Research Publication Results

This page lists research publications meeting your criteria, organized alphabetically by publication title. Scroll down the list to find the publication for your choice in the alphabetical title listing. Your search has returned 100 Matching Entries . A CONCISE REVIEW OF THE TOXICITY AND CARCINOGENICITY OF DIMETHYLARSINIC ACID Dimethylarsinic acid (DMA) has been used as an herbicide (cacodylic acid) and is the major metabolite formed after exposure to tri- (arsenite) or pentavalent (arsenate) inorganic a... A SENSITIVE IMMUNOFLUORESCENCE ASSAY FOR DETECTION OF P53 PROTEIN ACCUMULATION IN SPUTUM p53 mutations are common genetic alterations in lung cancers and usually result in p53 protein accumulation in tumor cells. Sputum is noninvasive to collect and ideal for screening... AIRBORNE ASBESTOS HEALTH ASSESSMENT UPDATE Recent data from population studies strengthened the association of asbestos with disease. Lung cancer and mesothelioma are the most important asbestos-related causes of death. The... AN UPDATE ON SOME ARSENIC PROJECTS AT THE UNITED STATES ENVIRONMENTAL PROTECTION AGENCY ABSTRACT Exposure to arsenic (As) has been reported to cause many adverse health effects in humans, including internal and skin cancers, vascular, neurological and dermal manifest... APPLICATION OF CDNA MICROARRAY TO THE STUDY OF ARSENIC TOXICOLOGY AND CARCINOGENESIS Arsenic (As) is a common environmental toxicant and known human carcinogen. Epidemiological studies link As exposure to various disorders and cancers. However, the molecular mech... APPLICATION OF PROTEOMIC METHODS TO ARSENIC EXPOSURE RESEARCH Arsenic, an environmental contaminant, is introduced to drinking water through the leaching of soil and the result of anthropogenic sources such as industrial effluents and combust... APPROACHING THE TOXICITY OF DISINFECTION BY-PRODUCTS IN DRINKING WATER AS A MIXTURE PROBLEM Abstract Assessment of human health risk from exposure to disinfection by-products (DBPs) in drinking water is of concern because of the wide spread exposure of persons who u... ASBESTOS IN DRINKING WATER AND CANCER IN THE SAN FRANCISCO BAY AREA: 1969-1974 INCIDENCE The relationship between ingested asbestos (through drinking water) and cancer of various body sites was examined. This study was a follow-up to another article that investigated t... ASBESTOS IN DRINKING WATER AND CANCER INCIDENCE IN THE SAN FRANCISCO BAY AREA Age-adjusted, sex- and race-specific 1969-1971 cancer incidence ratios for the 722 census tracts of the San Francisco-Oakland Standard Metropolitan Statistical Area were compared w... ASSIGNED SHARES IN COMPENSATION FOR RADIATION-RELATED CANCERS The preparation of radioepidemiologic tables requires extensive mathematical modeling because matters such as sex, size of dose, age at exposure, type of cancer, and age at diagnos... ASSOCIATION BETWEEN CANCER MORTALITY AND WHEAT ACREAGE AS A SURROGATE FOR CHLOROPHENOXY HERBICIDES IN COUNTIES OF OUR NORTHERN STATES Chlorophenoxy herbicides which have endocrine disrupting properties, are used widely both in cereal grain agriculture and in non-agricultural settings, such as right-of-ways, lawns... BROMODICHLOROMETHANE TOXICOKINETICS: LINKING METABOLISM TO EFFECT Bromodichloromethane (BDCM), a trihalomethane (THM), is among the most prevalent disinfection byproducts found in chlorinated drinking water. Weak associations between THM expo... CANCER AND DEVELOPMENTAL EXPOSURE TO ENDOCRINE DISRUPTORS ABSTRACT Developing organisms have been shown to have increased susceptibility to cancer if exposed to environmental toxicants during rapid growth and differentiation. Human ... CANCER INCIDENCE IN THE AGRICULTURAL HEALTH STUDY The Agricultural Health Study (AHS) was undertaken to ascertain the etiology of cancers observed to be elevated in agricultural populations. Methods: The AHS is a large prospectiv... CANCER INCIDENCE IN THE AGRICULTURAL HEALTH STUDY Despite low mortality and cancer incidence rates overall, farmers may experience excess risk of several cancers. These excesses have been observed in some, but not all, retrospe... CANCER MORBIDITY INVESTIGATIONS: LESSONS FROM THE DULUTH STUDY OF POSSIBLE EFFECTS OF ASBESTOS IN DRINKING WATER In 1973, 1 to 30 million asbestos-like fibers per liter of tap water were discovered in Duluth drinking water. Previous studies had linked mesothelioma, lung, and gastrointestinal ... CANCER MORTALITY AMONG UNITED STATES COUNTIES WITH HAZARDOUS WASTE SITES AND SOLE SOURCE DRINKING WATER CONTAMINATION Since the late 1950's more than 750 million tons of toxic wastes have been discarded in an estimated 30,000 to 50,000 hazardous waste sies (HWS). he uncontrolled discarding of chem... CANCER MORTALITY IN FOUR NORTHERN WHEAT PRODUCING STATES Chlorophenoxy herbicides are used both in cereal grain agriculture and in nonagricultural settings such as right-of-ways, lawns, and parks. Minnesota, North Dakota, South Dakota, a... CANCER RISK ASSESSMENT AND PREVENTION: WHERE DO WE STAND? This paper reviews selected aspects of progress and setbacks in cancer risk assessment and prevention during the four decades since the founding in 1947 of the Institute of Environ... CARCINOGENIC EFFECTS OF LOW DOSES OF IONIZING RADIATION Carcinogenic Effects of Low Doses of Ionizing Radiation R Julian Preston, Environmental Carcinogenesis Division, NHEERL, U.S. Environmental Protection Agency, Research Trian... CASE-CONTROL CANCER MORTALITY STUDY AND CHLORINATION OF DRINKING WATER IN LOUISIANA Several Louisiana parished (counties) using the Mississippi River for their source of public drinking water have the highest mortality rates (1950-69) in the United States for seve... CAUSES OF MORTALITY IN AN ARSENIC-AFFECTED AREAS OF INNER MONGOLIA, CHINA Introduction Shahai is a village in Inner Mongolia, China. In the early 1980s, the primary source of drinking water shifted away from large shallow wells to deeper artesian ... CHAPEL HILL BISPHENOL A EXPERT PANEL CONSENSUS STATEMENT:INTEGRATION OF MECHANISMS, EFFECTS IN ANIMALS AND POTENTIAL TO IMPACT HUMAN HEALTH AT CURRENT LEVELS OF EXPOSURE This document is a summary statement of the outcome from the meeting: “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assess... CHEMICAL AND RADIATION LEUKEMOGENESIS IN HUMANS AND RODENTS AND THE VALUE OF RODENT MODELS FOR ASSESSING RISKS OF LYMPHOHEMATOPOIETIC CANCERS This report is intended to provide an up-to-date overview of the lymphoid and hematopoietic diseases induced in humans and rodents following exposure to chemical agents. It include... CHEMICAL ENHANCEMENT OF VIRAL TRANSFORMATION IN SYRIAN HAMSTER EMBRYO CELLS BY GASEOUS AND VOLATILE CHLORINATED METHANES AND ETHANES Methods were developed for exposing cells in vitro to gases or vapors of volatilized organic liquids. Compounds were selected for their industrial importance, environmental impact,... CHILDREN AS A SENSITIVE SUBPOPULATION FOR THE RISK ASSESSMENT PROCESS Children as a sensitive subpopulation for the risk assessment process Abstract For cancer risk assessment purposes, it is necessary to consider how to incorporate sensitive s... CIGARETTE SMOKE AND LUNG CANCER Cigarette smoke has been implicated in a causal relationship with carcinoma of the lung. An intriguing feature of the disease is the site-selectivity with which bronchogenic cancer... CONCEPT OF ACTIVITY PROFILES OF ANTIMUTAGENS Experimental evidence suggests that chemical mutagenesis and carcinogenesis are related phenomena such that identification of causative agents and protection from exposure might pr... CONSEQUENCES OF ACUTE AND CHRONIC EXPOSURE TO ARSENIC Arsenic is a toxic chemical and may cause adverse health effects in children and adults. It is known to affect the nervous, gastrointestinal, and hematological systems and cause sk... CONSISTENT ONCOGENE METHYLATION CHANGES IN EPITHELIAL CELLS CHEMICALLY TRANSFORMED IN VITRO Many cancers occurring in humans and In animals are accompanied by alterations in oncogene DNA secluences, amplification, or changes in expression (1,2). In some cases the changes ... CONTROL OF ALKALINE PHOSPHATASE ACTIVITY IN C3H10T1/2 CELLS: ROLE OF RETINOIC ACID AND CELL DENSITY The enzyme alkaline phosphatase (AP) has been shown to be lost or inappropriately expressed during carcinogenesis in some tissues. ecause retinoic acid (RA) appears to play a role ... DELETION MUTATIONS IN THE HPRT GENE OF T-LYMPHOCYTES AS A BIOMARKER FOR GENOMIC REARRANGEMENTS IMPORTANT IN HUMAN CANCERS The DNA sequence of 11 in vivo-arising intragenic deletion breaksite junctions occurring in the hypoxanthine guanine phosphoribosyltransferase gene of human T-lymphocytes was deter... DEVELOPMENT OF ULTRATRACE LASER SPECTROMETRY TECHNIQUES FOR MEASUREMENTS OF ARSENIC Development of Arsenic Speciation Techniques Based on High Performance Liquid Chromatography and Atomic Fluorescence Spectrometry J.B. Simeonsson, H.D. Beach and D.J. Th... DIFFERENTIAL ACTIVATION OF AP-1 IN HUMAN BLADDER EPITHELIAL CELLS BY INORGANIC AND METHYLATED ARSENICALS Differential Activation of AP-1 in Human Bladder Epithelial Cells by Inorganic and Methylated Arsenicals Zuzana Drobna, Ilona Jaspers, David J. Thomas, and Miroslav Styblo DISINFECTION BY-PRODUCTS AND OTHER EMERGING CONTAMINANTS IN DRINKING WATER Although drinking water disinfection by-products (DBPs) have been studied for the last 30 years, significant, new concerns have arisen. These concerns include adverse reproductive... DOES RESPONSE EVALUATION OF GENE EXPRESSION PROFILES IN THE SKIN OF K6/ODC MICE EXPOSED TO SODIUM ARSENITE Abstract - Chronic drinking water exposure to inorganic arsenic and its metabolites increases tumor frequency in the skin of K6/ODC transgenic mice. To identify potential biomarke... DRINKING WATER AND CANCER INCIDENCE IN IOWA. 1. TRENDS AND INCIDENCE BY SOURCE OF DRINKING WATER AND SIZE OF MUNICIPALITY The available data resources in the State of Iowa were used to investigate the relationships of drinking water contaminants and cancer incidence rates for communities. Age-adjusted... DRINKING WATER AND CANCER INCIDENCE IN IOWA. 2. RADIOACTIVITY IN DRINKING WATER This paper presents a logical epidemiologic exploration into possible associations between exposures to radium-226 in drinking water and incidence rates for cancers of the bladder,... DRINKING WATER AND CANCER INCIDENCE IN IOWA. 3. ASSOCIATION OF CANCER WITH INDICES OF CONTAMINATION With data from the Iowa Cancer Registry, age-adjusted sex-specific cancer incidence rates for the years 1969-1981 were determined for towns with a population of 1,000-10,000 and a ... DRINKING WATER AND CANCER MORTALITY The problem of understanding the possible adverse health effects of organic chemical contaminants in drinking water is not new, but national concern has intensified in recent years... DRINKING WATER ISSUES According to recent reports by the California Department of Health Services, the State of Maine, and the United State Geological Survey (USGS); the fuel oxygenate methyl teri-butyl... EFFECT OF ARSENICALS ON CELL CYCLE DISTRIBUTION AND EXPRESSION OF CELL CYCLE PROTEINS IN HUMAN PRIMARY KERATINOCYTES Environmental exposure to arsenic is a major public health concern. Epidemiological studies have demonstrated a strong correlation between levels of arsenic in drinking water and i... EFFECT OF ARSENICALS ON THE EXPRESSION OF CELL CYCLE PROTEINS AND EARLY SIGNALING EVENTS IN PRIMARY HUMAN KERATINOCYTES. Effect of Arsenicals on the Expression of Cell Cycle Proteins and Early Signaling Events in Primary Human Keratinocytes. Mudipalli, A, Owen R. D. and R. J. Preston, Environm... EIGHTH ASPEN CANCER CONFERENCE: MOLECULAR MECHANISMS OF TOXICITY IN RELATION TO THE GENETICS OF ANIMAL AND HUMAN NEOPLASIA Cancers arise as a consequence of the interactions between environmental factors and specific genes. he environmental factors range from the ubiquitous, such as sunlight, to the hi... EPIDEMIOLOGY STUDY OF THE USE OF ASBESTOS-CEMENT PIPE FOR THE DISTRIBUTION OF DRINKING WATER IN ESCAMBIA COUNTY, FLORIDA Cancer mortality for the population census tracts of Escambia County, Florida, using asbestos-cement (A/C) pipe for public potable water distribution was compared with cancer morta... EVALUATION OF THE CARCINOGENICITY OF UNLEADED GASOLINE In the document the likelihood that unleaded gasoline vapors are carcinogenic to humans is evaluated. From carcinogenicity data in animals, an estimate is made of the magnitude of ... EVALUATION OF THE METHODS USED TO DETERMINE POTENTIAL HEALTH RISKS ASSOCIATED WITH ORGANIC CONTAMINANTS IN THE GREAT LAKES BASIN These results suggest that 'lake-bordering' populations (i.e., white populations) experience higher rates of mortality due to stomach and esophageal cancers as compared to 'non-lak... EVIDENCE FOR BROMODICHLOROMETHANE METABOLISM BY CYTOCHROME P-450 1A2 EVIDENCE FOR BROMODICHLOROMETHANE METABOLISM BY CYTOCHROME P-450 1A2. T M Ross1, B P Anderson1, G Zhao2, R A Pegram1 and J W Allis1. 1U.S. EPA, ORD, NHEERL, Research Triangle Par... EXCESS CANCER MORTALITY IN AGRICULTURAL REGIONS OF MINNESOTA Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); ... EXPRESSION OF INDUCIBLE HSP70 ENHANCES THE PROLIFERATION OF MCF-7 BREAST CANCER CELLS AND PROTECTS AGAINST THE CYTOTOXIC EFFECTS OF HYPERTHERMIA Heat shock proteins (HSPs) are ubiquitous proteins that are induced following exposure to sub-lethal heat shock, are highly conserved during evolution and protect cells from damage... FEDERAL REGULATIONS RELEVANT TO ASBESTOS POLLUTION CONTROL Health effects and epidemiological studies have established that breathing asbestos fibers can cause asbestosis, lung and other organ cancers, and mesothelioma. This has led to pub... FOLATE DEFICIENCY ENHANCES ARSENIC EFFECTS ON EXPRESSION OF GENES INVOLVED IN EPIDERMAL DIFFERENTIATION Chronic arsenic exposure in humans is associated with cancers of the skin, lung, and bladder. There is evidence that folate deficiency may increase susceptibility to arsenic¿s effe... HEALTH ASSESSMENT DOCUMENT FOR PHOSGENE. EXTERNAL REVIEW DRAFT Phosgene is primarily manufactured for the synthesis of isocyanate-based polymers, carbonic acid esters, and acid chlorides. Ambient and indoor air concentrations of phosgene are p... IDENTIFICATION OF DRINKING WATER CONTAMINANTS IN THE COURSE OF A CHILDHOOD CANCER INVESTIGATION IN TOMS RIVER, NEW JERSEY Using a combination of gas chromatography/mass spectrometry (GC/MS) and gas chromatography/infrared spectroscopy (GC/IR) spectroscopic techniques, chemical contaminants and their h... IDENTIFICATION OF THE ROLE OF APOPTOSIS PATHWAYS POTENTIALLY INVOLVED IN FORMALDEHYDE-INDUCED CARCINOGENESIS USING CDNA ARRAYS Identification of the Role of Apoptosis Pathways Potentially Involved in Formaldehyde- Induced Carcinogenesis Using cDNA Arrays. Formaldehyde (FA) is a genotoxic chemical fo... INDUCED AND SPONTANEOUS NEOPLASIA IN ZEBRAFISH. To address the potential of zebrafish as a cancer model, it is important to determine the susceptibility of zebrafish to tumors, and to compare zebrafish tumors with human tumors. ... INDUCTION OF CELL PROLIFERATION AND APOPTOSIS IN HL60 AND HACAT CELLS BY ARSENIC, ARSENATE, AND ARSENIC-CONTAMINATED DRINKING WATER Induction of cell proliferation and apoptosis in HL-60 and HaCaT cells by arsenite, arsenate and arsenic-contaminated drinking water. T-C. Zhang, M. Schmitt, J. L. Mumford National... INDUCTION OF TRANSTITIONAL CELL HYPERPLASIA IN THE URINARY BLADDER AND ABERRANT CRYPT FOCI IN THE COLON OF RATS TREATED WITH INDIVIDUAL AND A MIXTURE OF DRINKING WATER DISINFECTION BY-PRODUCTS ABSTRACT Cancer of the urinary bladder and colon are significant human health concerns. Epidemiological studies have suggested a correlation between these cancers and the... INFLUENCE OF SODIUM ARSENITE ON GAP JUNCTION COMMUNICATION IN RAT LIVER EPITHELIAL CELLS Influence of sodium arsenite on gap junction communication in rat-Iiver epitheiial cells. Arsenic is known to cause certain types of cancers, hepatitis, cirrhosis and neuro... INTERSPECIES SENSITIVITY TO CHEMICAL CARCINOGENS: RELATIONSHIPS BETWEEN MOUSE SKIN TUMORS AND HUMAN LUNG CANCER This review focuses on the relationships between mouse skin tumors and human lung cancer and discusses these relationships from several perspectives. hese perspectives include: mou... INVESTIGATIONS INTO AGE-RELATED SUSCEPTIBILITY TO ARSENIC CARCONOGENICITY Environmental Issue. Arsenic compounds are ubiquitous throughout the environment and are a major health problem in many parts of the world. Human exposure to arsenic has been ident... IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR CHLOROETHANE (EXTERNAL REVIEW DRAFT) Chloroethane (CE) is a gaseous halohydrocarbon under ambient conditions. Its uses include: a topical analgesic, an anesthetic when mixed with nitrous dioxide or trichloroethane, a ... IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR FORMALDEHYDE Formaldehyde (HCHO) is a pungent and irritating gas with extensive uses in industrial processes and manufacturing of consumer products. Both natural and anthropogenic mechanisms r... LNT IS THE BEST WE CAN DO - TO-DAY Abstract The form of the dose-response curve for radiation-induced cancers, particularly at low doses, is the subject of an ongoing and spirited debate. The present review d... MATHEMATICAL MODEL OF STEROIDOGENESIS: MOLECULAR RESPONSE TO ENDOCRINE DISRUPTOR EXPOSURES. Scientists have identified alterations in the concentration dynamics of specific hormones at risk factors for common cancers such as breast cancer, endometrial cancer, and prostate... MEETING AT CAMBRIDGE, MA: GENE EXPRESSION IN NORMAL HUMAN KERATINOCYTES MODULATED BY TRIVALENT ARSENICALS Arsenic exposure has been correlated with the development of several human cancers including those found in the skin, lung, liver, kidney and urinary bladder. Humans are generally... MEETING AT SAN DIEGO, CA: GENE EXPRESSION IN NORMAL HUMAN KERATINOCYTES MODULATED BY TRIVALENT ARSENICALS Arsenic exposure has been correlated with the development of several human cancers including those found in the skin, lung, liver, kidney and urinary bladder. Humans are generally ... METHYLATION OF ARSENITE BY SOME MAMMALIAN CELL LINES THIS ABSTRACT WAS SUBMITTED ELECTRONICALLY;. SPACE CONSTRAINTS WERE SEVERE) Methylation of Arsenite by Some Mammalian Cell Lines. Methylation of arsenite is thought... MODELING ACUTE EXPOSURE TO SOLAR RADIATION One of the major technical challenges in calculating solar flux on the human form has been the complexity of the surface geometry (i.e., the surface normal vis a vis the incident... MODELING THE ANATOMICAL DISTRIBUTION OF SUNLIGHT One of the major technical challenges in calculating solar irradiance on the human form has been the complexity of the surface geometry (i.e. the surface normal vis a vis the incid... MORTALITY AMONG FARMERS AND SPOUSES IN THE AGRICULTURAL HEALTH STUDY In the Agricultural Health Study we evaluated the mortality experience of 52,395 farmers and 32,347 of their spouses in Iowa and North Carolina obtain information on cancer and o... MORTALITY AMONG PARTICIPANTS IN THE AGRICULTURAL HEALTH STUDY Purpose: This analysis of the Agricultural Health Study cohort assesses the mortality experience of licensed pesticide applicators and their spouses. Methods: This report i... Monitoring of Microbes in Drinking Water Internationally there is a move towards managing the provision of safe drinking water by direct assessment of the performance of key pathogen barriers (critical control points), ra... NITROBENZENE CARCINOGENICITY Nitrobenzene (NB, CAS No. 98-95-3) oxidizes to p-aminophenol and p-nitrophenol in animals and humans, while being reduced also to nitrosobenzene, phenylhydroxylamine, and aniline. ... OBSERVATIONS OF CANCER INCIDENCE SURVEILLANCE IN DULUTH, MINNESOTA In 1973, amphibole asbestos fibers were discovered in the municipal water supply of Duluth, Minnesota. The entire city population of approximately 100,000 was exposed during the la... P450 AND METABOLISM IN TOXICOLOGY The cytochromes P450 catalyze the initial phase of detoxification of many environmental chemicals, xenobiotic, drugs and the secondary metabolic product of plants. Plant secondary ... P450 GENETIC VARIATION: IMPLICATIONS FOR ENVIRONMENTAL AND WORKPLACE EXPOSURE The Cytochrome P450 array detoxifies many chemicals by catalyzing the conversion of mostly hydrophobic chemicals into more hydrophilic forms that can subsequently be excreted by th... POTENTIAL ALTERATIONS IN GENE EXPRESSION ASSOCIATED WITH CARCINOGEN EXPOSURE IN MYA ARENARIA Gonadal cancers in soft-shell clams (Mya arenaria) have been found at high prevalences (20-40%) in populations in eastern Maine. The aetiology of these tumours is unknown. We hypot... PRACTICAL CONSIDERATIONS FOR APPROXIMATING RELATIVE RISK BY THE STANDARDIZED MORTALITY RATIO The standardized mortality ratio is a widely used and often criticized summary statistic for studies of occupational mortality. In the paper the authors discuss practical condition... PROFILES OF GENE EXPRESSION ASSOCIATED WITH TETRACYCLINE OVER EXPRESSION OF HSP70 IN MCF-7 BREAST CANCER CELLS Profiles of gene expression associated with tetracycline over expression of HSP70 in MCF-7 breast cancer cells. Heat shock proteins (HSPs) protect cells from damage through... PROTEOMIC PROFILING OF CULTURED HUMAN BLADDER CELLS AFTER TRIVALENT ARSENICAL EXPOSURES Chronic exposure to arsenic has been associated with human cancers of the bladder, kidney, lung, liver, and skin. Inorganic arsenic is biotransformed in a stepwise manner via both ... PROTEOMIC PROFILING OF CULTURED HUMAN BLADDER CELLS AFTER TRIVALENT ARSENICAL EXPOSURES (SOT 2008) Chronic exposure to arsenic has been associated with human cancers of the bladder, kidney, lung, liver, and skin. Inorganic arsenic is biotransformed in a stepwise manner via both ... Proteomic Analysis of Arsenic-Induced Oxidative Stress in Human Epidermal Keratinocytes Chronic exposure to inorganic arsenic (IAs) has been associated with the development of several human cancers, including those found in the skin, lung, urinary bladder, liver, pros... QUANTITATIVE EVALUATION OF BROMODICHLOROMETHANE METABOLISM BY RECOMBINANT RAT AND HUMAN CYTOCHROME P450S ABSTRACT We report quantitative estimates of the parameters for metabolism of bromodichloromethane (BDCM) by recombinant preparations of hepatic cytochrome P450s (CYPs) from rat... RECOMBINANT RAT CYT19, AN ARSENIC METHYLTRANSFERASE, EFFICIENTLY GENERATES TRIMETHYLARSINE OXIDE IN THE ABSENCE OF GLUTATHIONE Chronic exposure to inorganic arsenic (iAs), a toxic metalloid sometimes present in drinking water, is associated with increased prevalences of various cancers and other disorders.... RESEARCH INVESTIGATIONS ON THE PROTEOME: 1. MECHANISMS OF REGULATING PROTEIN SYNTHESIS, AND 2. GLOBAL CHARACTERIZATION OF PROTEOMIC RESPONSES TO ARSENIC EXPOSURES Eukaryotic Elongation Factor 2 (eEF2) mediates translocation in protein synthesis. eEF2 is modified by two post-translational modifications: the phosphorylation of Thr57 in the G d... SPECIAL REPORT ON INGESTED INORGANIC ARSENIC: SKIN CANCER; NUTRITIONAL ESSENTIALITY A Technical Panel of the U.S. Environmental Protection Agency's Risk Assessment Forum has studied three special issues regarding certain health effects, particularly skin cancer, a... SPECIAL REPORT ON INGESTED INORGANIC ARSENIC: SKIN CANCER; NUTRITIONAL ESSENTIALITY (SAB REVIEW DRAFT) A technical panel of EPA's Risk Assessment Forum has studied three special issues regarding certain health effects, particularly skin cancer, associated with arsenic ingestion: (1)... STABLE VARIANTS OF SPERM ANEUPLOIDY AMONG HEALTHY MEN SHOW ASSOCIATIONS BETWEEN GERMINAL AND SOMATIC ANEUPLOIDY Abstract. Our objective was to identify men who consistently produced high frequencies of sperm with numerical chromosomal abnormalities (stable variants) and to determine w... STRATOSPHERIC OZONE DEPLETION: A FOCUS ON EPA'S RESEARCH (EPA/640/K-95/004) This brochure describes the mechanisms of and problems associated with stratospheric ozone depletion as well as some of the Office of Research and Development's (ORD) associated re... THE EPIDEMIOLOGY OF CHEMICAL CONTAMINANTS OF DRINKING WATER A number of chemical contaminants have been identified in drinking water. These contaminants reach drinking water supplies from various sources, including municipal and i... THE USE OF STEM CELLS FOR TOXICOLOGY STUDIES AND RISK ASSESSMENTS In general terms, toxicology studies are used in support of risk assessments of adverse health outcomes as a result of exposures to chemical and physical agents. In particular, tox... TRACKING DOWN REPRODUCTIVE HEALTH RISKS FOR HUMANS EXPOSED TO ENVIRONMENTAL CONTAMINANTS Government agencies charged with protecting public health are concerned about the same things you are: being able to conceive and deliver healthy babies, and watching them grow up ... TRIBROMOMETHANE EXPOSURE AND DIETARY FOLATE DEFICIENCY IN THE FORMATION OF ABERRANT CRYPT FOCI IN THE COLONS OF F344/N RATS TRIBROMOMETHANE EXPOSURE AND DIETARY FOLATE DEFICIENCY IN THE FORMATION OF ABERRANT CRYPT FOCI IN THE COLONS OF F344/N RATS David R. Geter', Tanya M. Moore', Michael H. Geor... U.S. CANCER DEATH COUNTS 1950-1979 The tape contains death counts by five year age groups ending with age 85 and older by county, state and the U.S., by race-sex (white/non-white for male, female) for 35 groupings o... U.S. CANCER MORTALITY RATES AND TRENDS 1950-1979 The report contains cancer mortality rates and changes in rates for counties of the United States for 1950-1959, 1960-1969, and 1970-1979. This report includes the number of deaths... UNRECOGNIZED OR POTENTIAL RISK FACTORS FOR CHILDHOOD CANCER Traditional epidemiological studies suggest that the contribution of environmental agents to childhood cancer may be minor. However, epidemiological methods can only seldom identif... USE OF THE SPONTANEOUS TSC2 KNOCKOUT (EKER) RAT MODEL OF HEREDITARY RENAL CELL CARCINOMA FOR THE STUDY OF RENAL CARCINOGENS The kidney is a frequent site for chemically induced cancers in rodents and among the ten most frequent sites for cancer in human patients. Renal cell carcinoma (RCC) is the most ... USING PROTEOMICS TO MONITOR PROTEIN EXPRESSION IN HUMAN CELLS EXPOSED TO CARCINOGENS People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic properties in experimental systems. It has been estimated that... WASTE CRANKCASE OIL HEATER STUDY: PHASE 2. ORGANIC AND INORGANIC SPECIATION ANALYSES The report gives results of measurements of specific chemical species in emissions from two waste-oil-fired commercial heaters. The species were identified earlier in a Level 1 ana...

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