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(32)P-ADDUCT ASSAY: PRINCIPLE AND APPLICATIONS TO CARCINOGEN-EXPOSED ANIMAL AND HUMAN DNA |
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There is growing evidence that carcinogens initiate the malignant process via specific alterations in DNA structure, i.e., the covalent binding of carcinogens to DNA bases. Thus, c...
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1,2-DIBROMOETHANE CAUSES RAT HEPATIC DNA DAMAGE AT LOW DOSES |
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Two oral administrations of 1,2-dibromoethane to adult female rats at doses above 10 micromoles/kg (1.9 mg/kg) caused DNA damage as determined by the alkaline elution technique. Fa...
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1-CHLOROMETHYLPYRENE; A SKIN SENSITIZER AND GENOTOXIN |
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1-Chloromethylpyrene has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from BaP and 1-Nitropyren. t was mutagenic to salmonella 6100 pic...
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4-AMINOBIPHENYL & DNA REACTIVITY: CASE STUDY WITHIN THE CONTEXT OF THE 2006 IPCS HUMAN RELEVANCE FRAMEWORK FOR ANALYSIS OF A CANCER MODE OF ACTION FOR HUMANS |
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The IPCS Human Relevance Framework was evaluated for a DNA-reactive (genotoxic) carcinogen, 4-aminobiphenyl, based on a wealth of data in animals and humans. The mode of action inv...
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5-METHYLCYTOSINE IN CPG SITES AND THE REACTIVITY OF NEAREST NEIGHBORING GUANINES TOWARD THE CARCINOGEN AFLATOXIN B1-8,9-EPOXIDE. (R825809) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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7,12-DIMETHYLBENZ(A)ANTHRACENE-DEOXYRIBONUCLEOSIDE ADDUCT FORMATION 'IN VIVO': EVIDENCE FOR THE FORMATION AND BINDING OF A MONOHYDROXYMETHYL-DMBA (DIMETHYLBENZ(A)ANTHRACENE) METABOLITE TO RAT LIVER DNA (DEOXYRIBONUCLEIC ACID) |
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The polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA) is a potent carcinogen to the female Sprague-Dawley rat, and when administered under conditions that hav...
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7,12-DIMETHYLBENZ(A)ANTHRACENE-DNA ADDUCTS IN SPRAGUE-DAWLEY AND LONG-EVANS FEMALE RATS: THE RELATIONSHIP OF DNA ADDUCTS TO MAMMARY CANCER |
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7,12-dimethylbenz(a)anthracene (DMBA) is a powerful carcinogen to the mammary gland of the pubescent female Sprague-Dawley (S.D.) rat but is a much less potent inducer of mammary a...
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A CONCISE REVIEW OF THE TOXICITY AND CARCINOGENICITY OF DIMETHYLARSINIC ACID |
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Dimethylarsinic acid (DMA) has been used as an herbicide (cacodylic acid) and is the major metabolite formed after exposure to tri- (arsenite) or pentavalent (arsenate) inorganic a...
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A NOVEL PNYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL FOR DIMETHYLARSINIC ACID (DMA): THE LUNG AS A STORAGE COMPARTMENT |
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A NOVEL PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL FOR DIMETHYLARSINIC ACID (DMA): THE LUNG AS A STORAGE COMPARTMENT. Evans, M.V., Hughes, M.F., and Kenyon, E.M. USEPA, O...
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A NOVEL S-ADENOSYL-L-METHIONINE: ARSENIC (III) METHYLTRANSFERASE FROM RAT LIVER CYTOSOL |
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A Novel S-Adenosyl-L-methionine: Arsenic(III) Methyltransferase from Rat Liver Cytosol
Shan Lin, Qing Shi, F. Brent Nix, Miroslav Styblo, Melinda A. Beck, Karen M. Herbin-Davis,...
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A REVIEW OF THE GENETIC AND RELATED EFFECTS OF 1,3-BUTADIENE IN RODENTS AND HUMANS |
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In this paper, the metabolism and genetic toxicity of 1,3-butadiene (BD) and its oxidative metabolites in humans and rodents is reviewed with attention to newer data that have been...
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A REVIEW OF THE REFERENCE DOSE AND REFERENCE CONCENTRATION PROCESSES (EXTERNAL REVIEW DRAFT) |
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The RfD/RfC Technical Panel was established in response to a request from the Agency's 10X Food Quality Protection Act Task Force to the Science Policy Council and the Risk Assessm...
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ACB-PCR MEASUREMENT OF K-RAS CODON 12 MUTATION IN A/J MOUSE LUNG EXPOSED TO BENZO[A]PYRENE: A DOSE-RESPONSE ASSESSMENT |
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Benzo[a]pyrene (B[a]P) is a known human carcinogen and environmental contaminant. The direct measurement of K-Ras mutant fraction (MF) was developed as a metri...
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ACCUMULATION AND METABOLISM OF ARSENIC IN MICE AFTER REPEATED ADMINISTRATION OF ARSENATE |
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Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate, Hughes, M. F., Kenyon, E. M., Edwards, B. C., Mitchell, C. T., Del Razo, L. M., and T...
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ALTERATION OF IMMUNE FUNCTION IN MICE FOLLOWING CARCINOGEN EXPOSURE |
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Treatment of mice with the direct-acting alkylating agent methyl methanesulfonate produced marked suppression of the humoral response to sheep erythrocytes and suppression of T cel...
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AN AIR QUALITY DATA ANALYSIS SYSTEM FOR INTERRELATING EFFECTS, STANDARDS, AND NEEDED SOURCE REDUCTIONS: PART 13. APPLYING THE EPA PROPOSED GUIDELINES FOR CARCINOGEN RISK ASSESSMENT TO A SET OF ASBESTOS LUNG CANCER MORTALITY DATA |
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The Clean Air Act Amendments of 1990 (CAAA-90) list 189 hazardous air pollutants (HAPs) for which "safe" ambient concentrations are to be determined. For a carcinogen, such as as...
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AN ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) FOR DETERMINING DIOXINS IN SEDIMENT AND SOIL SAMPLES |
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The dioxins comprise a family of compounds chemically referred to as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). The most toxic of these co...
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AN EVALUATION OF THE HUMAN CARCINOGENIC POTENTIAL OF ETHYLENE GLYCOL BUTYL ETHER (EGBE) |
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Background
The position paper, "An Evaluation of the Human Carcinogenic Potential of Ethyle...
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AN EVALUATION OF THE RELATIVE GENOTOXICITY OF ARSENITE, ARSENATE, AND FOUR METHYLATED METABOLITES IN VITRO USING THE ALKALINE SINGLE CELL GEL ASSAY |
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An Evaluation of the Relative Genotoxicity of Arsenite, Arsenate, and Four Methylated
Metabolites In Vitro Using the Alkaline Single Cell Gel Assay (ASCG).
Arsenic ( A...
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ANALYSIS BY CHEMICAL CLASS OF SALMONELLA MUTAGENICITY TESTS AS PREDICTORS OF ANIMAL CARCINOGENICITY (JOURNAL VERSION) |
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For a number of years, investigators have recognized that humans potentially are exposed to large numbers of genotoxicants. Many efforts have attempted to validate various short-te...
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ANALYSIS OF 2,3,7,8-TCDD TUMOR PROMOTION ACTIVITY AND ITS RELATIONSHIP TO CANCER |
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has a high estimated cancer potency in animals which has been reasoned to imply that TCDD might be carcinogenic to man. The animal cancer...
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ANALYSIS OF DNA-CARCINOGENS ADDUCTS BY ELECTROSPRAY CZE-MS |
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Polycyclic aromatic hydrocarbons are an important class of chemical carcinogen to which there is potentially extensive chronic human exposure. t is generally believed that an inter...
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ANALYSIS OF THE GENE-TOX CARCINOGEN DATA BASE (JOURNAL VERSION) |
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The Gene-Tox Carcinogen Data Base is an evaluated source of cancer data on 506 chemicals, selected, in part, for their previous assessment in genetic toxicology bioassays. The data...
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ANALYSIS OF THERMAL DECOMPOSITION PRODUCTS OF FLUE GAS CONDITIONING AGENTS |
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The report gives results of a study of reactions of several flue gas conditioning agents in a laboratory-scale facility simulating conditions in the flue gas train of a coal-burnin...
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ANALYTICAL PROCEDURES AND QUALITY ASSURANCE CRITERIA FOR THE DETERMINATION OF MAJOR AND MINOR DEOXYNUCLEOSIDES IN FISH DNA BY LIQUID CHROMATOGRAPHY - ULTRAVIOLET |
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Analytical procedures and quality assurance criteria have been established for enzyme of fish tissue DNA to free nucleosides and their subsequent characterization by liquid chromat...
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ANTIMUTAGENICITY PROFILES FOR SOME MODEL COMPOUNDS |
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The concept of activity profile listings and plots, already applied successfully to the display of mutagenicity data, has been modified for the application to antimutagenicity data...
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ANTIMUTAGENICITY PROFILES OF SYNTHETIC AND NATURAL ANTIMUTAGENS |
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The concept of activity profile listings and plots, already applied successfully to the display of mutagenicity data, has been modified for application to antimutagenicity data. he...
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APPLICATION OF CDNA MICROARRAY TO THE STUDY OF ARSENIC TOXICOLOGY AND CARCINOGENESIS |
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Arsenic (As) is a common environmental toxicant and known human carcinogen. Epidemiological studies link As exposure to various disorders and cancers. However, the molecular mech...
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ARE THERE CARCINOGENS IN WATER FOR HUMAN CONSUMPTION? AN EPIDEMIOLOGIST'S VIEWPOINT |
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Carcinogenesis is a complex and dynamic interaction of host and environment. Important host factors include genetic constitution and health status. Among environmental factors, die...
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ARSENIC |
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The report is an in-depth study that attempts to assemble, organize, and interpret present-day information on arsenic and its compounds, and the effects of these substances on man,...
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ARSENIC EFFECTS ON TELOMERE AND TELOMERASE ACTIVITY |
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Arsenic effects on telomere and telomerase activity. T-C. Zhang, M. T. Schmitt, J. Mo, J. L. Mumford, National Research Council and U.S Environmental Protection Agency, NHEERL, Res...
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ARSENIC IS A GENOTOXIC CARCINOGEN -- ACTING AS A CLASTOGEN AND A MITOTIC INHIBITOR |
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Introduction
The ability of arsenic to induce cancer in humans is beyond dispute. How arsenic induces cancer is the subject of much conjecture. Various modes of ...
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ARSENIC: CARCINOGENIC MECHANISMS, RISK ASSESSMENT AND THE MAXIMUM CONTAMINANT LEVEL (MCL) |
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This workshop will provide an up-to-date overview on key issues related to cancer risk assessment of arsenic: carcinogenic mechanisms; application of mechanistic information to...
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ASSESSING ARSENIC EXPOSURE AND SKIN HYPERKERATOSIS IN INNER MONGOLIA, CHINA |
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Arsenic is a known human carcinogen. The inorganic forms, especially arsenite (As+3), are believed to be the most toxic species. Methylation is often considered to be the
deto...
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ATRAZINE INCREASES DIMETHYLBENZ[A]ANTHRACENE-INDUCED MAMMARY TUMOR INCIDENCE IN LONG EVANS OFFSPRING EXPOSED IN UTERO |
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ATRAZINE INCREASES DIMETHYLBENZ[A]ANTHRACENE-INDUCED MAMMARY TUMOR INCIDENCE IN LONG EVANS OFFSPRING EXPOSED IN UTERO.
SE Fenton and CC Davis
Reproductive Toxicology...
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AUTOMOTIVE EMISSIONS OF ETHYLENE DIBROMIDE |
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Ethylene dibromide, a suspected carcinogen, and ethylene dichloride are commonly used in leaded gasoline as scavengers. Ethylene dibromide emission rates were determined from seven...
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BACTERIAL PATHOGENIC RESEARCH IN RESPONSE TO CONTAMINANT CANDIDATE LIST NEEDS |
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The Safe Drinking Water Act, as amended in 1996, requires EPA to establish a Contaminant Candidate List (CCL) of unregulated microbiological and chemical contaminants to aid in pri...
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BENZENE OXIDE PROTEIN ADDUCTS AS BIOMARKERS OF BENZENE EXPOSURE |
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Benzene is known to be hematotoxic and carcinogenic in animals and humans. While metabolism is required for toxicity, the identity of the ultimate carcinogen(s) remains unknown. ...
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BENZO(A)PYRENE DIOL EPOXIDE I BINDS TO DNA AT REPLICATION FORKS (JOURNAL VERSION) |
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The distribution in replication forks of DNA lesions caused by the treatment of S phase calls with benzo(a)pyrene-diol-epoxide-1 (BPDE-1) was studied in synchronized C3H10T1/2 cell...
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BENZO(A)PYRENE METABOLISM IN THE AMERICA OYSTER 'CRASSOSTREA VIRGINICA' |
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The research program was initiated with the overall objective of determining the role of NADPH-dependent microsomal mono-oxygenase in the metabolism of the widespread environmental...
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BENZO[ A ]PYRENE-7,8-QUINONE FORMS COVALENT-DNA ADDUCTS IN VITRO BUT NONE WERE DETECTED IN THE LUNGS OR LIVERS OF STRAIN A/J MICE IN VIVO |
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Benzo[a]pyrene (B[a]P) is a potent human and rodent lung carcinogen. This activity has been ascribed in part to the formation of B[a]P-7,8-diol-9,10-epoxide (B...
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BENZO[A]PYRENE-7,8-QUINONE FORMS COVALENT-DNA ADDUCTS IN VITRO BUT NONE WERE DETECTED IN THE LUNGS OR LIVERS OF STRAIN A/J MICE IN VIVO |
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Benzo[a]pyrene (B[a]P) is a potent human and rodent lung carcinogen. This activity has been ascribed in part to the formation of B[a]P-7,8-dio1-9,10-epoxide (BPDE)-DNA adducts. Oth...
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BINDING OF CHEMICAL CARCINOGENS AND MUTAGENS TO RAT HEMOGLOBIN |
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The alkylation of hemoglobin is a proposed dose monitor for chemical carcinogens and mutagens. The binding of fifteen chemical carcinogens and mutagens to rat hemoglobin was determ...
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BIOCHEMICAL EFFECTS OF THREE CHLORINATED PHENOLS IN RAT LIVER |
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The hepatic biochemical effects of four chlorinated oxygen containing environmental contaminants were determined. wo oral doses of 1/5 the LD50 of 2,4-dichlorophenoxyacetic acid, 2...
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BIOCHEMICAL STUDIES OF SIX NITROGEN-CONTAINING HETEROCYCLES IN RAT TISSUES |
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Female rats were orally dosed with 1/5 the LD50 of either 1-nitro-sopiperidine (a carcinogen), cyclohexylamine, piperidine, 4-carboxy-1-nitrosopiperidine, 4-cyclohexyl-1-nitrosopip...
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BIOMARKERS OF EXPOSURE: A CASE STUDY WITH INORGANIC ARSENIC |
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Inorganic arsenic (iAs) is a human toxicant and carcinogen that is found in the environment as a natural contaminant and from anthropogenic sources. Most mammalian species metabol...
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BLACK BULLHEAD: AN INDICATOR OF THE PRESENCE OF CHEMICAL CARCINOGENS |
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The usefulness of exposing caged fish to polluted water to detect chemical carcinogens was demonstrated by the development of neoplasms on black bullheads. Chemical analysis in thi...
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BOLISM OF ARSENITE IN CULTURED PRIMARY HEPATOCYTES FROM SIX MAMMALIAN SPECIES |
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Inorganic arsenic (iAs) is an environmental toxin and carcinogen. Biomethylation is the major pathway for the metabolism of iAs in many mammalian species, including the human. The ...
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BOTH HYPOMETHYLATION AND HYPERMETHYLATION OF DNA ASSOCIATED WITH ARSENITE EXPOSURE IN CULTURES OF HUMAN CELLS IDENTIFIED BY METHYLATION-SENSITIVE ARBITRARILY-PRIMED PCR |
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Differentially Methylated DNA Sequences Associated with Exposure to Arsenite in Cultures of Human Cells Identified by Methylation-Sensitive-Primed PCR
Arsenic, a known hu...
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BROMATE-INDUCED TRANSCRIPTIONAL CHANGES IN LONG-EVANS RAT KIDNEYS |
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Bromate-Induced Transcriptional Changes in Long-Evans Rat Kidneys.
Ozone disinfection of surface waters containing bromide ion (Br-) results in the oxidation of bromide ...
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CADMIUM AS A RESPIRATORY TOXICANT |
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Cadmium is a major respiratory toxicant as evidenced by numerous human and animal studies. Controlled animal inhalation studies provide supporting evidence to the associations obse...
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CANCER GUIDELINES IMPLEMENTATION: SETTING PRIORITIES FOR FUTURE ASSESSMENTS OF CHEMICALS/AGENTS (DRAFT) |
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The Agency is committed to implement its revised Guidelines for Carcinogen Risk Assessment ("Guidelines") through future reassessment and new assessment activities (subsequently re...
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CANCER RISK ASSESSMENT FOR 1,3 BUTADIENE: DATA INTEGRATION OPPORTUNITIES |
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The U.S. Environmental Protection Agency recently released its new Guidelines for Carcinogen Risk Assessment together with Supplemental Guidance for Assessing Susceptibility from E...
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CANCER RISK ASSESSMENT FOR 1,3-BUTADIENE: DATA INTEGRATION OPPORTUNITIES |
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The U.S. Environmental Protection Agency recently released its new Guidelines for Carcinogen Risk Assessment together with Supplemental Guidance for Assessing Susceptibility from E...
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CANCER RISK ASSESSMENT FOR CHLOROFORM |
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Chloroform is a common chlorination by-product in drinking water. EPA has regulated chloroform as a probable human carcinogen under the Safe Drinking Water Act. The cancer risk est...
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CANDIDATE SAMPLING AND ANALYSIS METHODS FOR 21 SUSPECT CARCINOGENS IN COMBUSTION EMISSIONS |
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The report identifies candidate sampling and analysis methods for 21 suspect carcinogens in conventional coal and fuel oil combustion emissions. The methods were selected from an e...
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CARCINOGEN ASSESSMENT OF COKE OVEN EMISSIONS |
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Coke oven workers in Allegheny County, Pennsylvania and at 10 non-Allegheny County coke plants in the United States and Canada were found to be at an excess risk of mortality from ...
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CARCINOGEN ASSESSMENT OF COKE OVEN EMISSIONS (REVISED DRAFT) |
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Coke oven workers in Allegheny County, Pennsylvania and at 10 non-Allegheny County coke plants in the United States and Canada were found to be at an excess risk of mortality from ...
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CARCINOGEN RISK ASSESSMENT OF CHROMIUM COMPOUNDS |
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Hexavalent chromium has been identified as a human carcinogen. Evidence to support this contention derives from epidemiologic, animal, and genotoxicity studies. Although workers ex...
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CARCINOGEN-DNA ADDUCTS IN CULTURES OF RAT AND HUMAN HEPATOCYTES |
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Exposure to chemical carcinogens can often be identified by detection of DNA adduct lesions. rimary cultures of isolated rat and human hepatocytes were exposed to 2-acetyl-aminoflu...
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CARCINOGEN-DNA ADDUCTS: INTRODUCTION, LITERATURE SUMMARY, AND RECOMMENDATIONS |
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The report summarizes the literature concerning adducts formed by xenobiotics with DNA and/or protein and discusses their feasibility as a monitoring tool for use in exposure and r...
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CARCINOGENIC EFFECTS OF BENZENE: AN UPDATE (FINAL) |
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The major issue addressed in this document involves the nature and magnitude of the risk of cancer to humans exposed to low levels of benzene. Occupational studies continue to prov...
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CARCINOGENICITY AND PESTICIDES: BIOLOGICAL ISSUES IN EXTRAPOLATION |
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Approximately 41% (26/63) of the pesticides evaluated in the chronic toxicity and carcinogen lofty studies of the National Toxicology Program (NTP) showed varying degrees of carcin...
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CARCINOGENICITY ASSESSMENT OF ALDRIN AND DIELDRIN |
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Evidence pertaining to the carcinogenicity of aldrin/dieldrin is reviewed and evaluated. The report covers studies completed before 1985. Case reports and epidemiologic studies of ...
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CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE |
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Evidence pertaining to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide is reviewed and evaluated. The report covers studies completed before 1985. Case reports a...
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CARCINOGENICITY OF THE CHLORINATED ACETIC ACIDS |
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Dichloroacetic Acid (DCAA) and trichloroacetic acid (TCAA) comprise a major fraction of the reaction products formed when water containing a variety of precursor humic materials is...
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CAUSES OF PAPILLOMAS ON FISH LIVING IN CHLORINATED SEWAGE EFFLUENT |
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This research was initiated to determine the cause of the oral papillomas on black bullheads (Ictalurus melas) from the final oxidation pond of the Tuskegee, Alabama, sewage treatm...
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CD34 EXPRESSION BY HAIR FOLLICLE STEM CELLS IS REQUIRED FOR SKIN TUMOR DEVELOPMENT IN MICE |
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We used knockout mice to show that a cell surface protein called CD34 is required for skin tumor formation in mice. Wild type mice treated with 7-12-Dimethylbenz(a)anthracene (DMBA...
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CELL-MEDIATED MUTAGENESIS, AN APPROACH TO STUDYING ORGAN SPECIFICITY OF CHEMICAL CARCINOGENS |
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A number of approaches have been employed to elucidate the causes of organ and species specificity. In the earlier studies, homogenates of various tissues were used to metabolicall...
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CHAPTER 6: CARCINOGENICITY OF TCDD IN ANIMALS - HEALTH ASSESSMENT FOR 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) AND RELATED COMPOUNDS |
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The U.S. Environmental Protection Agency (EPA) is conducting a scientific reassessment of the risks of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and chemically similar...
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CHARACTERISTICS AND TOXICITY OF THE CHLORINATED DRINKING WATER DISINFECTION BY-PRODUCT 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2[5H]-FURANONE (MX) TO MEDAKA (ORYZIAS LATIPES) |
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The compound 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, also know as MX, is a by-product of wood pulp manufacture and a contaminant of chlorinated drinking and sewage w...
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CHARACTERISTICS OF BENZO(A)PYRENE AND A-RING REDUCED 7,12-DIMETHYL BENZ(A)ANTHRACENE INDUCED NEOPLASTIC TRANSFORMATION OF HUMAN CELLS IN VIVO |
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The polynuclear aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and the A-ring reduced analogue of 7,12-dimethylbenz(a)anthracene (DMBA), 1,2,3,4-tetrahydro-7,12-dimethylbenz(a)ant...
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CHARACTERIZATION OF ARSENOSUGARS AND ASSOCIATED DEGRADATION PRODUCTS FOLLOWING AN AGGRESSIVE ACID/BASE EXTRACTION PROCEDURE |
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The speciation of arsenic in seafood products is important for the determination of an improved toxicity based relative source (water vs. diet) contribution estimate. The two majo...
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CHARACTERIZATION OF EMISSIONS FROM THE SIMULATED OPEN BURNING OF SCRAP TIRES |
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The report gives results of a small-scale combustion study, designed to collect, identify, and quantify products emitted during the simulated open burning of scrap tires. Fixed com...
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CHARACTERIZATION OF HUMAN URINARY BLADDER CELL LINE UROTSA TRANSDUCED WITH RAT ASLLL-METHYLTRANSFERASE |
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In humans, the biomethylation of arsenic (As) is catalyzed by an As(III)-methyltransferase (Cyt19) and yields pentavalent and trivalent methylated arsenicals. Cyt19 activity an...
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CHARACTERIZATION OF STABLE BENZO(A)PYRENE-7,8-QUINONE-DNA ADDUCTS IN CALF THYMUS DNA |
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Benzo[alpyrene-7,8-dione (BPQ) is a reactive aldo-keto reductase-mediated product of B[a]P-7,8-diol, a major P450/epoxide hydrolase metabolite of the multi-species carcinogen, B[a]...
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CHARACTERIZATION OF STABLE BENZOLALPYRENE-7,8-QUINONE-DNA ADDUCTS IN CALF THYMUS DNA AND POLYDEOXYNUCLEOTIDES |
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Bcnzo[a]pyrene-7,8-dione (BPQ) is a reactive aldo-keto reductase-mediated product of B[a]P-7,8-diol, a major P450/epoxide hydrolase metabolite of the multi-species carcinogen, B[a]...
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CHEMICAL CARCINOGENS: A REVIEW AND ANALYSIS OF THE LITERATURE OF SELECTED CHEMICALS AND THE ESTABLISHMENT OF THE GENE-TOX CARCINOGEN DATA BASE |
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The literature of 506 chemicals has been evaluated for evidence that these chemicals induce tumors in experimental animals and this assessment comprises the Gene-Tox Carcinogen Dat...
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CHEMICAL OF CURRENT INTEREST PROPYLENE OXIDE: HEALTH AND ENVIRONMENTAL EFFECTS PROFILE |
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This article reviews all of the relevant information on propylene oxide including physical and chemical properties, environmental fate and transport processes, exposure (water, foo...
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CHLOROFORM INHIBITION OF 1,2-DIMETHYLHYDRAZINE-INDUCED GASTROINTESTINAL TRACT TUMORS IN THE FISHER 344 RAT |
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The effect of chloroform (CHCl3), administered at 0, 900, and 1800 mg/l in the drinking water, on the carcinogenic potency of 1,2-dimethylhydrazine (DMH) was investigated. roups of...
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CHRONIC EFFECTS OF DIETARY EXPOSURE TO AMOSITE AND CHRYSOTILE ASBESTOS IN SYRIAN GOLDEN HAMSTERS |
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Bioassays of amosite, short range (SR), intermediate range (IR) or intermediate range chrysotile asbestos in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydr...
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CHRONIC EFFECTS OF DIETARY EXPOSURE TO AMOSITE ASBESTOS AND TREMOLITE IN F344 RATS |
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Carcinogenesis bioassays of blocky (nonfibrous) tremolite and amosite asbestos alone or in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) we...
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COMPARATIVE CARCINOGENIC AND MUTAGENIC ACTIVITY OF COAL TAR AND PETROLEUM ASPHALT PAINTS USED IN POTABLE WATER SUPPLY SYSTEMS |
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Coal tar and petroleum asphalt paints used as coatings for water pipes and storage tanks were tested in the Ames mutagenesis and the mouse skin carcinogenesis bioassays. One coal t...
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COMPARATIVE GENOTOXIC RESPONSES TO ARSENITE IN GUINEA PIG, MOUSE, RAT AND HUMAN LYMPHOCYTES |
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Comparative genotoxic responses to arsenite in guinea pig, mouse, rat and human
lymphocytes.
Inorganic arsenic is a known human carcinogen causing skin, lung, and bladde...
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COMPARATIVE METABOLISM OF ARSENIC IN MICE AFTER A SINGLE OR REPEATED ORAL ADMINISTRATION OF ARSENATE |
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COMPARATIVE METABOLISM OF ARSENIC IN MICE AFTER A SINGLE OR REPEATED ORAL ADMINISTRATION OF ARSENATE
Michael F. Hughes*1, Elaina M. Kenyon1, Brenda C. Edwards1, Carol T. Mitchel...
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COMPARATIVE POTENCY METHOD FOR CANCER RISK ASSESSMENT: APPLICATION TO DIESEL PARTICULATE EMISSIONS |
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An estimation of the human lung cancer 'unit risk' from diesel engine particulate emissions has been made using a comparative potency approach. This approach involves evaluating th...
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COMPARATIVE POTENCY METHOD FOR CANCER RISK ASSESSMENT: APPLICATION TO THE QUANTITATIVE ASSESSMENT OF THE CONTRIBUTION OF COMBUSTION EMISSIONS TO LUNG CANCER RISK |
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Combustion sources emit soot particles containing carcinogenic polycyclic organic compounds which are mutagenic in short-term genetic bioassays in microbial and mammalian cells and...
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COMPARISON OF ENVIRONMENTAL AND THEORETICAL PARAMETERS OF THE MOOLGAVKAR-VENZON-KNUDSON INCIDENCE FUNCTION FOR THE STAGES OF INITIATION AND PROMOTION IN RAT HEPATOCARCINOGENESIS |
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This manuscript describes biologically based models for cancer risk assessment. t also presents data derived in a rat hepatocarciongenesis model that was used to compare theoretica...
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COMPARISON OF GENE EXPRESSION IN KIDNEY AND URINARY BLADDER FROM RATS TREATED WITH DIMETHYLARSINIC ACID |
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Arsenic is widespread in the environment and a human carcinogen. A major metabolite of inorganic arsenic (iAs) in most species, including humans, is dimethylarsinic acid (DMA), whi...
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COMPARISON OF THE USE OF A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL AND A CLASSICAL PHARMACOKINETIC MODEL FOR DIOXIN EXPOSURE ASSESSMENTS |
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In epidemiological studies, exposure assessments to TCDD, known as a possible human carcinogen, assume mono or biphasic elimination rates. Recent data suggests a dose dependent el...
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CONCEPT OF ACTIVITY PROFILES OF ANTIMUTAGENS |
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Experimental evidence suggests that chemical mutagenesis and carcinogenesis are related phenomena such that identification of causative agents and protection from exposure might pr...
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CONSIDERATIONS IN THE U.S. ENVIRONMENTAL PROTECTION AGENCY'S TESTING APPROACH FOR MUTAGENICITY |
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Historically the U.S. Environmental Protection Agency has used mutagenicity information as part of its weight-of-evidence approach to discern the potential for human carcinogenicit...
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CONTROL OF MICROBIAL CONTAMINANTS AND DISINFECTION BY-PRODUCTS (DBPS): COST AND PERFORMANCE |
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The USEPA is in the process of developing a sophisticated regulatory strategy in an attempt to balance the complex trade-offs in risks associated with controlling disinfectants and...
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CORRELATION OF CARCINOGENIC POTENCY WITH MOUSE SKIN 32P-POSTLABELING AND LAC Z-MUTATION DATE FOR DMBA AN ITS K-REGION SULPHUR ISOSTERE: COMPARISON WITH ACTIVITIES OBSERVED IN STANDARD GENOTOXICITY ASSAYS |
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6,11-Dimethylbenzo(b]naphtho[2,3-d]thiophene (S-DMBA) is one of several carcinogenic analogs of the reference mouse skin carcinogen 7,12-dimethylbenz[alanthracene (OMBA)Demonstrati...
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CUMULATIVE EXPOSURE TO ARSENIC AND ITS RELATIONSHIP TO RESPIRATORY CANCER AMONG COPPER SMELTER EMPLOYEES |
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To explore the role of arsenic as a human carcinogen, the respiratory cancer mortality experience (1938 to 1977) of 8,045 white male smelter employees in Montana was examined relat...
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CURRENT STATUS OF ANEUPLOIDY TESTING IN DROSOPHILA |
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A committee of scientists was established by the U.S. Environmental Protection Agency to appraise the current state of aneuploidy test methodology, to compile and analyze published...
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CYCLOPENTA[CD]PYRENE-INDUCED TUMORIGENICITY, KI-RAS CODON 12 MUTATIONS AND DNA ADDUCTS IN STRAIN A/J MOUSE LUNG |
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Cyclopenta[cd]pyrene (CPP) is a ubiquitous cyclopenta-fused polycyclic aromatic hydrocarbon. PP is highly genotoxic in bacterial and mammalian systems inducing gene mutations, sist...
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CYTOTOXICITY OF CHEMICAL CARCINOGENS TOWARDS HUMAN BRONCHIAL EPITHELIAL CELLS EVALUATED IN A CLONAL ASSAY |
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Survival of human bronchial epithelial cells after administration of four chemical carcinogens was measured in a clonal assay. Human bronchial epithelial cells were obtained from o...
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DETERMINING THE STRUCTURE-ACTIVITY RELATIONSHIPS OF AMINOBIPHENYL AND BENZIDINE ANALOGS |
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Determining the structure-activity relationships of aminobiphenyl and benzidine analogues
Benzidine is a confirmed human carcinogen causing bladder and other types of cancer...
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DETOXIFICATION RESPONSE IN MEDAKA (ORYZIAS LAPTIPES) EXPOSED TO MX, A DRINKING WATER CARCINOGEN |
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When chlorine is introduced into public drinking water for disinfection, it can react with organic compounds in surface waters to form toxic by-products such as 3-chloro-4-(dichlor...
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DEVELOPMENT AND VALIDATION OF A TEST METHOD FOR ACRYLONITRILE EMISSIONS |
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Acrylonitrile (AN) has been identified as a suspected carcinogen and may be regulated in the future as a hazardous air pollutant under Section 112 of the Clean Air Act. A method wa...
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DEVELOPMENT OF A CARCINOGEN ASSAY SYSTEM UTILIZING ESTUARINE FISHES |
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The objective of this project was the development of systems to assay the effects of chemical carcinogens on marine teleosts. It was determined that the LC-50 for benzidine with re...
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DEVELOPMENT OF NORMAL HUMAN COLON CELL CULTURES TO IDENTIFY UNREGULATED DISINFECTION BY-PRODUCTS (DBPS) WITH CARCINOGENIC POTENTIAL. |
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Epidemiological studies have linked the consumption of chlorinated surface waters to an increased risk of colorectal cancer. Approximately 600 DBPs, less than half of the total org...
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DICHLOROACETATE TOXICOKINETICS AND DISRUPTION OF TYROSINE CATABOLISM IN B6C3F1 MICE: DOSE RESPONSE RELATIONSHIPS AND AGE AS A MODIFYING FACTOR. (R825954) |
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Dichloroacetate (DCA) is a rodent carcinogen commonly found in municipal drinking water supplies. Toxicokinetic studies have established that elimination of DCA is controlled by...
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DIETARY ARSENIC EXPOSURE ASSESSMENT USING ENZYMATIC BASED EXTRACTION CONDITIONS AND DETECTION OF URINARY THIO-ARSENICALS AS METABOLITES OF EXPOSURE - MCEARD2 |
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Inorganic arsenic is classified as a carcinogen and has been linked to lung and bladder cancer as well as other non-cancerous health effects. Because of these health effects the U....
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DIETARY FOLATE DEFICIENCY ENHANCES INDUCTION OF MICRONUCLEI BY ARSENIC IN MICE |
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Folate deficiency increases background levels of DNA damage and can enhance the genotoxicity of chemical agents. Arsenic, a known human carcinogen present in drinking water suppli...
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DIRECT SUPPRESSION OF IN VITRO ANTIBODY PRODUCTION BY MOUSE SPLEEN CELLS BY THE CARCINOGEN BENZO-(A)-PYRENE BUT NOT BY THE NONCARCINOGENIC CONGENER BENZO-(E)-PYRENE. (R823881) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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DIRECT-ACTING, DNA-DAMAGING AS (III)-METHYLATED SPECIES: IMPLICATIONS FOR A CARCINOGENIC MECHANISM OF ACTION OF ARSENICALS |
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Direct-acting, DNA-damaging As (III)-methylated species: implications for a carcinogenic . mechanism of action of arsenicals
Inorganic arsenic (iAs, arsenite and arsenate)...
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DNA DAMAGE INDUCED BY METHYLATED TRIVALENT ARSENICALS IS MEDIATED BY REACTIVE OXYGEN SPECIES |
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Abstract
Arsenic is a human carcinogen; however, the mechanisms of arsenic's induction of carcinogenic effects have not been identified clearly. We have shown previously that mo...
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DNA DAMAGE INDUCED BY METHYLATED TRIVALENT ARSENICALS IS MEDIATED BY REACTIVE OXYGEN SPECIES |
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Abstract
Arsenic is a human carcinogen; however; the mechanisms of arsenic's induction of carcinogenic effects have not been identified clearly. We have shown previously t...
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DOSE PARADIGMS FOR INHALED VAPORS OF PRIMARY CARCINOGENS AND THEIR IMPACT ON RISK ASSESSMENT |
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In the assessment of risk, several factors affect predictions: election of reactive agent, selection of tumor incidence data, modeling of dose, scaling across species, adjustment f...
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DOSE RELATED DIFFERENCES IN DNA ADDUCT LEVELS IN RODENT TISSUES FOLLOWING SKIN APPLICATIONS OF COMPLEX MIXTURES FROM AIR POLLUTION SOURCES |
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Dose-related differences in the binding of DNA reactive intermediates for three environmentally important complex particulate extracts and a well studied carcinogen Benzo(a)Pyrene ...
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DOSE RESPONSE MODELING FOR 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN |
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As science continues to appreciate the prevalence and power of dioxins, so it learns more about the harmful effects and effective preventive measures regarding these chemicals. Upd...
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DRAFT FINAL GUIDELINES FOR CARCINOGEN RISK ASSESSMENT (EXTERNAL REVIEW DRAFT, FEBRUARY 2003) |
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In 1986, EPA published a set of risk assessment guidelines, including Guidelines for Carcinogen Risk A...
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DRAFT REVISED GUIDELINES FOR CARCINOGEN RISK ASSESSMENT (EXTERNAL DRAFT, JULY 1999) |
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EPA published its first cancer risk guidelines in 1986 (Guidelines for Carcinogen Risk Assessment<...
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EFFECT OF DIBUTYLNITROSAMINE AND SACCHARIN ON GLUTAMYL TRANSPEPTIDASE-POSITIVE FOCI AND LIVER CANCER |
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An attempt was made to evaluate whether the simultaneous administration of the urinary bladder tumor promoter, saccharin, and the substance being tested for carcinogenicity could b...
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EFFECT OF DIETARY FOLATE DEFICIENCY ON ARSENIC GENOTOXICITY IN MICE |
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Arsenic, a human carcinogen found in drinking water supplies throughout the world, is clastogenic in human and rodent cells. An estimated ten percent of Americans are deficient in ...
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EFFECTS OF 1,3-BUTADIENE, ISOPRENE, AND THEIR PHOTOCHEMICAL DEGRADATION PRODUCTS ON HUMAN LUNG CELLS |
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Because of potential exposure both in the workplace and from ambient air, the known carcinogen 1,3-butadiene (BD) is considered a priority hazardous air pollutant. BD and its 2-met...
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EFFECTS OF 4,4'-METHYLENEBIS-(2-CHLOROANILINE) AND BENZOTRICHLORIDE IN HUMAN AND/OR ANIMAL TISSUES |
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4,4'-Methylene-bis(2-chloraniline)(MOCA) is an aromatic amine with structural similarity to known human bladder carcinogens, and induces urothelial tumors in dogs. Therefore, the a...
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EFFECTS OF ARSENITE IN TELOMERE AND TELOMERASE IN RELATION TO CELL PROLIFERATION AND APOPTOSIS IN HUMAN KERATINOCYTES AND LEUKEMIA CELLS IN VITRO |
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Telomeres are critical in maintaining chromosome and genomic stability. Arsenic, a human carcinogen as well as an anticancer agent, is known for its clastogenicity. To better under...
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EFFECTS OF DIETARY FOLATE ON ARSENIC-INDUCED GENE EXPRESSION IN MICE |
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Effects of Dietary Folate on Arsenic-induced Gene Expression in Mice
Arsenic, a drinking water contaminant, is a known carcinogen. Human exposure to inorganic arsenic has b...
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EFFECTS OF HEAT SHOCK PROTEIN 70 (HSP70) ON ARSENITE INDUCED GENOTOXICITY |
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Arsenic (As), a human carcinogen, is known to be genotoxic although its mechanism(s) of action for tumorigenesis is not well understood. Among the toxicity-related properties of th...
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EFFECTS OF SELENIUM ON 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED MAMMARY CARCINOGENESIS AND DNA ADDUCT FORMATION |
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The purpose of the present investigation was to determine the effects of dietary selenium deficiency or excess on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary neoplasia in...
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EMISSIONS OF POLYCHLORINATED BIPHENYLS AS PRODUCTS OF INCOMPLETE COMBUSTION FROM INCINERATORS |
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The paper discusses emissions of polychlorinated biphenyls (PCBs) as products of incomplete combustion from incinerators. PCBs were used widely as industrial chemicals, particularl...
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EMPIRICAL COMPARISONS OF CARCINOGEN POTENCIES ACROSS SPECIES AND THEIR BEARING ON APPROPRIATE SCALING OF DOSES FOR RISK ASSESSMENT |
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This chapter is adapted from the recent proposal by the Interagency Pharmacokinetics Group (IPG) advocating the adoption by the participating Federal regulatory agencies of a unifi...
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ENHANCEMENT OF BENZO(A)PYRENE MUTAGENICITY BY CHRYSOTILE ASBESTOS IN RAT LIVER EPITHELIAL CELLS |
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The co-mutagenicity of chrysotile asbestos and benzo(a)pyrene (B(a)P) was studied in adult rat liver (ARL-18) epithelial cells. Exposure to chrysotile alone did not increase the mu...
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ENVIRONMENTAL CHEMISTRY OF CHROMIUM |
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Chromium is of great environmental concern because hexavalent chromium is a potent carcinogen. he health effects resulting from chromium exposure have received as much attention as...
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ENVIRONMENTAL TECHNOLOGY VERIFICATION EVALUATIONS OF ARSENIC REDUCTION SYSTEMS FOR DRINKING WATER |
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Arsenic in drinking water is a known carcinogen with additional adverse human health impacts. For the 4,100 affected systems, 37 to 55 cancer cases per year are estimated, with abo...
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EPA GUIDELINES FOR CARCINOGEN RISK ASSESSMENT: PAST AND FUTURE (1996) |
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NO ABSTRACT PROVIDED...
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EPA PROGRAMS AND THE REGULATION OF CARCINOGENS: METHODS AND PHILOSOPHIES |
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This report is part of the National Network for Environmental Studies Program conducted under the auspices of the Office of Cooperative Environmental Management, U.S. Environmental...
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ESTABLISHMENT OF TWO RAT HEPATOMA CELL STRAINS PRODUCED BY A CARCINOGEN INITIATION PHENOBARBITAL PROMOTION PROTOCOL |
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Primary tumor formation was induced in a two-thirds partially hepatectomized rat by a single low dose (70 mg/kg of diethylnitrosamine followed by chronic phenobarbital administrati...
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ESTIMATION OF MUTAGENIC/CARCINOGENIC POTENTIAL OF ENVIRONMENTAL CONTAMINANTS BY ION-MOLECULE REACTIONS AND TANDEM MASS SPECTROMETRY |
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The ability to produce and detect products of model DNA/carcinogen ion-molecule reactions is demonstrated in the ion source and the collision cell of a triple quadrupole tandem mas...
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ESTIMATION OF RISK FROM CARCINOGENS IN DRINKING WATER |
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The report gives results of a study aimed at developing a means for estimating cancer mortality as a function of carcinogen concentration in drinking water. Cancer risk data for ci...
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EVALUATION AND ESTIMATION OF POTENTIAL CARCINOGENIC RISKS OF POLYNUCLEAR AROMATIC HYDROCARBONS (PAH) |
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The evaluation and estimation of the potential risk of human exposures to a hazardous substance requires the analysis of all relevant data to answer two questions (1) does the agen...
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EVALUATION OF A PILOT-SCALE ULTRAVIOLET (UV) LIGHT AND OZONE TREATMENT SYSTEM FOR REMOVAL OF MTBE FROM DRINKING WATER SOURCES |
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The U.S. Environmental Protection Agency (EPA) is currently evaluating package plant advanced oxidation process (AOP) systems to treat methyl tertiary butyl ether (MTBE) in drinkin...
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EVALUATION OF THE CARCINOGENIC RISK OF BIOCHEMICALLY INERT, INSOLUBLE PARTICLES BY THE U.S. EPA USING RAT INHALATION DATA |
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Regulations pertaining to inhalable particulate matter are promulgated primarily by three program offices of the U.S. Environmental Protection Agency (EPA): Pollution Prevention an...
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EVALUATION OF THE CARCINOGENICITY OF UNLEADED GASOLINE |
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In the document the likelihood that unleaded gasoline vapors are carcinogenic to humans is evaluated. From carcinogenicity data in animals, an estimate is made of the magnitude of ...
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EVALUATION OF THE MUTAGENIC ACTIVITY OF 3-NBA (3-NITROABENZANTHRONE) USING STRAINS OF SALMONELLA TYPHIMURIUM WITH DIFFERENT LEVELS OF THE ENZYMES NITROREDUCTASE AND ACETYLTRANSFERASE |
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The 3-NBA (3-nitro-7H- benz[d,e]antracen-7-one) is extremely potent in the Ames test an useful test for mutagenicity, being a possible inducer of tumors in animals and possible car...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,1,1,2-TETRACHLOROETHANE |
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1,1,1,2-Tetrachloroethane is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). videnc...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,1,2,2-TETRACHLOROETHANE |
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1,1,2,2-Tetrachloroethane is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). videnc...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,1,2-TRICHLOROETHANE |
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1,1,2-Trichloroethane is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,1-DIMETHYL-HYDRAZINE |
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1,1-Dimethylhydrazine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2,3,4-DIEPOXYBUTANE |
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Diepoxybutane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potent...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2-DIBROMO-3-CHLOROPROPANE |
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1,2-Dibromo-3-chloropropane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vid...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2-DICHLOROETHANE |
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1,2-Dichloroethane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on p...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2-DIETHYLHYDRAZINE |
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1,2-Diethylhydrazine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2-DIMETHYL-HYDRAZINE |
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1,2-Dimethylhydrazine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2-DIPHENYLHYDRAZINE |
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1,2-Diphenylhydrazine is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2-PROPYLENEIMINE |
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1,2-Propylenmine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,2:7,8-DIBENZOPYRENE |
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1,2:7,8-Dibenzopyrene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,3-PROPANE SULTONE |
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1,3-propane sultone is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1,4-DIOXANE |
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1,4-Dioxane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potentia...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 1-NAPHTHYLAMINE |
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The substance 1-Naphthylamine is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 986a). vid...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN |
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2,4,5-TRICHLOROPHENOL |
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2,4,5-Trichlorophenol cannot be assessed as a potential human carcinogen, and is therefore classified as weight-of-evidence Group D under the EPA Guidelines for Carcinogen Risk.Ass...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2,4,6-TRICHLOROPHENOL |
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2,4,6-Trichlorophenol is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2,4-DINITROTOLUENE |
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2,4-Dinitrotoluene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on p...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2,6-DINITROTOLUENE |
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2,6-Dinitrotoluene is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on po...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2-NAPHTHYLAMINE |
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2-Naphthylamine is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carc...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 2-NITROPROPANE |
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2-Nitropropane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 3,3'-DICHLOROBENZIDINE |
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3,3'-Dichlorobenzidine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 3,3'-DIMETHOXYBENZIDINE |
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3,3'-dimethoxybenzidine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 3,3'-DIMETHYL-BENZIDINE |
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3,3'-Dimethylbenzidine is a possible human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S- EPA, 4986a). vidence ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 3-METHYLCHLOLANTHRENE |
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3-Methylcholanthrene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 4,4'-METHYLENEBIS (2-CHLOROANILINE) |
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4,4'-Methylenebis (2-chloroaniline) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 198...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 4-CHLORO-O-TOLUIDINE HYDROCHLORIDE |
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4-Chloro-o-toluidine hydrochloride is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 5-NITRO-O-TOLUIDINE |
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5-Nitro-o-toluidine is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on p...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF 7,12-DIMETHYLBENZ(A) ANTHRACENE |
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7,12-Dimethylbenz(a)anthracene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. E-PA, 1986a)....
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ACETAMIDE, N-FLUOREN-2-YL |
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Acetamide, N-Fluoren-2-yl is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential ca...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ACRYLONITRILE |
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Acrylonitrile is a probable human carcinogen, classified as weight-of-evidence Group Bl under the EPA Guidelines for Carcinogen Risk Assessment. vidence, on potential carcinogenici...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ALDRIN |
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Aldrin is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinogenicity from ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ALPHA-HEXACHLOROCYCLOHEXANE |
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Alpha-Hexachlorocyclohexane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. PA, 1986a). vide...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF AMITROLE |
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Amitrole is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinogenicity fro...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ARSENIC COMPOUNDS |
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Arsenic and inorganic compounds a human carcinogens, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinog...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ASBESTOS |
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Asbestos is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF AURAMINE |
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Auramine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinogenicity fro...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF AZASERINE |
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Azaserine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinogenicity fr...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF AZIRIDINE |
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Aziridine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinogenicity fr...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZ(A)ANTHRACENE |
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Benz[a]anthracene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential .carcinoge...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZ(C)ACRIDINE |
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Benz(c)acridine is a probable human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinogenici...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZENE |
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Benzene is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment. vidence on potential carcinogenicity from animal st...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZIDINE AND ITS SALTS |
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Benzidine is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carcinogen...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZOTRICHLORIDE |
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Benzotrichloride is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZO[A]PYRENE |
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Benzo[a]pyrene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZO[B]FLUORANTHENE |
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Benzo[b]fluoranthene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZO[K]FLUORANTHENE |
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Benzo[k]fluoranthene is not classifiable as a human carcinogen, and is, therefore, placed in weight-of-evidence Group D under the EPA Guidelines for Carcinogen Risk Assessment (U.S...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BENZYL CHLORIDE |
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Benzyl chloride is a probable human carcinogen, classified as weight-of-evidence roup B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BERYLLIUM, BERYLLIUM CHLORIDE, BERYLLIUM FLUORIDE, AND BERYLLIUM NITRATE |
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Beryllium is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BETA-HEXACHLORO-CYCLOHEXANE |
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Beta-Hexachlorocyclohexane is a probable human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). viden...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BIS (2-CHLOROETHYL) ETHER |
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Bis(2-chloroethyl)ether is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BIS(2-ETHYLHEXYL) PHTHALATE |
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Bis(2-ethylhexyl) phthalate is a probable human carcinogen, classified as weight-of-evidence Group B2 under the. PA Guidelines for Carcinogen Risk Assessment (U.S EPA, 1986a). vide...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF BIS(CHLOROMETHYL) ETHER |
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Bis(chloromethyl)ether is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potenti...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CACODYLIC ACID |
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The weight-of-evidence for cacodylic acid is Group D under the EPA Guidelines for Carcinogen Risk Assessment. vidence on the potential carcinogenicity for cacodylic acid from anima...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CADMIUM (7740-43-9), CADMIUM ACETATE (543-90-8), CADMIUM BROMIDE (7789-42-6), AND CADMIUM CHLORIDE (10108-64-2) |
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Cadmium is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a)- Evidence on potential c...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CARBON TETRACHLORIDE |
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Carbon tetrachloride is a probable human carcinogen, classified as weight-of-evidence Group B2 under he EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a).Evidence on ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CHLORAMBUCIL |
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Chlorambucil is a probable human carcinogen, classified as weight-of-evidence Group Bl under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potenti...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CHLORDANE |
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Chlordane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CHLORNAPHAZINE |
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Chlornaphazine is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potent...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CHLOROFORM |
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Chloroform is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CHLOROMETHYL METHYL ETHER (TECHNICAL GRADE) |
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Technical grade chloromethyl methyl ether is contaminated with between 1 and 8 percent bis(chloromethyl)ether, which is a known human carcinogen. ence, the human evidence for this ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CHROMIUM AND HEXAVALENT CHROMIUM COMPOUNDS |
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exavalent chromium compounds are human carcinogens, classified as weight-of-evidence Group A (based on chromate production workers and animal data which indicate that inhaled hexav...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CHRYSENE |
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Chrysene is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential ca...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF COKE OVEN EMISSIONS |
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Coke oven emissions are known human carcinogens, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pote...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CREOSOTE |
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Creosote is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on .potential ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF CYCLOPHOSPHAMIDE |
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Cyclophosphamide is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a).Evidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DAUNOMYCIN |
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Daunomycin is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DDD |
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1,1-Dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DDE |
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DDE is a probable human carcinogen, classified as weight-of-evidence Group B2 under the E@A Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carcin...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DDT |
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DDT is a probable human carcinogen, classified as weight-of-evidence Group B2 under the ERA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carcin...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIALLATE |
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Diallate is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on .potential c...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIAMINOTOLUENE (MIXED) |
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Diaminotoluene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIBENZ[A,H] ANTHRACENE |
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Dibenz[a,h]anthracene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DICHLOROPHENYLARSINE |
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The weight-of-evidence for dichlorophenylarsine is Group D under the EPA Guidelines for Carcinogen Risk Assessment. here are "No Data" on the potential carcinogenicity for dichloro...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIELDRIN |
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Dieldrin is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential c...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIETHYLARSINE |
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The weight-of-evidence for diethylarsine is Group D under the EPA Guidelines for Carcinogen Risk Assessment. vidence on the potential carcinogenicity for diethylarsine from animal ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIETHYLSTILBESTROL |
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Diethylstilbestrol is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential c...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIHYDROSAFROLE |
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Dihydrosafrole is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIMETHYL SULFATE |
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Dimethyl sulfate is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIMETHYLAMINOAZOBENZENE |
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Dimethylaminoazobenzene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S- EPA, 1986a). vidence...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIMETHYLCARBAMOYL CHLORIDE |
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Dimethylcarbamoyl Chloride is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vide...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DINITROTOLUENE |
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Carcinogenicity data for mixed dinitrotoluenes are inadequate. ince the technical grade mixture consists of approximately 75% 2,4-dinitrotoluene and 19.5% 2,6-dinitrotoluene, hazar...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF EPICHLOROHYDRIN |
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Epichlorohydrin is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pote...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ETHYL 4,4'-DICHLOROBENZILATE |
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Ethyl 4,4'-dichlorobenzilate is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vi...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ETHYL CARBAMATE (URETHANE) |
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Ethyl carbamate is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ETHYL METHANESULFONATE |
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Ethyl methanesulfonate is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ETHYLENE DIBROMIDE |
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Ethylene dibromide is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on p...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ETHYLENE OXIDE |
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Ethylene oxide is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ETHYLENETHIOUREA |
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Ethylenethiourea is a probable human carcinogen, classified as weight-of-evidence roup B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pote...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF FORMALDEHYDE |
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Formaldehyde is a probable human carcinogen, classified Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carcinogenicity fro...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF GAMMA-HEXACHLOROCYCLOHEXANE (LINDANE) |
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Gamma-Hexachlorocyclohexane (gamma-BHC or Lindans) is a probable to possible human carcinogen, classified as weight-of-evidence Group B2/C under the EPA Guidelines for Carcinogen R...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF GLYCIDYLADEHYDE |
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Glycidylaldehyde is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF HEPTACHLOR |
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Heptachlor is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF HEPTACHLOR EPOXIDE |
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Heptachlor epoxide is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on p...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF HEXACHLOROBENZENE |
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Hexachlorobenzene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on po...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF HEXACHLOROBUTADIENE |
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Hexachlorobutadiene is a probable human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on p...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF HEXACHLOROETHANE |
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Hexachloroethane is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF HYDRAZINE |
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Hydrazine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF INDENO[1,2,3-CD]PYRENE |
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Indeno[1,2,3-cd]pyrene is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF ISOSAFROLE |
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Isosafrole is a probable human carcinogen, classified as weight-of-evidence G under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carcin...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF KEPONE |
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Kepone (chlordecone) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF LASIOCARPINE |
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Lasiocarpine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen,Risk Assessment (U.S. EPA, 1986a). vidence on potenti...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF LEAD AND LEAD COMPOUNDS: IN SUPPORT OF REPORTABLE QUANTITY ADJUSTMENTS PURSUANT TO CERCLA SECTION 102 |
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Information on the potential carcinogenicity of lead and lead compounds is summarized and evaluated under EPA's Guidelines for Carcinogen Risk Assessment. The human studies provide...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF MELPHALAN |
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Melphalan is a probable human carcinogen, classified as weight-of-evidence Group Bl under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF METHYL CHLORIDE |
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Methyl Chloride is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF METHYL IODIDE |
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Methyl iodide is a possible human,carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potenti...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF METHYLTHIOURACIL |
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Methylthiouracil is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF MITOMYCIN |
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Mitomycin C Is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potentia...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE |
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N-Methyl-N'-nitro-N-nitrosoguanidine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 19...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSODI-N-BUTYLAMINE |
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Nitrosodi-n-butylamine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSODI-N-PROPYLAMINE |
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N-Nitrosodi-n-propylamine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). viden...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSODIETHANO-LAMINE |
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N-Nitrosodiethanolamine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSODIETHYLAMINE |
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N-Nitrosodiethylamine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSODIMETHYLAMINE |
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N-Nitrosodimethylamine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSOPIPERIDINE |
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N-Nitrosopiperidine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSOPYRROLIDINE |
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N-Nitrosopyrrolidine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSOSO-N-ETHYLUREA |
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N-Nitroso-N-ethylurea is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence o...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSOSO-N-METHYLUREA |
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N-Nitroso-N-methylurea is a probable,human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF N-NITROSOSOMETHYL-VINYLAMINE |
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N-Nitrosomethylvinylamine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). ioass...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF NICKEL |
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Nickel is assigned a hazard ranking of "LOW," based on limited animal evidence of carcinogenicity (Group C). he available data are not suitable for estimating nickel's potency. ick...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF O-TOLUIDINE |
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The assessment of o-toluidine for potential carcinogenicity is based on data from studies using o-toluidine hydrochloride, since o-toluidine is rapidly and completely converted to ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF O-TOLUIDINE HYDROCHLORIDE |
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o-Toluidine hydrochloride is a potential human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vide...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF P-TOLUIDINE |
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p-Toluidine is a probable human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF PENTACHLOROETHANE |
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Pentachloroethane is a probable human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on pot...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF PENTACHLORONITROBENZENE |
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Pentachloronitrobenzene is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF PENTACHLOROPHENOL |
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Pentachlorophenol cannot be identified as a potential human carcinogen, therefore, ft is classified as weight-of-evidence Group D under the EPA Guidelines for Carcinogen Risk Asses...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF PHENACETIN |
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Phenacetin is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF POLYCHLORINATED BIPHENYLS INCLUDING SPECIFIC AROCLORS |
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Polychlorinated biphenyls (PCBS) are probable human carcinogens, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a)...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF SACCHARIN |
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Saccharin is a possible human carcinogen, classified as weight-of-evidence Group C under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential c...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF SAFROLE |
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Safrole is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential ca...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF SELENIUM SULFIDE (SELENIUM DISULFIDE) |
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Selenium sulfide (selenium disulfide) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF STREPTOZOTOCIN |
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Streptozotocin is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF TETRACHLOROETHYLENE |
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Tetrachloroethylene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF THIOACETAMIDE |
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Thioacetamide is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potent...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF THIOUREA |
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Thiourea is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential c...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF TOXAPHENE |
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Toxaphene is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential ...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF TRICHLOROPHENOL |
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Trichlorophenol (mixed) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF TRIS (2,3-DIBROMOPROPYL) PHOSPHATE |
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Tris(2,3-dibromopropyl) phosphate is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF TRYPAN BLUE |
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Trypan blue is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potentia...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF URACIL MUSTARD |
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Uracil mustard is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on poten...
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EVALUATION OF THE POTENTIAL CARCINOGENICITY OF VINYL CHLORIDE |
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Vinyl Chloride is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). vidence on potential carci...
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EVALUATION OF TOXICS IN RUNOFF FROM COATED SURFACES |
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Presented in this paper are results from a field and laboratory study of the potential runoff toxicity from coated surfaces. The study results qualified and quantified the types an...
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EXOCRINE PANCREATIC CARCINOGENESIS IN THE GUPPY (POECILIA RETICULATA). |
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Exocrine pancreatic neoplasms developed in the guppy (Poecilia reticulata) following exposure to the direct acting carcinogen, methylazoxymethanol acetate (MAM-Ac). Fish 6- to 10-d...
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EXOCRINE PANCREATIC CARCINOGENESIS IN THE GUPPY POECILIA RETICULATA |
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Exocrine pancreatic neoplasms developed in the guppy Poecilia reticulata following exposure to the direct acting carcinogen, methylazoxymethanol acetate (MAM-Ac). Fish 6- to 10-day...
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EXPERIMENTAL RESPIRATORY CARCINOGENESIS IN SMALL LABORATORY ANIMALS |
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Studies designed to test the ability of environmental pollutants to induce lung cancer in experimental animals by chronic inhalation exposure are summarized in this review. The stu...
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EXPRESSON OF AS3MT ALTERS TRANSCRIPTIONAL PROFILES IN HUMAN UROTHELIAL CELLS EXPOSED TO ARSENITE |
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Inorganic arsenic (iAs) is an environmental toxin and human carcinogen. The enzymatic methylation of iAs that is catalyzed by As (3+ oxidation state)-methyltransferase (AS3MT) gene...
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FACTORS INFLUENCING AGE AND STRAIN-RELATED SUSCEPTIBILITY TO 3-METHYLCHOLANTHRENE CARCINOGENICITY |
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Fetal mice are more sensitive to chemical carcinogens than are adults. Further, some strains of mice are more susceptible to chemical carcinogens than others. We have been conducti...
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FATE OF 3,3'-DICHLOROBENZIDINE IN AQUATIC ENVIRONMENTS |
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Several aspects of the aquatic environmental fate of 3,3'-dichlorobenzidine (DCB), a suspected human carcinogen, were examined. Greater than 95% of dichlorobenzidine present was ad...
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FOCAL AND NON-FOCAL HEPATIC EXPRESSION OF PLACENTAL GLUTATHIONE S-TRANSFERASE IN CARCINOGEN-TREATED RATS |
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Carcinogenesis is a multistep, multistage process that begins with irreversible, but heritable damage to a single cell. The partial hepatectomy/diethylnitrosamine (DEN) model of ra...
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FORMATION OF MUTAGENIC URINARY METABOLITES FROM 1-NITROPYRENE IN GERM-FREE AND CONVENTIONAL RATS: ROLE OF THE GUT FLORA |
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1-Nitropyrene (NP), an environmental pollutant, a potent mutagen and an animal carcinogen, undergoes reduction, acetylation, ring hydroxylation and conjugation in the rat in vivo t...
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FURTHER EVIDENCE THAT DICHLOROMETHANE DOES NOT INDUCE CHROMOSOME DAMAGE |
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Dichloromethane (DCM) is a widely used industrial solvent which has been determined to be a carcinogen in rats and mice. n vitro and in vivo analyses of chromosome damage induced b...
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GENE EXPRESSION PROFILING OF RESPONSES TO DIMETHYLARSINIC ACID IN FEMALE F344 RAT UROTHELIUM |
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Arsenic is a human carcinogen and epidemiologic evidence implicates it in the development of urinary bladder cancer. Even though several mechanisms have been proposed for arsenic c...
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GENE EXPRESSION PROFILING OF THE RAT KIDNEY FOLLOWING CHRONIC EXPOSURE (100 WKS) TO THE WATER DISINFECTANT BYPRODUCT AND RENAL CARCINOGEN, POTASSIUM BROMATE. |
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Gene expression profiling of the rat kidney following chronic exposure (100 wks) to the water
disinfectant byproduct and renal carcinogen, potassium bromate.
Don Delker, ...
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GENE PROFILING IN WILD TYPE AND PPARÁ NULL MICE EXPOSED TO PFOA |
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Perflurooctanoic acid (PFOA) is a perfluoroalkyl acid used in a variety of commercial applications. Concerns have been raised because PFOA is ubiquitous in the environment and can...
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GENE-TOX CARCINOGEN DATA BASE: CONSTRUCTION, DESCRIPTION, AND ANALYSIS |
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The Gene-Tox Carcinogen Data Base is an evaluated source of cancer data on 506 chemicals selected in part for their previous assessment in genetic toxicology bioassays. Chemicals i...
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GENE-TOX CARCINOGENS AND NON-CARCINOGENS: AN ANALYSIS OF SHORT-TERM BIOASSAYS IN GENETIC TOXICOLOGY |
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The Gene-Tox Carcinogen Data Base is an evaluated source of cancer data on 506 chemicals selected in part for their previous assessment in genetic toxicology bioassays. The data ba...
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GENOTOXICITY AND METABOLISM OF THE SOURCE-WATER CONTAMINANT 1,1-DICHLOROPROPENE: ACTIVATION BY GSTT1-1 AND STRUCTURE-ACTIVITY CONSIDERATIONS |
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1, 1 -Dichloropropene (1,1-DCPe) is a contaminant of some source waters used to make drinking water. Because of this and the fact that no toxicological data were available for this...
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GENOTOXICITY OF 1,3-DICHLOROPROPANE, 2,2-DICHLOROPROPANE, AND 1,1-DICHLOROPROPENE IN SALMONELLA, THE E. COLI PROPHAGE-INDUCTION ASSAY, AND HUMAN HEPH2 CELLS |
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Genotoxicity of 1,3-Dichloropropane, 2,2-Dichloropropane, and 1,1-Dichloropropene in Salmonella, the E. coli Prophage-Induction Assay and Human HepG2 Cells
1,3-Dichloroprop...
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GENOTOXICITY OF 1,3-DICHLOROPROPANE, 2,2-DICHLOROPROPANE, AND L,1-DICHLOROPROPENE IN SALMONELLA AND E. COLI PROPHAGE-INDUCTION ASSAYS |
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Genotoxicity of 1,3-Dichloropropane, 2,2-Dichloropropane, and 1,1-Dichloropropene in
Salmonella and E. coli Prophage-Induction Assays
1,3-Dichloropropane (1,3-DCP), 2,2...
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GUIDELINES FOR CARCINOGEN RISK ASSESSMENT (1986) |
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In 1983, the National Academy of Sciences (NAS)/National Research Council (NRC) published its report entitled Risk Assessment in the Federal Government: Managing the Process. In th...
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GUIDELINES FOR CARCINOGEN RISK ASSESSMENT (1996) |
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EPA's cancer guidelines set forth recommended principles and procedures to guide EPA scientists in assessing the cancer risks from chemicals or other agents in the environment. The...
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GUIDELINES FOR CARCINOGEN RISK ASSESSMENT (2005) |
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In an effort to update key scientific risk assessment methodologies, EPA has published the revised |
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,1-DIMETHYLHYDRAZINE |
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The Health and Environmental Effects Profile for 1,1-dimethylhydrazine was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Offi...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,2,3,4,5-PENTA-BROMO-6-CHLOROCYCLOHEXANE |
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The Health and Environmental Effects Profile for 1,2,3,4,5-penta-bromo-6-chloro-cyclohexane was prepared by the Office of Health and Environmental Assessment, Environmental Criteri...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,2-DIMETHYLHYDRAZINE |
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The Health and Environmental Effects Profile for 1,2-dimethylhydrazine was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Offi...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,3-DICHLOROPROPENE |
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The Health and Environmental Effects Profile for 1,3-dichloropropene was prepared by the Office of Health and Environmental Assessment. Environmental Criteria and Assessment Office...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4-DIMETHYLANILINE AND 2,4-DIMETHYLANILINE HYDROCHLORIDE |
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The Health and Environmental Effects Profile for 2-4-Dimethylaniline and 2,4-Dimethylaniline Hydrochloride was prepared to support listings of hazardous constituents of a wide rang...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4-TOLUENEDIAMINE |
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The Health and Environmental Effects Profile for 2,4-Toluenediamine was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHOXY-5-NITROANILINE |
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The Health and Environmental Effects Profile for 2-Methoxy-5-nitroaniline was prepared to support listings of hazardous constituents of a wide range of waste streams under Section ...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYL-5-NITROANILINE |
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The Health and Environmental Effects Profile for 2-methyl-5-nitroaniline was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-METHYLANILINE AND 2-METHYLANILINE HYDROCHLORIDE |
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The report was prepared to support listings of hazardous constituents of a wide range of waste streams and to provide health-related limits for emergency actions. Published literat...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-NITROPROPANE |
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The Health and Environmental Effects Profile for 2-nitropropane was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cin...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-PHENYLPHENOL |
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The Health and Environmental Effects Profile for 2-phenylphenol was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cin...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3,3'-DIMETHOXYBENZIDINE |
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The Health and Environmental Effects Profile for 3,3'-dimethoxybenzidine was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3,3'-DIMETHYLBENZIDINE |
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The Health and Environmental Effects Profile for 3,3'-Dimethylbenzidine was prepared to support listings of hazardous constituents of a wide range of waste streams under section 33...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4,4'-METHYLENEBIS(N,N-DIMETHYL)ANILINE |
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The Health and Environmental Effects Profile for 4,4'-methylenebis-(N,N-dimethyl)-aniline was prepared by the Office of Health and Environmental Assessment, Environmental Criteria ...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-CHLORO-2-METHYLANILINE AND 4-CHLORO-2-METHYLANILINE HYDROCHLORIDE |
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The Health and Environmental Effects Profile for 4-chloro-2-methylaniline and 4-chloro-2-methylaniline hydrochloride was prepared to support listings of hazardous constituents of a...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE |
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The Health and Environmental Effects Profile for acephate was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnat...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACRYLONITRILE |
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The Health and Environmental Effects Profile for acrylonitrile was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cinc...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR |
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The Health and Environmental Effects Profile for alachlor was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnat...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL CHLORIDE |
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The Health and Environmental Effects Profile for Allyl Chloride was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of th...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANILINE |
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The Health and Environmental Effects Profile for aniline was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinatti...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AZOBENZENE |
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The Health and Environmental Effects Profile for azobenzene was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinn...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZENAMINE, 4, 4'-METHYLENEBIS |
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The Health and Environmental Effects Profile for benzenamine, 4,4'-methylene bis was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Asses...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZIDINE |
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The Health and Environmental Effects Profile for Benzidine was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Res...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZOTRICHLORIDE |
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The Health and Environmental Effects Profile for Benzotrichloride was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of ...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZYL CHLORIDE |
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The Health and Environmental Effects Profile for Benzyl Chloride was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of t...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMACIL |
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The Health and Environmental Effects Profile for Bromacil was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnat...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOETHENE (VINYL BROMIDE) |
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The Health and Environmental Effects Profile for bromoethene was prepared by the Office of Health and Environmental Assessment. Environmental Criteria and Assessment Office, Cincin...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL |
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The Health and Environmental Effects Profile for captafol was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnat...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAN |
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The Health and Environmental Effects Profile for captan was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati,...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBAZOLE |
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The Health and Environmental Effects Profile for Carbazole was prepared for the Office of Solid Waste and Emergency Response to support listings of hazardous constituents of a wide...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORANIL |
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The Health and Environmental Effects Profile for Chloranil was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Res...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROBENZILATE |
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The Health and Environmental Effects Profile for chlorobenzilate was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Ci...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROETHENE |
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The Health and Environmental Effects Profile for chloroethene was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cinci...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORTHALONIL |
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The Health and Environmental Effects Profile for chlorthalonil was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cinc...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOPHORONE |
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The Health and Environmental Effects Profile for Isophorone was prepared support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resou...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR LINURON |
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The Health and Environmental Effects Profile for Linuron was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYLHYDRAZINE |
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The Health and Environmental Effects Profile for methylhydrazine was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Ci...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR OXIRANE |
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The Health and Environmental Effects Profile for oxirane was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLORONITROBENZENE |
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The Health and Environmental Effects Profile for Pentachloronitrobenzene was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID ESTERS |
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The report was prepared to support listings of hazardous constituents of a wide range of waste streams and to provide health-related limits for emergency actions. Published literat...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROFLURALIN |
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The Health and Environmental Effects Profile for profluralin was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincin...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPAZINE |
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The Health and Environmental Effects Profile for propazine was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinna...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPYLENE OXIDE |
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The Health and Environmental Effects Profile for propylene oxide was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Ci...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR QUINOLINE |
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The Health and Environmental Effects Profile for quinoline was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinna...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SODIUM DIETHYLDITHIOCARBAMATE |
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The Health and Environmental Effects Profile for sodium diethyl dithiocarbamate was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assess...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS |
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The Health and Environmental Effects Profile for stirofos was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnat...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STYRENE |
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The Health and Environmental Effects Profile for styrene was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES |
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The Health and Environmental Effects Profile for Toluidines was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinn...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN |
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The Health and Environmental Effects Profile for trifluralin was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincin...
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HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIMETHYL PHOSPHATE |
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The Health and Environmental Effects Profile for trimethyl phosphate was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office...
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HEALTH ASSESSMENT DOCUMENT FOR 1,2-DICHLOROETHANE (ETHYLENE DICHLORIDE). EXTERNAL REVIEW DRAFT. PARTS 1 AND 2 |
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Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indic...
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HEALTH ASSESSMENT DOCUMENT FOR 1,2-DICHLOROETHANE (ETHYLENE DICHLORIDE). FINAL REPORT |
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Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indic...
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HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. FINAL REPORT |
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Acute acrylonitrile intoxication in humans, like many volatile organic compounds, results in irritation of the eyes and nose, weakness, labored breathing, dizziness, impaired judge...
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HEALTH ASSESSMENT DOCUMENT FOR DICHLOROMETHANE (METHYLENE CHLORIDE) UPDATED CARCINOGENICITY ASSESSMENT OF DICHLOROMETHANE (METHYLENE CHLORIDE): ADDENDUM |
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The addendum contains a review of the data from the latest National Toxicology Program (NTP) inhalation bioassay of dichloromethane (DCM) and an update of the inhalation cancer ris...
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HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. FINAL REPORT |
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This document summarizes current scientific information regarding the health and environmental effects of epichlorohydrin. Specifically, this document discusses the following topic...
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HEALTH ASSESSMENT DOCUMENT FOR POLYCYCLIC ORGANIC MATTER |
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The document responds to Section 122 of the Clean Air Act as Amended August 1977, which requires the Administrator to decide whether atmospheric emissions of polycyclic organic mat...
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HEALTH ASSESSMENT DOCUMENT FOR TETRACHLOROETHYLENE (PERCHLOROETHYLENE) |
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Tetrachloroethylene (PERC) is believed to exert its adverse effects upon humans via metabolism by the liver. Concern that PERC is likely to be a human carcinogen is based upon the ...
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HEALTH CONSEQUENCES OF DIOXIN EXPOSURE |
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Abstract TCDD is often called the most toxic man-made chemical because of its potency to cause health effects in a wide variety of vertebrates. Structurally related persis...
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HEALTH EFFECTS OF CHRONIC EXPOSURE TO ARSENIC VIA DRINKING WATER IN INNER MONGOLIA: II. VIBROTACTILE AND VISUAL MEASURES FINAL DOCUMENT TITLE. |
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HEALTH EFFECTS OF CHRONIC EXPOSURE TO ARSENIC IN DRINKING WATER IN INNER MONGOLIA: II. VIBROTACTILE AND VISUAL MEASURES.
David Otto, Ph.D., Judy Mumford, Ph.D., Richard Kwo...
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HEALTH EFFECTS OF PASSIVE SMOKING: ASSESSMENT OF LUNG CANCER IN ADULTS AND RESPIRATORY DISORDERS IN CHILDREN |
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This draft document addresses the scientific, mostly epidemiologic, evidence on the potential association between passive smoking or Environmental Tobacco Smoke (ETS) and (1) lung ...
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HEALTH RISK ASSESSMENT OF 1,3-BUTADIENE (EXTERNAL REVIEW DRAFT) |
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This risk assessment of 1,3-butadiene, a gas used commercially in the production of various resins and plastics, concludes that 1,3-butadiene is a known human carcinogen, based on ...
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HEMOGLOBIN BINDING AS A DOSE MONITOR FOR CHEMICAL CARCINOGENS |
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The covalent binding of chemical carcinogens and mutagens to hemoglobin has been proposed as a dose monitor for environmental exposure. The binding of chloroform and bromoform to h...
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HOW POISONING EPISODES INFORM OUR UNDERSTANDING OF POPULATION EFFECTS AT BACKGROUND EXPOSURES |
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During the past one hundred years, there have been a number of episodes involving high exposures to 2.3.7.8-TCDD or related compounds. Some of these have been accidental; others i...
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HUMAN CARCINOGENESIS BY ARSENIC |
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Arsenic is one of the few human carcinogens for which there is not yet a reliable animal cancer model. s such, the classification of arsenic as a carcinogen is based upon data deri...
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HUMAN EPITHELLIAL CELL ACTIVATION SYSTEMS |
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Much effort has been placed on the development of short-term assay systems that use the induction of mutations in bacterial and mammalian cells as the basis for predicting the carc...
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HUMAN EXPOSURE AND DOSIMETRY OF POLYCYCLIC AROMATIC HYDROCARBONS IN URINE FROM XUAN WEI, CHINA WITH HIGH LUNG CANCER MORTALITY ASSOCIATED WITH EXPOSURE TO UNVENTED COAL SMOKE |
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Lung cancer mortality rate in Xuan Wei (XW) county, China is 5 times the China national average; women's rate is China's highest. W residents have been exposed to unvented coal or ...
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HYPERPLASTIC LESIONS OF THE PRIMITIVE MENINX OF FATHEAD MINNOWS, 'PIMEPHALES PROMELAS', INDUCED BY AMMONIA SPECIES POTENTIAL FOR CARCINOGEN TESTING |
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In the laboratory, fathead minnows were reared from time of hatching to adulthood at 5 concentrations of ammonia in a toxicity test lasting 304 days. The ammonia concentration test...
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IDENTIFICATION OF INTERSPECIES CONCORDANCE OF MECHANISMS OF ARSENIC INDUCED BLADDER CANCER BY GENE EXPRESSION. |
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Arsenic is a human carcinogen that induces urinary bladder cancer. Several mechanisms have been proposed for arsenic-induced cancer. Although inorganic arsenic (iAs) does not induc...
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IMMUNOHISTOCHEMICAL DETECTION OF TUMOR-ASSOCIATED ALDEHYDE DEHYDROGENASE IN FORMALIN-FIXED RAT AND MOUSE NORMAL LIVER AND HEPATOMAS |
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This paper describes a method and the results from the immunohistochemical (IHC) detection of tumor-associated isozyme of aldehyde dehydrogenase (B-ALDH). he method can be used to ...
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IN VIVO AND IN VITRO CHARACTERISTICS OF EARLY CARCINOGEN-INDUCED PREMALIGNANT PHENOTYPES IN CULTURED RAT TRACHEAL EPITHELIAL CELLS (JOURNAL VERSION) |
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The initial stages of neoplastic transformation in respiratory tract epithelial cells were defined and studied by characterizing a series of morphologically transformed cell coloni...
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INCORPORATION OF MOLECULAR ENDPOINTS INTO QUANTITATIVE RISK ASSESSMENT |
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The U.S. Environmental Protection Agency has recently released its Guidelines for Carcinogen Risk Assessment. These new guidelines benefit from the significant progress that has be...
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INCREASED OGG1 EXPRESSION IN PERIPHERAL BLOOD CELLS OF THE INDIVIDUALS EXPOSED TO ARSENIC-CONTAMINATED WATER |
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Arsenic, a human carcinogen, is known to induce oxidative stress and DNA damage in human cells. The aims of this study are (1) to determine gene expression of an oxidative stress-...
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INDOOR AIR - ASSESSMENT - METHODS FOR ANALYSIS FOR ENVIRONMENTAL CARCINOGENS |
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This monograph describes, in a general way, published sampling procedures and analytical approaches for known and suspected carcinogens. he primary focus is upon carcinogens found ...
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INDOOR AIR ASSESSMENT - INDOOR CONCENTRATIONS OF ENVIRONMENTAL CARCINOGENS |
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In this report, indoor concentration data are presented for the following general categories of air pollutants: adon-222, environmental tobacco smoke (ETS), asbestos, gas phase org...
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INDOOR AIR EXPOSURE TO COAL AND WOOD COMBUSTION EMISSIONS IN XUAN WEI, CHINA, WITH A HIGH LUNG CANCER RATE |
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Residents of Xuan Wei County in China have unusually high lung cancer mortality that cannot be attributed to tobacco use or occupational exposure. hey are exposed to smoke from unv...
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INDUCED AND SPONTANEOUS NEOPLASIA IN ZEBRAFISH. |
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To address the potential of zebrafish as a cancer model, it is important to determine the susceptibility of zebrafish to tumors, and to compare zebrafish tumors with human tumors. ...
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INDUCTION OF ANCHORAGE-INDEPENDENT GROWTH IN HUMAN DIPLOID FIBROBLASTS BY THE CYCLOPENTA-POLYCYCLIC AROMATIC HYDROCARBON, BENZ(1)ACEANTHRYLENE |
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Cyclopenta-fused polycyclic aromatic hydrocarbons are a class of environmental PAH that has been recently identified. any of these chemicals have been found to be more active that ...
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INDUCTION OF CELL PROLIFERATION AND APOPTOSIS IN HL60 AND HACAT CELLS BY ARSENIC, ARSENATE, AND ARSENIC-CONTAMINATED DRINKING WATER |
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Induction of cell proliferation and apoptosis in HL-60 and HaCaT cells by arsenite, arsenate and arsenic-contaminated drinking water. T-C. Zhang, M. Schmitt, J. L. Mumford National...
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INDUCTION OF DNA-PROTEIN CROSSLINKS BY THE METABOLISM OF DICHLOROMETHANE IN V79 CELL LINES TRANSFECTED WITH THE MURINE GLUTATHIONE-S-TRANSFERASE THETA 1 GENE |
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Dichloromethane (DCM) is considered a probable human carcinogen. Laboratory studies have shown an increased incidence of lung and liver cancer in mice but not in rats or hamsters. ...
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INDUCTION OF GASTROINTESTINAL TRACT NUCLEAR ANOMALIES IN B6C3F1 MICE BY 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2-(5H)-FURANONE, MUTAGENIC BYPRODUCTS OF CHLORINE DISINFECTION |
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Two chlorinated hydroxylated furanones, 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) and 3,4-(dichloro)-5-hydroxy-2[5H]-furanone (MA), potent bacterial mutagens and by...
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INDUCTION OF SKIN PAPILLOMAS IN THE SENCAR MOUSE AS A TIER 2 CARCINOGENESIS BIOASSAY |
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The Toxic Substances Control Act mandates the testing of industrial chemicals for which insufficient evidence of safety exists. One of the more critical areas in chemical carcinoge...
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INFLUENCE OF METHYL TERT-BUTYL ETHER (MTBE) ON LAKE WATER ALGAE |
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Methyl tert-butyl ether (MTBE) has been used as an octane booster in gasoline in the United States since the 1970s. MTBE use increased greatly in the 1990s with the implementation ...
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INFLUENCE OF METHYL TERT-BUTYL ETHER (MTBE) ON LAKE WATER ALGAE: JOURNAL ARTICLE |
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NRMRL-ADA-01209
Kampbell*, D.H., An, Y, and Williams, VR. Influence of Methyl tert-Butyl Ether (MTBE) on Lake Water Algae. Bulletin of Env...
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INHIBITION OF BENZO(A)PYRENE-INDUCED TRANSFORMATION OF C3H/10T1/2 CELLS BY ALLYLISOPROPYLACETAMIDE AND ISOPROPYLVALERAMIDE |
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Allylisopropylacetamide (AIA) and isopropylvaleramide (IVA) have been demonstrated previously to protect in vivo against the acute toxicity and adrenal necrotic effect of 7, 12-dim...
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INHIBITION OR ENHANCEMENT OF MORPHOLOGICAL TRANSFORMATION OF C3H10T1/2CL BY MULTIPLE CARCINOGEN TREATMENT |
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C3H10Tl/2CL8 cells treated on the first day after seeding with benzo(a)pyrene [B(a)P] and than treated again with B(a)P displayed an enhanced or inhibited response of morphological...
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INTEGRATED QUANTITATIVE CANCER RISK ASSESSMENT OF INORGANIC ARSENIC |
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This paper attempts to make an integrated risk assessment of arsenic, using data on humans exposed to arsenic via inhalation and ingestion. he data useful for making an integrated ...
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INTERACTIONS OF HEAVY METALS WITH THE PULMONARY METABOLISM OF (3H)BENZO(A)PYRENE |
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To test the hypothesis that the inhalation of heavy metal aerosols from polluted air or cigarette smoke could alter the metabolism of polycyclic aromatic hydrocarbons, isolated, ve...
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INTERPRETATION OF THE CANCER RESPONSE TO POTENTIAL RENTAL CARCINOGENS IN THE TSC2 KNOCKOUT (EKER) RAT IS DEPENDENT ON LENGTH OF TREATMENT. |
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INTERPRETATION OF THE CANCER RESPONSE TO POTENTIAL RENAL CARCINOGENS IN THE TSC2 KNOCKOUT (EKER) RAT IS DEPENDENT ON LENGTH OF TREATMENT.
Genetically increasing the functio...
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INTRODUCTION TO A SERIES OF U.S. ENVIRONMENTAL PROTECTION AGENCY SPECIAL COMMITTEE REPORTS ON TESTING APPROACHES FOR THE DETECTION OF CHEMICALLY INDUCED ANEUPLOIDY |
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A committee of scientists was established by the U.S. Environmental Protection Agency to appraise the current state of aneuploidy test methodology, to compile and analyze published...
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INVADING AND METASTASIZING CARDIAC HEMANGIOENDOTHELIAL NEOPLASMS IN A COHORT OF THE FISH RIVULUS MARMORATUS: UNUSUALLY HIGH PREVALENCE, HISTOPATHOLOGY, AND POSSIBLE ETIOLOGIES |
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An unusually high, unprecedented prevalence of cardiac hemangioendotheliosarcomas (HES) and hemangioendotheliomas (HE) was found in a cohort of the small, teleost fish Rivulus marm...
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INVESTIGATIONS INTO THE GC/MS DECOMPOSITION OF TRIBROMONITROMETHANE IN DRINKING WATER DISINFECTION BY-PRODUCT ANALYSIS |
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Tribromonitromethane (bromopicrin) has been found to be a disinfection by-product (DBP) in
chlorinated1 and ozonated2 drinking water, and is structurally similar to dibromonitro...
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INVESTIGATIONS INTO THE MODE OF ACTION (MOA) OF ARSENIC USING THE SINGLE CELL GEL (SCG) ASSAY AND CYTOGENETICS |
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Arsenic is a globally important pollutant found in the air, food, and in many water systems causing significant human exposure and in some cases illness. While there is no doubt th...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR ACETALDEHYDE (EXTERNAL REVIEW DRAFT) |
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There is some concern that the ambient level of acetaldehyde is likely to increase should ethanol be substituted for MTBE in reformulated gasoline (RFG). Re-evaluation of acetaldeh...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR ACETONE (EXTERNAL REVIEW DRAFT) |
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Acetone is produced endogenously in the human body, although usually under conditions of stress such as starvation or high levels of exertion. Acetone is also produced syntheticall...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR ACROLEIN (EXTERNAL REVIEW DRAFT) |
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Acrolein is a colorless to yellowish flammable liquid with a disagreeable, choking odor. The principal use of acrolein is as an intermediate in the synthesis of acrylic acid, whic...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR CHLOROETHANE (EXTERNAL REVIEW DRAFT) |
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Chloroethane (CE) is a gaseous halohydrocarbon under ambient conditions. Its uses include: a topical analgesic, an anesthetic when mixed with nitrous dioxide or trichloroethane, a ...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR ETHYLENE OXIDE'S CARCINOGENICITY |
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The known carcinogenic effects of ethylene oxide will be summarized, with citations from current scientific literature. A hazard characterization consisting of a weight-of-evidenc...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR FORMALDEHYDE |
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Formaldehyde (HCHO) is a pungent and irritating gas with extensive uses in industrial processes and manufacturing of consumer products. Both natural and anthropogenic mechanisms r...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR VINYL CHLORIDE (EXTERNAL REVIEW DRAFT) |
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The Draft Toxicological Review was developed to evaluate both the cancer and non cancer human health risks from environmental exposure to vinyl chloride. A reference concentration ...
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IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR XYLENES (EXTERNAL REVIEW DRAFT) |
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This draft assessment is a reevaluation of the toxicity of mixed xylenes. Mixed xylenes consists of the three isomers of xylenes and commonly contains ethylbenzene. Xylenes expos...
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IS 1,4-DIOXANE A GENOTOXIC CARCINOGEN? |
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Linear models of risk assessment may be appropriate for chemicals that are initiators of carcinogenesis while threshold models of risk assessment have been proposed for promoters. ...
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IS GENOTOXICITY A POTENTIAL MODE OF ACTION FOR THE CARCINOGENICITY OF BROMATE |
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The EPA Office of Drinking Water is currently performing a risk assessment analysis of bromate, an ozonation disinfection by-product. Possible exposure to chlorination disinfection...
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IS INHALED ARSENIC CARCINOGENIC FOR SITES OTHER THAN THE LUNG? |
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The carcinogenic risk from inhaled arsenic for sites other an the lung is discussed. Data from persons ingesting arsenic as well as from persons inhaling arsenic are considered in ...
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KIDNEY TOXICOGENOMICS OF CHRONIC POTASSIUM BROMATE EXPOSURE IN F344 MALE RAT |
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Potassium bromate (KBrO3), used in both the food and cosmetics industry, and a drinking water disinfection by-product, is a nephrotoxic compound and rodent carcinogen. To gain insi...
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LABORATORY EVALUATION OF MARINE FISHES AS CARCINOGEN ASSAY SUBJECTS |
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The U.S. Environmental Protection Agency (EPA) and the National Cancer Inst. (NCI) have major responsibilities for determining the fate and risks of carcinogenic agents in the natu...
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LACK OF DNA SINGLE STRAND BREAKS IN A LUNG EPITHELIAL CELL LINE AFTER EXPOSURE TO ARSENIC |
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Arsenic (As) is a carcinogen whose most important target organs include the skin and lungs. Exposure can occur via water ingestion, or inhalation, as As is a by-product of fossil f...
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LACK OF INITIATING AND/OR PROMOTING ACTIVITY OF SODIUM MALONDIALDEHYDE ON SENCAR MOUSE SKIN |
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Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis in part for its reported mutagenic activity. It was of interest therefore, to determine i...
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LACK OF LIVER MUTATIONS IN MEDAKA EXPOSED TO MX |
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Mutagenicity assays with Salmonella have shown that 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX), a drinking water disinfection by-product is a potent mutagen, account...
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LARGE SCALE CARCINOGEN DOSE RESPONSE STUDIES WITH JAPANESE MEDAKA (ORYZIAS LATIPES) |
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To investigate the responses to low carcinogen doses in animal models, large sample sizes are needed and it is an advantage if the model has a low spontaneous tumor rate. Three lar...
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LUNG CANCER AND INDOOR EXPOSURE OF UNVENTED COAL AND WOOD COMBUSTION EMISSIONS IN XUAN WEI, CHINA |
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Residents of Xuan Wei County in China have unusually high lung cancer mortality that cannot be attributed to tobacco use or occupational exposure. They are exposed to smoke from un...
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LUNG TUMOR INDUCTION IN STRAIN A MICE WITH BENZOTRICHLORIDE (JOURNAL VERSION) |
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Benzotrichloride (BTC) is used in the synthesis of benzoyl chloride and benzoyl peroxide. Epidemiological data suggest that BTC is a human lung carcinogen. In the present study, BT...
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Low dose-response for benzo[a]pyrene induced stable DNA adducts and gene expression in strain A/J mouse lung |
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Benzo[a]pyrene (B[a]P) is a potent human and rodent lung carcinogen. The current EPA cancer risk assessment of B[a]P assumes that the risk posed by low level e...
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MAMMARY GLAND DEVELOPMENT: EARLY LIFE EFFECTS FROM THE ENVIRONMENT |
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Mammary Gland Development: Early Life Effects from the Environment
S.E. Fenton. Reproductive Toxicology Division, National Health and Environmental Effects Laboratory, ORD,...
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MEASUREMENT OF EXHALED BREATH AND VENOUS BLOOD TO DEVELOP A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR HUMAN EXPOSURE TO METHYL TERTIARY-BUTYL ETHER AND THE PRODUCTION OF THE BIOMARKER TERTIARY-BUTYL ALCOHOL |
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Methyl tertiary-butyl ether (MTBE) is a common fuel additive used to increase the availability of oxygen in gasoline to reduce winter-time carbon monoxide emissions from automobi...
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MECHANISMS OF DMN-INDUCED HEPATIC PRENEOPLASIA IN MEDAKA |
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Dimethylnitrosamine (DMN), a known carcinogen and hepatotoxin, is capable of inducing tumors in a variety of tissues and is used in a rodent model of human alcoholic cirrhosis. DMN...
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METABOLITES OF A TOBACCO-SPECIFIC LUNG CARCINOGEN IN THE URINE OF ELEMENTARY SCHOOL-AGED CHILDREN. (R825813) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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METABOLITES OF A TOBACCO-SPECIFIC LUNG CARCINOGEN IN THE URINE OF ELEMENTARY SCHOOL-AGED CHILDREN. (R826789) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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METABOLSM OF PENTAVALENT AND TRIVALENT DIMETHYLARSENIC ARSENIC IN THE MOUSE |
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Dimethylarsinic acid (DMA(V)) is a rat bladder carcinogen after chronic exposure in either drinking water or the diet. DMA(V) is also a major urinary metabolite of mammals exposed...
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METHOD 529, DETERMINATION OF EXPLOSIVES AND RELATED COMPOUNDS IN DRINKING WATER BY SOLID PHASE EXTRACTION AND CAPILLARY COLUMN GAS CHROMATOGRAPHY/MASS SPECTROMETRY |
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Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a military explosive which is known to have contaminated groundwater on and near military installations where it has been used and ...
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METHOD DEVELOPMENT FOR THE ANALYSIS OF N-NITROSODIMETHYLAMINE AND OTHER N-NITROSAMINES IN DRINKING WATER AT LOW NANOGRAM/LITER CONCENTRATIONS USING SOLID PHASE EXTRACTION AND GAS CHROMATOGRAPHY WITH CHEMICAL IONIZATION TANDEM MASS SPECTROMETRY |
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N-Nitrosodimethylamine (NDMA) is a probable human carcinogen that has been identified as a drinking water contaminant of concern. United States Environmental Protection Agency (US...
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METHODOLOGY FOR EVALUATING POTENTIAL CARCINOGENICITY IN SUPPORT OF REPORTABLE QUANTITY ADJUSTMENTS PURSUANT TO CERCLA SECTION 102 |
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The Agency's Human Health Assessment Group (HHAG) has developed a methodology for ranking CERCLA hazardous substances for the purpose of establishing reportable quantities (RQs) ba...
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METHODS FOR EMERGING CONTAMINANT GROUPS: EXPLOSIVES AND NITROSAMINES |
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Background
In support of requirements in the Safe Drinking Water Act, the National Exposure Research Laboratory (NERL), has been developing analytical methods for chemicals on t...
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METHODS FOR THE RECOVERY OF ORGANIC CARCINOGENS FROM WATER |
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The organic carcinogens benzo(a)pyrene, dieldrin, and N-acetyl-2-aminofluorene were recovered on XAD-2 macroreticular resin in yields of 90 percent or more from distilled water or ...
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METHYLATED TRIVALENT ARSENICALS AS CANDIDATE ULTIMATE GENOTOXIC FORMS OF ARSENIC: INDUCTION OF CHROMOSOMAL MUTATIONS BUT NOT GENE MUTATIONS |
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ABSTRACT
Arsenic is a prevalent human carcinogen whose mutagenicity has not been characterized fully. Exposure to either form of inorganic arsenic, AsIII or AsV, can result in...
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MICROINJECTION OF FISH EMBRYOS AS A LABORATORY ASSAY FOR CHEMICAL CARCINOGENS |
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Techniques were developed for microinjection of chemicals into fish embryos for use in carcinogenicity assays. Eggs of the following were injected: gulf killifish (Fundulus grandis...
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MINI REVIEW - EPIGENETIC PROCESSES AND CANCER RISK ASSESSMENT |
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Abstract: The U.S. Environmental Protection Agency's Guidelines for Carcinogen Risk Assessment encourages the use of mechanistic data in the assessment of human cancer risk at low ...
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MOLECULAR PROCESSES IN CELLULAR ARSENIC METABOLISM |
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Elucidating molecular processes that underlie accumulation, metabolism, and binding of iAs and its methylated metabolites provides a basis for understanding the modes of action by ...
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MORPHOLOGIC ANALYSIS CORRELATES WITH GENE EXPRESSION CHANGES IN CULTURED F344 RAT MESOTHELIAL CELLS |
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The gene expression pattern of mesothelial cells in vitro was determined after 4 or 12 h exposure to the rat mesothelial, kidney and thyroid carcinogen, and oxidative stressor pota...
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MOUSE SKIN TUMORIGENICITY STUDIES OF INDOOR COAL AND WOOD COMBUSTION EMISSIONS FROM HOMES OF RESIDENTS IN XUAN WEI, CHINA WITH HIGH LUNG CANCER MORTALITY |
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The rural Xuan Wei County, Yunnan Province, China, has an unusually high lung cancer mortality rate that cannot be attributed to tobacco smoke or occupational exposure. he lung can...
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MULTI-FACTOR POTENCY SCHEME FOR COMPARING THE CARCINOGENIC ACTIVITY OF CHEMICALS |
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A scheme for ranking the quantitative activity `of chemical carcinogens is described. his activity scheme uses as its base, dose potency measured as TD50, which after conversion in...
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MULTI-FACTOR RANKING SCHEME FOR COMPARING THE CARCINOGENIC ACTIVITY OF CHEMICALS |
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A scheme for ranking the quantitative activity of chemical carcinogens is described. his activity scheme uses as its base, dose potency measured as TD50, the chronic dose rate that...
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MULTIPLE-SITE CARCINOGENICITY OF BENZENE IN FISCHER 344 RATS AND B6C3F MICE |
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Two-year toxicology and carcinogenesis studies of benzene were conducted in groups of 50 F344/N rats and 50 B6C3F1 mice of each sex and for each of three exposure doses and vehicle...
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MUTAGENIC AND CARCINOGENIC POTENCY OF EXTRACTS OF DIESEL AND RELATED ENVIRONMENTAL EMISSIONS: TWO-STAGE CARCINOGENESIS IN SKIN TUMOR SENSITIVE MICE (SENCAR) |
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Skin tumors can be induced by the sequential application of a subthreshold dose of a carcinogen (initiation phase), followed by repetitive treatment with a noncarcinogenic tumor pr...
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MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1,3-BUTADIENE |
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1,3-Butadiene has been shown to be an indirect mutage in bacteria. Two of its potential metabolites, 3,4- epoxybutene and diepoxybutane, are genotoxic in prokaryote as well as euka...
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MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1,3-BUTADIENE. REVIEW DRAFT |
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The Mutagenicity and Carcinogenicity Assessment of 1,3-Butadiene was prepared to serve as a source document for Agency-wide use. In the development of this assessment document, the...
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MUTAGENICITY AND CARCINOGENICITY OF COMPLEX COMBUSTION EMISSIONS:EMERGING MOLECULAR DATA TO IMPROVE RISK ASSESSMENT |
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The dichloromethane-extractable particulate organics of various combustion emissions, as well as urban air, have been evaluated for their ability to induce mutations in Salmonella ...
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MUTAGENICITY OF 7H-DIBENZO(C,G)CARBAZOLE AND METABOLITES IN SALMONELLA TYPHIMURIUM |
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7H-Dibenzo(c,g)carbazole (DBC) is a potent carcinogen of environmental import. Reverse-mutation plate-incorporation assays for mutagenicity were undertaken in Salmonella typhimuriu...
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MUTAGENICITY, CARCINOGENICITY, AND HUMAN CANCER RISK FROM INDOOR EXPOSURE TO COAL AND WOOD COMBUSTION IN XUAN WEI, CHINA |
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The residents in Xuan Wei County, China, have been exposed to high levels of combustion emissions from smoky and smokeless coal and wood combustion under unvented conditions in hom...
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MUTATION AND ENHANCED VIRUS TRANSFORMATION OF CULTURED HAMSTER CELLS BY EXPOSURE TO GASEOUS ETHYLENE OXIDE |
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Ethylene oxide is a classical mutagen and a carcinogen based on evidence from studies in experimental animals. It is widely distributed in industrial, research, hospital, and food ...
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MUTATION SPECTRA IN SALMONELLA OF SUNLIGHT, WHITE FLUORESCENT LIGHT, AND LIGHT FROM TANNING SALON BEDS: INDUCTION OF TANDEM MUTATIONS AND ROLE OF DNA REPAIR |
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We evaluated the mutagenicity of sunlight (SUN), uncovered cool white fluorescent light (FLR), and light from a tanning salon bed (TAN) at the base-substitution allele hisG46 of Sa...
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MUTATION SPECTRUM OF A BINARY MIXTURE OF MUTAGENS (METHAPYRILENE AND SODIUM AZIDE) IN STRAIN TA1535 OF SALMONELLA |
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Methapyrilene (MP) is a rat-liver carcinogen and cocarcinogen that exhibits a narrow spectrum of mutagenic activity in Salmonella, inducing only a 2-fold increase in revertants onl...
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MUTATIONS IN THE VHL GENE FRIOM POTASSIUM BROMATE-INDUCED RAT CLEAR CELL RENAL TUMORS |
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Potassium bromate (KBrO3) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common fo...
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MX, A DRINKING WATER CARCINOGEN, DOES NOT INDUCE MUTATIONS IN THE LIVER OF CII TRANSGENIC MEDAKA |
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MX, a drinking water carcinogen, does not induce mutations in the liver of cII transgenic medaka
Geter, DR; Winn, RN; Fournie, JW; Norris, MB; DeAngelo, AB; and Hawkins, WE
<...
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MX-INDUCED URINARY BLADDER EPITHELIAL HYPERPLASIA IN EKER RATS |
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MX-INDUCED URINARY BLADDER EPITHELIAL HYPERPLASIA IN EKER RATS
Epidemiological studies have shown a positive association between chronic exposure to chlorinated drinking wa...
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Mechanistic Investigation of the Non-Cytochrome P450 Mediated Metabolism of Triadimefon and Implications for Toxicity |
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Triazole containing compounds have been used for decades as agricultural and medicinal fungicides. Recently, emphasis has been placed on the potential adverse effects of these com...
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NHEERL RESEARCH ON CARCINOGENIC CONTAMINANTS IN DRINKING WATER |
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Water research in the Environmental Carcinogenesis Division focuses on improved understanding of the mechanisms of mutagenesis and carcinogenesis of water contaminants for incorpor...
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NITROBENZENE CARCINOGENICITY |
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Nitrobenzene (NB, CAS No. 98-95-3) oxidizes to p-aminophenol and p-nitrophenol in animals and humans, while being reduced also to nitrosobenzene, phenylhydroxylamine, and aniline. ...
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OCCURRENCE OF METYL TERT-BUTYL ETHER (MTBE) AT FIVE MARINAS IN LAKE TEXOMA |
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Occurrence of methyl tert-butyl ether (MTBE) in five marinas was monitored between June 1999 and November 2000 in Lake Texoma located on the border of Oklahoma and Texas. M...
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OCCURRENCE, GENOTOXICITY, AND CARCINOGENICITY OF EMERGING DISINFECTION BY-PRODUCTS IN DRINKING WATER: A REVIEW AND ROADMAP FOR RESEARCH |
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Occurrence, Genotoxicity, and Carcinogenicity of Emerging Disinfection By-products in Drinking Water: A Review and Roadmap for Research
Summary of Paper
What is study?...
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OCCURRENCE, GENOTOXICITY, AND CARCINOGENICITY OF EMERGING DISINFECTION BY-PRODUCTS IN DRINKING WATER: A REVIEW AND ROADMAP FOR RESEARCH |
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Disinfection by-products (DBPs) are formed when disinfectants (chlorine, ozone, chlorine dioxide, or chloramines) react with naturally occurring organic matter, anthropogenic conta...
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OPPORTUNITIES FOR APPLICATION OF TOXICOGENOMIC DATA IN RISK ASSESSMENT |
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Toxicogenomic data, in this caser transcriptional profiling, has been valuable in providing a deeper understanding of the cellular and molecular pathways that are altered in respon...
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OVERVIEW OF PROBLEMS AND UTILIZATION OF PATHOLOGY DATA FOR CARCINOGEN ASSESSMENT |
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Long-term animal tests, particularly in laboratory rodents, are referred to as bioassays. The animal bioassay is still the most commonly employed method for detecting potential hum...
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OXIDATIVE DNA DAMAGE AND REPAIR IN RATS TREATED WITH POTASSIUM BROMATE AND A MIXTUE OF DRINKING WATER DISINFECTION BY-PRODUCTS |
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Oxidative DNA Damage and Repair in Rats Treated with Potassium Bromate and a Mixture of Drinking Water Disinfection By-Products
Public drinking water treated with chemical ...
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OXIDATIVE DNA DAMAGE FROM POTASSIUM BROMATE EXPOSURE IN LONG-EVANS RATS IS NOT ENHANCED BY A MIXTURE OF DRINKING WATER DISINFECTION BY-PRODUCTS |
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Public drinking water treated with chemical disinfectants contains a complex mixture of disinfection by-products (DBPs) for which the relative toxicity of the mixtures needs to be ...
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P-NITROPHENOL AND GLUTATHIONE RESPONSE IN MEDAKA (ORYZIAS LATIPES) EXPOSED TO MX, A DRINKING WATER CARCINOGEN. |
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When chlorine is introduced into public drinking water for disinfection, it can react with organic compounds in surface waters to form toxic by-products such as 3-chloro-4- (dic...
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P-POSTLABELING ANALYSIS OF AROMATIC DNA ADDUCTS IN FISH FROM POLLUTED AREAS |
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Brown bullheads (Ictalurus nebulosus) were sampled from sites in the Buffalo and Detroit Rivers where fish are exposed to high levels of sediment bound polycyclic aromatic hydrocar...
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POTASSIUM BROMATE-INDUCED RAT CLEAR CELL RENAL TUMOR IS INDEPENDENT OF CODING REGION MUTATIONS IN THE VON HIPPEL- LINDAU GENE |
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Potassium bromate (KBr03) is a rat renal carcinogen and a major drinking water disinfection by-product from ozonization. While KBr03 is a human nephro- and neuro-toxicant, its carc...
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POTENTIAL ALTERATIONS IN GENE EXPRESSION ASSOCIATED WITH CARCINOGEN EXPOSURE IN MYA ARENARIA |
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Gonadal cancers in soft-shell clams (Mya arenaria) have been found at high prevalences (20-40%) in populations in eastern Maine. The aetiology of these tumours is unknown. We hypot...
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POTENTIAL ATMOSPHERIC CARCINOGENS, PHASE 1. IDENTIFICATION AND CLASSIFICATION |
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A comprehensive literature search identified more than 125 high-volume chemicals having the potential of becoming airborne carcinogenic pollutants. Based on carcinogenicity and mut...
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PRELIMINARY ANALYSIS OF CANCER RATES IN PRIMARY ORGANIC CHEMICAL-PRODUCING COUNTIES |
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The study is designed to determine whether there is an association between cancer mortality and the production of environmental carcinogens. Mortality rates of counties containing ...
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PRESENCE OF DICHLOROMETHANE ON CLEANED XAD-2 RESIN: A POTENTIAL PROBLEM AND SOLUTIONS |
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Preparation of XAD-2 resin for indoor air sampling with commonly used cleaning methods, such as Soxhlet extraction with dichloromethane (DCM) followed by vacuum drying and nitrogen...
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PRIMARY CELL CULTURES FROM THE TELEOST, 'CYPRINODON VARIEGATUS': CULTURE ESTABLISHMENT AND APPLICATION IN CARCINOGEN EXPOSURE STUDIES |
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Methods were developed for aseptic maintenance of Cyprinodon variegatus fry for extended periods. Preliminary studies indicated that under optimum conditions sterile embryos develo...
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PROBABILISTIC VIEW OF THE TRANSFORMATION OF CULTURED C3H/10T1/2 MOUSE EMBRYO FIBROBLASTS BY 3-METHYLCHOLANTHRENE (CELL TRANSFORMATION/CHEMICAL CARCINOGENISIS) |
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When C3H/10T1/2 cells are treated with a given concentration of a chemical carcinogen, the transformation frequency can vary over 4 orders of magnitude, depending primarily upon th...
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PROCEDURES FOR CALCULATING LAG |
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Environmental regulations aimed at reducing cancer risks usually have the effect of reducing exposure to a carcinogen at the time the regulation is implemented. The reduction of ca...
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PROCEEDINGS OF INTERNATIONAL SYMPOSIUM ON RECENT ADVANCES IN THE ASSESSMENT OF THE HEALTH EFFECTS OF ENVIRONMENTAL POLLUTION, HELD AT PARIS (FRANCE) ON 24-28 JUNE 1974. VOLUME IV |
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;Partial contents: The state of the art regarding the experimental investigations of the effects of pollutants; The assessment of environmental carcinogen risks in terms of life sh...
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PRODUCTION AND BIOLOGICAL SIGNIFICANCE OF METHYLATED TRIVALENT ARSENICALS |
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PRODUCTION AND BIOLOGICAL SIGNIFICANCE OF METHYLATED TRIVALENT ARSENICALS
Miroslav Styblo1,2,*, Zuzana Drobna1, Felecia S. Walton1, Ilona Jaspers1,2, Shan Lin3,
Stephen ...
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PROMOTION BY 17BETA-ESTRADIOL AND BETA-HEXACHLOROCYCLOHEXANE OF HEPATOCELLULAR TUMORS IN MEDAKA, ORYZIAS LATIPES. (R825298) |
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AbstractA feature common to many laboratory and field studies with various fish species is a higher prevalence of hepatocellular neoplasia in females than in males. Dur...
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PROPOSED CARCINOGENIC MECHANISMS FOR ARSENIC |
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PROPOSED CARCINOGENIC MECHANISMS FOR ARSENIC.
Arsenic is a human carcinogen in skin, lung, liver, urinary bladder and kidney. In contrast,
there is no accepted experime...
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PROPOSED GUIDELINES FOR CARCINOGEN RISK ASSESSMENT |
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The Proposed Guidelines for Carcinogen Risk Assessment were published in the Federal Register on April 23, 1996 (Federal Register: 17960-18011) for a 120-day public review and com...
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QUANTITATIVE AND TEMPORAL RELATIONSHIPS BETWEEN DNA ADDUCT FORMATION IN TARGET AND SURROGATE TISSUES: IMPLICATIONS FOR BIOMONITORING |
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DNA-carcinogen adducts offer a potential dosimeter for environmental genotoxicants reaching the exposed individual. ecause the target tissues for many chemical carcinogens are not ...
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QUANTITATIVE EVALUATION OF PUTATIVE HUMAN CARCINOGENS AND RELATED CHEMICALS ON HUMAN FORESKIN FIBROBLASTS |
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We have evaluated 12 compounds representative of diverse classes of chemicals for their cytotoxicity and transforming ability of human skin fibroblasts in vitro in the presence and...
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QUANTITATIVE TOXICOPROTEOMIC ANALYSIS OF CARCINOGEN-TREATED ANIMAL TISSUES AND HUMAN CELLS FOR HUMAN HEALTH RISK ASSESSMENT |
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Humans are exposed to a variety of environmental toxicants, and this together with a large number of interacting factors can contribute to an individual's risk for health. To under...
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RAINBOW TROUT EMBRYOS: ADVANTAGES AND LIMITATIONS FOR CARCINOGENESIS RESEARCH |
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Rainbow trout embryos are sensitive to the initiation of neoplasms in various tissues by brief exposures to solutions of water-soluble carcinogens. This characteristic was first de...
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RAT LIVER SUBCELLULAR FRACTIONS CATALYZE AEROBIC BINDING OF 1-NITRO((SUP 14)C)PYRENE TO DNA (DEOXYRIBONUCLEIC ACIDS) |
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The recently characterized environmental mutagen and potential carcinogen 1-nitropyrene (NP) is known to bind to DNA in Salmonella typhimurium, and also in anaerobic incubations ca...
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RAT TRACHEAL CELL CULTURE TRANSFORMATION SYSTEM FOR ASSESSMENT OF ENVIRONMENTAL AGENTS AS CARCINOGENS AND PROMOTERS |
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A tracheal cell culture system which can be used for detection of hazardous environmental agents is described. The culture system makes use of primary tracheal cells that are isola...
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REGULATORY PERSPECTIVE ON MANAGING RISKS AT WOOD TREATING SITES |
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Over 700 sites in the United States have been identified where wood preserving operations have been conducted. The most common types of wood preservatives found at these sites are...
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REMEDIATION OF SITES CONTAMINATED WITH TCE |
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Widespread use of trichloroethylene (TCE) in the U.S. has resulted in its frequent detection in soil and groundwater. CE can become a health hazard after being processed in the hum...
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REPORT ON THE WORKSHOP ON CANCER RISK ASSESSMENT GUIDELINES ISSUES |
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This report highlights issues and conclusions from an EPA Risk Assessment Forum and Office of Health and Environmental Assessment (OHEA) sponsored workshop on reviewing the Agency'...
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RESPIRATORY HEALTH EFFECTS OF PASSIVE SMOKING (ALSO KNOWN AS EXPOSURE TO SECONDHAND SMOKE OR ENVIRONMENTAL TOBACCO SMOKE - ETS) |
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In 1992, the EPA completed its risk assessment on The Respiratory Health Effects of Passive Smoking: Lu...
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RESPIRATORY HEALTH EFFECTS OF PASSIVE SMOKING: LUNG CANCER AND OTHER DISORDERS |
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This draft report addresses the weight of evidence on the potential associations between passive smoking or Environmental Tobacco Smoke (ETS) and (1) lung cancer in nonsmoking adul...
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RESPONSE TO ISSUES AND DATA SUBMISSIONS ON THE CARCINOGENICITY OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE) |
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The scientific debate over the potential carcinogenicity of tetrachloroethylene (perchloroethylene, perc, PCE) spans several years. his document reviews the issues considered by th...
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RESPONSE TO KLAUNIG, J.E. ET AL, EPIGENETIC MECHANISMS OF CHEMICAL CARCINOGENESIS |
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The article by Klaunig et al. is a comprehensive review of the general principles underlying the induction of tumors by epigenetic mechanisms. The review describes the roles of cel...
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RETINOIDAL BENZOIC ACIDS (AROTENOIDS) AND OTHER RETINOIDS INHIBIT IN VITRO TRANSFORMATION OF EPITHELIAL CELLS |
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Five retinoids were calcluated for their ability to inhibit N-methyl-N'nitro-N-nitrosoguanidine (MNNG)-induccd transformation of primary rat trachcal epithelial (RTE) cells in cult...
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RHABDOMYOSARCOMA IN THE JAPANESE MEDAKA, 'ORYZIAS LATIPES' (TEMMINCK AND SCHLEGEL) AND GUPPY, 'POECILIA RETICULATA' PETERS (JOURNAL VERSION) |
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Three cases of skeletal muscle neoplasms occurring in two small fish species used in carcinogen tests are reported. The cases illustrated a wide range of histologic patterns includ...
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RISK ASSESSMENT ON (2,4,5-TRICHLOROPHENOXY) ACETIC ACID (2,4,5-T), (2,4,5-TRICHLOROPHENOXY) PROPIONIC ACID, 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) |
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Carcinogenic responses have been induced in mice and rats at low doses of TCDD. TCDD has been shown to be a cancer promoter. These results, together with the strongly suggestive ev...
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SENSITIVITY, SPECIFICITY AND ACCURACY OF THE ARABIDOPSIS ASSAY IN THE IDENTIFICATION OF CARCINOGENS |
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The paper compares the sensitivity, specificity and accuracy of Arabidopsis multilocus assay with several other in vitro and in vivo bioassays. Sensitivity was defined as a percent...
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SEROLOGICAL ALTERATIONS IN CARCINOGEN-EXPOSED TELEOSTS: PROCEDURES FOR PREPARATION AND ANALYSIS OF SAMPLES FROM SMALL FISH |
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To study the effects of environmental carcinogens on the immune system of Cyprinodon variegatus, the authors had to miniaturize or modify standard immunological procedures due to t...
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SOME IMPLICATIONS OF TOXICOLOGY AND PHARMACOKINETICS FOR EXPOSURE ASSESSMENT |
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In assessing adverse health risks from exposure to potential carcinogens, the usual practice is to use cumulative amount or total exposure received over a lifetime as the measure o...
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SOME INSIGHTS INTO THE MODE OF ACTION OF BUTADIENE BY EXAMINING THE GENOTOXICITY OF ITS METABOLITES |
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1,3-Butadiene (BTD) is an important commodity chemical and air pollutant that has been shown to be a potent carcinogen in mice, and to a lesser extent, a carcinogen in rats. To bet...
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SPECIAL REPORT ON INGESTED INORGANIC ARSENIC |
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Arsenic exposure has long been associated with several different forms of human cancer. The association between inhaled arsenic and an elevated risk of lung cancer is well docum...
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SPECIAL REPORT ON INGESTED INORGANIC ARSENIC: SKIN CANCER; NUTRITIONAL ESSENTIALITY |
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A Technical Panel of the U.S. Environmental Protection Agency's Risk Assessment Forum has studied three special issues regarding certain health effects, particularly skin cancer, a...
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STATUS ASSESSMENT OF TOXIC CHEMICALS: BENZIDINE |
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The properties, sources, production processes, and uses of benzidine are reviewed in the report. Benzidine is a proven human carcinogen, and its widespread use as a dye intermediat...
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STUDIES ON THE METABOLISM OF 6-NITROCHRYSENE AND THE FORMATION OF DNA ADDUCTS IN THE LIVER, LUNG AND BLADDER OF A/J MICE |
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Studies On The Metabolism of 6-Nitrochrysene and The Formation of DNA Adducts in the Liver, Lung and Bladder ofAJJ Mice
Moses McDaniel*, Linda Adamst, Joycelyn Allisont, ...
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STUDY OF THE EFFECT OF WHOLE ANIMAL EXPOSURE TO ACID MISTS AND PARTICULATES ON THE PULMONARY METABOLISM OF BENZO(A)PYRENE IN THE ISOLATED PERFUSED LUNG MODEL |
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Lung cancer represents the highest single cause of cancer deaths in the U.S. Epidemiological and experimental evidence indicates that the interplay of multiple environmental factor...
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SUMMARY REVIEW OF HEALTH EFFECTS ASSOCIATED WITH MERCURIC CHLORIDE: HEALTH ISSUE ASSESSMENT |
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Mercuric chloride (HgCl2) is a white crystalline substance that is currently used as a catalyst or reagent in various chemical reactions, and to a lesser extent as a disinfectant o...
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SUMMARY REVIEW OF THE HEALTH EFFECTS ASSOCIATED WITH PROPYLENE: HEALTH ISSUE ASSESSMENT |
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Propylene's major use is as a starting material in the manufacture of polypropylene, acrylonitrile, propylene oxide, and as a component in fuel. Ambient concentrations in urban are...
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SUPPLEMENTAL GUIDANCE FOR ASSESSING CANCER SUSCEPTIBILITY FROM EARLY-LIFE EXPOSURE TO CARCINOGENS (EXTERNAL REVIEW DRAFT) |
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The Draft Final Guidelines for Carcinogen Risk Assessment, also issued today for comment, expl...
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SYNTHESIS, IN VITRO METABOLISM, CELL TRANSFORMATION, MUTAGENICITY, AND DNA ADDUCTION ON NAPHTHO[1,2-A]PYRENE |
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Polycyclic aromatic hydrocarbons (PAHs ) are ubiquitous environmental pollutants. Due to its structural similarity with the potent carcinogen dibenzo[a,l]pyrene (DB[a,l]P) ...
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TCE REMOVAL FROM CONTAMINATED SOIL AND GROUND WATER |
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Widespread use of trichloroethylene (TEE) in the U.S. has resulted in its frequent detection in soil and groundwater. EE can become a health hazard after being processed in the hum...
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THE AMERICAN OYSTER ('CRASSOSTREA VIRGINICA') AS AN INDICATOR OF CARCINOGENS IN THE AQUATIC ENVIRONMENT |
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The American oyster (C. virginica) was used as the experimental animal for chronic exposure to 3-methylcholanthrene (3-MC) and benzo(a)pyrene (BP) in an exposure system in which th...
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THE APPLICATION OF COMPUTATIONAL MOLECULAR METHODS TO UNDERSTAND THE HEALTH EFFECTS OF ENVIRONMENTAL CHEMICALS-POLYCYCLIC AROMATIC HYDROCARBONS |
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In evaluating the risk posed by chemicals introduced into the environment, information
about their molecular mechanism of action provides a basis for extrapolating from the<...
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THE CARCINOGEN ASSESSMENT GROUP'S FINAL RISK ASSESSMENT ON ARSENIC |
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An estimate of the potential cancer hazard to populations exposed to airborne arsenic is given. Data analyzed are from occupational studies, estimates of ambient exposure and the n...
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THE CELLUAR METABOLISM OF ARSENIC |
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Because the methylation of arsenic produces intermediates and terminal products that exceed inorganic arsenic in potency as enzyme inhibitors, cytotoxins, and genotoxins, the methy...
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THE CELLULAR METABOLISM AND SYSTEMIC TOXICITY OF ARSENIC |
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Abstract
Toxic Consequences of the Metabolism of Arsenic. David J. Thomas, Miroslav Styblo, and Shan Lin. (2001). Toxicol. Appl. Pharmacol. 000, xxx-yyy.
Although it h...
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THE COMBINED CARCINOGENIC RISK FOR EXPOSURE TO MIXTURES OF DRINKING WATER DISINFECTION BY-PRODUCTS MAY BE LESS THAN ADDITIVE |
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The Combined Carcinogenic Risk for Exposure to Mixtures of Drinking Water Disinfection By-Products May be Less Than Additive
Risk assessment methods for chemical mixtures i...
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THE EFFECTS OF HEAT SHOCK PROTEIN 70 (HSP70) AND EXPOSURE PROTOCOL ON ARSENITE INDUCED GENOTOXICITY |
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The Effects of Heat Shock Protein 70 (Hsp70) and Exposure Protocol on Arsenite Induced Genotoxicity
Barnes, J.A.1,2, Collins, B.W.2, Dix, D.J.3 and Allen J.W2.
1National...
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THE FAILURE OF CHLOROFORM ADMINISTERED IN THE DRINKING WATER TO INDUCE RENAL TUBULAR CELL NEOPLASIA IN MALE F344/N RATS |
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The failure of chloroform administered in drinking water to induce renal tubular cell neoplasia in male F344/N rats
Chloroform (TCM) has been demonstrated to be a renal ...
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THE INDUCTION OF ABERRANT CRYPT FOCI (ACF) IN MALE AND FEMALE F344/N RATS BY BROMOCHLOROACETIC ACID (BCA) ADMINISTERED IN THE DRINKING WATER |
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The Induction of Aberrant Crypt Foci (ACF) in Male and Female F344/N Rats by Bromochloroacetic Acid (BCA) Administered in the Drinking Water.
M.H. George1, D. Delker1, D.R. ...
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THE NEED TO CONTROL ASBESTOS FIBERS IN POTABLE WATER SUPPLY SYSTEMS |
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Occupational studies have shown that asbestos is a human carcinogen. Because many inhaled asbestos fibers deposited in the lung are cleared and swallowed, workers are also exposed ...
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THE REACTIVE OXYGEN SPECIES (ROS) THEORY OF ARSENIC CARCINOGENESIS |
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Arsenic is a human carcinogen in skin, lung, liver, urinary bladder
and kidney. At this time, there is not a scientific consensus on the
mechanisms/modes of a...
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THE REACTIVE OXYGEN SPECIES (ROS) THEORY OF ARSENIC CARCINOGENESIS |
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At this time, there is not a scientific consensus on the mechanisms/modes of action for arsenic carcinogenesis. Proposed mechanisms/modes of action for arsenic carcinogenesis incl...
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THE ROLE OF BIOMETHYLATION IN THE TOXICITY AND CARCINOGENICITY OF ARSENIC. A RESEARCH UPDATE |
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The Role of Biomethylation in the Toxicity and Carcinogenicity of Arsenic. A Research Update
Miroslav Styblo, Zuzana Drobna, Ilona Jaspers, Shan Lin, and David J. Thomas
...
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THE ROLE OF HUMAN GLUTATHIONE S-TRANSFERASES (HGSTS) IN THE DETOXIFICATION OF THE FOOD-DERIVED CARCINOGEN METABOLITE N-ACETOXY-PHIP, AND THE EFFECT OF A POLYMORPHISM IN HGSTA1 ON COLORECTAL CANCER RISK. (R825280) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoi...
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THERMOSPRAY MASS SPECTROMETRY & THERMOSPRAY MS/MS/ OF 2 DEOXYGUANOSINE CARCINOGEN ADDUCTS |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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THERMOSPRAY MASS SPECTROMETRY AND THERMOSPRAY MASS SPECTROMETRY/MASS SPECTROMETRY OF TWO DEOXYGUANOSINE CARCINOGEN ADDUCTS |
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Analysis of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) and N-(deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) by thermospray mass spectrometry (TSP/MS) provided (MH)+ ...
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THYROID FOLLICULAR CELL CARCINOGENESIS: MECHANISTIC AND SCIENCE POLICY CONSIDERATIONS |
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EPA's Guidelines for Carcinogen Risk Assessment call for use of mechanistic and other relevant information in making choices about the models to be used in extrapolating hazard est...
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TISSUE DISPOSITION OF DIMETHYLARSINIC ACID IN THE MOUSE AFTER ACUTE ORAL ADMINISTRATION |
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TISSUE DISPOSITION OF DIMETHYLARSINIC ACID IN THE MOUSE
AFTER ACUTE ORAL ADMINISTRATION
Michael F. Hughes, Ph.D., Brenda C. Edwards, Carol T. Mitchell and Elaina M. Ken...
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TISSUE DISTRIBUTION OF INORGANIC ARSENIC (AS) AND ITS METHYLATED METABOLITES IN MICE FOLLOWING ORAL ADMINISTRATION OF ARSENATE (ASV) |
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TISSUE DISTRIBUTION OF INORGANIC ARSENIC (iAs) AND ITS METHYLATED METABOLITES IN MICE FOLLOWING ORAL ADMINISTRATION OF ARSENATE (AsV). E M Kenyon1, L M Del Razo2, and M F Hughes1....
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TISSUE DOSIMETRY, METABOLISM AND EXCRETION OF PENTAVALENT AND TRIVALENT DIMETHYLATED ARSENIC IN MICE AFTER ORAL ADMINISTRATION |
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Dimethylarsinic acid (DMA(V)) is a rat bladder carcinogen and the major urinary metabolite of inorganic arsenic in most mammals. This study examined the disposition of pentavalent...
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TISSUE-SPECIFIC SISTER CHROMATID EXCHANGE ANALYSES IN MUTAGEN-CARCINOGEN EXPOSED ANIMALS |
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The phenomenon of sister chromatid exchange (SCE) has been extensively reviewed. Sister chromatid exchanges are intrachromosomal events, wherein segments of DNA are reciprocally sw...
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TOXICOLOGICAL REVIEW OF CADMIUM AND COMPOUNDS (EXTERNAL REVIEW DRAFT) |
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The critical effect proposed for both the oral RfD and inhalation RfC is renal dysfunction as judged by minimal proteinuria/enzymuria. This critical effect is evidenced from severa...
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TOXICOLOGICAL REVIEW OF HEXACHLOROCYCLOPENTADIENE [AND IRIS SUMMARY] (EXTERNAL REVIEW DRAFT) |
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Hexachlorocylopentadiene (HCCPD) is a dense oily liquid with a pungent, unpleasant odor. It is an intermediate in the production of compounds used as dyes, resins, pharmaceuticals,...
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TOXICOLOGICAL REVIEW OF QUINOLINE [AND IRIS SUMMARY] (EXTERNAL REVIEW DRAFT) |
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Quinoline can be derived from petroleum, coal processing, production and use facilities, and shale oil. It is used as an intermediate in the production of various compounds and pai...
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TREATMENT OF CHLORINATED VOLATILE ORGANIC COMPOUNDS IN UPFLOW WETLAND MESOCOSMS. (R828773C003) |
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Sorption, biodegradation and hydraulic parameters were determined in the laboratory for two candidate soil substrate mixtures for construction of an upflow treatment wetland for...
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TRENDS OF POLYCYCLIC AROMATIC HYDROCARBON LEVELS AND MUTAGENICITY IN SANTIAGO'S INHALABLE AIRBORNE PARTICLES IN THE PERIOD 1992-1996. |
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Abstract
Trends of polycyclic aromatic hydrocarbons (PAHs) for 1992-1996 (cold season) and their mutagenic activity were investigated in organic extracts from the Santiago....
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TUMOR MULTIPLICITY, DNA ADDUCTS AND K-RAS MUTATION PATTERN OF 5-METHYLCHRYSENE IN STRAIN A/J MOUSE LUNG |
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This study was undertaken to evaluate the carcinogenic potential of 5-methylchrysene (5-MeC) in strain A/J mouse lung and to correlate the mutation spectrum in the K-ras gene of lu...
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TUMORIGENIC EFFECT OF DIMETHYLARSINIC ACID IN THE RAT |
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The development of neoplasms in humans exposed to arsenic in the environment and in industry has been suggested by epidemiological and several recent animal studies. Sodium arsenit...
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TUMORIGENIC EFFECT OF SODIUM ARSENITE IN RAT KIDNEY |
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Exposure of humans to inorganic arsenic has been associated with the development of neoplasms. This has led to the conclusion that arsenic is a carcinogen but this is without subst...
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Tracking the pathway of arsenic metabolism |
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Although the toxic and carcinogenic properties of arsenic have been recognized for centuries, only in the past few decades has research focused on understanding the metabolic fate ...
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U.S. EPA'S METHODOLOGY FOR ASSESSING RISK OF EXPOSURE TO NASAL CARCINOGENS |
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The U.S. Environmental Protection Agency has carried out risk assessments on a variety of chemicals that have been shown to induce nasal tumors in animals and/or humans. Human canc...
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UNDER WHAT CONDITIONS IS TRICHLOROETHYLENE LIKELY TO BE A CARCINOGEN IN HUMANS? |
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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field....
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UNIQUE CHEMISTRY SOLUTIONS TO REGIONAL ISSUES |
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Many of ORD's research projects relate to broad scientific themes, such as biological and chemical indicators or computational toxicology .Others are discrete studies resulting fro...
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UPDATED CARCINOGENICITY ASSESSMENT FOR TETRACHLOROETHYLENE (PERCHLOROETHYLENE, PERC, PCE): ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR TETRACHLOROETHYLENE (PERCHLOROETHYLENE). EXTERNAL REVIEW DRAFT |
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The Office of Health and Environmental Assessment has prepared the addendum to serve as a source document for EPA use. The addendum updates EPA's July 1985 Health Assessment Docume...
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UPDATED MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF CADMIUM: ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT FOR CADMIUM |
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The document evaluates the mutagenicity and carcinogenicity of cadmium, supplementing an earlier document (Health Assessment Document for Cadmium, May 1981) which dealt with all he...
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UPPER-BOUND QUANTITATIVE CANCER RISK ESTIMATES FOR POPULATION ADJACENT TO SULFUR MUSTARD INCINERATION FACILITIES |
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This document characterizes the potential cancer hazard to populations residing near sulfur mustard incineration facilities while the incineration is taking place. he carcinogenici...
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URINARY BIOMARKERS OF DI-ISONONYL PHTHALATE IN RATS |
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Commercial di-isononyl phthalate (DiNP) is a mixture of various branched-chain dialkyl phthalates mainly containing ninecarbon alkyl isomers. At high doses in rodents, DiNP is a ca...
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USE OF CARBON STABLE ISOTOPE FOR THE DECHLORINATION OF TRICHLOROETHYLENE ON GRANULAR-GRAPHITE PACKED ELECTRODES (PRESENTATION) |
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Trichloroethylene (TCE) is widely used as a solvent in metal processing and electronic manufacturing industries, but waste and spilled TCE often results in blocks of non-aqueous li...
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USE OF GENE PROFILING TO DIFFERENTIATE A CARCINOGENIC FROM A NONCARCINOGENIC ALDEHYDE IN THE RAT NOSE |
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Abstract
Formaldehyde (FA) is cytotoxic and is carcinogenic to the rat nasal respiratory epithelium producing tumors after twelve months of exposure. In contrast, glutaraldeh...
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USEFULNESS OF 'CYPRINODON VARIEGATUS' AND 'FUNDULUS GRANDIS' IN CARCINOGENICITY TESTING: ADVANTAGES AND SPECIAL PROBLEMS |
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Cyprinodon variegatus and Fundulus grandis, two species of Cyprinodontid fishes extensively studied and used in toxicological and biological investigations, are reviewed and compar...
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WATER QUALITY AT FIVE MARINAS IN LAKE TEXOMA AS RELATED TO METHYL TERT-BUTYL ETHER (MTBE) |
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Occurrence of methyl tert-butyl ether (MTBE) in five marinas was monitored between June 1999 and November 2000 in Lake Texoma located on the border of Oklahoma and Texas. MTBE is a...
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WATER QUALITY AT FIVE MARINAS IN LAKE TEXOMA AS RELATED TO METHYL TERT-BUTYL ETHER (MTBE): JOURNAL ARTICLE |
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NRMRL-ADA- 02224
An, Y, Kampbell*, D.H., and Sewell*, G.W. WATER QUALITY AT FIVE MARINAS IN LAKE TEXOMA AS RELATED TO METHYL TERT-BUTYL ET...
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WHEN IS THERE ENOUGH EVIDENCE TO PERFORM A NONLINEAR CANCER ASSESSMENT? |
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Under U.S. EPA's Proposed Guidelines for Carcinogen Risk Assessment (FR 61:179670-18011, 199996), departure from the default linear cancer assessment may be made for carcinogens fo...
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WORKSHOP REPORT ON U.S. EPA GUIDELINES FOR CARCINOGEN RISK ASSESSMENT |
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In 1986, EPA issued guidelines for assessing human risk from exposure to environmental carcinogens. The guidelines set forth principles and procedures to guide EPA scientists in th...
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WORKSHOP REPORT ON U.S. EPA GUIDELINES FOR CARCINOGEN RISK ASSESSMENT: USE OF HUMAN EVIDENCE |
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In 1986, EPA issued guidelines for assessing human risk from exposure to environmental carcinogens. The guidelines set forth principles and procedures to guide EPA scientists in th...
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ZEOLITES: EFFECTIVE WATER PURIFIERS |
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Zeolites are known for their adsorption, ion exchange and catalytic properties. Various natural zeolites are used as odor and moisture adsorbents and water softeners. Due to their ...
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