene (B(j)A), benz(e)aceanthrylene (B(e)A), benz(l)aceanthrylene (B(l...
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MUTAGENICITY OF DIESEL-EXHAUST PARTICLE EXTRACT, 1-NITROPYRENE, AND 2,7-DINITROFLUORENONE IN SALMONELLA TYPHIMURIUM UNDER VARIOUS METABOLIC ACTIVATION CONDITIONS |
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The mutagenic activities of 1-nitropyrene, 2,7-dinitrofluorenone, and a diesel-exhaust extract were compared using the Salmonella typhimurium plate-incorporation assay. Each sample...
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MUTAGENICITY OF DIESEL-EXHAUST PARTICLE EXTRACTS COLLECTED UNDER SMOG-CHAMBER CONDITIONS USING THE 'SALMONELLA TYPHIMURIUM' TEST SYSTEM |
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The study was designed to detect the effect that different environmental conditions have upon diesel-exhaust organics. In this study, diesel-exhaust was injected into the Calspan s...
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MUTAGENICITY OF DRINKING WATER FOLLOWING DISINFECTION |
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Many drinking water utilities in the USA are considering alternatives to chlorine for disinfection in order to comply with federal regulations regarding disinfection by-products. A...
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MUTAGENICITY OF DRINKING WATER FOLLOWING DISINFECTION |
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Many drinking water utilities in the USA are considering alternatives to chlorine for disinfection in order to comply with federal regulations regarding disinfection by-products. n...
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MUTAGENICITY OF EMISSIONS FROM THE SIMULATED OPEN BURNING OF SCRAP RUBBER TIRES |
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The report describes a follow-up to a small-scale combustion study to collect, identify, and quantify products emitted during the simulated open combustion of scrap tires. The init...
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MUTAGENICITY OF HPLC-FRACTIONATED URINARY METABOLITES FROM 2,4,6-TRINITROTOLUENE-TREATED FISCHER 344 RATS |
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NO ABSTRACT PROVIDED...
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MUTAGENICITY OF INDOOR AIR PARTICLES IN A RESIDENTIAL PILOT FIELD STUDY: APPLICATION AND EVALUATION OF NEW METHODOLOGIES |
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The mutagenicity of indoor air particulate matter has been measured in a pilot field study of homes in Columbus, Ohio, during the 1984 winter. The study was conducted in eight all ...
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MUTAGENICITY OF MUNITIONS COMPOUNDS AND THEIR METABOLITES IN A MICROSUSPENSION BIOASSAY |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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MUTAGENICITY OF NITRITE-TREATED AQUEOUS EXTRACT OF 'PIPER BETLE'; L |
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Betel quid is chewed as a masticatory material by people in certain areas of Asia. The quid chewing has been related to oral cancer by epidemiological study. The mutagenic componen...
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MUTAGENICITY OF NITRO COMPOUNDS IN SALMONELLA TYPHIMURIUM IN THE PRESENCE OF FLAVIN MONONUCLEOTIDE IN A PREINCUBATION ASSAY |
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A series of nitro compounds (18 aromatic and one aliphatic) was evaluated using a modification of the standard Salmonella typhimurium mutagenicity assay. reincubation protocol was ...
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MUTAGENICITY OF NITRODIBENZOPYANONES IN THE SALMONELLA PLATE-INCORPORATION AND MICROSUSPENSION ASSAYS |
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The mutagenicity of three isomers of nitro-6-H-dibenzo[b,d]pyran-6-one (NDBP), 3-NDBP and 4-NDBP, was characterized in the plate-incorporation (P1) and microsuspension (MS) assays ...
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MUTAGENICITY OF ORGANIC EMISSIONS FROM UNVENTED KEROSENE HEATERS IN A CHAMBER STUDY |
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A study was conducted to assess the mutagenicity of semivolatile organics and particle-bound organics emitted from unvented kerosene space heaters. The units tested included a well...
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MUTAGENICITY OF PAH-CONTAMINATED SOILS DURING BIOREMEDIATION |
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Bioremediation of contaminated soils is considered an effective method for reducing potential health hazards. Although it is assumed that (bio)remediation is a detoxifying process,...
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MUTAGENICITY OF SELECTED ORGANIC SOLVENTS |
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Mutagenicity of selected organic solvents. Scand J Work Environ Health 11 (1985): suppl 1, 75-82. For certain organic solvents, such as benzene, vinyl chloride, styrene, technical ...
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MUTAGENICITY OF TEFLON-COATED GLASS FIBER FILTERS: A POTENTIAL PROBLEM AND SOLUTIONS |
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Teflon-coated glass fiber filters, used in studies of airborne particulate matter, were tested for mutagenic activity using the Salmonella/mammalian-microsome (Ames) assay. For eac...
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MUTAGENICITY OF THE FRACTIONATED ORGANIC EMISSIONS FROM DIESEL, CIGARETTE SMOKE CONDENSATE, COKE OVEN, AND ROOFING TAR IN THE AMES ASSAY |
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Mobile and stationary sources emit particle-bound organics that have demonstrated mutagenicity. The objective of this study was to measure the mutagenicity of the fractionated orga...
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MUTAGENICITY OF TRICHLOROETHYLENE AND ITS METABOLITES: IMPLICATIONS FOR THE RISK ASSESSMENT OF TRICHLOROETHYLENE |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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MUTAGENICITY TESTING IN MAMMALIAN CELLS. MULTIPLE DRUG-RESISTANCE MARKERS |
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Chinese hamster ovary (CHO) cell lines heterozygous at the adenine phosphoribosyltransferase (aprt) and thymidine kinase (tk) loci were isolated and used for single-step selection ...
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MUTAGENICITY, CARCINOGENICITY, AND HUMAN CANCER RISK FROM INDOOR EXPOSURE TO COAL AND WOOD COMBUSTION IN XUAN WEI, CHINA |
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The residents in Xuan Wei County, China, have been exposed to high levels of combustion emissions from smoky and smokeless coal and wood combustion under unvented conditions in hom...
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MUTANT FREQUENCIES AND LOSS OF HETEROZYGOSITY INDUCED BY N-ETHYL-N-NITROSOUREA (ENU) IN THE THYMIDINE KINASE (TK) GENE OF L5178YTK+/-3.7.2C MOUSE LYMPHOMA CELLS |
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MUTANT FREQUENCIES AND LOSS HETEROZYGOSITY INDUCED BY N-ETHYK-N-NITROSOUREA (ENU) IN THE THYMIDINE KINASE (tk) GENE IF l5178Y/TK+/-3.7.2C MOUSE LYMPHOMA CELLS
N-ethyl-N-nitr...
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MUTANT FREQUENCY AND MUTATIONAL SPECTRA IN THETK AND HPRT GENES OF N-ETHYL-N-NITROSOUREA TREATED MOUSE LYMPHOMA CELLS |
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Abstract
The mouse lymphoma assay (MLA) utilizing the Tk locus is widely used to identify chemical mutagens. The autosomal location of the Tk locus allows for the detection...
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MUTATION SPECTRA IN SALMONELLA OF CHLORINATED, CHLORAMINATED, OR OZONATED DRINKING WATER EXTRACTS: COMPARISON TO MX |
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Drinking water samples were prepared in a pilot-scale treatment plant by chlorination (C12), chloramination (NH2Cl), ozonation (O3), or O3 followed by C12 or NH2Cl; and the nonvola...
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MUTATION SPECTRA IN SALMONELLA OF SUNLIGHT, WHITE FLUORESCENT LIGHT, AND LIGHT FROM TANNING SALON BEDS: INDUCTION OF TANDEM MUTATIONS AND ROLE OF DNA REPAIR |
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We evaluated the mutagenicity of sunlight (SUN), uncovered cool white fluorescent light (FLR), and light from a tanning salon bed (TAN) at the base-substitution allele hisG46 of Sa...
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MUTATION SPECTRA OF SMOKY COAL COMBUSTION EMMISSIONS IN SALMONELLA REFLECTS THE TP53 AND KRAS MUTATIONS IN LUNG TUMORS FROM SMOKY COAL EXPOSED INDIVIDUALS |
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Mutation Spectra of Smoky Coal Combustion Emissions in Salmonella Reflect the TP53
and KRAS Mutations in Lung Tumors from Smoky Coal-Exposed Individuals
Abstract |
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MUTATIONAL AND TRANSCRIPTIONAL RESPONSE OF SALMONELLA TO MX: CORRELATION OF MUTATIONAL DOSE RESPONSE TO CHANGES IN GENE EXPRESSION |
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We measured the mutational and transcriptional response of Salmonella TA100 to 3 concentrations of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy2(5H)-furanone (M...
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MUTATIONAL AND TRANSCRIPTIONAL RESPONSES OF SAMMONELLA TO MX: CORRELATION OF MUTATIONAL DOSE RESPONSE TO CHANGES IN GENE EXPRESSION |
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We measured the mutational and transcriptional response of Salmonella TA 100 to 3 concentrations of a drinking water mutagen -chloro-4-(dichloromethyl)-5-hydroxy2(5H)-furanone (MX)...
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MUTATIONAL AND TRANSCRIPTIONAL RESPONSES OF STATIONARY- AND LOGARITHMIC-PHASE SALMONELLA TO MX: CORRELATION OF MUTATIONAL RESPONSE TO CHANGES IN GENE EXPRESSION |
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We measured the mutational and transcriptional response of stationary-phase and logarithmic-phase S. typhimurium TA100 to 3 concentrations of the drinking water mutagen 3-chloro-4-...
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MUTATIONAL SPECTRUM AND RECOMBINOGENIC EFFECTS INDUCED BY AMINOFLUORENE ADDUCTS IN BACTERIOPHAGE M13 (JOURNAL VERSION) |
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Double stranded replicative form (RFI) DNA of bacteriophage M13mp10 has been modified in vitro to various extents with N-hydroxy-2-aminofluorene (N-OH-AF) and then transfected into...
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MUTATIONS IN SOIL: A REVIEW |
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The intentional and accidental discharges of toxic pollutants into the lithosphere results in soil contamination. In some cases (e.g., wood preserving wastes, coal-tar, airborne co...
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MUTATIONS INDUCED BY BENZO[ A ]PYRENE AND DIBENZO[ A,L ]PYRENE IN LACI TRANSGENIC B6C3F1 MOUSE LUNG RESULT FROM STABLE DNA ADDUCTS |
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Dibenzo[a,l]pyrene (DB[a,l]P) and benzo[a]pyrene (B[a]P) are carcinogenic polycyclic aromatic hydrocarbons (PAH) that are each capable of forming a vari...
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MX, A DRINKING WATER CARCINOGEN, DOES NOT INDUCE MUTATIONS IN THE LIVER OF CII TRANSGENIC MEDAKA |
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MX, a drinking water carcinogen, does not induce mutations in the liver of cII transgenic medaka
Geter, DR; Winn, RN; Fournie, JW; Norris, MB; DeAngelo, AB; and Hawkins, WE
<...
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NEW APPROACHES TO THE DECONTAMINATION OF HAZARDOUS WASTES |
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The Hazardous Waste Engineering Research Laboratory is currently supporting a number of research projects to develop innovative chemical and biological systems capable of detoxifyi...
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NEW STANDARD GUIDE FOR PERFORMING THE MOUSE LYMPHOMA ASSAY FOR MAMMALIAN CELL MUTAGENICITY |
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The purpose and scope of the standard guide is to present background material and to establish criteria by which protocols and procedures for conducting the L5178Y/TK+/- -3.7.2C mo...
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NEW YORK CITY BUS TERMINAL DIESEL EMISSIONS STUDY: MEASUREMENT AND COLLECTION OF DIESEL EXHAUST FOR CHEMICAL CHARACTERIZATION AND MUTAGENIC ACTIVITY |
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The paper is concerned with the impact of diesel emissions on the quality of the ambient air and the resulting effects on human health. The study was designed to chemically charact...
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NHEERL RESEARCH ON CARCINOGENIC CONTAMINANTS IN DRINKING WATER |
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Water research in the Environmental Carcinogenesis Division focuses on improved understanding of the mechanisms of mutagenesis and carcinogenesis of water contaminants for incorpor...
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NITROBENZENE CARCINOGENICITY |
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Nitrobenzene (NB, CAS No. 98-95-3) oxidizes to p-aminophenol and p-nitrophenol in animals and humans, while being reduced also to nitrosobenzene, phenylhydroxylamine, and aniline. ...
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NON-ADDITIVE DNA-DAMAGING EFFECTS OF GENOTOXINS IN MIXTURE: 3. MUTAGENICITY OF METHYL-NITROSO-UREA/ACETYLAMINOFLUORENE MIXTURES AND DNA REPAIR IN SALMONELLA. (R825809) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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NON-ADDITIVE DNA-DAMAGING EFFECTS OF GENOTOXINS IN MIXTURE: 1. MUTAGENICITY OF AFLATOXIN B1 AND ACETYLAMINOFLUORENE IN SALMONELLA. (R825809) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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NON-ADDITIVE DNA-DAMAGING EFFECTS OF GENOTOXINS IN MIXTURE: 3. MUTAGENICITY OF METHYL-NITROSO-UREA/ACETYLAMINOFLUORENE MIXTURES AND DNA REPAIR IN SALMONELLA. (R825809) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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NONVOLATILE ORGANICS IN DISINFECTED WASTEWATER EFFLUENTS: CHEMICAL CHARACTERIZATION AND MUTAGENICITY |
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Principal objectives of this research program were to examine the effects of disinfection by chlorine, ozone, and ultraviolet light irradiation on nonvolatile organic constituents ...
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OCCURRENCE, GENOTOXICITY, AND CARCINOGENICITY OF EMERGING DISINFECTION BY-PRODUCTS IN DRINKING WATER: A REVIEW AND ROADMAP FOR RESEARCH |
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Occurrence, Genotoxicity, and Carcinogenicity of Emerging Disinfection By-products in Drinking Water: A Review and Roadmap for Research
Summary of Paper
What is study?...
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OIL SPILL CLEANUP |
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Due to the consideration of bioremediation for oil spills, it is important to understand the ecological and human health implications of bioremediation efforts. uring biodegradatio...
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ORGANIC CHARACTERIZATION OF AEROSOLS AND VAPOR PHASE COMPOUNDS IN URBAN ATMOSPHERES |
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Organic pollutants in urban atmospheres were characterized by analyzing particulate and/or vapor-phase samples collected by EPA in St. Louis, Missouri; Miami, Florida; Denver, Colo...
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OUTDOOR AIR POLLUTION AND DNA DAMAGE |
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Although working outdoors has frequently been considered more healthful than working indoors, a growing literature suggests that outdoor air exposures increase the risk for a varie...
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OVERVIEW OF THE MUTAGENICITY OF URBAN AIR |
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For the past 25 years, there has been great interest in the mutagenicity and carcinogenicity of ambient air and in the sources of those genotoxicants. Prior to the 1980's, the eval...
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PAPILLOMAS ON FISH EXPOSED TO CHLORINATED WASTEWATER EFFLUENT |
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The presence of carcinogenic and mutagenic chemical(s) in the effluent of a wastewater treatment plant was indicated by papillomas developing on caged black bullheads (Ictaluraus m...
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PENTACHLOROPHENOL EFFECT ON THE ACTIVATION OF 2,6-DINITROTOLUENE TO GENOTOXIC URINARY METABOLITES IN CD-1 MICE: A COMPARISON OF GI ENZYME ACTIVITIES AND URINE MUTAGENICITY |
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2,6-Dinitrotoluene (2,6-DNT) and pentachlorophenol (PCP) are used for industrial purposes and are found in the environment as hazardous contaminants. ecause exposure to both compou...
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PHENYLENE HOMOLOGS OF BENZIDINE: MUTAGENICITY AND USE IN DYE/PIGMENT SYNTHESIS |
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In a previous paper in this area, we reported results from studies pertaining to the use of molecular modeling methods in predicting the properties of some Congo Red analogs contai...
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PLATFORM SESSION "IMMUNOTOXICOLOGY", SOCIETY OF TOXICOLOGY 45TH ANNUAL MEETING, MARCH 5-9, 2006, SAN DIEGO, CA |
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For many years the primary endpoints for evaluating the toxicity of xenobiotics were carcinogenicity and mutagenicity. However, it gradually became apparent that exposure to chemi...
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POTENTIAL ATMOSPHERIC CARCINOGENS, PHASE 1. IDENTIFICATION AND CLASSIFICATION |
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A comprehensive literature search identified more than 125 high-volume chemicals having the potential of becoming airborne carcinogenic pollutants. Based on carcinogenicity and mut...
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POTENTIAL GENOTOXICITY OF WASTEWATER-CONTAMINATED PORE WATERS WITH COMPARISON TO SEDIMENT TOXICITY AND MACROBENTHIC COMMUNITY COMPOSITION |
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The objective of this baseline study was to determine and compare sediment quality above and below 10 wastewater outfalls in Gulf of Mexico near-coastal areas using genotoxic assay...
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PREDICTIVE ASSAY FOR RODENT CARCINOGENICITY USING IN VIVO BIOCHEMICAL PARAMETERS: OPERATIONAL CHARACTERISTICS AND COMPLEMENTARITY |
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Linear models of risk assessment may be appropriate for chemicals that are initiators of carcinogenesis while threshold models of risk assessment have been proposed for promoters. ...
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PRELIMINARY REPORT ON THE MUTAGENICITY OF CARBARYL |
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Carbaryl has been reported to cause point mutations in bacteria, Drosophila, and mammalian cells in vitro; unscheduled DNA synthesis in human cells in culture; and chromosome effec...
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PRIMER ON THE AMES 'SALMONELLA TYPHIMURIUM' ASSAY FOR MUTAGENICITY |
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Since interaction with deoxyribonucleic acid (DNA) defines the genotoxic end points detected, simple in vitro tests can be used to monitor or screen most chemicals or mixtures of c...
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PROCEEDINGS OF THE SEMINAR ON BIOLOGICAL MONITORING AND ITS USE IN THE NPDES (NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM) PERMIT PROGRAM HELD AT CHICAGO, ILLINOIS ON OCTOBER 2, 1979 |
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This seminar brought together representatives from industry, state and local governments and biological monitoring consulting firms to present the U.S. Environmental Protection Age...
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PROGRESS REPORT ON THE DSSTOX DATABASE NETWORK: NEWLY LAUNCHED WEBSITE, APPLICATIONS, FUTURE PLANS |
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Progress Report on the DSSTox Database Network: Newly Launched Website, Applications, Future Plans
Progress will be reported on development of the Distributed Structure-Sear...
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PUBLIC SOURCES OF MUTAGENICITY AND CARCINOGENICITY DATA: USE IN STRUCTURE-ACTIVITY RELATIONSHIP MODELS |
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No Abstract - first paragraph of INTRODUCTION
Publicly supported compilations of mutagenicity and carcinogenicity data are available
for a significant number and varie...
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REACTION OF CYCLOPENTA[CD]PYRENE-3,4-EPOXIDE WITH DNA AND DEOXYNUCLEOTIDES |
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Cyclopenta[cd]pyrene (CPP) is a ubiquitous polycyclic aromatic hydrocarbon with potent mutagenic and carcinogenic activity. he trans isomer of 3,4-dihydro-3,4-dihydroxy-cyclopenta[...
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RECEPTOR MODELING RESULTS FROM THE INTEGRATED AIR CANCER PROJECT |
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EPA's Integrated Air Cancer Project has produced comprehensive winter time ambient air data bases from three widely separated airsheds (Albuquerque, NM, Raleigh, NC, Boise, ID), wh...
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RECOVERY OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE FROM WATER SAMPLES ON XAD RESINS AND THE EFFECT OF CHLORINE ON ITS MUTAGENICITY |
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The recovery of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) from granular activated carbon (GAC)/distilled water by adsorption on XAD-8 resin was approximately 3-fold...
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RECOVERY OF MUTAGENICITY FROM DISINFECTED WATER BY XAD RESIN ADSORPTION COMPARED TO REVERSE OSMOSIS |
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Recovery of Mutagenicity from Disinfected Water Samples by XAD Resin Adsorption Compared to Reverse Osmosis
K. M. Schenck1, T. F. Speth1, R. J. Miltner1, M. Sivaganesan1 and...
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RECOVERY OF MUTAGENICITY FROM DISINFECTED WATER SAMPLES BY XAD RESIN ADSORPTION COMPARED TO REVERSE OSMOSIS |
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the presence of a complex misture of disinfection byproducts in drinking waters continues to cause concern over the potential long-term health effects of exposure to these compound...
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REMOVAL OF MUTAGENS FROM DRINKING WATER BY GRANULAR ACTIVATED CARBON: EVALUATION USING BACTERIAL MUTAGENICITY TESTS |
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The performance of a full-scale granular activated carbon (GAC) treatment system in removing mutagens from drinking water obtained from the Ohio River has been evaluated using two ...
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REPRODUCTIVE EFFECTS ASSESSMENT GROUP'S REPORT ON THE MUTAGENICITY OF 1.3-BUTADIENE AND ITS REACTIVE METABOLITES |
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A major data gap for assessing heritable risk from exposure to 1,3-butadiene is the lack of mammalian mutagenicity data. The data base on the mutagenic potential of 1,3-butadiene i...
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REPRODUCTIVE EFFECTS ASSESSMENT GROUP'S REPORT ON THE MUTAGENICITY OF INORGANIC ARSENIC |
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Various inorganic compounds of arsenic have been tested for mutagenicity in a variety of test systems ranging in complexity from bacteria to peripheral lymphocytes of exposed human...
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REPRODUCTIVE EFFECTS ASSESSMENT GROUP'S REVIEW OF THE MUTAGENICITY OF VINYLIDENE CHLORIDE |
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A large number of studies indicate that vinylidene chloride is mutagenic to bacteria and that this activity is largely dependent on microsomal activation. Vinylidene chloride was r...
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RESIDUAL MUTAGENICITY OF THE ALASKAN OIL SPILL ORGANICS |
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RESIDUAL MUTAGENICITY OF THE ALASKAN OIL SPILL ORGANICS. L.D.
The Exxon Valdez, on March 24, 1989, spilled approximately eleven million gallons of Prudhoe Bay crude oil into...
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RESPONSE TO ISSUES AND DATA SUBMISSIONS ON THE CARCINOGENICITY OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE) |
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The scientific debate over the potential carcinogenicity of tetrachloroethylene (perchloroethylene, perc, PCE) spans several years. his document reviews the issues considered by th...
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RETROSPECTIVE VIEW OF THE VALUE OF SHORT-TERM GENETIC BIOASSAYS IN PREDICTING THE CHRONIC EFFECTS OF DIESEL SOOT |
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In retrospect, it is now safe to conclude that short-term mutagenicity assays were not only useful but instrumental in: (1) indicating that diesel soot was potentially carcinogenic...
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REVIEW OF THE ENVIRONMENTAL EFFECTS OF POLLUTANTS: X. TOXAPHENE |
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The environmental effects of toxaphene are extensively reviewed. Information is presented on chemical properties and analytical techniques, environmental occurrence, cycling, and f...
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REVIEW OF THE MUTAGENICITY OF CHLOROFORM |
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Although chloroform (CHCl3) is metabolized in vivo and in vitro to a substance that covalently interacts with protein and lipid, its potential for binding to DNA is low. In additio...
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REVIEW OF THE MUTAGENICITY OF ETHYLENE OXIDE |
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Ethylene oxide has been shown to be an effective mutagen in a variety of organisms ranging from bacteria to mammalian cells. here is also an association between ethylene oxide expo...
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REVIEW OF THE SALMONELLA TYPHIMURIUM MUTAGENICITY OF BENZIDINE, BENZIDINE ANALOGUES, AND BENZIDINE-BASED DYES |
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The mutagenicity of benzidine analogues (including benzidine-based dyes) was reviewed with a primary emphasis on evaluating results of the Salmonella/microsome mutagenicity assay. ...
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ROLE OF MUTAGENICITY IN DETERMINING DRINKING WATER QUALITY |
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This paper will discuss the mutagenicity of water samples following several alternative treatment processes and possible correlations with the presence of disinfection by-products....
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S9-DEPENDENT ACTIVATION OF 1-NITROPYRENE AND 3-NITROFLUORANTHENE IN BACTERIAL MUTAGENICITY ASSAYS |
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Nitro-substituted polycyclic aromatic hydrocarbons (N02PAH) such as 1-nitropyrene (NP) and 3-nitrofluoranthene (3-NFA), both widespread environmental mutagens, generally require ac...
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SALMONELLA ASSAY SOFTWARE (VERSION 2.2) AND USER'S MANUAL. STANDARDIZED PROCEDURE FOR ANALYSIS AND INTERPRETATION OF MUTAGENICITY DATA |
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Computer software for the management of Salmonella mutagenicity assay data has been developed based on the recommendations of genetic toxicologists and statisticians. The panels of...
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SAMPLE COLLECTION AND PREPARATION METHODS AFFECTING MUTAGENICITY AND CYTOTOXICITY OF COAL FLY ASH |
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Reports by several investigators describing the biological activity of coal fly ash have presented a variety of results which in some cases are conflicting. The biological activity...
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SAR STUDY OF NASAL TOXICITY: LESSONS FOR MODELING SMALL TOXICITY DATASETS |
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Most toxicity data, particularly from whole animal bioassays, are generated without the needs or capabilities of structure-activity relationship (SAR) modeling in mind. Some toxici...
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SCREENING COMPLEX HAZARDOUS WASTES FOR MUTAGENIC ACTIVITY USING A MODIFIED VERSION OF THE TLC/SALMONELLA ASSAY |
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Ten complex hazardous wastes were tested for mutagenic activity using a modified version of the TLC/Ames assay developed by Bjorseth et al. (1982). This fractionation/bioassay sche...
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SEASONAL AND SPATIAL VARIATION OF THE BACTERIAL MUTAGENICITY OF FINE ORGANIC AEROSOL IN SOUTHERN CALIFORNIA. (R824970) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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SELECTION OF A SUITABLE EXTRACTION METHOD FOR WOODSMOKE IMPACTED AIR PARTICLES |
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Extraction methods were evaluated for recovery of mutagenic activity from woodsmoke-impacted air particles. Soxhlet and sonication techniques were utilized with a variety of solven...
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SOIL REDUCES 2,4,6-TRINITROTOLUENE BIOAVAILABILITY AND GENOTOXICITY IN VIVO |
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Soil Reduces 2,4,6- Trinitrotoluene Bioavailability and Genotoxicity In Vivo
As chemicals age in soil, irreversible binding of chemical contaminants to organic compon...
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SOURCE APPORTIONMENT OF FINE PARTICLE ORGANICS AND MUTAGENICITY IN WINTERTIME ROANOKE |
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During the 1988-1989 winter the U.S. EPA conducted a comprehensive field study in Roanoke VA as part of its Integrated Air Cancer Project (IACP). his paper presents results of the ...
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SOURCE APPORTIONMENT OF MUTAGENIC ACTIVITY OF FINE PARTICLE ORGANICS IN BOISE, IDAHO |
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A multiple linear regression receptor model has been used to apportion ambient concentrations of fine particle extractable organic matter (EOM) and associated mutagenicity (Salmone...
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SOURCE ASSESSMENT: TEXTILE PLANT WASTEWATER TOXICS STUDY--PHASE I |
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The report gives results of the first phase of a study to provide chemical and toxicological baseline data on wastewater samples collected from textile plants in the U.S. Raw waste...
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SOURCES OF VARIATION IN THE MUTAGENIC POTENCY OF COMPLEX CHEMICAL MIXTURES BASED ON THE SALMONELLA/MICROSOME ASSAY |
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Twenty laboratories worldwide participated in a collaborative trial sponsored by the International Programme on Chemical Safety on the mutagenicity of complex mixtures as expressed...
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SPONTANEOUS AND MNNG-INDUCED REVERSION OF AN EGFP CONSTRUCT IN HELA CELLS: AN ASSAY FOR OBSERVING MUTATIONS IN LIVING CELLS BY FLUORESCENT MICROSCOPY |
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A HeLa cell line stably expressing the Enhanced Green Fluorescence Protein (EGFP) gene, interrupted by the IVS2-654 intron, was studied without treatment and after treatment with a...
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STABILITY OF THE MUTAGENICITY IN STORED CIGARETTE SMOKER'S URINE AND EXTRACT |
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Urine from cigarette smokers was analyzed for the effect upon mutagenic activity when stored for as long as 175 days. rozen aliquots of urine were thawed out at various time points...
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STANDARD GUIDE FOR THE 'SALMONELLA TYPHIMURIUM'/MAMMALIAN MICROSOME TESTS FOR BACTERIAL MUTAGENICITY |
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Since its development by Dr. Bruce Ames and his coworkers, the Salmonella typhimurium/mammalian microsome mutagenicity assay has been used widely throughout the world. Many authors...
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STRATEGIES FOR USING BIOASSAY METHODS FOR THE IDENTIFICATION OF HAZARDOUS COMPONENTS AND COMPARATIVE RISK ASSESSMENT OF COMPLEX MIXTURES |
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Two strategies particularly useful for approaching the toxicology of complex mixtures are: (1) bioassay-directed chemical characterization; and, (2) comparative bioassay studies. B...
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STRUCTURAL BASIS OF THE MUTAGENCITY OF CHEMICALS IN SALMONELLA TYPHIMURIUM: THE GENE-TOX DATA BASE |
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The case structure-activity methodology has been applied to a Gene-Tox derived Salmonella mutagenicity data base consisting of 808 chemicals. ased upon qualitative structural featu...
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STRUCTURE-ACTIVITY RELATIONSHIPS (SARS) AMONG MUTAGENS AND CARCINOGENS: A REVIEW |
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The review is an introduction to methods for evaluating structure-activity relationships (SARs), and, in particular, to those methods that have been applied to study mutagenicity a...
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STRUCTURE-GENOTOXIC ACTIVITY RELATIONSHIPS OF PESTICIDES: COMPARISON OF THE RESULTS FROM SEVERAL SHORT-TERM ASSAYS |
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The Computer-Automated Structure Evaluation (CASE) program has been applied to the analysis of the genotoxic activity of 54 pesticides (31 insecticides, 15 herbicides and 8 fungici...
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STUDIES ON THE POTENT BACTERIAL MUTAGEN, 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5'H')-FURANONE: AQUEOUS STABILITY, XAD RECOVERY AND ANALYTICAL DETERMINATION IN DRINKING WATER AND IN CHLORINATED HUMIC ACID SOLUTIONS |
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3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was detected by gas chromatography/mass spectrometry in drinking water samples from three locations in the United States, ...
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SUMMARY OF THE ISSUES WITH REGARD TO THE CARCINOGENICITY, MUTAGENICITY, AND EXPOSURE OF POLYCYCLIC ORGANIC MATTER (POM) |
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Polycyclic organic matter (POM) is emitted from a variety of sources in the environment. Evidence of the carcinogenicity of emissions from coke production, motor vehicles (includes...
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SUMMARY OVERVIEW OF HEALTH EFFECTS ASSOCIATED WITH CHLOROPRENE: HEALTH ISSUE ASSESSMENT |
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The purpose of the report is to summarize available information concerning possible health effects associated with exposure to chloroprene. Emphasis has been placed on reviewing th...
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SUMMARY REVIEW OF THE HEALTH EFFECTS ASSOCIATED WITH PROPYLENE OXIDE: HEALTH ISSUE ASSESSMENT |
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The report provides a brief summary of the data available on the health effects of exposure to propylene oxide. Emphasis is placed on determining whether there is evidence to sugge...
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SURVEY OF EPA/OPP AND OPEN LITERATURE DATA ON SELECTED PESTICIDE CHEMICALS TESTED FOR MUTAGENICITY I. INTRODUCTION AND FIRST TEN CHEMICALS |
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Parties interested in registering a pesticide chemical with the U. S. Environmental Protection Agency's (USEPA's) Office of Pesticide Programs (OPP) must submit toxicity informatio...
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SYMPOSIUM ON THE APPLICATION OF SHORT-TERM BIOASSAYS IN THE ANALYSIS OF COMPLEX ENVIRONMENTAL MIXTURES (4TH) PROCEEDINGS |
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The document is a proceedings of the fourth symposium on the 'Application of Short-Term Bioassays in the Analysis of Complex Environmental Mixtures' held March 27-29, 1985 in Chape...
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SYMPOSIUM ON THE APPLICATION OF SHORT-TERM BIOASSAYS IN THE ANALYSIS OF COMPLEX ENVIRONMENTAL MIXTURES, PROCEEDINGS (3RD) |
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The U.S. Environmental Protection Agency's Third Symposium on the Application of Short-Term Bioassays in the Analysis of Complex Environmental Mixtures was held January 25-27, 1982...
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SYNTHESIS AND BIOLOGICAL ACTIVITY OF CYCLOPENTA EPOXIDES OF PAH (POLYCYCLIC AROMATIC HYDROCARBONS) CONTAINING PERIPHERALLY FUSED CYCLOPENTA RINGS |
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Polycyclic aromatic hydrocarbons (PAH) containing peripherally fused cyclopenta rings have been identified in soots from many different combustion sources. Metabolism and mutagenic...
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SYNTHESIS AND MUTAGENIC PROPERTIES OF 4,4'-DIAMINO-PARA-TERPHENYL AND 4,4'-DIAMINO-PARA-QUATERPHENYL |
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DBPs in drinking water can be controlled by the type of treatment and by knowing andd controlling major sources of DBP toxicant precursors and toxicants that "evade" treatment proc...
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SYNTHESIS AND MUTAGENICITY OF DIRECT DYES FROM 4,4'-DIAMINO-PARA-TERPHENYL AND 4,4'-DIAMINO-PARA-QUATERPHENYL |
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DBPs in drinking water can be controlled by the type of treatment and by knowing and controlling major sources of DBP toxicant precursors and toxicants that "evade" treatment proce...
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SYNTHESIS, IN VITRO METABOLISM, AND MUTAGENICITY OF NAPHTHO[1,2-A]PYRENE, A LIKELY ENVIRONMENTAL CONTAMINANT |
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Organic solvent extracts from coal tar, coal combustion emissions, soil, aquatic sediments and urban airborne particles contain C24HI14. PAR of Molecular mass 302. Representative e...
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SYNTHESIS, IN VITRO METABOLISM, CELL TRANSFORMATION, MUTAGENICITY, AND DNA ADDUCTION ON NAPHTHO[1,2-A]PYRENE |
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Polycyclic aromatic hydrocarbons (PAHs ) are ubiquitous environmental pollutants. Due to its structural similarity with the potent carcinogen dibenzo[a,l]pyrene (DB[a,l]P) ...
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SYNTHESIS, IN VITRO METABOLISM, MUTAGENICITY, AND DNA-ADDUCTION OF NAPHTHO[1,2-E]PYRENE |
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SYNTHESIS, IN V1TRO METABOLISM, MUTAGENICITY , AND DNA-ADDUCnON OF NAPHTHO[l ,2-e ]PYRENE
Literature data, although limited, underscore the contribution of C24HI4 polycycli...
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SYNTHESIS, MUTAGENICITY, CELL TRANSFORMATION, AND IN VITRO METABOLISM OF NAPHTHO[1,2-E]PYRENE |
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Synthesis, mutagenicity, cell transformation, and in vitro metabolism of naphtho[ I ,2-e ]pyrene
Relatively, little attention has been given to C24HJ4- PAH; in part due to ...
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TESTING AND COMMERCIALIZATION OF BYPRODUCT DIBASIC ACIDS AS BUFFER ADDITIVES FOR LIMESTONE FLUE GAS DESULFURIZATION SYSTEMS |
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The paper gives results of pilot plant (0.1 MW) tests and utility boiler full-scale demonstration (194 MW) of byproduct organic dibasic acids (DBAs) as buffer additives to limeston...
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TEXTILE PLANT WASTEWATER TOXICITY |
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The paper gives results of a study to provide chemical and toxicological baseline data on wastewater samples collected from 32 textile plants in the U.S. Raw waste and secondary ef...
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THE BACTERIAL MUTAGENICITY OF URBAN AEROSOL SOURCES IN COMPARISON TO ATMOSPHERIC SAMPLES. (R824970) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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THE CASE FOR THE CONTRIBUTION OF CRISTAIS RIVER NITRO-AMINOBENZENE DYES TO THE MUTAGENICITY OF AMBIENT SAMPLES |
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In order to verify if dyestuffs within an effluent of a textile industry was contributing to the systematic mutagenicity detected in the Cristais River, within the metropolitan reg...
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THE CONTRIBUTION OF AZO DYES TO THE MUTAGENIC ACTIVITY OF THE CRISTAIS RIVER |
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To verify if compounds within the discharge of a dye processing plant were contributing to the mutagenicity repeatedly found in the Cristais River, Sao Paulo, Brazil, we chemically...
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THE DELTA UVRB MUTATIONS IN THE AMES STRAINS OF SALMONELLA SPAN 15-119 GENES |
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Abstract
The 4uvrB mutationesent in strains of Salmonella enterica Typhirnurium used commonly in the Salmonella (Ames) mutagenicity assay were isolated independently on se...
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THE EXPANDING ROLE OF PREDICTIVE TOXICOLOGY: AN UPDATE ON THE (Q)SAR MODELS FOR MUTAGENS AND CARCINOGENS. |
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Different regulatory schemes worldwide, and in particular the preparation for the new REACH legislation in Europe, increase the reliance on estimation methods for predicting potent...
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THE GENE-TOX PROGRAM: GENETIC ACTIVITY EVALUATION |
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The GENE-TOX (evaluation of current status of bioassays in genetic toxicology) is a systematic scientific evaluation of selected bioassays currently used for detecting mutagenicity...
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THE GENERATION OF MUTAGENIC TRANSFORMATION PRODUCTS DURING THE IRRADIATION OF SIMULATED URBAN ATMOSPHERES |
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Mixtures of air pollutants simulating urban atmospheres were irradiated in a smog chamber, and the resultant products were monitored for the production of mutagenic and other hazar...
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THE GENETIC TOXICOLOGY OF PUTATIVE NONGENOTOXIC CARCINOGENS |
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This report examines a group of putative nongenotoxic carcinogens that have been cited in the published literature. Using short-term test data from the U.S. Environmental Protectio...
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THE GENOTOXICITY OF AMBIENT OUTDOOR AIR, A REVIEW: SALMONELLA MUTAGENICITY |
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The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity
Abstract
Mutagens in urban air pollution come from anthropogenic sources (especially combustio...
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THE GENOTOXICITY OF PRIORITY POLYCYCLIC AROMATIC HYDROCARBONS IN COMPLEX MIXTURES |
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Risk assessment of complex environmental samples suffers from difficulty in identifying toxic components, inadequacy of available toxicity data, and a paucity of knowledge about th...
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THE MUTAGENICITY OF METALLIZED AND UNMETALLIZED AZO AND FORMAZAN DYES IN THE SALMONELLA MUTAGENICITY ASSAY |
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The mutagenicity of metallized and unmetallized azo and formazan dyes in the Salmonella mutagenicity
Laura. C. Edwards', Harold S. Freeman'*, and Larry D. Claxton2
Abstra...
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THE MUTATION SPECTRA OF DRINKING WATER SAMPLES USING THE BASE-SPECIFIC TA7000 STRAINS OF SALMONELLA IN THE MICROSUSPENSION ASSAY |
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Previous studies showed that disinfected drinking water samples gave mutagenic spectra typical of halogenated furanones. In this study, we used the TA7000 base-¿specific Salmonella...
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THE SOURCES, FATE AND HAZARDS OF MUTAGENS IN SURFACE WATERS |
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A variety of industrial, domestic and agricultural wastes are discharged into rivers, lakes, streams, and estuaries. In some instances, these wastes contain substances that are cap...
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TOPICAL REVIEW: MUTAGENICITY AND CARCINOGENICITY OF AIR |
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Although both outdoor and indoor airs provide exposure to mutagens and carcinogens, this review shows that the level of hazard is highly variable. Outdoor air was first shown to be...
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TOXAPHENE IN THE GREAT LAKES. (R825246) |
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This paper presents the most current data for toxaphene in the water, sediments, and biota of the Laurentian Great Lakes of North America. Concentrations in water range from 1.1...
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TOXICITY AND MUTAGENICITY OF A MIXTURE OF 25 CHEMICALS FOUND IN CONTAMINATED GROUNDWATER |
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A defined mixture of 25 chemicals that are often found in contaminated ground water was prepared as a water solution and studied for mutagenicity in bacteria, for prophage inductio...
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TOXICITY OF LEACHATES |
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The report represents a multidisciplinary effort to establish a data base for evaluation of the toxicity of extracts from solid wastes representative of various industries. Sevente...
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TOXICITY REDUCTION EVALUATION (TRE) AT A MUNICIPAL WASTEWATER TREATMENT PLANT USING MUTAGENICITY AS AN END- POINT |
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Previous work revealed substantial levels of mutagenicity in effluents from certain municipal wastewater treatment plants. One of these treatment plants was selected for further st...
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TOXICITY REDUCTION EVALUATIONS IN MUNICIPAL WASTEWATER TREATMENT PLANTS |
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Early work evaluating toxicity reduction in municipal treatment plants revealed substantive ecosystem toxicity and Ames mutagenicity in plant effluents. The ecosystem toxicity in o...
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TOXICO-CHEMINFORMATICS AND QSAR MODELING OF THE CARCINOGENIC POTENCY DATABASE |
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This abstract concludes that QSAR approaches combined with toxico-chemoinformatics descriptors can enhance predictive toxicology models....
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TOXICOLOGICAL EVALUATION OF COMPLEX INDUSTRIAL WASTES: IMPLICATIONS FOR EXPOSURE ASSESSMENT |
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We evaluated a variety of short-term bioassays to construct a battery of tests that could be used for assessing the biological effects of potentially hazardous complex industrial w...
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TOXICOLOGICAL REVIEW OF HEXACHLOROCYCLOPENTADIENE [AND IRIS SUMMARY] (EXTERNAL REVIEW DRAFT) |
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Hexachlorocylopentadiene (HCCPD) is a dense oily liquid with a pungent, unpleasant odor. It is an intermediate in the production of compounds used as dyes, resins, pharmaceuticals,...
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TRACE ORGANICS REMOVAL USING ACTIVATED CARBON AND POLYMERIC ADSORBENTS |
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A survey of trace organic matter in 14 water supplies was conducted and an investigation was made to compare the effectiveness of granular activated carbon with polymeric adsorbent...
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TRENDS OF POLYCYCLIC AROMATIC HYDROCARBON LEVELS AND MUTAGENICITY IN SANTIAGO'S INHALABLE AIRBORNE PARTICLES IN THE PERIOD 1992-1996. |
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Abstract
Trends of polycyclic aromatic hydrocarbons (PAHs) for 1992-1996 (cold season) and their mutagenic activity were investigated in organic extracts from the Santiago....
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Technology Demonstration Summary Shirco Electric Infrared Incineration At The Peak Oil Superfund Site |
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Under the auspices of the Superfund Innovative Technology Evaluation or SITE Program, a critical assessment is made of the performance of the transportable Shirco Infrared Thermal ...
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Toxico-Cheminformatics and QSPR Modeling of the Carcinogenic Potency Database (S) |
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A report on the development of a tiered, confirmatory scheme for prediction of chemical carcinogenicity based on QSAR studies of compounds with available mutagenic and carcinoenic ...
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U.S. EPA'S GUIDELINES FOR MUTAGENICITY RISK ASSESSMENT AND SOME COMMENTS ON ANEUPLOIDY |
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The paper describes the risk assessment strategy used by the U.S. Environmental Protection Agency (EPA) to evaluate mutagenic risk. The Agency considers all endpoints relevant to g...
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U.S. EPA'S RISK ASSESSMENT GUIDELINES. HEALTH RISKS OF NONCRITERIA POLLUTANTS |
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In recent years, the EPA has moved toward a risk assessment/risk reduction framework for making regulatory decisions. The Agency has taken a number of steps to assure the quality a...
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ULTRAMICRO FORWARD-MUTATION ASSAY AND IT'S APPLICATION TO THE SURVEY OF INDOOR AIR POLLUTION |
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A highly sensitive ultramicro forward-mutation assay using Salmonella lyphimurium TM677 was achieved by the introduction of micro-vessel in the preincubation step. his assay was ab...
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UNVENTED KEROSENE HEATER EMISSIONS FROM MOBILE HOMES: STUDIES ON INDOOR AIR PARTICLES, SEMI-VOLATILE ORGANICS, CARBON MONOXIDE AND MUTAGENICITY |
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This study was conducted to assess human exposure to air pollutants resulting from the use of kerosene heaters in mobile homes. t has been estimated that 15-17 million unvented ker...
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UNVENTED KEROSENE HEATER EMISSIONS FROM MOBILE HOMES: STUDIES ONINDOOR AIR PARTICLES, SEMI-VOLATILE ORGANICS, CARBON MONOXIDE, ANDMUTAGENICITY |
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This study was conducted to assess human exposure to air pollutantsresulting from the use of kerosene heaters in mobile homes. t hasbeen estimated that 15-17 million unvented keros...
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UPDATED MUTAGENCITY AND CARCINOGENICITY ASSESSMENT OF CADMIUM: ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR CADMIUM (MAY 1981) EPA-600/8-81-023 |
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This draft document evaluates the mutagenicity and carcinogenicity of cadmium, supplementing an earlier document (Health Assessment Document for Cadmium, May 1981) which dealt with...
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UPDATED MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF CADMIUM: ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR CADMIUM |
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The document evaluates the mutagenicity and carcinogenicity of cadmium, supplementing an earlier document (Health Assessment Document for Cadmium, May 1981) which dealt with all he...
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UPDATED MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF CADMIUM: ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR CADMIUM (MAY 1981) EPA-600/8-81-023. EXTERNAL REVIEW DRAFT |
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This draft document evaluates the mutagenicity and carcinogenicity of cadmium, supplementing an earlier document (Health Assessment Document for Cadmium, May 1981) which dealt with...
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URINARY BIOMARKERS IN CHARCOAL WORKERS EXPOSED TO WOOD SMOKE IN BAHIA STATE, BRAZIL |
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Charcoal is an important source of energy for domestic and industrial use in many countries. In Brazil, the largest producer of charcoal in the world, approximately 350,000 worker...
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URINARY MUTAGENESIS AS AN EXPOSURE BIOMARKER OF COOKED-MEAT-ASSOCIATED MUTAGENS: INFLUENCE OF COOKING TEMPERATURE, PHENOTYPE, AND GENOTYPE IN A CONTROLLED METABOLIC FEEDING STUDY |
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ABSTRACT
We evaluated urinary mutagenicity and selected phenotypes and genotypes in 60 subjects in a metabolic feeding study in which meat cooked at low temperature (100oC) wa...
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URINARY MUTAGENICITY AND COLORECTAL ADENOMA RISK |
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Abstract
We investigated urinary mutagenicity and colorectal adenoma risk in a clinic-based, case-control study of currently nonsmoking cases (n = 143) and controls (n = 156...
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URINARY MUTAGENICITY AS A BIOMARKER IN WORKERS EXPOSED TO BENZIDINE: CORRELATION WITH URINARY METABOLITES AND UROTHELIAL DNA ADDUCTS |
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NO ABSTRACT PROVIDED...
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URINARY MUTAGENICITY AS A BIOMARKER OF COOKED-MEAT-ASSOCIATED MUTAGENS AND RISK FOR COLORECTAL ADENOMA |
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Urinary Mutagenicity as a Biomarker of Cooked-Meat-Associated Mutagens and Risk for Colorectal Adenoma
In a controlled feeding study involving 60 subjects, we have investiga...
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URINARY MUTAGENICITY IN CHARCOAL WORKERS: A CROSS-SECTIONAL STUDY IN NORTHEASTERN BRAZIL |
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Urinary Mutagenicity in charcoal workers: a cross-sectional study in northeastern Brazil
Charcoal production by wood carbonization is an ancient process that has changed l...
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URINARY MUTAGENICITY: A BIOMARKER OF GENOTOXIC EXPOSURES VIA AIR, WATER, AND DIET |
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During the past 30 years, ~100 studies have evaluated human urine for mutagenic activity using the Salmonella (Ames) mutagenicity assay. Urinary mutagenicity has been shown to corr...
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URINE MUTAGENICITY AND BIOCHEMICAL EFFECTS OF THE DRINKING WATER MUTAGEN, 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROX-2[5H]-FURANONE (MX), FOLLOWING REPEATED ORAL ADMINISTRATION TO MICE AND RATS |
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Mutagenicity analysis of urine from rats treated by oral gavage with MX at a dose of 64 mg/kg for 14 days revealed that only 0.3% of the administered cmpound was excreted in a geno...
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URINE MUTAGENICITY AND BIOCHEMICAL EFFECTS OF THE DRINKING WATER MUTAGEN, 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2[5H]-FURANONE (MX), FOLLOWING REPEATED ORAL ADMINISTRATION TO MICE AND RATS |
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Mutagenicity analysis of urine from rats treated by oral gavage with MX at a dose of 64 mg/kg for 14 days revealed that only 0.3% of the administered compound was excreted in a gen...
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USE OF BIOASSAY METHODS TO EVALUATE MUTAGENICITY OF AMBIENT AIR COLLECTED NEAR A MUNICIPAL WASTE COMBUSTOR |
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An ambient air sampling study was conducted around a municipal waste combustor with a primary goal being to develop procedures to evaluate the emissions of organic mutagens resulti...
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USE OF BIOASSAY-DIRECTED CHEMICAL ANALYSIS FOR IDENTIFYING MUTAGENIC COMPOUNDS IN URBAN AIR AND COMBUSTION EMISSIONS |
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Bioassay-directed chemical analysis fractionation has been used for 30 years to identify mutagenic classes of compounds in complex mixtures. Most studies have used the Salmonella (...
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USE OF BIOASSAYS TO EVALUATE ORGANIC EXTRACT OF PARTICLES EMITTED FROM MUNICIPAL WATER COMBUSTORS AND A ROTARY KILN INCINERATOR |
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The organic components in combustion emissions are composed of thousands of chemicals. nalyzing such a complex mixture for the presence of even a few selected chemicals is difficul...
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USE OF CYANOPROPYL-BONDED HPLC COLUMN FOR BIOASSAY-DIRECTED FRACTIONATION OF ORGANIC EXTRACTS FROM INCINERATOR EMISSIONS |
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The present study has shown that cyanopropyl-(CN) bonded silica HPLC columns are applicable for the fractionation of mass and mutagenic activity of organic extracts from some incin...
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USE OF LIMITED PROTOCOLS TO EVALUATE THE GENOTOXICITY OF HAZARDOUS WASTES IN MAMMALIAN CELL ASSAYS: COMPARISON TO 'SALMONELLA' |
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Dichloromethane extracts of four diverse hazardous wastes (coke plant, herbicide mfg., pulp and paper, and oil refining) were evaluated for mutagenicity in strains TA98 and TA100 o...
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USE OF MUTAGENICITY FOR PREDICTING CARCINOGENICITY |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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USE OF SALMONELLA MICROSUSPENSION BIOASSAY TO DETECT THE MUTGENICITY OF MUNITIONS COMPOUNDS AT LOW CONCENTRATIONS |
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Use of a Salmonella Microsuspension Bioassay to Detect the Mutagenicity of
Munitions Compounds at Low Concentrations
Abstract
Past production and ha...
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USE OF SHORT-TERM BIOASSAYS TO EVALUATE ENVIRONMENTAL IMPACT OF LAND TREATMENT OF HAZARDOUS INDUSTRIAL WASTE |
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A four phase study was conducted to evaluate utility of short-term bioassays in monitoring environmental impact of land treatment of hazardous waste. During phase one, three microb...
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USE OF SPATIAL SALMONELLA ASSAY TO DETECT THE MUTAGENICITY OF COMPLEX ENVIRONMENTAL MIXTURES |
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The success demonstrated by the spiral Salmonella assay in a recent study of 20 chemical compounds (Houk et al., 1989) prompted us to examine the effectiveness of this automated ba...
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USE OF THE MICROSCREEN PHAGE-INDUCTION ASSAY TO ASSESS THE GENOTOXICITY OF 14 HAZARDOUS INDUSTRIAL WASTES |
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The Microscreen phage-induction assay, which quantitatively measures the induction of prophage lambda in Escherichia coli WP2s lambda, was used to test 14 crude (unfractionated) ha...
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USEFULNESS OF THE SELF-FERTILIZING CYPRINODONTID FISH, 'RIVULUS MARMORATUS' AS AN EXPERIMENTAL ANIMAL IN STUDIES INVOLVING CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS |
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Rivulus marmoratus is a naturally self-fertilizing cyprinodontid fish inhabiting mangrove marshes throughout the Caribbean. As a result of internal self-fertilization this oviparou...
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USING BASE-SPECIFIC SALMONELLA TESTER STRAINS TO CHARACTERIZE THE TYPES OF MUTATION INDUCED BY BENZIDINE AND BENZIDINE CONGENERS AFTER REDUCTIVE METABOLISM |
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Abstract
Benzidine, 4-aminobiphenyl, 3,3'-dichlorobenzidine HCl, 3,3'-dimethylbenzidine, 3,3'- dimethoxybenzidine and benzidine congener-based dye trypan blue were mutagenic in...
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VALIDATION OF CHEMICAL AND BIOLOGICAL TECHNIQUES FOR EVALUATION OF VAPORS IN AMBIENT AIR/MUTAGENICITY TESTING OF TWELVE (12) VAPOR-PHASE COMPOUNDS |
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The overall objective of this research was to further validate Ames mutagenicity preincubation system for detection of vapors in ambient air. Parametes for detection of vapors in t...
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WASTE OIL HEATERS: ORGANIC, INORGANIC, AND BIOASSAY ANALYSES OF COMBUSTION SAMPLES |
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The paper describes tests on two typical designs of waste-oil space heaters, firing two different types of waste crankcase oils. Study results can be summarized according to the fo...
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WATER DISTRIBUTION SYSTEM AS A POTENTIAL SOURCE OF MUTAGENS IN DRINKING WATER |
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The primary objective of this study was to examine the changes in concentration of 6 PAHs and the possibility of changes in mutagenic potential of treated waters as a result of lea...
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WHEN IS THERE ENOUGH EVIDENCE TO PERFORM A NONLINEAR CANCER ASSESSMENT? |
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Under U.S. EPA's Proposed Guidelines for Carcinogen Risk Assessment (FR 61:179670-18011, 199996), departure from the default linear cancer assessment may be made for carcinogens fo...
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WOOD SMOKE IMPACTED AIR: MUTAGENICITY AND CHEMICAL ANALYSIS OF AMBIENT AIR FROM RESIDENTIAL AREAS |
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An ambient air sampling program was conducted in a wood smoke impacted residential area of Junea, Alaska during the winter of 1985-86. The study was undertaken to determine the bac...
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WOOD SMOKE IMPACTED AIR: MUTAGENICITY AND CHEMICAL ANALYSIS OF AMBIENT AIR IN A RESIDENTIAL AREA OF JUNEAU, ALASKA (JOURNAL VERSION) |
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The study was undertaken to determine the bacterial mutagenicity (Ames test) and chemical characteristics of respirable particulate matter collected in the area. Fine particle conc...
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WOOD SMOKE IMPAIRED AIR: MUTAGENICITY AND CHEMICAL ANALYSIS OF AMIBIENT AIR IN A RESIDENTIAL AREA OF JUNEAU, ALASKA |
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An ambient air sampling program was conducted in a wood smoke impacted residential of Juneau, Alaska during the winter of 1985-86. his study was undertaken to determine the bacteri...
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WOODSMOKE AND MOTOR VEHICLE CONTRIBUTION TO AMBIENT AEROSOL MUTAGENICITY |
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A receptor model analysis of the mutagenicity of ambient fine particles in air samples collected under EPA's Integrated Air Cancer Project has been performed. he analysis was based...
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WORKSHOP PROCEEDINGS: APPROACHES FOR IMPROVING THE ASSESSMENT OF HUMAN GENETIC RISK--HUMAN BIOMONITORING |
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Federal laws require a consideration of adverse health effects, including mutagenicity, in arriving at regulatory decisions on chemical substances. Certain laws require balancing t...
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