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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Ball clay was the source of dioxin contamination discovered in selected chickens analyzed as part of a joint U.S. Department of Agriculture/U.S. Environmental Protection Agency nat...
For molecules of its size and weight, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is one of the most toxic, least water soluble, least volatile, and most resistant to therma...
This report describes the bioaccumulation and depuration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-TCDF) and polychlorinated b...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
In female rats, in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during critical periods of organogenesis causes a permanent thread of tissue across the vaginal open...
While the developmental toxicology of TCDD and its congeners has received considerable attention, the impact of advanced age on the biochemical effects and the pharmacokinetics of ...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The environment has become contaminated with complex mixtures of planar, chlorinated hydrocarbons (PCHs) such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been detected at levels ranging from 20 to 173 parts per trillion in adipose tissue from three Vietnam veterans who were 'heavily exp...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The paper describes a visit to the People's Republic of China (China) by members of the Air & Waste Management Association in October-November 2001 as part of a People to People Am...
C14H9F3N2O5, M - 342.24, monoclinic, P21/c, a = 12.397(5), b = 8.277(4), c = 15,169(6) A, B = 109.8(3), V = 1464 (1) A3, Z = 4, Dc = 1.55 g Cm-3., (MoKa) = 0.7107, u = 1.4 cm-1, F(...
A COMPARISON OF THE METABOLISM OF METHOXYRESORUFIN, ACETANILIDE AND CAFFIENE IN RAT AND HUMAN CYP1A2 SUPERSOMES AND THEIR INHIBITION BY 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD). ...
Male rats exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) display reduced fertility as a consequence of the direct action of TCDD on the epididymides, as well as del...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin) and related polyhalogenated aromatic hydrocarbons (PHAHs) alter the reproductive development of laboratory animals. Therefore, we...
Data from several studies suggest that concentrations of dioxins rose in the environment from the 1930s to about the 1960s/70s and have been declining over the last decade or two. ...
The exposure portion of the United States Environmental Protection Agency's (EPA) Dioxin Reassessment has concluded that over 90% of human exposure to dioxin (and related compounds...
A novel effect of dioxin: Exposure during pregnancy severely impairs mammary gland differentiation. Beth A. Vorderstrasse1, Suzanne E. Fenton2, Andrea A. Bohn3, Jennifer A. Cun...
Empirical evidence suggests that exposure of Americans to dioxin-like compounds was low during the early decades of the 20th century, then increased during the 1940s and 1950s reac...
The current toxic equivalency factors (TEFs) for PCDD/Fs and "dioxin-like" PCBs represent consensus-based values that were recommended by an international panel of experts convened...
Testing for emissions of dioxins from the stack of the Columbus, Ohio Waste to Energy (WTE) municipal solid waste combustion facility in 1992 implied that dioxin concentrations in ...
The USEPA and the USDA completed the first statistically designed survey of the occurrence and concentration of dibenzo-p-dioxins (CDDs), dibenzofurans (CDFs), and coplanar polychl...
The purpose of this paper is to report on the results of a joint survey of the United States Department of Agriculture (USDA) and the United States Environmental Protection Agency ...
The paper reports on the results of a joint survey of the United States Department of Agriculture (USDA) and the United States Environmental Protection Agency (EPA) on the rate of ...
Soils have accumulated CDDs/CDFs both from air deposition and from direct application associated with a variety of human activities. If even limited quantities of these dioxins ca...
Consumption of animal fats account for as much as 95% of the human background exposure to compounds with dioxin-like activity. Although it is generally believed that most domestic...
The Environmental Protection Agency (EPA), in cooperation with USDA and the US Food and Drug Administration (FDA), has undertaken a program to study the presence of dioxin-like com...
Polychlorinated dibenzo-p-dioxins (CDDs), polychlorinated dibenzofurans (CDFs) and certain non- and mono-ortho substituted polychlorinated biphenyls (cp-PCBs) are a general class o...
The terminal differentiation of B cells in lymphoid organs into antibody-secreting plasma cells upon antigen stimulation is a crucial step in the humoral immune response. The archi...
The terminal differentiation of B lymphocytes into antibody-secreting plasma cells upon antigen stimulation is a crucial step in the humoral immune response. The mutually-repressi...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Many aquatic species, including the estuarine fish Fundulus heteroclitus (mummichogs), adapt to local environmental conditions. We conducted studies to evaluate whether highly expo...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Recent studies have demonstrated variable effects on mammary gland development in rat offspring exposed to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin, 1 ug/kg, gavage) on day 15 of ...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent and widespread environmental contaminant, has diverse biological effects which include carcinogenesis, hepatotoxicity, thymic i...
Altered sensitivity of the mouse fetus to impaired prostatic bud formation by dioxin: Influence of genetic background and null expression of TGF and EGF. Rasmussen, N.T., Lin...
In response to reports of elevated dioxin concentrations in the blood of several people in southern Louisian and requests by local citizens and regulatory agencies, United States E...
A number of investigators have recently examined the utility of applying probabilistic techniques in the derivation of toxic equivalency factors (TEFs) for polychlorinated dibenzo-...
Currently, regulatory agencies utilize the toxic equivalency factor (TEF) approach to evaluate potential health risks associated with exposure to polychlorinated dibenzo-p-dioxins ...
The current approach for evaluating potential health risks associated with exposure to mixtures of polychlorinated dibenzo-p-dixoins (PCDDs), polychlorinated dibenzofurans (PCDFs) ...
The presence of dioxin-like compounds in ball clay was discovered in 1996 as a result of an investigation to determine the sources of elevated levels of dioxin found in two chicken...
The Environmental Technology Verification (ETV) Program, beginning as an initiative of the U.S. Environmental Protection Agency (EPA) in 1995, verifies the performance of commercia...
The dioxins comprise a family of compounds chemically referred to as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). The most toxic of these co...
A simple, one-compartment, first-order pharmacokinetic model is used to predict the infant body burden of dioxin-like compounds that results from breast-feeding. Validation testin...
Three empirical air-to-leaf models for estimating grass concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (abbreviated dioxins and furans) from air concentratio...
EPA has released an external review draft entitled, “An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios(External Review Draft).” The public ...
An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the United States for the Years 1987, 1995, and 2000 (EPA/600/P-03/002F, November 2006), is a peer re...
Toxic contaminants are one of the most pressing environmental concerns in the Lake Superior Basin. The "Binational Program to Protect and Restore the Lake Superior Basin," a U.S. a...
An IP3 Receptor-Sensitive Ca2+ Store Mediates Disturbances In Intracellular Ca2+ Upon Exposure To Aroclor 1254 And Ortho-Substituted PCBs JR Inglefield, WR Mundy, and TJ Shafer. N...
The Air Pollution Technology Branch (APTB) of the U.S. Environmental Protection Agency's National Risk Management Research Laboratory, located in Research Triangle Park, North Caro...
The Air Pollution Technology Branch (APTB) of the U.S. Environmental Protection Agency's National Risk Management Research Laboratory, located in Research Triangle Park, North Caro...
This seminar will provide a basic overview of how 2,3,7,8-tetrachlorodibenzo-p-dioxin (a.k.a. TCDD or "dioxin") and dioxin-like chemicals (e.g., certain PCBs) bioaccumulate and aff...
This report is intended to assist ecological risk assessors who must characterize risks to birds from exposure to dioxin-like chemicals. Those chemicals include the halogenated dib...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has a high estimated cancer potency in animals which has been reasoned to imply that TCDD might be carcinogenic to man. The animal cancer...
During a national survey of polychlorinated dibenzo-p-dioxins (CDD), dibenzofurans (CDF), and dioxin-like coplanar PCBs (PCB) in poultry, elevated concentrations above 20 parts per...
This report describes the analytical procedures and quality assurance plan used for the determination of polychlorinated dibenzo-p-dioxins and dibenzofurans in fish for Phase II of...
This report describes the analytical procedures and quality assurance plan used for the determination of xenobiotic chemical contaminants including select pesticides, polynuclear a...
The U.S. EPA established the National Dioxin Monitoring Network (NDAMN) to meet an identified need for a national network to monitor ambient air concentrations of dioxin-like compo...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
A critical review of biological treatment processes for remediation of contaminated soils is presented. The focus of the review is on documented cost and performance of biological...
In the days following the September 11, 2001, terrorist attack on New York City's World Trade Center (WTC) towers, EPA, other federal agencies, and New York City and New York State...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been reported to decrease host resistance to a variety of infectious agents when exposure occurs prior to infection. esistance to vir...
The EPA, under the Toxic Substances Control Act, has been mandated to develop appropriate regulations for the control of exposure to polychlorinated biphenyls (PCBs). In light of t...
Dioxins are very toxic contaminants and warrant study under a variety of experimental conditions. Studies were performed to evaluate the mobility of several of the dioxins in both ...
Dioxins are very toxic contaminants and warrant study under a variety of experimental conditions. Studies were performed to evaluate the mobility of several of the dioxins in both ...
The U.S. EPA has established a National Dioxin Air Monitoring Network (NDAMN) to address three primary objectives: (1) to determine the atmospheric levels and occurrences of dioxin...
The U.S. EPA established a National Dioxin Air Monitoring Network (NDAMN) to determine the temporal and geographical variability of atmospheric CDDs, CDFs and coplanar PCBs through...
The addition of the "dioxin-like" polychlorinated biphenyl (PCB) congeners to the assessment of risk associated with the 2,3,7,8-chlorine substituted dioxins and furans has dramati...
This report sought to determine the initial oxidative pathways for dibenzodioxin and dibenzofuran compounds by bacteria in aquatic systems. Bacterial cultures were isolated and oxi...
In the late 1970s thousands of gallons of transformer fluid contaminated with PCBs were illegally sprayed along approximately 210 miles of North Carolina state roadways. Listed as ...
The primary impact of this presentation will be to raise awareness in the New York area of the advances made in this field since the late l980s when Superfund sites in the Niagara ...
The paper reports on a bench-scale experimental study to characterize a newly built reactor system that was built to: produce levels and distributions of polychlorinated dibenzo-p-...
Benchmark doses (BMDs), defined as doses of a substance that are expected to result in a pre-specified level of "benchmark" response (BMR), have been used for quantifying the risk ...
It has been postulated that reversible, high-affinity binding of 3-methyl-cholanthrene (MC)-type inducers to a receptor protein (the Ah receptor) in hepatic cytosol is essential fo...
In order to complete ecological or human health risk assessments, exposure of aquatic organisms to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related chemicals must be linked t...
One of the most commercially valuable farm animals in the United States is the domestic chicken (Gallus domesticus). Rapidly reared in controlled, intensive environments, the US D...
The risk assessment process is fundamental in understanding and controlling environmental health risks. Risk assessment includes four steps: hazard identification, dose-response ...
The bioaccumulation and depuration of 2,3,7,8-tetrachloro-dibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and polychlorinated biphenyls by marine benthos exposed to environmental...
The bioavailability of 2,3,7,8-TCDD from municipal incinerator fly ash to freshwater fish was determined. It was observed that carp exposed to fly ash containing all 22 TCDD isomer...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
A bacterium tentatively identified as an Erwinia sp. was isolated from sewage by enrichment on menthanol and lignin. everal mutants developed from this strain were studied for thei...
The white rot fungus, Phanerochaete chrysosporium secretes a unique hydrogen peroxide-dependent oxidase capable of degrading lignin, a highly complex, chemically resistant, non-rep...
Over the last several years we have conducted both laboratory and field studies to develop a better understanding of the movement of chlorinated organic compounds through aquatic e...
Because of the extensive cost, in personnel, time, equipment, and money to measure dioxin-like chemicals analytically, alternative technologies have been developed to measure the i...
In recent years contamination of the Great Lakes ecosystem with planar chlorinated hydrocarbons (PCHS) has attracted considerable concern due to their known reproductive and terato...
A set of high-quality, age-specific biota-sediment accumulation factors (BSAFs) for polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) have been...
ABSTRACT Developing organisms have been shown to have increased susceptibility to cancer if exposed to environmental toxicants during rapid growth and differentiation. Human ...
CHANGES IN EXPRESSION OF PHOSPHORYLATED AND TOTAL ERK1/2 IN TCDD-EXPOSED EMBRYONIC MOUSE PALATES. C Wolf and B Abbott, USEPA, ORD, NHEERL, Reproductive Toxicology Division, Rese...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The Chemically Activated Luciferase gene expression (CALUX) in vitro cell bioassay is an emerging bioanalytical tool that is increasingly being used for the screening and relative ...
In 2002, dioxins were discovered in animal feed ingredients during a random sampling by Irish officials and subsequently traced to particular mineral supplements produced at a Minn...
Numerous research studies have been conducted to establish indicator compounds for fast and less costly predictive monitoring of polychlorinated dibenzo-p-dioxin and furan (PCDD/F)...
Research has sought indicator compounds for fast and less costly predictive monitoring of polychlorinated dibenzo-p-dioxin and furans, PCDD/F, toxic equivalent concentrations or TE...
The U.S. Environmental Protection Agency Mobile Incineration System, which was operated at the Denney Farm site in southwestern Missouri between October 1985 and June 1989, treated...
The article: (1) identifies specific combustion conditions which are postulated to lead to low emission of organics--components of good combustion practice (GCP), (2) summarizes ex...
The paper summarizes studies sponsored by the EPA to assess combustion practice that can be used to minimize trace organic emissions. Although the study was concerned primarily wit...
Toxic equivalency factors have been proposed for dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls (PCBs). The proposed TEFs, which are presently being evaluate in our...
Known mixtures and unknown atmospheric sample extracts containing polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/P) were analyzed by both electron impact...
The high-resolution gas chromatographic-mass spectrometric analysis of 25 Great Lakes fish extracts confirmed the identities of several 2,3,7,8-tetrasubstituted polychlorinated dib...
We have carried out an ab initio STO-5G computational analysis of the electrostatic potential of four structural analogues of the highly toxic 2,3,7,8-tetrachlorodibenzo-p-dioxin (...
Comparative molecular field analysis was performed on polyhalo-genated dibenzo-p-dioxins, dibenzofurans, and biphenyls for Ah receptor binding and enzyme inducing activities determ...
The early life stages of fish are known to be more sensitive than the adults to the toxicological effects of 2,3,7,8-tetrachlorodibenzo(p)dioxin (TCDD). Embryo larval stages of med...
COMPARING ENVIRONMENTALLY RELEVANT PCBS TO TCDD. D E Burgin1, J J Diliberto2 and L S Birnbaum3.1UNC, Chapel Hill, NC, USA; 2USEPA/ORD/NHEERL, ETD, RTP, NC, USA
The role of CYP1A2 on the interactions of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin, dioxin), dioxin-like (DL) and non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) was co...
COMPARING MIXTURES OF DIOXIN-LIKE AND NON DIOXIN-LIKE PCBS TO TCDD. D E Burgin1, J J Diliberto2 and L S Birnbaum3.1University of North Carolina/Toxicology, Chapel Hill, NC, USA; 2U...
Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) [hereafter referred to as ¿dioxin-like compounds¿] are persis...
In epidemiological studies, exposure assessments to TCDD, known as a possible human carcinogen, assume mono or biphasic elimination rates. Recent data suggests a dose dependent el...
Humans are exposed to mixtures of dioxins and the potential health effects of these exposures are uncertain. he present study compares the body burdens of dioxins which produce ef ...
Cleft palate (CP) can be Induced In embryonic mice by a Wide range of compounds, including glucocorticoids and 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD). ydrocortisone (HC), a gl...
Determination of toxic organic compounds in ambient air is a complex task, primarily because of the wide variety of compounds of interest and the lack of standardized sampling and ...
During sexual differentiation there are a number of critical periods when the reproductive system is uniquely susceptible to chemically-induced perturbations. At these times an ina...
The U.S. EPA National Exposure Research Laboratory (NERL), in conjunction with our Regional offices, established a network of air monitoring sites to characterize ambient air con...
The U.S. EPA National Exposure Research Laboratory (NERL), in conjunction with our Regional offices, established a network of air monitoring sites to characterize ambient air con...
Although 210 chemically different polychlorinated dibenzo-p-dioxin and dibenzofuran congeners can be produced during combustion, it is currently believed that fewer than ...
This report was prepared by Eastern Research Group, Inc. (ERG), an EPA contractor, as a general record of discussion for the peer review meeting. This report captures the main poin...
A survey of contamination of fish from major watersheds in the United States by 2,3,7,8-TCDD has been conducted by the U.S. EPA. ottom feeding and predator fish were collected at 9...
This research was initiated to determine the operating conditions necessary to effect complete thermal destruction (greater than 99.99%) of pentachlorophenol (PCP)-treated wood in ...
The paper discusses controlling polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDF) emissions from incinerators by flue gas cleaning. New Source performance Standards for muni...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
Isomer composition of polychlorinated naphthalenes (PCNs) was measured for municipal waste incinerator fly ash samples,and for emission samples produced from soot and copper deposi...
We examined populations of an estuarine fish species (Fundulus heteroclitus) resident to a highly contaminated site and a reference site for their ability to metabolize an importan...
Emission samples from a simulated hazardous waste-fired North American Package Boiler (NAPB) and a refuse-derived fuel incineration facility (RDFF) were analyzed separately and com...
A specific teratogenic response is elicited in the mouse as a result of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin). he characteristic spectrum of structural mal...
CYP1A2 IS NOT REQUIRED FOR 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED IMMUNOSUPPRESSION Smialowicz, Ralph J1; Burgin, Deborah E2; Williams, Wanda C1; Diliberto, Janet J1; Birnbaum...
ABSTRACT One of the most sensitive and reproducible immunotoxic endpoints of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) exposure is suppression of the antibody response to shee...
Na/NH3 reductions have been used to dehalogenate polychlorinated biphenyls (PCBs), chlorinated aliphatic hydrocarbons (CAHs) and pesticides at diffusion controlled ra...
The lake trout, Salvelinus namaycush, is the predominant top predator native fish species of the Great Lakes. Lake trout are valued for commercial and recreational use in addition ...
The Superfund Innovative Technology Evaluation (SITE) Program has successfuly promoted the development, commercialization and implementation of innovative hazardous waste treatment...
The demonstration of technologies for determining the presence of dioxin in soil and sediment is being conducted under the U.S. Environmental Protection Agency Superfund Innovative...
The ATP system is designed to desorb, collect, and recondense contaminants. The kiln contains four separate internal thermal zones: preheat, retort, combustion, and cooling. In the...
Hazards from environmental contaminants have become a necessary part of life in industrial countries. In the past few decades, a number of 'new' problems have arisen (termiticide-t...
This final report presents a concise description and evaluation of the approaches used in the Agency for dermal exposure assessment including a discussion about harmonization and r...
The EPA Mobile Incineration System, which consists of a kiln, secondary combustion chamber, air pollution control unit, and separate continuous stack gas analysis capabilities, was...
An analytical procedure has been developed for the determination of the 18 PCB congeners which are inducers of methylcholanthrene-like mixed function oxidase activity in animals an...
As part of the U.S. EPA Dioxin Reassessment Program, the 2,3,7,8-chlorine-substituted dibenzo-p-dioxins and furans were measured at part per trillion (ppt) levels in beef fat colle...
A convenient method for water and wastewater samples is presented that will determine 2,3,7,8-TCDD concentrations to a Method Detection Limit (MDL) of 2 ng/L. The method uses solve...
The in vitro induction of the cytochorm P1-450-dependent monooxygenases, aryl hydrocarbon hydroxylase (AHH) or ethoxyresorufin O-deethylase (EROD) by 2,3,7,8-TCDD and related toxic...
Validated sample preparation procedures and high resolution gas chromatography-high resolution mass spectrometry techniques were utilized for the quantitative measurement of 4 to 6...
A preliminary study was performed to evaluate the potential formation and persistence of tetrachlorodibenzo-p-dioxins (TCDDs) and tetrachlorodibenzo furans (TCDFs) in the effluent ...
This program was undertaken in an effort to develop an analytical method for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in industrial and municipal wastewaters...
Vapor pressures were determined for several polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) at 75–275°C, extending the available lite...
U.S. Environmental Protection Agency (EPA) guidance issued in April 1994 for performing screening level risk analyses of emissions from facilities that burn hazardous waste does no...
A model for predicting concentrations of dioxin-like compounds in beef is developed and tested. The key premise of the model is that concentrations of these compounds in air are t...
The toxic equivalency factor (TEF) approach has been widely accepted as the most feasible method available at present for evaluating potential health risks associated with exposure...
The toxic equivalency factor (TEF) approach has been widely accepted as the most feasible and plausible method presently available for evaluating potential health risks associated ...
Results of an experiment in which grass was grown in a greenhouse and outdoors, and in soils of different concentration levels of dioxins and furans, were used in a modeling exerci...
In this study, the development of a toxicity evaluation method for dioxins in human milk by enzyme-linked immunosorbent assay (ELISA) was reported. A total of 17 human milk samp...
The paper summarizes the rationale for EPA's good combustion practice (GCP) strategy. OTE: The EPA is developing new air pollution rules for all new and existing municipal waste co...
Potential health risks associated with exposure to mixtures of dioxin-like compounds are currently assessed using a toxic equivalency factor (TEF) approach. Recently, both the WH0...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The potent developmental toxicity of dioxin in multiple species has been known for a number of years. owever, recent studies have indicated that dioxin also induces functional deve...
The issue of the developmental toxicity of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) and related compounds has been the subject of two recent reviews (Morrissey and Schwetz, 1989...
This work not only establishes clear epidemiological connection between the known toxicity of dioxin-like chemicals and failure and recovery of the Lake Ontario lake trout populati...
Introduction Polychlorinated biphenyls (PCBs) are widely used in industry as heat transfer and dielectric fluids for transformers and capacitors1. PCBs were commercially produce...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The manufacture of halogenated organic chemicals results in the formation of small amounts of undesirable side reaction by-products. These contaminants may be contained in the prod...
To establish the relationship between specific chlorophenol (CP) congener distributions and polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) products this work investigat...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
Laboratory analyses for polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzo-furans (PCDF) were performed on waste fuels and stack gas emission samples from five in...
Emissions of polychlorinated dibenzodioxins and dibenszofurans (PCDD/PCDF) from uncontrolled burring of biomass and waste are responsible for a significant, if not major, portion o...
The paper reports results from tests designed to examine some of the factors influencing the emissions of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs...
The U.S. Environmental Protection Agency (EPA) is progressing toward completion of its comprehensive reassessment of dioxin exposure and human health effects entitled, Exposure ...
Procedures have been developed by the US EPA for estimating the risk associated with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Concentrations of dioxin at the conta...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The endangered Forster's tern (Sterna forsteri) population on Green Bay, Wisconsin has exhibited symptoms of embryotoxicity, congenital deformities, and poor hatching success. he p...
This report deals with a group of hazardous chemical compounds known as dioxins. The extreme toxicity of one of these chemicals, 2,3,7,8-tetrachlor-dioxin (2,3,7,8-TCDD), has been ...
A potential connection exists between the increasing prevalence of endometriosis and exposure to organochlorine chemicals. There is evidence that dioxin (2,3,7,8-TCDD) can increas...
Kanawha Valley of West Virginia has a history of 2,3,7,8-tetrachlorodibenzo-p-dioxin contamination (dioxin, TCDD). The bulk of the dioxin found in this area appears to be derived ...
Concern about the potential contamination of the environment by dibenzo-p-dioxins through the use of certain chemicals and disposal of associated wastes prompted this study. The vo...
Chemical reaction mechanisms by which dioxins may be formed are reviewed, particularly those likely to occur within commercially significant processes. Various routes of formation ...
Introduction: Dioxins have been featured in the news recently following a poisoning incident in Europe.1-3 Because physicians are not usually taught much about the dioxins, this a...
Polybrominated dibenzodioxins and dibenzofurans are of toxicologic interest due to potential occupational and environmental exposure and because of their structural similarity to t...
The biologic activity and pharmacokinetic properties of 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) are similar to those of the chlorinated congener, 2,3,7,8-tetrachlorodibenzo-p-dio...
Recent epidemiology studies have shown an association between type II diabetes and exposure to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin). A possible explanation is that diabetics...
The United States Environmental Protection Agency (EPA) and the United States Department of Agriculture (USDA) recently collaborated on a statistically-based, national survey of di...
As science continues to appreciate the prevalence and power of dioxins, so it learns more about the harmful effects and effective preventive measures regarding these chemicals. Upd...
The dose response relationships for different endpoints in different tissues were compared in response to TCDD treatment. CDD was administered 5 days/week for 13 weeks at doses ran...
The objectives of this study were to determine in mice the effects of dose (0, 0.1, 1, or 10 ug [3H]TCDD/kg) and time (7, 14, 21, & 35 days post treatment) on tissue distribution (...
The U.S. Environmental Protection Agency's (EPA) is progressing toward completion of its comprehensive reassessment of dioxin exposure and human health effects...
The Office of Drinking Water (ODW), U.S. Environmental Protection Agency has prepared a Drinking Water Criteria Document on 2,3,7,8-TCDD. This Criteria Document is an extensive rev...
In their recent reevaluation of the TEF methodology, the WHO expert panel indicated that consideration should be given to developing weighted distributions of REP values to establi...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The ELI Eco Logic International Inc. (Eco Logic) process thermally separates organics, then chemically reduces them in a hydrogen atmosphere, converting them to a reformed gas that...
Sediment box cores have frequently been used to determine organochlorine chemical loading histories of lakes and reservoirs. ? Typical profiles for PCBs or DDT show concentrations...
Sediment box cores have frequently been used to determine organochlorine chemical loading histories of lakes and reservoirs. 137Cs and 210Pb radionuclide dating techniques are empl...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The paper gives results of an examination of the catalytic effects of copper and iron compounds for their behavior in promoting formation of chlorine (C12), the major chlorination ...
How does the addition of oxygen improve the applicability of incineration? his paper addresses that question by evaluating the performance of oxygen enhanced hazardous waste incine...
The laterally halogenated chemicals 2,3,7,8-tetrachlorodibenzofuran (TCDF) and 3,3',4,4 1-tetrachlorobiphenyl (TCB) exhibit the same spectrum of toxic effects as 2,3,7,8-tetrachlor...
The conventional drinking water treamtent processes of coagulation, flocculation, and filtration as well as specialized treatment processes have been examined for their capacity to...
EFFECTS OF 2,2',4,4,'-TETRABROMODIPHENYL ETHER ON CAR AND PXR REGULATED GENE EXPRESSION IN WEANLING FEMALE RATS. V M RICHARDSON1, K M CROFTON2, AND M J DEVITO1. USEPA, ORD/NHEERL/E...
Two groups of C57BL/6J mice received a single oral dose of 1 nmol/kg 2,3,7,8- [3H]-tetrachlorodibenzo-p-dioxin (TCDD) alone or in combination with 300 gmol/kg 2,2',4,4',5,5'-hexach...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), produces hydronephrosis by altering the differentiation and proliferation of ureteric epithelial cells in the embryonic C57BL/6N mouse u...
While the effect that TCDD has on humoral immunity in the mouse has been well documented, it has not been for the rat. n this study, the effect that TCDD has on the antibody plaque...
Fundulus heteroclitus populations indigenous to certain highly contaminated sites demonstrate an inherited tolerance to the toxic effects of local chemical contaminants. Our initia...
Fundulus heteroclitus populations indigenous to certain highly contaminated sites demonstrate an inherited tolerance to the toxic effects of local chemical contaminants. Our initia...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Lake trout embryos and sac fry are very sensitive to toxicity associated with maternal exposures to 2,3,7,8-tetrachlorodibenza-p-dioxin (TCDD) and structurally related chemicals th...
Effects of a model polycyclic aromatic hydrocarbon (PAH) were compared in populations of the estuarine fish Fundulus heteroclitus indigenous to a reference site and one highly cont...
This chapter describes a matrix modeling approach to characterize and project risks to wildlife populations subject to chronic stress. Population matrix modeling was used to estima...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Fish from a highly PCB-contaminated Superfund site (New Bedford, Massachusetts, USA) that show genetically-based tolerance to DLCs (Nacci, D. et al. 1999. Mar.Biol.134: 9-17) also ...
The absorption, distribution, metabolism and excretion of 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) was studied in male F344 rats. ral absorption was dose-dependent. bsorption of 1...
Polybrominated dibenzo-p-dioxins (PBDDS) and dibenzofurans (PBDFS) are of major concern because of potential occupational and environmental exposures and their structural similarit...
In mammals, the androgens testosterone (T) and dihydrotestosterone (DHT) are critical for normal male reproductive development and function. In humans, drugs that act as androgen...
In mammals, the androgens testosterone (T) and dihydrotestosterone (DHT) are critical for normal male reproductive development and function. In humans, drugs that act as androgen...
The present study was designed to obtain a measure of the change in phototransformation efficiency in the presence of other chemicals. The efficiency of the phototransformation ...
The data from preliminary investigations of the efficiency of dioxin recovery from fly ash samples during sample extraction and subsequent column cleanup of sample extracts are dis...
Abstract The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces cleft palate (CP) and hydronephrosis (HN) in mice. The etiology of these defects invol...
SCF-MO computations have been performed on tetra- to octa-chlorinated dibenzo-p-dioxin congeners (PCDD) using an MNDO-PM3 Hamiltonian. Qualitative relationships were deve...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Brominated dibenzodioxins (PBDDs) may be widely dispersed in the environment, arising from the oxidative ring closure of fire retardant brominated biphenyl ethers, from the combust...
The electrostatic potential V(r) that is created in the space around a molecule by its nuclei and electrons is a rigorously defined property that is useful in (a) analyzing and pre...
This study examines development of rat, mouse and human embryonic palates in submerged, serum-free organ culture. he concentration-response profiles for retinoic acid (RA), triamci...
Wildlife populations from contaminated ecosystems display a variety of reproductive alterations including cryptorchidism in the Florida panther, small baculum in young male otters,...
This process is a two-stage photolytic and biological soil detoxification process that has application to treatment of soils contaminated with polychlorinated biphenyls (PCBs) and...
This report presents the results of bench-scale testing on degradation of 2,3,7,8-TCDD using W photolysis, and PCB degradation using UV photolysis, chemical oxidation and biologica...
Bench-scale tests were conducted to investigate the feasibility of a two phase detoxification process that would have application to the treatment of soils contaminated with polych...
A detailed literature search was performed to collect and collate available data reporting emissions of toxic organic substances into the air from open burning sources. Availabilit...
A detailed literature search was performed to collect and collate available data reporting emissions of organic air toxics from open burning sources. Availability of data varied ac...
Environmental Factors Affecting Breast Cancer Susceptibility Suzanne. E. Fenton US EPA, ORD, MD-67 NHEERL, Reproductive Toxicology Division, Research Triangle Park, NC 27711....
The U.S. EPA National Exposure Research Laboratory (NERL), in conjunction with our Regional offices, established a network of air monitoring sites to characterize ambient air con...
The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) program evaluates the performance of innovative air, water, pollution and monitoring tech...
The performance of four dioxin emission monitors including two long-term sampling devices, the DMS (DioxinMonitoringSystem) and AMESA (Adsorption Method for Sampling Dioxins and Fu...
Environmental Toxicants and Altered Mammary Gland Development: The window of susceptibility. Suzanne E. Fenton, National Health and Environmental Effects Research Laboratory, U.S....
Environmental Toxicants and Altered Mammary Gland Development: The window of susceptibility. Suzanne E. Fenton, National Health and Environmental Effects Research Laboratory, U.S....
The experimental design and results of an interlaboratory study for dioxin in water is described herein. The interlaboratory study of EPA Method 613 consisted of the replicate anal...
This report covers the field demonstration activities of the U.S. Environmental Protection Agency's Mobile Incineration System (MIS) from February 1986 to June 1989 at the Denney F...
EPA currently has regulations relating to release of dioxin-like compounds from air sources and from pulp and paper mills into water bodies. Information on these...
The paper discusses EPA's new clean air technologies and opportunities for cooperative development. ew clean air technologies for commercial application have recently been develope...
The United States Environmental Protection Agency initiated a reassessment of the risk of exposure to dioxin in the spring of 1991 because of the evolution of scientific thinking a...
The primary purpose of this document is to present procedures for conducting site-specific exposure assessments to dioxin-like compounds. In addition, information is provided on th...
This document consists of three volumes addressing human exposure, to dioxin-like compounds. olume I is an Executive Summary of Volumes II and III. olume I also includes a unique s...
This document consists of three volumes addressing human exposure, to dioxin-like compounds. olume I is an Executive Summary of Volumes II and III. olume I also includes a unique s...
This document consists of three volumes addressing human exposure, to dioxin-like compounds. olume I is an Executive Summary of Volumes II and III. olume I also includes a unique s...
Over the last few years, the International Joint Commission has been supporting development of a PC-based transfer model, derived from the HYSPLIT model created at the National Oce...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
ETD QA CORE TEAM: AN ELOQUENT SOLUTION TO A COMPLEX PROBLEMThomas J. Hughes, QA and Records Manager, Experimental Toxicology Division (ETD), National Health and Environmental Effec...
Four polychlorinated dibenzodioxin and furan (PCDD/F) emission monitors were tested under the EPA Environmental Technology and Verification (ETV) program. Two long-term sampling de...
Prior to the mid 1980s, assessments of health impacts from dioxin-like compounds released into the air only evaluated the inhalation exposure pathway. In the latter 1980s it was ...
A High-Volume air sampler was evaluated for collection of poly-chlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF). The sampler consists of a filter, poly...
Continuous samplers and real or semi-real-time continuous monitors for polychlorinated dibenzodioxins and furans provide significant advantages relative to conventional methods of ...
Milk fat is likely to be among the highest dietary sources of exposure to persistent, bioaccumulative, and toxic (PBT) contaminants, thus it is important to understand PBT levels i...
An analytical protocol for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and total TCDDs in soil, sediment and aqueous samples using high-resolution gas c...
The study investigated the use of personal coolers to increase worker productivity and safety while working at elevated, ambient temperatures cleaning up dioxin contaminated soil.^...
The immunotoxicity of TCDD in the mouse has been well documented. o date, the most sensitive endpoint to TCDD-induced toxicity in mice is that reported by Clark et al. (1) who foun...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment...
Triclosan is an industrial antibacterial agent commonly used in soaps, toothpaste and cleaners. The present investigation was designed to examine the endocrine modulating potential...
Triclosan is an industrial antibacterial agent commonly used in soaps, toothpaste and cleaners. The present investigation was designed to examine the endocrine modulating potential...
EVIDENCE FOR BROMODICHLOROMETHANE METABOLISM BY CYTOCHROME P-450 1A2. T M Ross1, B P Anderson1, G Zhao2, R A Pegram1 and J W Allis1. 1U.S. EPA, ORD, NHEERL, Research Triangle Par...
EVIDENCE FOR EGFR PATHWAY MEDIATION OF CLEFT PALATE INDUCTION BY TCDD. B D Abbott, A R Buckalew, and K E Leffler. RTD, NHEERL, ORD,US EPA, RTP, NC, USA.
In 1997, the United States (US) Environmental Protection Agency (EPA) conducted a mass balance study of polychlorinated dibenzo-p-dioxins (CDDs) and dibenzofurans (CDFs) in lactati...
Adult female B6C3F1 mice were given a single IP dose of 0, 0.1, 1.0, or 10.0 ug/kg TCDD and examined for immune function and host resistance seven to ten days later. xposure to TCD...
The report gives results of experiments to determine the effect of flame zone temperature on gas-phase flame formation and destruction of products of incomplete combustion (PICS) d...
Toxicology and teratology studies routinely utilize animal models to determine the potential for chemical and physical agents to produce reproductive and developmental toxicity, ...
In the days following the September 11, 2001, terrorist attack on New York City's World Trade Center (WTC) towers, many Federal agencies, including the U.S. Environmental Protectio...
Exposure Assessment to Dioxins from the Use of Tampons and Diapers Michael J. DeVito and Arnold Schecter Abstract Methods: Four brands of tampons and four brands of in...
EXPRESSION OF EGFR AND ITS LIGANDS IN RESPONSE TO TCDD OR RETINOIC ACID IN EGF AND TGF" KO FETAL MOUSE PALATE. Abbott, Barbara D.1; Boyd, Hadiya2; Wood, Carmen1; Held, Gary1. 1.EPA...
Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are typically reported only in terms of the tetra-through octa-CDD/CDF isomers...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The report gives results of a determination of the recovery efficiencies from XAD-2 resin (Amberlite) and Florisil of spiked 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), in ...
This paper summarizes the various system performance tests and the long-term operating experience of the LINDE(r) Oxygen Combustion System (OCS) installed on the U.S. Environmental...
The paper gives results of an examination of the formation mechanisms of polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) and their precursors in a l...
The formation mechanisms of the precursors of polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) were examined in a laboratory reactor. Both homogeneou...
To offer a polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) parameter for plant operation control, the on-line estimation of PCDD/Fs emissions by surrogates like...
Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) are commonly found as contaminants in complex mixtures in the environment. Several of thes...
A model has been developed which successfully predicts the order of elution and relative retentions of tetra-, penta and hexachlorodibenzo-p-dioxins for gas chromatography (GC) col...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
Several studies have shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has inhibitory effects on ovulation. This action may be the result of either d...
This paper provides guidance for evaluating the key aspects of study design and conduct that must be considered in judging the reliability and adequacy of reported laboratory data....
Fish-eating waterbirds from the Great Lakes of North America have shown symptoms of poisoning similar to those observed in laboratory exposures of various avian species to planar h...
Concentration-dependent induction of cytochrome P4501A (CYP1A) and intracellular porphyrin accumulation were observed following treatment of chicken embryo hepatocyte (CEH) culture...
The U.S. Environmental Protection Agency has undertaken the task of preparing a scientific reassessment of the health risks of exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin and ch...
The U.S. Environmental Protection Agency has undertaken the task of preparing a scientific reassessment of the health risks of exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin and ch...
The U.S. Environmental Protection Agency has undertaken the task of preparing a scientific reassessment of the health risks of exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin and ch...
Dioxins are a class of compounds that contain the dibenzo-p-dioxin nucleus. In the chlorinated dioxins, the dibenzo-p-dioxin nucleus is substituted with chlorine at different posit...
Abstract TCDD is often called the most toxic man-made chemical because of its potency to cause health effects in a wide variety of vertebrates. Structurally related persis...
The document represents a brief, quantitatively oriented scientific summary of health effects data. It was developed by the Environmental Criteria and Assessment Office to assist t...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic and environmentally stable pollutants. In addition to various toxic effects, TCDD has been found to cause terato...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
This CD ROM is a result of several healthcare guidance documents coming into existence around the same time and the need for one tool where healthcare facilities could have access ...
Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known highly toxic compound that is present in nearly all components of the global ecosystem, including air, soil, sediment, ...
We have previously shown decreased resistance to Trichinella spiralis (Ts) infection, and reduced parasite antigen-specific responses in mice exposed to TCDD before infection. he p...
The report gives results of an evaluation of the sampling and analysis of ultratrace levels of dibenzodioxins using EPA's recommended source sampling procedures (Modified Method 5 ...
During the past one hundred years, there have been a number of episodes involving high exposures to 2.3.7.8-TCDD or related compounds. Some of these have been accidental; others i...
Exposure assessment procedures have been developed using relevant and likely scenarios through which humans could be exposed to dioxin-contaminated soil. Five exposure pathways wer...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent inducer of hydronephrosis in mice both pre- and post-natally. ritical period of sensitivity to TCDD could not be identified f...
It is well established that human diseases associated with abnormal immune function, including some common infectious diseases and asthma, are considerably more prevalent at younge...
Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are considered highly toxic contaminants and the environmental and biological monitoring of th...
Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are considered highly toxic contaminants with the environmental monitoring of these compounds be...
The aryl hydrocarbon receptor (AhR) and the AhR nuclear translocation protein (ARNT) are helix-loop-helix (HLH) proteins involved in transcriptional regulation. olycyclic aromatic ...
The United States Naval Air Facility at Atsugi, Japan (NAF Atsugi) is located in the Kanto Plain area on the island of Honshu, Japan. Directly to the south of the facility, in the...
Polychlorinated dioxins and dibenzofurans induce exthoxyresorufin-O-deethylase (EROD) activity, a marker for CYP1A1. Differences in potency of these compounds can be attributed to ...
Recently, it was demonstrated that administration of TCDD during gestation permanently alters 'the reproductive potential of male rat and male hamster offspring. he objectives of t...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
13C12-labeled mono-, di-, and tri-chlorinated dibenzo-p-dioxin (CDD) and -chlorinated dibenzofuran (CDF) standards have been tested for their applicability to standard EPA sampling...
In the early 1980s, exposures and subsequent health impact assessments from contaminants emitted into the air from stationary sources focused on the inhalation pathway. This 'direc...
Influence of type II diabetes, obesity and exposure 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on the expression of hepatic CYPIA2 in a murine model of type II diabetes. S...
Dioxins have been shown to bind and induce rodent CYP1A2, producing a dose-dependent hepatic sequestration in vivo. The induction of CYP1A2 activity has been used as a noninvasive...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The U.S. Environmental Protection Agency (EPA) has determined the need to develop in-situ continuous or semi-continuous emissions monitoring (GEM) techniques for assessing dioxin, ...
The aryl hydrocarbon receptor (AhR) and the AhR nuclear translocator (ARNT) are members of the Per-ARNT-Sim (PAS) family of proteins. The AhR binds members of the chemical family ...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that produces adverse biological effects including carcinogenesis, reproductive toxicity, immun...
In April 1991, the Administrator of the U.S. Environmental Protection Agency (EPA) announced that the Agency would conduct a scientific reassessment of the risk of 2,3,7,8-tetrachl...
As part of its effort to address risks posed by chlorinated dibenzo-p-dioxins and dibenzofurans(CDDs and CDFs) in the environment, EPA has adopted an interim procedure, based on di...
As part of its effort to address risks posed by chlorinated dibenzo-p-dioxins and chlorinated dibenzofurans (CDDs and CDFs) in the environment, EPA has adopted an interim procedure...
A demonstration of screening technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under the U.S. Environmental Protectio...
Alkali polyethylene glycolate (APEG) was field tested at Shenandoah Stables in Moscow Mills, Missouri, to evaluate the chemical's potential to dechlorinate 2,3,7,8-tetrachlorodiben...
Carefully prepared isomer standard solutions of all 17 of the 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans and their corresponding crysta...
The United States (US) Environmental Protection Agency (EPA) estimated that the use of technical grade pentachlorophenol (PCP) between 1970 and 1995 to treat wood was approximately...
Endometriosis consists of the growth of endometrial tissue outside the uterus. A rat model of endometriosis is available to evaluate the potential for environmental chemicals to pr...
Combustion experiments in a laboratory-scale fixed bed reactor were performed to determine the role of temperature and time in PCDD/F formation allowing a global kinetic expression...
Lack of Expression of EGF and TGF in the Fetal Mouse Alters Formation of Prostatic Epithelial Buds and Responsiveness to TCDD-Induced Impairment of Prostatic Bud Formation. <...
Palatal shelves from embryos exposed on gestation day (GD) 12 to either retinoic acid (RA) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) contact but fail to fuse. It is of interest...
Implementation of the Great Lakes Water Quality Agreement depends in part on knowing which chemicals under what conditions have impacted different fish species, either independentl...
C57BL/6N mice, used to model induction of cleft palate and kidney malformations in offspring following maternal treatment with TCDD, were dosed on gestation day (gd) 9 with ,2',4,4...
The Great Lakes of North America are large aquatic ecosystems that have been greatly impacted by human activities in the 20th century. Introduction of non-native species, both adv...
The USEPA's NRMRL conducted successful treatability tests of innovative solidification/stabilization (S/S) formulations to treat soils contaminated with dioxins, pentachlorophenol ...
The USEPA's National Risk Management Research Laboratory condcuted successful treatability tests of innovative solidification/stablization (S/S) formulations to treat soils contami...
An environmental monitoring project is being conducted to determine if TCDD is accumulating in the environment. TCDD is an extremely toxic, chlorocrigenic, and teratogenic material...
Due to the extensive use of brominated flame retardants (BFRs), including brominated diphenylether (BDE) formulations, for various domestic and industrial applications, the presenc...
This review covers applications of mass spectrometry to the environmental sciences. From the early applications of mass spectrometry to environmental research in the 1960s and 197...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
1,2,4,5-Tetrachlorobenzene (TCB) is an industrial intermediate used in the production of 2,4,5-trichlorophenoxyacetic acid. This herbicide contains trace quantities of 2,3,7,8-tetr...
The biological potency (relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) of planar polychlorinated aromatic hydrocarbons (PCHs) in extracts of eggs and flesh from spawning fe...
An earlier study indicated that dermal absorption of a 40 nmol dose of TCDD decreased with aging in rats, suggesting that the potential for systemic exposure following dermal conta...
Data on reproductive success of Forster's tern (Sterna fosteri) from Green Bay, Lake Michigan in 1983 are compared with data collected in 1988. n 1988 measures of reproductive perf...
Risk characterization involves hazard identification, determination of dose/response relationships, and exposure assessment. mprovement of the risk assessment process requires incl...
The paper discusses mechanistic and source understanding of polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) formation. (NOTE: Considerable research effort has been expe...
An extensive investigation was done to understand polychlorinated dibenzo-p-dioxin and furan (PCDD/F) formation mechanisms and their relationship with other organic compounds. PCD...
Whole cells of the parent strain of Beijerinckia, grown with succinate and biphenyl, oxidized dibenzo-p-dioxin and several chlorinated dioxins. The rate of oxidation of the chlorin...
The National Center for Environmental Assessment has prepared this methodology in response to the 1993 Combustion Strategy for Hazardous Waste Incinerators released by the Administ...
The report describes technical methods of degradation, destruction, detoxification, and disposal of wastes containing chlorinated dibenzo-p-dioxins and dibenzofurans. ncluded are d...
Nine analytical methods covering 54 organic contaminants which may be present in drinking water or drinking water sources are described in detail. even of these methods cover compo...
This preliminary report has revealed new information on several highly toxic substances which exist within the continental U.S. for which there is no satisfactory means of disposal...
The white rot fungus Phanerochaete chrysosporium is able to degrade lignin, a structurally complex, naturally occurring and environmentally persistent, non-repeating heteropolyrner...
Humans are exposed to chemical mixtures via diet, occupation, and the environment. Previous data demonstrated that low doses of polycyclic halogenated aromatic hydrocarbons (PHAHs...
Exposure of humans to polychlorinated biphenyls has been associated with different adverse effects such as immune impairment, changes in hormone levels, reproductive and neuropsyc...
The paper discusses a homogeneous, gas-phase reaction mechanism that has been developed to explain sulfur (S) and chlorine (Cl) interactions in an industrial, fire-tube boiler, usi...
The paper discusses a model, based on experimental data, that was developed to describe the profile of polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCD...
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD), a widespread polychlorinated aromatic hydrocarbon, caused tumors in the liver and other sites when administered chronically to r...
Abstract One reasonable approach to the analysis of the relationships between molecular structure and toxic activity is through the investigation of the forces and intermolecula...
A thyroglobulin conjugate of dioxin (thyroglobulin-2 adipamide, 3,7,8-trichlorodibenzo-p-dioxin) (TG-TCDD) was used to immunize BALB/c mice. ybridomas were produced by cell fusion ...
Abstract Increased mortality following influenza A infection was reported in B6C3F1 mice exposed to a low (0.01 g/kg) dose of dioxin. However, mortality was not associated wit...
The report defines and characterizes types of medical waste, discusses the impacts of burning medical waste on combustor emissions, and outlines important handling and operating co...
The report defines and characterizes types of medical waste, discusses the impacts of burning medical waste on combustor emissions, and outlines important handling and operating co...
This is a survey for persistent, bioaccumulative, and toxic (PBT) pollutants in the U.S. milk supply. The EPA Environmental Radiation Ambient Monitoring System (ERAMS) was used to ...
The National Dioxin Air Monitoring Network (NDAMN) was designed to determine the temporal and geographical variability of atmospheric CDDs, CDFs and dioxin-like PCBs at rural locat...
Breast cancer is the most common type of non-dermal cancer among women in this country. Breast cancer risk in women is known to be significantly influenced by genetics, but over 70...
The first known program to sample mobile heavy duty diesel engine emissions for polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran ("PCDD/F") during highway and in-c...
The paper describes the recent modifications made to the U.S. Environmental Protection Agency's (EPA) Mobile Incineration System. These modifications were aimed toward increasing t...
A laboratory experiment was conducted to investigate the transfer of organic contaminants from an environmentally contaminated marine sediment through a simple marine food chain. T...
Medical waste contains many substances ranging from pathological material to various chemical compounds. onsequently, the incineration of medical waste may result in the emissions ...
We measured organochlorine residues in three species of sea turtles from the Baja California peninsula, Mexico. Seventeen of 21 organochlorine pesticides analyzed were detected, w...
Exposure to TCDD and related compounds leads to a plethora of effects in multiple species, tissues and stages of development. The response spectrum ranges from simple biochemical ...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The toxic equivalency factor (TEF) approach is one of the ways to assess the risk associated with exposure to complex mixture of polychlorinated biphenyls (PCBs) and structurally r...
Formation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzefurans (PCDDs/Fs) from carbons that were produced from pyrolysis of paper fibers and from a wood charcoal ...
A desorption experiment is described in which the sediment-to-water partition coefficient for 2,3,7,8-tetrachlorodibenzo-p-dioxin is measured for a sample from Lake Ontario. fter a...
An overview of research on reproductive failure of lake trout and possibly other species associated with exposures to dioxin-like chemicals during the last half century. These rese...
Introduction Historical exposure trends to persistent organic pollutants (POPs) indicate that the primary route of exposure in humans is traditionally dietary intake, contributi...
ABSTRACT BODY: Polybrominated diphenylether (PBDE) flame retardants are currently used in the USA to a larger extent than in Europe. They have recently been measured in human tissu...
Polybrominated diphenyl ethers (PBDEs) have been major commercial products used as flame retardants. While two of the commercial mixtures, Penta and Octa, have either been withdra...
A cancer dose-response assessment is developed for PCBS, considering toxicity, disposition, and environmental processes to evaluate human cancer risk. ow-dose linear models are app...
Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD/F) emissions from combustion of forest biomass were sampled to obtain an estimated emission factor for fores...
Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD/F) emissions from combustion of forest biomass were sampled to obtain an estimated emission factor for fores...
The abstract discusses polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD,F) from fly ash and methane combustion carbon sources. (NOTE: PCDD,Fs are formed in t...
Numerous research studies have been conducted to establish indicator compounds for fast and less costly prediction of polychlorinated dibenzo-p-dioxin/dibenzofurans (PCDD/F) toxix ...
Emissions of polychlorinated dibenzodioxin and polychlorinated dibenzofuran (PCDD/F) from simulated grassland and forest fires were quantitatively sampled to derive emission factor...
The paper reports results of several EPA-supported field evaluations of data on gaseous pollutant emissions from modern municipal waste combustors/incinerators and emissions contro...
A demonstration of screening technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under the U.S. Environmental Protectio...
The Jet REMPI monitor was recently tested on a hazardous-waste firing boiler for its ability to determine real time concentrations of polychlorinated dibenzodioxins and dibenzofura...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure during gestation has revealed reproductive anomalies in rat offspring, including inconclusive reports of stunte...
Abstract The outcome of perinatal low-level TCDD exposure on the T cell-mediated contact hypersensitivity response (CHS) in adult F344 rats was investigated. Suppression of t...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Photoreduction of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to 2,3,7-trichloro-2-dioxin (TrCDD) in isooctane was found to account for approximately 10 of the loss of TCDD and is t...
Photolysis of octachlorodibenzo-p-dioxin (OCDD) on soils results in production of the lower chlorinated dibenzo-p-dioxins, notably 2,3,7,7-tetrachloro-dibenzo-p-dioxin (2,3,7,8-TCD...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Biologically-based models are a useful way to integrate mechanistic pharmacokinetic data by explicitly defining important determinants of chemical disposition. he objective of the ...
Physiologically-based pharmacokinetic (PB-PK) models attempt to provide both a realistic anatomic description of the animal to which a drug or toxic chemical has been administered ...
EPA has released a final report entitled, “Pilot Survey of Levels of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, Polychlorinated Biphenyls and Mercury in Rura...
The addition of brominated organic compounds to the feed of a pilot-scale incinerator burning chlorinated waste has been found previously, under some circumstances, to enhance emis...
Reproductive impairment of double-crested cormorants (Phalacrocorax auritis) and Caspian terns Hydroprogne caspia) has recently been observed in the Great Lakes of North America. l...
Concentrations of 17 polychlorinated biphenyl (PCB) congeners were measured in liver of gonadally mature winter flounder collected from Fox Island and Gaspee Point, RI, and from Ne...
The immune system is believed to be a sensitive indicator for adverse polychlorinated biphenyl (PCB)-induced health effects. Four commercial PCB mixtures (Arocl...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
Among the environmental chemicals believed to have the potential to disrupt the endocrine systems of animals including humans, the polychlorinated biphenyls are a chemical class of...
Gas-phase reactions with the hydroxyl radical (OH) are expected to be an important removal pathway of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F)
Analyses are performed on samples collected from various effluent streams of a fluidized-bed and infrared furnace during reactivation of granular activated carbon (GAC) used in tre...
We evaluated a population of migratory fish (Menidia menidia) that spawn in New Bedford Harbor (NBH), MA, USA, a U.S. EPA Superfund site with extreme polychlorinated biphenyl (PCB)...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
POSTNATAL DISPOSITION OF TCDD IN LONG EVANS RATS FOLLOWING GESTATIONAL EXPOSURE. J J Diliberto', J T Hamm'.2, F McQuaid', and L S Birnbaum'. 'US EPA, ORD/NHEERL/ETD, RTP, NC; 2C...
Gonadal cancers in soft-shell clams (Mya arenaria) have been found at high prevalences (20-40%) in populations in eastern Maine. The aetiology of these tumours is unknown. We hypot...
In the past decade, there has been an increased use of chemical dust suppressants such as i water, salts, asphalt emulsion, vegetable oils, molasses, synthetic polymers, mulches, a...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
A population of the non-migratory estuarine fish species Fundulus heteroclitus (mummichog) indigenous to a polychlorinated biphenyl (PCB)-contaminated Superfund site (New Bedford H...
Emissions of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs/PCDFs) from incinerators and other stationary combustion sources are of environmental concer...
A special seminar on Prospective Research and Regulatory Issues Involving Dioxins and Related Compounds was held at the Eighth International Symposium on Chlorinated Dioxins and Re...
The three-volumes document 82 presentations by authors from 15 countries at the Second International Conference on Municipal Waste Combustion (MWC) in Tampa, Florida, April 16-19, ...
The three-volumes document 82 presentations by authors from 15 countries at the Second International Conference on Municipal Waste Combustion (MWC) in Tampa, Florida, April 16-19, ...
The three-volumes document 82 presentations by authors from 15 countries at the Second International Conference on Municipal Waste Combustion (MWC) in Tampa, Florida, April 16-19, ...
The report is a compilation of technical papers and visual aids presented by representatives of industry, academia, and government agencies at a workshop on multipollutant sorbent ...
An analytical protocol for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total TCDDs in soil, sediment and aqueous samples using high-resolution gas chromatog...
The U.S. Environmental Protection Agency initiated the National Dioxin Air Monitoring Network (NDAMN) in 1998. NDAMN has three primary purposes: 1. To provide measurements of...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
Max Weintraub, MS, Toxics Office, US Environmental Protection Agency, 75 Hawthorne Street, Mail Code CMD-4, San Francisco, CA 94105 and Linda S. Birnbaum, PhD, Experimental Toxicol...
During the 20th century, declines of lake trout (Salvelinus namaycush) populations to virtual extinction in all the Great Lakes except Lake Superior were followed by failure of sto...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
Since the enactment of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and the Resource Conservation and Recovery Act (RCRA), as amended, many dir...
RELATIONSHIP BETWEEN HEPATIC MICROSOMAL THYROXINE GLUCURONIDATION AND TOTAL SERUM THYROXINE CONCENTRATIONS IN RATS TREATED WITH PCDDs, PCDFs AND PCBs. D G Ross, K M Crofton, M J...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
The Columbus Municipal Waste-to-Energy (Columbus WTE) facility in Columbus, Ohio, began operation in June, 1983 and ceased operation in December, 1994. During its operation, it wa...
EPA collected ambient air samples in lower Manhattan for about nine months following the September 11, 2001 (9/11) World Trade Center (WTC) attacks. Measurements were made of a ho...
Induction of cytochrome P450 (CYPIA) mRNA by polychlorinated dibenzo-p-dioxin (PCDD), polychlorinated dibenzo (PCDF) and polychlorinated biphenyl (PCB) congeners was measured in a ...
Improvements in risk assessment require better linkage of exposure to response by the determination of target tissue dose. he relative sensitivity of several responses in female B6...
A growing body of scientific information has shown that man-made industrial chemicals and pesticides may interfere with the normal functioning of human and wildlife endocrine syste...
This report summarizes the expert scientific peer review of the April 1998 external review draft of "The Inventory of Sources of Dioxin in the United States," published by the Offi...
The workshop evaluated ongoing research on bioavailability of chlorinated dioxins and related chemicals, to identify research needs for development of a research plan. Three areas ...
The project was designed to verify in proof-of-principle studies, the efficacy of newly developed chemical reagents to destroy 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) dissolved ...
ABBOTT, B. D., LEFFLER, K.E. AND BUCKALEW, A.R, Reproductive Toxicology Division, NHEERL, ORD, US EPA, Research Triangle Park, North Carolina. Retinoic acid induction of cleft pal...
Early developmental stages of fish are extremely sensitive to a class of toxic and persistent environmental contaminants known as dioxin-like compounds (DLCs). Most of the toxicolo...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant that produces adverse biological effects including developmental toxicity and teratogenesis. n the mouse ...
In the paper, the authors present generation and waste characteristics information for dioxin wastes and discuss the state of the art for several treatment processes for dioxin was...
Carcinogenic responses have been induced in mice and rats at low doses of TCDD. TCDD has been shown to be a cancer promoter. These results, together with the strongly suggestive ev...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; "Dioxin") is the most toxic member of a family of structurally related compounds which are ubiquitous environmental pollutants. ...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or Dioxin ) is the most toxic member of a family of structurally related compounds which are ubiquitous environmental pollutants. The mo...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
This research uses experimental data and a statistical approach to determine the effect of combustion- and sorbent-injection-related parameters on the mechanism of polychlorinated ...
The article describes research that uses experimental data and a statistical approach to determine the effect of combustion- and sorbent-injection-related parameters on the mechani...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
Roles of Epidermal Growth Factor (EGF) and Transforming Growth Factor-alpha (TGF-a) in Mediation of Dioxin (TCDD)-Induced Delays in Development of the Mouse Mammary Gland. Suzan...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzo-furans (PCDFs) are two classes of extremely toxic compounds produced and emitted into the environment as a res...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Polychlorinated biphenyl (PCBs) mixtures contain a number of different congeners, some of which have been proposed to be neuroactive. Recent studies have suggested that ortho-subst...
Although reproductive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure have been reported in numerous investigations of animals, studies of...
The compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is produced as an unwanted by-product of various chemical reactions and combustion processes, including the manufac...
The U.S. Environmental Protection Agency (EPA) reassessment of the toxicity of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDF) and dioxin-like polychlorinated biphe...
Single-laboratory testing of RCRA Method 8280 for the analysis of chlorinated dibenzop-dioxins and dibenzofurans has been initiated on sample matrices including pottery clay soil, ...
The U.S. Environmental Protection Agency (EPA) Superfund Innovative Technology Evaluation (SITE) program selected the Glass Furnace Technology (GFT) treatment process for evaluatio...
Over 600 curent and former wood preserving sites have been identified across the U.S. Many of these have been placed on the EPA Superfund NPL (National Priorities List). Most of t...
The concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in high purity water pumped through a generator column at lml/min is strongly dependent on temperature. Concentrations of d...
Bench-scale solvent extraction and soil washing studies were performed on soil samples obtained from three abandoned wood preserving sites that included in the NPL. The soil sample...
Sorption of 14 C-labeled 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCCD) to Soils from water/methanol mixtures has been evaluated by batch shake testing. ncontaminated soils from Times ...
The sorption of 14C-labelcd 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from water by two uncontaminated surface soils from the Times Beach, MO, area was evaluated by using batch sh...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Nondetect (ND) or below detection limit (BDL) results cannot be measured accurately, and, therefore, are reported as less than certain detection limit (DL) values. However, since t...
In 1983, the U.S. Environmental Protection Agency (EPA) embarked on an extensive investigation of the presence and extent of contamination of the national environment by chlorinate...
A process termed chlorinolysis (exhaustive chlorination) was applied to samples of USAF Herbicide ORANGE. The ORANGE (50/50 volume mixture of the n-butyl esters of 2,4-D and 2,4,5-...
14 C-dioxin tracers were used to evaluate whole MM5 sampling train recoveries of dioxin and to determine the distribution of dioxins spiked into a sampling train that was concurren...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
In August of 1986, Shirco was contracted by Dekonta GmbH, a Vest German hazardous waste treatment company, to perform treatability studies at one of the largest dioxin-contaminated...
This newsletter reports on the Huber Technology Groups (HTG) high temperature advanced hazardous waste treatment technology capable of very high destruction and removal efficienci...
During the period of July 8 - July 12, 1985, the Shirco Infrared Systems Portable Pilot Test Unit was in operation at the Times Beach Dioxin Research Facility to demonstrate the ca...
This treatability study reports on the results of one of a series of field trials using various remedial action technologies that may be capable
of restoring Herbicide Orange (HO)...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
This treatability study report presents the results of laboratory and field tests on the effectiveness of a new decontamination process for soils containing 2,4-D/2,4,5-T and t...
An analytical technique has been developed to demonstrate both mass spectral and gas chromatographic resolution during each HRGC/HRMS-M5D determination of TCDD. The technique uses ...
Abstract Exposure to various xenobiotics, including oxidant gases, diesel exhaust and certain pesticides, has been reported to exacerbate pulmonary allergic hypersensitivity r...
Palatal fusion occurs on GD 14-15 in the mouse, accompanied by a decrease in EGF receptor (EGFR) at the medial edge of the palatal shelves. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCD...
TCDD is a highly persistent trace environmental contaminant and is one of the most potent toxicants known to man. Our laboratory has previously reported an increase in the product...
The report provides information that can be used by environmental regulatory agencies and others as a source of technical information describing waste management options for wastes...
A demonstration of technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under EPA's Superfund Innovative Technology Eval...
A demonstration of technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under EPA's Superfund Innovative Technology Eval...
A demonstration of technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under EPA's Superfund Innovative Technology Eval...
A demonstration of technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under EPA's Superfund Innovative Technology Eval...
A demonstration of technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under EPA's Superfund Innovative Technology Eval...
Chlorophenols have been studied as precursors to PCDD/F formation but generally these experiments have been carried out with unrepresentative concentrations and potentially overlap...
Changes in the specific activity (S) and radiopurity (R) of tritiated 2,3,7,8-TCDD were measured by gas chromatography/mass spectrometry in order to accurately characterize TCDD do...
Changes in ethoxyresorufin-0-deethylase (EROD) activity were monitored through an extended 6-month dietary exposure to determine the relationship between EROD activity and uptake o...
Changes in ethoxyresorufin-O-deethylase (EROD) activity were monitored through an extended 6-month dietary exposure to determine the relationship between EROD activity and uptake o...
Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure produces hydronephrosis and cleft palate in mice. These responses are correlated with disruption of expression of...
The central purpose of our study was to examine the performance of the United States Environmental Protection Agency's (EPA) nonreactive Gaussian air quality dispersion model, the ...
Infrared diffuse reflectance spectra were recorded for the 22 tetrachlorodibenzodioxin isomers (TCDDs). By use of micro-DRIFT techniques and signal averaging, identifiable spectra ...
In June 2005 a WHO-IPCS expert meeting was held in Geneva during which the toxic equivalency factors (TEFs) for dioxin like compounds, including some polychlorinated biphenyls (PCB...
Jet REMPI-TOFMS is a measurement technique which combines laser induced photoionization with mass spectrometry to create a two-dimensional (wavelength / mass) detection method. In...
It is well established that human diseases associated with abnormal immune function, including some common infectious diseases and asthma, are considerably more prevalent at younge...
This study was performed to determine the best palatal organ culture model to use in evaluating the role of epidermal growth factor (EGF) signaling in the response to 2,3,7,8-tetra...
All projects planned and implemented under the EPA Dioxin Exposure Initiative (DEI) are required to have completed Quality Assurance Project Plans (QAPPs) EPA Order 5360.1 A2 stat...
The catalytic effects of copper and iron compounds were examined for their behavior in promoting formation of chlorine (Cl2), the major chlorinating agent of polychlorin...
Background: In 1992, the U.S. Environmental Protection Agency's (EPA's) Office of Research and Development (ORD) began an effort to reassess the exposure and health effects ...
The U.S. EPA has established a National Dioxin Air Monitoring Network (NDAMN) to determine the temporal and geographical variability of atmospheric CDDs, CDFs and coplanar PCBs at ...
In June, 1998, the U.S. EPA established the National Dioxin Air Monitoring Network (NDAMN). The primary goal of NDAMN is determine the temporal and geographical variability of atm...
There is poor correlation between total chlorine in waste streams and formation of polychlorinated dibenzodioxin and polychlorinated dibenzofuran (PCDD/F) during waste combustion. ...
TIME-DEPENDENT EFFECTS ON GENE EXPRESSION IN RAT SEMINAL VESICLE DEVELOPMENTALLY ALTERED BY IN UTERO EXPOSURE TO TCDD. V M Richardson', J T Hamm2, and L S Birnbaum1. 'USEPA, ORD/NH...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is often called the most toxic man-made compound. However, it is but the prototype for a family of structurally related compound...
The toxicity of TCDD to early life stages of F1 generation brook trout (Salvelinus fontinalis) was determined when dosed by maternal transfer. Effects were compared across six trea...
The toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the early life stages of F1 generation brook trout (Salvelinus fontinalis) was determined, when dosed by maternal tran...
Fish early life stages are exceptionally sensitive to the lethal toxicity of chemicals that act as arylhydrocarbon receptor (AhR) agonists. Toxicity characterizations based on 2,3...
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
Data from several studies suggest that concentrations of dioxins rose in the environment from the 1930s to about the 1960s/70s and have been declining over the last decade or two....
The EPA Mobile Incinerator has demonstrated its ability to successfully destroy dioxin. rial burn conducted in 1987 demonstrated the incinerator's ability to destroy a wide variety...
The U.S. EPA has established a National Dioxin Air Monitoring Network (NDAMN) to determine the temporal and geographical variability of atmospheric chlorinated dibenzo-p-dioxins (C...
Plant uptake rates were determined for airborne 2,3,7,8-TCDD using grass foliage. he primary elimination mechanisms for 2,3,7,8-TCDD from grass, photodegradation and volatility, we...
The uptake of persistent polychlorinated hydrocarbons (PCHs) by four avian species was investigated at upper trophic levels of two aquatic food chains of the lower Fox River and Gr...
An urban air transect study was undertaken in Oklahoma City, OK, to investigate whether urban areas represent sources of dioxin-like compounds to the rural environment. This study...
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
There is no abstract for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly lipophilic chemical which distributes into adipose tissue, especially at low doses. However, at high doses TCDD sequesters in...
USE OF CYP1A2 (-/-) KNOCKOUT AND CYP1A2 (+/+) C57BL/6N PARENTAL STRAINS OF MICE TO COMPARE METABOLISM OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD). J J Diliberto1 and H Hakk2. 1...
The toxicity equivalence (TEQ) model for assessing aryl hydrocarbon receptor (AHR) mediated toxicity risks associated with polyhalogenated aromatic chemicals structurally similar t...
Utilization of A PBPK model to predict the distribution of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in humans during critical windows of development. C Emond1, MJ DeVito2 and ...
The uncontrolled burning of household waste in barrels has recently been implicated as a major source of airborne emissions of polychlorinated dibenzo-p-dioxins and polychlorinated...
Populations of the non-migratory estuarine fish species Fundulus heteroclitus indigenous to a PCB-contaminated Superfund site (New Bedford Harbor, MA, USA) are markedly less sensit...
The reassessment of dioxin consists of two documents (each consisting of three volumes). One of these addresses human health effects of dioxin; the second focuses on sources and le...
Population declines of bull trout, Salvelinus confluentus, have occurred in recent decades throughout much of the species' natural range in the Columbia River watershed and other r...
The Jet REMPI (Resonance Enhanced Multiphoton Ionization) monitor was tested on a hazardous waste firing boiler for its ability to determine concentrations of polychlorinated diben...
Structure-selective measurement techniques are needed for the assessment of the toxic loading of incinerator gases. This review article shows that wavelength-resolved, resonance-en...
In April 1991, EPA initiated efforts to conduct a scientific reassessment of the human health and environmental risks of TCDD and related compounds. The first document to address e...
As part of an ongoing effort to understand and address the short and long-term consequences of increasing levels of environmental contaminants, we used suppressive subtractive hydr...
