Laboratory Information:
UCLA - Laboratory of Structural Biology and Molecular Medicine
P.O. Box 951570
Los Angeles, CA 90095-1570
Phone: 310-825-3754
Fax: 310-206-3914
Email: david@mbi.ucla.edu
Website: http://www.doe-mbi.ucla.edu/
Technology Transfer Website: http://www.research.ucla.edu/oipa/
Agency/Department: Dept. of Energy
Region: Far West
FLC Laboratory Representative:
Dr. David Eisenberg
Phone: 310-825-3754
Fax: 310-206-3914
Email: david@mbi.ucla.edu
Background/History of the Laboratory:
The Laboratory of Structural Biology and Molecular Medicine is an Organized Research unit at the University of California, Los Angeles. Core funding and oversight is provided by the Department of Energy. Programs include: 1. the use of Positron emission tomography for studying basic processes in disease and health, especially in neurological and cardiovascular areas, 2. basic cellular biology concerned with gene expression and the earliest molecular events associated with cancer induction, and 3. the physiological ecology of arid region plants. Collaborative research with other agencies and organizations is fostered by the Laboratory.
Mission of the Laboratory:
The missions of the Laboratory of Structural Biology and Molecular Medicine are:
the partnering of structural and computation biology in the determination of folds for proteins in genomes, and the analysis of function and interactions from genome sequences; the development of molecular nuclear medicine, including new diagnostic biological imaging procedures and their relationship to drug therapies to improve the quality of life.
Technology Transfer Mechanisms:
- Cooperative Research and Development Agreements (CRADAs)
- Facility Sharing
- Commercial Outreach
- Educational Outreach
- Workshops
- Interaction through Computer Networks
Technology Areas of Expertise:
- Algorithms for inverted and direct protein folding
- Gene expression processes imaging
- Human Genome
- Human subject protection
- Imaging reporter gene expression in vivo
- Merger of PET and MRI into a single imaging technology
- Merging Biology, Biotechnology, and Advanced Imaging Technologies with Drug Design
- Miniaturization of PET technology
- Molecular biology with advanced imaging methods
- Molecular nuclear medicine
- Protein (and RNA and DNA) structures
- X-ray and NMR structural efforts
